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中华医学杂志(英文版) 2025年第2期138卷 219-221页

作者： Yan Kexiang Zhu Jie Zhang Mengmeng Zhang Fuxin Wang bing Han ling Huang Qiong Tang Yulong li Yuan Yawalkar Nikhil Zhang Zhenghua Niu Zhenmin Department of Dermatology Huashan Hospital Fudan University Shanghai China State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences Human Phenome Institute Fudan University Shanghai China Department of Dermatology Inselspital Bern University Hospital University of Bern Bern CH-Bern Switzerland Department of Genetics Shanghai-MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science &amp Technology (SAST) Shanghai China

Review of rare earth oxide doping-modified laser cladding of Fe-based alloy coatings

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China Foundry 2025年第1期22卷 12-22页

作者： Han-yu Zhou li-yao li Yang Zhao Ming-xue Shen Huo-ping Zhao Ye-long Xiao Shao-peng liu School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China

Conventional Fe-C alloy parts used in mechanical transmission and braking systems exposed to the external environment often suffer from wear and corrosion *** coating strengthening technologies have been explored to improve the surface performance and prolong service life of these *** these technologies,laser cladding has shown promise in producing Fe-based alloy coatings with superior interfacial bonding properties to the Fe-C alloy ***,the microstructure of the Fe-based alloy coating is more uniform and the grain size is finer than that of surfacing welding,thermal spraying,and plasma cladding,and the oxide film of alloying elements on the coating surface can improve the coating ***,Fe-based alloy coatings produced by laser cladding typically exhibit lower hardness,lower wear resistance,corrosion resistance,and oxidation resistance compared to coatings based on Co and Ni ***,these coatings are susceptible to defects such as pores and *** address these limitations,the incorporation of rare-earth oxides through doping in the laser cladding process has garnered significant *** approach has demonstrated substantial improvements in the microstructure and properties of Fe-based alloy *** paper reviewed recent research on the structure and properties of laser-cladded Fe-based alloy coatings doped with various rare earth oxides,including La_(2)O_(3),CeO_(2),and Y_(2)O_(3).Specifically,it discussed the effects of rare earth oxides and their concentrations on the structure,hardness,friction,wear,corrosion,and oxidation characteristics of these ***,the mechanisms by which rare earth oxides influence the coating’s structure and properties were *** review aimed to serve as a valuable reference for the application and advancement of laser cladding technology for rare earth modified Fe-based alloy coatings.

关键词： Fe-based alloys laser cladding rare-earth oxides microstructure tribological properties

TavWA1 is critical for wheat growth by modulating cell morphology and arrangement

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Journal of Integrative Plant Biology 2025年第1期67卷 71-86页

作者： Guowei Chang Yue li Lei Peng Chuncai Shen Yipeng Lu Wan Teng Yangyang liu Yingchun Wang Weiqi Zhu Cuimin liu xue He Yiping Tong xueqiang Zhao Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Zhaoxian Experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 515300China

Plant growth is determined by the production of cells and initiation of new *** genes that control cell number and cell size is of great significance for understanding plant growth *** this study,we characterized two wheat mutants,ah and dl,with abnormal *** ah mutant is a naturally occurring variant characterized by severe dwarfism,increased tiller number,and reduced grain length,while the dl mutant is derived from an ethyl methane sulfonate(EMS)-mutagenized population and exhibits smaller grain size and slightly reduced plant *** analyses revealed abnormal cell number,cell morphology and arrangement in the stems and leaves of the ah mutant,along with reduced cell length in the grains of the dl ***-based cloning identified that both mutants carry mutations in the same gene TavWA1-7D,which encodes a protein with a von Willebrand factor A(vWA)*** ah mutant harbors a 174-bp insertion in the 1,402-bp coding sequence(CDS)of TavWA1-7D,causing premature termination of protein translation,while the dl mutant contains a Glu420Lys *** the TavWA1-7D ahthrough clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease 9-mediated genome editing leads to a severe dwarfism *** C-terminus of the protein is crucial for its correct subcellular localization and interaction,supporting its critical role for TavWA1-7D *** analysis showed that the dwarf phenotype of the ah mutant is associated with impaired photosynthesis,ribosome function,and nucleosome ***,TavWA1-7D interacts with an E3 ligase,Ta VIP1-3B,the expression levels of which are elevated in both *** and knockout studies of TaVIP1-3B demonstrated its negative regulatory role in cell length and grain ***,our findings suggest that TavWA1-7D plays a vital role in regulating wheat growth and yield-related traits,with the dl mutant's short grain phen

关键词： grain size severe dwarf TaVIP1 TavWA1 wheat

SpaGRA:Graph augmentation facilitates domain identification for spatially resolved transcriptomics

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Journal of Genetics and Genomics 2025年第1期52卷 93-104页

作者： xue Sun Wei Zhang Wenrui li Na Yu Daoliang Zhang Qi Zou Qiongye Dong Xianglin Zhang Zhiping liu Zhiyuan Yuan Rui Gao Center of Intelligent Medicine School of Control Science and EngineeringShandong UniversityJinanShandong 250061China MOE Key Lab of Bioinformatics and Bioinformatics Division of BNRIST Department of AutomationTsinghua UniversityBeijing 100084China Institute of Precision Medicine Peking University Shenzhen HospitalShenzhenGuangdong 518036China Department of Clinical Laboratory The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Institute of Science and Technology for Brain-Inspired Intelligence Center for Medical Research and InnovationShanghai Pudong HospitalFudan University Pudong Medical CenterFudan UniversityShanghai 200433China

Recent advances in spatially resolved transcriptomics(SRT)have provided new opportunities for characterizing spatial structures of various ***-based geometric deep learning has gained widespread adoption for spatial domain identification ***,most methods define adjacency relation between cells or spots by their spatial distance in SRT data,which overlooks key biological interactions like gene expression similarities,and leads to inaccuracies in spatial domain *** tackle this challenge,we propose a novel method,SpaGRA(https://***/sunxue-yy/SpaGRA),for automatic multi-relationship construction based on graph *** uses spatial distance as prior knowledge and dynamically adjusts edge weights with multi-head graph attention networks(GATs).This helps SpaGRA to uncover diverse node relationships and enhance message passing in geometric contrastive ***,SpaGRA uses these multi-view relationships to construct negative samples,addressing sampling bias posed by random *** results show that SpaGRA presents superior domain identification performance on multiple datasets generated from different *** SpaGRA,we analyze the functional regions in the mouse hypothalamus,identify key genes related to heart development in mouse embryos,and observe cancer-associated fibroblasts enveloping cancer cells in the latest Visium HD ***,SpaGRA can effectively characterize spatial structures across diverse SRT datasets.

关键词： Spatial domain identification Spatially resolved transcriptomics Multi-head graph attention networks Graph augmentation Geometric contrastive learning

Longitudinal Associations between Vitamin D Status and Systemic Inflammation Markers among Early Adolescents

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Biomedical and Environmental Sciences 2025年第1期38卷 94-99页

作者： Ting Tang Xinhui Wang xue Wen Min li Mengyuan Yuan Yonghan li Xiaoqin Zhong Fangbiao Tao Puyu Su Xihua Yu Gengfu Wang Department of Maternal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Xiamen Key Laboratory of Maternal and Fetal Health&Nutrition Products Xiamen 361000FujianChina Key Laboratory of Population Health Across life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Hefei 230032AnhuiChina

Vitamin D deficiency(VDD)has emerged as a major nutritional problem among children and *** studies have documented the adverse health effects of VDD,including conditions such as chronic kidney diseases,hypoparathyroidism,and autoimmune ***,these studies were conducted only in adults and among individuals with underlying medical *** is at a unique stage of growth,where nutritional deficiencies may have profound implications on their future ***,there is an urgent need to conduct research on the impact of vitamin D deficiency on adolescent health.

关键词： vitamin Marker among

Significant reduction of anisotropy in stress relaxation aging and mechanical properties improvement for 2195 Al-Cu-li alloy subjected to plastic loading

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Chinese Journal of Aeronautics 2025年第1期38卷 217-234页

作者： liwen ZHANG Heng li Tianjun BIAN Changhui WU Yanfeng YANG State Key Lab of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Aeronautical Polytechnic Institute Xi’an 710089China Shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Although the plastic loading can enhance creep deformation and yield strength,the anisotropic Stress Relaxation Aging(SRA)behavior and mechanism under plastic loading remain unclear,which presents a significant challenge in accurately shaping aluminum alloy *** this study,the SRA behavior of 2195-T4 Al-Cu-li alloys were thoroughly studied under initial loading stresses within the elastic(210/250 MPa)and plastic(380/420 MPa)ranges at 180℃by stress relaxation and tensile tests as well as microstructure *** findings reveal that compared with those under elastic loadings,in-plane anisotropy(IPA)values of the stress relaxation amount,yield strength and fracture elongation under plastic loadings are reduced by 60%–80%,70%–90% and 72%–89%,***,IPA values of precipitate size in grains and PrecipitationFree Zones(PFZ)width at grain boundaries under plastic loading decrease by 31.4%and 94.4%*** results indicate plastic loading significantly weakens the anisotropic SRA behavior,owing to numerous uniformly distributed fine T1phases and small IPA values of both T1precipitates size and PFZ width in various loading *** with those of elastic loadingaged alloys,yield strength of plastic loading-aged alloys shows high strength-ductility because of the combined effect of closely dispersed fine T1precipitates,narrowed PFZ and numerous sheared and rotated T1phases at different locations during tensile *** uniformly distributed larger Kernel Average Misorientation(KAM)and Schmidt factor values of the plastic loading-aged alloy,as well as the cross-slip generated,also help to enhance the strength and ductility of the alloy.

关键词： Aluminum-lithium alloy Stress relaxation aging Precipitation-free zones In-plane anisotropy Stress relaxation

NIR-Ⅱfluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers

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Chinese Chemical Letters 2025年第1期36卷 469-473页

作者： Zhaorui Song Qiulian Hao bing li Yuwei Yuan Shanshan Zhang Yongkuan Suo Hai-Hao Han Zhen Cheng Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China State Key Laboratory of Drug Research Molecular Imaging CenterShanghai Institute of Materia MedicaShanghai 201203China Institute of Molecular Medicine Joint Laboratory for Molecular Medicine Northeastern University Shenyang 110000China Pharmacy College Shandong First Medical University&Shandong Academy of Medical SciencesJi’nan 250117China University of Chinese Academy of Sciences Beijing 100049China

Fluorescence lateral flow immunoassay(LFA)has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity,sensitivity and *** is noteworthy that fluorescent probe mainly determines the analytical performance of *** to the emission and excitation wavelengths are located in the visible region,most fluorophores are inevitably subject to light scattering and background ***,we reported a novel LFA sensor based on the second near-infrared(NIR-Ⅱ)fluorescent probe with excellent anti-interference *** designed NIR-Ⅱprobe was the Nd^(3+)and Yb^(3+)doped rare earth nanoparticles(RENPs)by employing Nd^(3+)as energy donor and Yb^(3+)as energy acceptor,which of the donor-acceptor energy transfer(ET)efficiency reached up to 80.7%.Meanwhile,relying on the convenient and effective encapsulation strategy of poly(lactic-co-glycolic acid)(PLGA)microspheres to RENPs,the surface functionalized NIR-Ⅱprobe(RE@PLGA)was obtained for subsequent *** from the optical advantages of NIR-Ⅱprobe,this proposed NIR-ⅡLFA displayed a good linear relationship ranging from 7 ng/mL to 200 ng/mL for the detection ofα-fetoprotein(AFP),an important biomarker of hepatocellular carcinoma(HCC).The limit of detection(LOD)was determined as low as 3.0 ng/m L,which was of 8.3 times lower than clinical cutoff *** is promising that LFA sensor based on this efficient RENPs probe provides new opportunities for high sensitive detection of various biomarkers in biological samples.

关键词： Donor-acceptor energy transfer(ET) Lateral flow immunoassay(LFA) The second near-infrared(NIR-Ⅱ) fluorescence Rare-earth nanoparticles(RENPs) Poly(lactic acid-co-glycolic acid)(PLGA) Tumor biomarker

Retinexformer+:Retinex-Based Dual-Channel Transformer for Low-light Image Enhancement

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Computers, Materials & Continua 2025年第2期82卷 1969-1984页

作者： Song liu Hongying Zhang xue li Xi Yang School of Information Engineering Southwest University of Science and TechnologyMianyang621000China Criminal Investigation Department Sichuan Police CollegeLuzhou646000China School of Electronics and Information Mianyang PolytechnicMianyang621000China

Enhancing low-light images with color distortion and uneven multi-light source distribution presents challenges. Most advanced methods for low-light image enhancement are based on the Retinex model using deep learning. Retinexformer introduces channel self-attention mechanisms in the IG-MSA. However, it fails to effectively capture long-range spatial dependencies, leaving room for improvement. Based on the Retinexformer deep learning framework, we designed the Retinexformer+ network. The “+” signifies our advancements in extracting long-range spatial dependencies. We introduced multi-scale dilated convolutions in illumination estimation to expand the receptive field. These convolutions effectively capture the weakening semantic dependency between pixels as distance increases. In illumination restoration, we used Unet++ with multi-level skip connections to better integrate semantic information at different scales. The designed Illumination Fusion Dual Self-Attention (IF-DSA) module embeds multi-scale dilated convolutions to achieve spatial self-attention. This module captures long-range spatial semantic relationships within acceptable computational complexity. Experimental results on the Low-light (LOL) dataset show that Retexformer+ outperforms other State-Of-The-Art (SOTA) methods in both quantitative and qualitative evaluations, with the computational complexity increased to an acceptable 51.63 G FLOPS. On the LOL_v1 dataset, RetinexFormer+ shows an increase of 1.15 in Peak Signal-to-Noise Ratio (PSNR) and a decrease of 0.39 in Root Mean Square Error (RMSE). On the LOL_v2_real dataset, the PSNR increases by 0.42 and the RMSE decreases by 0.18. Experimental results on the Exdark dataset show that Retexformer+ can effectively enhance real-scene images and maintain their semantic information.

关键词： Low-light image enhancement Retinex transformer model

CT whole lung radiomic nomogram:a potential biomarker for lung function evaluation and identification of COPD

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Military Medical Research 2025年第1期12卷 36-47页

作者： Tao-Hu Zhou Xiu-Xiu Zhou Jiong Ni Yan-Qing Ma Fang-Yi Xu bing Fan Yu Guan Xin-Ang Jiang Xiao-Qing lin Jie li Yi Xia Xiang Wang Yun Wang Wen-Jun Huang Wen-Ting Tu Peng Dong Zhao-Bin li Shi-Yuan liu li Fan Department of Radiology the Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China School of Medical Imaging Shandong Second Medical UniversityWeifang 261053ShandongChina Department of Radiology School of MedicineTongji HospitalTongji UniversityShanghai 200065China Department of Radiology Zhejiang Province People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of Radiology Sir Run Run Shaw HospitalZhejiang 310018China Jiangxi Provincial People’s Hospital the First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China College of Health Sciences and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology the Second People’s Hospital of DeyangDeyang 618000SichuanChina Department of Radiation Oncology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Background:Computed tomography(CT)plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease(COPD).This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD ***:This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD *** radiomic features of the whole lung volume were *** absolute shrinkage and selection operator(LASSO)logistic regression was applied for feature selection and radiomic signature construction.A radiomic nomogram was established by combining the radiomic score and clinical *** operating characteristic(ROC)curve analysis and decision curve analysis(DCA)were used to evaluate the predictive performance of the radiomic nomogram in the training,internal validation,and independent external validation ***:Eighteen radiomic features were collected from the whole lung volume to construct a radiomic *** area under the curve(AUC)of the radiomic model in the training,internal,and independent external validation cohorts were 0.888[95%confidence interval(CI)0.869–0.906],0.874(95%CI 0.844–0.904),and 0.846(95%CI 0.822–0.870),*** were higher than the clinical model(AUC were 0.732,0.714,and 0.777,respectively,Plinical factor ***:The intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study.

关键词： Chronic obstructive pulmonary disease(COPD) Computed tomography(CT) Radiomic

The regulatory effects of gut microbiota on breast health and human milk composition via gut-mammary gland axis

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Food Science and Human Wellness 2025年

作者： Manlin Zhou Xi He Qidi xue Muhammad Naveed Binqi Rui Ye Wang Yinhui liu Ming li Department of Microecology， College of Basic Medical Science， Dalian Medical University

The gut-mammary gland axis connects the communication between the gut microbiota and the mammary gland. Studies have reported that dysbiosis in gut microbiota is involved in the pathogenesis of breast diseases such as mastitis and breast cancer. In addition， different diets， including the supplementation of probiotics or prebiotics， which are closely related to the alteration of gut microbiota， were found to affect the nutritional contents of human milk and contribute to the development or alleviation of breast diseases. These studies suggested that the gut microbiota might be a new target for the regulation of human milk components or breast diseases. In this article， we summarized recent research advances in the gut-mammary gland axis and discussed some of the effective mechanisms and pathways involved， including distal translocation of gut microbiota， circulation of metabolites across the blood-milk barrier， the delivery of immune cells and their secreted antibodies to the mammary gland. This article also provides new strategies for preventing women's breast diseases and improving the composition of human milk through the gut-mammary axis.

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