检索结果-南通市图书馆

Effect of calcium supplementation on severe hypocalcemia in patients with secondary hyperparathyroidism after total parathyroidectomy

引用

World Journal of Clinical Cases 2022年第13期10卷 4033-4041页

作者： Jun Liu xue-feng fan Meng Yang Lin-Ping Huang Ling Zhang Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of General Surgery Shougang General HospitalShougang 553000Guizhou ProvinceChina Department of Nephrology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Severe hypocalcemia(SH)is a dreaded complication of total parathyroidectomy(TPTX)without *** To compare conventional and preventive calcium supplementation(CS)regimens in terms of SH occurrence after *** This retrospective study included patients who underwent TPTX between January 2015 and May 2018 at the China-Japan Friendship *** January 2015 to May 2016,conventional CS was performed in patients who underwent TPTX,with calcium amounts adjusted according to postoperative serum calcium *** October 2016 to May 2018,preventive CS was performed according to preoperative alkaline phosphatase(ALP)*** patients were defined as lowrisk(ALP500 U/L)for *** preoperative blood samples were collected in the fasting state on the day before *** blood samples were obtained at 6-7 AM from the first postoperative *** A total of 271 patients were *** patients were 47.7±11.1 years old,and 57.6%were *** mean body mass index(BMI)was 22.9±3.8 kg/m^(2).There were no significant differences in sex,age,BMI,preoperative ALP,serum calcium,serum phosphorus,calcium-phosphorus ratio,and intact parathyroid hormone(iPTH)between the two CS *** with conventional CS,preventive CS led to lower occurrence rates of hypocalcemia within 48 h(46.0%vs 74.5%,P<0.001)and SH(31.7%vs 64.1%,P<0.001).Multivariable analysis showed that preoperative iPTH levelsodds ratio(OR)=1.001,95%confidence interval(CI:1.000-1.001,P=0.009),preoperative ALP amounts(OR=1.002,95%CI:1.001-1.003,P=0.002),preoperative serum phosphorus levels(OR=8.729,95%CI:1.518-50.216,P=0.015)and preventive CS(OR=0.132,95%CI:0.067-0.261,P<0.001)were independently associated with *** patients with preoperative ALP≥500 U/L,only preventive CS(OR=0.147,95%CI:0.038-0.562.P=0.005)was independently associated with *** This study suggests that preventive CS could reduce the occurrence of SH,indica

关键词： End-stage renal disease Secondary hyperparathyroidism Parathyroidectomy Hypocalcemia Calcium supplementation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide analysis of OCT4 binding sites in glioblastoma cancer cells

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 812-819页

作者： xue-feng fan Wei-yi ZHANG Na ZHAO Wei YU Dong DING Xu HONG Li-sha LI Hua-rong ZHANG Shu ZHENG Biao-yang LIN Key Laboratory of Cancer Prevention and Intervention of Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences of Zhefiang Province Cancer Institute the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Systems Biology Div＆ion Zhejiang-California International Nanosystems Institute （ZCNI） Zhejiang University Hangzhou 310029 China

OCT4, a member of the POU family of gene products, is an octamer motif-binding transcription factor. As it is known to play a crucial role in cancer processes including proliferation, invasion, and chemoradioresistance, it is important to identify the direct targets of OCT4 in living cancer cells. Here, chromatin immunoprecipitation-sequencing （ChlP-seq） was used to identify OCT4 binding sites in glioblastoma cancer cells. The results showed that 5438 OCT4 binding sites were localized in the glioblastoma cancer genome and that these sites contained a consensus sequence TTTkswTw （k=T or G, s=C or G, w=A or T）, which occurred 3931 times in 2312 OCT4 binding regions. Furthermore, binding motifs of some other transcription factors were identified in OCT4 binding regions. Our results provide a valuable dataset for understanding gene regulation mechanisms underlying the function of OCT4 in glioblastoma cancer.

关键词： OCT4 Chromatin immunoprecipitation-sequencing (ChlP-seq) DNA binding region Glioblastoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Celecoxib plays a multiple role to peripheral blood lymphocytes and anografts in acute rejection in rats after cardiac transplantation

引用

Chinese Medical Journal 2009年第2期122卷 188-192页

作者： ZHANG xue-feng ZHANG fan LIU Hong-yu SUN Guo-dong LIU Zong-hong LU Hang CHI Chao LI Chun-yu Department of Cardiac Surgery the First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background Celecoxib, a selective cyclooxygenase-2 （COX-2） inhibitor, is a non-steroidal anti-inflammatory drug used as an adjuvant to sensitize cancer cells to apoptosis. However, in rats suffering from acute rejection, celecoxib reduced apoptosis of myocardial cells. We hypothesize that celecoxib reduces myocardial apoptosis either by inducing apoptosis in peripheral blood lymphocytes （PBLs） or by altering the percentage of CD4~ and CD8~ lymphocytes. Methods After cardiac transplantation, rats were administered intragastrically with celecoxib （50 mg/kg per day） for 3, 5 or 7 days, at which time the graft was excised and evaluated for organ rejection. In addition, PBLs were isolated from the blood to determine PBLs apoptosis, and the percentage of CD4＋ and CD8＋ lymphocytes. Results Celecoxib induced PBLs apoptosis in 3 days, but protected the cells from apoptosis at 5 and 7 days. Also, the percentage of CD4＋ lymphocytes decreased only at 3 days, but a reduction in the percentage of CD8＋ lymphocytes was not seen until 7 days after the transplant surgery. Celecoxib only decreased acute rejection at 5 days, with no discernible difference in rejection after 3 and 7 days. Conclusions The results suggested that celecoxib displayed a multiple physiological function in a time-dependent manner. Chin Med J 2009; 122（2）： 188-192

关键词： celecoxib mitochondria apoptosis transplantation, heart

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

引用

Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of a Carbon Fibre-steel Fibre-graphite Conductive Filler on the Electrothermal Properties of Cementitious Materials

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 141-151页

作者： fan Yanan WEI Hong ZHENG Hongyong DU Hongxiu Department of Architecture and Environmental Engineering Taiyuan UniversityTaiyuan 030032China College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030032China

Carbon fibre,steel fibre and graphite were used as conductive fillers to prepare cementitious materials with excellent electrothermal *** electrically conductive cementitious materials with different volume dosages were analysed through compressive and flexural strength,electrochemical impedance spectroscopy and temperature rise *** equivalent circuit model was established to study the electrically conductive heat generation mechanism in the electrically conductive cementitious *** results indicate that the mechanical properties of cementitious composite materials with a ternary conductive phase are better than those of pristine cementitious materials because the fibrous filler improves their mechanical ***,the incorporation of graphite in the material reduces its *** fibrous and point-like conductive phase materials into the cementitious material enhances the overall conductive pathway and considerably reduces the electrical resistance of the cementitious material,enhancing its conductive *** volume ratios of carbon fibre,steel fibre and graphite that achieve an optimal complex doping in the cementitious material were 0.35%,0.6%and 6%,*** was determined using the mutation point of each circuit element parameter as the percolation *** addition,at a certain safety voltage,there is a uniform change between the internal and surface temperatures of the conductive cementitious material,and the heating effect in this materialis is considerably better than that in the pristine cementitious material.

关键词： cementitious composites conductive fillers electrothermal properties electrochemical impedance spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopy-assisted lightweight diagnosis system based on transformers for colon polyp detection

引用

Optoelectronics Letters 2025年第1期21卷 57-64页

作者： fan Weiming YU Jiahui JU Zhaojie School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University School of Computing University of Portsmouth

The integration of endoscopy has significantly propelled the diagnosis and treatment of gastrointestinal diseases, with colonoscopy establishing itself as the primary method for early diagnosis and preventive care in colorectal cancer(CRC). Although deep learning holds promise in mitigating missed polyp rates, modern endoscopy examinations pose additional challenges, such as image blurring and atomizing. This study explores lightweight yet powerful attention mechanisms, introducing the spatial-channel transformer(SCT), an innovative approach that leverages spatial channel relationships for attention weight calculation. The method utilizes rotation operations for inter-dimensional dependencies, followed by residual transformation, encoding inter-channel and spatial information with minimal computational overhead. Extensive experiments on the CVC-Clinic DB polyp detection dataset, addressing endoscopy pitfalls, underscore the superiority of our SCT over other state-of-the-art methods. The proposed model maintains high performance, even in challenging scenarios.

关键词： Endoscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

引用

Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin feng Min Liu fan Zheng Shuang Huang Yanpeng fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Macro-mechanics and Microstructure of Nanomaterial-modified Geopolymer Concrete: A Comprehensive Review

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 204-214页

作者： WANG Tao fan Xiangqian GAO Changsheng QU Chiyu The National Key Laboratory of Water Disaster Prevention Nanjing Hydraulic Research InstituteNanjing 210024China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou 450001China

We have described in detail the effects of nano-SiO_(2),nano-CaCO_(3),carbon nanotubes,and nano-Al_(2)O_(3) on geopolymer concrete from the perspectives of macro mechanics and *** existing research results show that the mechanism of nano-materials on geopolymer concrete mainly includes the filling effect,nucleation effect,and bridging effect,the appropriate amount of nano-materials can be used as fillers to reduce the porosity of geopolymer concrete,and can also react with Ca(OH)2 to produce C-S-H gel,thereby improving the mechanical properties of geopolymer *** optimum content of nano-SiO_(2) is between 1.0%and 2.0%.The optimum content of nano-CaCO_(3) is between 2.0%and 3.0%.The optimum content of carbon nanotubes is between 0.1%and 0.2%.The optimum content of nano-Al_(2)O_(3) is between 1.0%and 2.0%.The main problems existing in the research and application of nanomaterial-modified geopolymer concrete are summarized,which lays a foundation for the further application of nanomaterial in geopolymer concrete.

关键词： nanomaterials low carbon geopolymer concrete macro-mechanics microstructure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unmasking Social Robots’Camouflage:A GNN-Random Forest Framework for Enhanced Detection

引用

Computers, Materials & Continua 2025年第1期82卷 467-483页

作者： Weijian fan Chunhua Wang Xiao Han Chichen Lin School of Data Science and Intelligent Media Communication University of ChinaBeijing100024China School of Computer and Cyber Sciences Communication University of ChinaBeijing100024China Institute of Communication Studies Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content *** robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading *** graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human *** unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and Random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing ***,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored *** culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection *** experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.

关键词： Social robot detection graph neural networks random forest homophily heterophily

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：