检索结果-南通市图书馆

World Journal of Clinical Cases 2022年第34期10卷 12551-12558页

作者： Wei-Ning Gong Yun-He Zhang Jing Niu xue-bing li Department of Nuclear Medicine Jincheng People's HospitalJincheng 048000Shanxi ProvinceChina Institutes of Brain Science Fudan UniversityShanghai 200032China

BACKGROUND ***/CT is a commonly used examination method in nuclear ***,patients receiving ***/CT have insufficient knowledge of this method and worry about the examination *** To investigate the effect of teach-back health education combined with structured psychological nursing on adverse emotion and cooperation in patients undergoing ***/CT *** Ninety patients undergoing ***/CT examinations were divided into a study group and a control group using a simple random number table,and 45 cases were allocated to each *** nursing was provided to the control group,and teach-back health education combined with structured psychological nursing was provided to the study group on the basis of the control *** rate,diastolic blood pressure,systolic blood pressure,self-rating depression scale(SDS),and self-rating anxiety scale(SAS)were assessed before and after the intervention,and examination cooperation and intervention satisfaction were assessed in the two groups before,during,and after the *** Before the examination,heart rate,diastolic blood pressure,and systolic blood pressure in the study group were not significantly different from the values of the control group(P>0.05).The results of the study group before and after the examination were lower than those in the control group(P0.05).After the intervention,SDS and SAS scores in the study group were lower than those in the control group(Plity of bloo

关键词： Bad mood Cooperation Nuclear medicine Structured psychological care Teach-back health education 99mTc-3PRGD2.SPECT/CT examination

Estrogen-induced Tgfbrl and Bmprla Expression Repressed via Estrogen Receptor Beta in MC3T3-E1 Cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第21期131卷 2558-2565页

作者： Han-liang He Chao liu bing-xue li Chen-Qiu Wang Hai-Tao li lin Gu Department of Orthopedics Benq Medical Center of Suzhou Suzhou Jiangsu 215000 China Department of Neurosurgery Benq Medical Center of Suzhou Suzhou Jiangsu 215000 China Department of Endocrinology Benq Medical Center of Suzhou Suzhou Jiangsu 215000 China

Background： Estrogen, as an important hormone in human physiological process, is closely related to bone metabolism. The aim of this study was to investigate the mechanism of estrogen on osteoblasts metabolisrn in MC3T3-EI cells. Methods： We treated the MC3T3-EI cells with different concentrations of β-estradiol （0.01, 0.1, 1, and 10 nmol/L）, observed the morphological changes of the cells, and detected the cell＇s proliferation and apoptosis of MC3T3-EI cells. Two transcriptome libraries were constructed and sequenced. Quantitative real-time polymerase chain reaction （qRT-PCR） was performed to confirm the differentially expressed genes （DEGs）, and then treated the MC3T3-EI cells with estrogen receptor （ER） inhibitors α and β, respectively, and then examined the expression of Tgfbr1 and Bmprla genes. The promoter of Tg/brl and Bmprla gene was analyzed, and the ER response elements were identified. Finally, Chip was used to verity the binding of ER to Tgfbr1 and Bmprla promoter. Results： In the high-concentration β-estradiol treatment group （1 nmol/L and 10 nmol/L）, there was no significant difference in the morphology of the cells under the microscope, 1 nmol/L and 10 nmol/L treated group appeared statistically significant difference in cell apoptosis and proliferation （P 〈 0.05 and P 〈 0.01, respectively）. We found 460 DEGs compared with the control group. Among the DEGs, there were 66 upregulated genes and 394 downregulated genes. Gene ontology classification and Kyoto Encyclopedia of Genes and Genornes pathway analysis revealed that many bone metabolism-related biological processes and cell signaling pathways were disordered. The qRT-PCR verification showed that the expressions of Tgfbrl- and Bmprl a-related genes in bone metabolism pathway in the 10 nmol/L treatment group were significantly decreased （P 〈 0.05）. ER β was involved in the inhibitory effect of Tgfbr1 and Bmprla genes. The bioinformatics of the promoter found that there were three ER response element

关键词： Bmprla Estrogen Receptor Beta Estrogen MC3T3-EI Ceils Tgfhr1

Initial Study on the Antibacterial Action of Mentha spicata linn Extract in Vitro

在线全文

学校读者我要写书评

暂无评论

Agricultural Science & Technology 2010年第11期11卷 47-49页

作者： ZHANG Hong-ying WANG xue-bing HAN Wei-li CUI Bao-an Key Laboratory of Animal Food Security in Henan Province College of Animal Husbandry and Veterinary in Henan Agricultural UniversityZhengzhou 450002

[Objective] The research aimed to study the antibacterial action of Mentha spicata linn extract in vitro.[Method] The cylinder-plate method was used to measure the inhibitory zone size of Mentha spicata linn *** test-tube double dilution method was used to measure the minimal inhibitory concentration(MIC)of Mentha spicata linn extract on the four kinds of animal pathogenic bacteria,which could determine the antibacterial effect.[Result] The decoction,alcohol extract and volatile oil of Mentha spicata linn had the different antibacterial effects on the four kinds of animal pathogenic *** the inhibition effect on the pig staphylococcus was comparatively *** of Mentha spicata linn decoction I,alcohol extract III,volatile oil V and volatile oil VI were respectively 31.25,62.5,2.32 and 2.31 mg/ml.[Conclusion] The decoction,alcohol extract and volatile oil of Mentha spicata linn had the certain antibacterial effect in vitro,and the extracts which were gained by the different extraction methods had the different inhibition effects on the experimental bacteria.

关键词： Mentha spicata linn Extract Minimal inhibitory concentration

Effects of morphine dependence and withdrawal on sensory information processing in cerebellar granule cell layer in vivo in mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of morphine dependence and withdrawal on sensory inf...

An NMDA receptor and NO cascades dependent presynaptic LTP at glutamatergic synapses of the PVN magnocellular neurosecretory cells in vitro in rats

中国神经科学学会第十二届全国学术会议

作者： li-jie Zhan bing-xue li Dan Wang De-lai Qiu Yan Lan Cellular Function Research Center Yanbian University Department of Physiology and Pathophysiology College of Medicine Yanbian University Department of pharmacology College of Medicine Yanbian University Key Laboratory of Natural Resource of the Changbai Mountain and Functional Molecular of the Ministry of Education Yanbian University

Background: It has been reported that the mechanisms of morphine addiction is the homeostasis dysregulation of brain. The cerebellum is involved in control of motor coordination and receives sensory inputs to execute complex motor tasks. Increasing evidence has involved that addiction is related to a disruption in cerebellar processing and connectivity with other brain regions. However, the changes of information processing in cerebellum in morphine addiction is unknown. In present research, our aim is to observe the effects of morphine dependence and withdrawal on sensory information processing in cerebellar granule cell layer in vivo in mice. Methods and Main Results: Forty male KM mice were randomly divided into four groups（n=10）: the morphine dependence group, morphine withdraw 1 day group, morphine withdrawal 7 days group, and the saline control group. The mice in dependence group and withdrawal group were administered with morphine by subcutaneous injection through the method of "increasing addiction for 7 days", and the saline group were injected saline. Mice administered morphine exhibited opioid-like responses including Straub tail and hyperlocomotion in behavior. Electrophysiological methods were used in our research to record the field potential of granule cell layer（GCL）. Air-puff stimulation of the ipsilateral whisker-pad evoked stimulus-on（N1） and stimulus-off responses（N2） in GCL of cerebellar Crus II. The amplitude of N1 and N2 in dependence group, withdrawal 1 day group and withdrawal 7 day group are obviously decreased compared with control group（p＜0.05）, and withdrawal 1 day group shows a marked drop compared with dependence group and withdrawal 7 day group（p＜0.05）. The onset latency of the sensory stimulationevoked responses has no change. Conclusion: These results indicate that morphine dependence and withdrawal affect the homeostatic regulation of sensory information processing in cerebellar granule cell layer.

关键词： Morphine dependence Morphine withdrawal Cerebellar granule cell Mice Sensory stimulation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

An NMDA receptor and NO cascades dependent presynaptic LTP a...

Role of NMDARs during the sensory stimulation-evoked field potential responses in mouse cerebellar cortical molecular layer

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者： bing-xue li Bin-Bin ZHANG Hua JIN De-Lai QIU Chun-Ping CHU Brain Science Research Center Yanbian University Yanbian University Hospital Yanbian University

Objective The magnocellular neurosecretory cells(MNCs) of the hypothalamic paraventricular nucleus(PVN) integrate incoming signals to secrete oxytocin(OT) and vasopressin(VP) from their nerve terminals in the posterior pituitary *** has been demonstrated that high frequency stimulation(HFS) of afferent fibers induced an NMDA receptor-dependent LTP of excitatory glutamatergic inputs in the supraoptic nucleus(SON) MNCs of rat hypothalamic slices,therefore, the N-methyl-D-aspartic acid(NMDA) receptors-dependent plasticity in PVN MNCs may be involved in nitric oxide(NO) production and PKA signaling ***, the NO and PKA signaling cascades in the long-term plasticity in PVN MNCs is currently *** we used whole-cell patch-clamp recording, single-cell reverse transcription-multiplex polymerase chain reaction(SC-RT-mPCR), biocytin histochemistry and pharmacological methods to examine the mechanism of high frequency stimulus(HFS, 100 Hz)-induced long-term potentiation(LTP) at glutamatergic synapses in the PVN MNCs of juvenile male *** HFS-induced LTP at glutamatergic synapses was accompanied by a decrease in the paired-pulse ratio(PPR) of the PVN *** these MNCs, HFS-induced LTP persisted in the presence of a group 1 metabotropic glutamate receptor(mGluR1) antagonist;however, it was abolished by an NMDA receptor ***, HFS-induced LTP in the PVN MNCs was completely prevented by a nitric oxide synthase(NOS) *** application of an NO donor not only induced the LTP of excitatory glutamatergic inputs in the PVN MNCs, but also occluded the HFS-induced LTP in these ***, HFS-induced LTP in the PVN MNCs was also abolished by a specific protein kinase A(PKA) inhibitor, *** Our results indicate that a HFS can induce an NMDA receptor and NO cascades dependent on presynaptic glutamatergic LTP in the PVN MNCs via a PKA signaling pathway.

关键词： hypothalamic paraventricular nucleus(PVN) long-term synaptic plasticity NMDA receptor nitric oxide whole-cell recording protein kinase A

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Role of NMDARs during the sensory stimulation-evoked field p...

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

中国神经科学学会第十二届全国学术会议

作者： Fang-ling Xuan Ke-Ming Zhang bing-xue li li-Na Cui De-Lai Qiu Chun-Ping Chu Cellular Function Research Center Yanbian University

Objective In mammalian cerebellar cortex, NMDARs are found existed on the membrane of granule cells（GC）, terminals of parallel fibers（PF）, molecular layer interneurons（Mli） and climbing fiber-Purkinje cell（PC） synapses, but the functional NMDARs are absence in the membrane of the adult PCs. We previously found that the air-puff stimulation on ipsilateral whisker pad evoked a sequence of transient tiny excitation response followed by strong inhibitory response in cerebellar molecular layer via mossy fiber pathway. In the present study, we investigated the role of NMDARs during the air-puff stimulation evoked field potential responses in cerebellar molecular layer of urethane-anesthetized mice. Methods Local field potential recordings from the cerebellar molecular layer were performed with an Axopatch-200 B amplifier. Sensory stimulation was performed using air-puff（60 ms, 60 psi） of ipsilateral whisker pad through a 12-gauge stainless tube connected with a pressurized injection system. The airpuff stimulations were controlled by a personal computer, which were synchronized with the electrophysiological recordings and delivered at 0.05 Hz through a Master 8 controller. All chemicals were applied to the cerebellar surface at 0.4 ml/min in ACSF. Results（1） Administration of NMDA affected the dynamic properties of sensory stimulation-evoked P1 in mouse cerebellar molecular layer, which expressed decreases in decay time, half-width and area under curve（AUC） of P1.（2） Application of NMDA induced significant increases in the decay time, half-width and AUC values of the facial stimulation-evoked excitatory responses（N1） in cerebellar molecular layer. However, NMDA did not significantly affect the amplitude, half-amplitude of N1 and rise time of N1.（3） Application an NMDAR blocker, D-APV（250 μM） abolished the facial stimulation-evoked GABAergic inhibitory components（P1） in mouse cerebellar molecular layer.（4） Blockade of NMDARs did not significantly change the amplitude and h

关键词： Cerebellar cortical molecular layer field potential recording NMDA receptors air-puff stimulation GABAergic responses parallel fiber

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

在线全文

学校读者我要写书评

暂无评论

半环中生成模糊理想的构造

山东大学学报（理学版） 2003年第1期38卷 41-44页

作者：姚炳学李勇山东大学数学与系统科学学院济南250100

在半环中引入由模糊子集生成的模糊半环与模糊左理想 (模糊右理想 ,模糊理想 ,模糊双理想 )的概念 ,讨论了它们的一些性质。

关键词：模糊半环模糊左理想模糊右理想模糊理想模糊双理想

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie li Wenbo Yu Zhenyu Sun Weichen Zheng liangwei Zhang Yanling xue Wenning liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment