检索结果-南通市图书馆

Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections

引用

World Journal of Psychiatry 2024年第9期14卷 1319-1325页

作者： Gui-Bo Wang xue-Feng Zhang bing liang Jie Lei Jun xue Department of Pediatric Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of General Surgery the First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Pediatric abdominal infection is a common but serious disease that requires timely and effective *** surgical treatment,accurate diagnosis and rational application of antibiotics are the keys to improving treatment *** To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic *** A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were *** observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing,and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing;the control group only sent bacterial culture and drug sensitivity testing during the *** White blood cell count,C-reactive protein,procalcitonin,3 days after surgery,showed better postoperative index than the control group(P<0.05).The hospital stay in the observation group was significantly shorter than that in the control *** hospitalization cost in the observation group was significantly lower than that in the control group,and the difference between the two groups was statistically significant(P<0.05).CONCLUSION Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics,improving treatment outcomes and reducing medical costs to some extent.

关键词： Pediatric abdominal infection Nucleic acid detection of broad-spectrum bacterial infection Bacterial culture Drug sensitivity testing Treatment effect Cost Mental health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Single-Atom Nanozymes Research

引用

Chinese Journal of Chemistry 2021年第1期39卷 174-180页

作者： bing Jiang Minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes with intrinsic enzyme-like properties have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility,high cost and dificult mass ***,the currently reported nanozymes are generally less active than natural *** recent years,with the rapid development of nanoscience and nanotechnology,single-atom nanozymes(SAzymes)with well-defined electronic and geometric structures have shown a promise to serve as direct surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural *** this review,we will introduce the enzymatic characteristics and recent advances of SAzymes,and summarize their significant applications from in vitro detection to in vivo monitoring and therapy.

关键词： Nanozyme Single-atom nanozyme Biomedical application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sufficient Conditions for Amalgamated 3-Manifolds to be ∂-Irreducible

引用

Chinese Annals of Mathematics,Series B 2024年第2期45卷 161-172页

作者： bing FANG Fengchun LEI liang liang School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina School of Mathematics Liaoning Normal UniversityDalian 116029LiaoningChina

In this paper,the authors give some sufficient conditions for an amalgamated 3-manifold along a compact connected surface F with boundary to be ∂-irreducible in terms of distances between some kinds of vertex subsets ... 详细信息

关键词： ∂-Irreducibility Irreducibility Amalgamated 3-manifold Curve complex Arc complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ginsenoside Rb1 relieves glucose fluctuationinduced oxidative stress and apoptosis in Schwann cells

引用

Neural Regeneration Research 2012年第30期7卷 2340-2346页

作者： bing xue Lianqing Sun Xiaojin Li Xuan Wang Ying Zhang Yiming Mu Linlang liang Department of Endocrinology Chinese PLA General Hospital Beijing 100853 China Department of Endocrinology General Hospital of Shenyang Military Region Shenyang 110016 Liaoning Province China

Cultured Schwann cells were treated with 5.6 mM and 50 mM glucose alternating every 8 hours to simulate intermittent high glucose. The present study analyzed the neuroprotective effects of 1, 10 and 100 μM ginsenoside Rbl on oxidative damage and apoptosis in Schwann cells induced by intermittent high glucose. Flow cytometry demonstrated that ginsenoside Rbl reduced intermittent high glucose-mediated reactive oxygen species production. Enzyme linked immunosorbent assay showed that 8-hydroxy-2-deoxy guanosine levels in Schwann cells decreased following ginsenoside Rbl treatment. Quantitative real-time reverse transcription-PCR and western blot assay results revealed that ginsenoside Rbl inhibited intermittent high glucose-upregulated Bax expression, but antagonized intermittent high glucose-downregulated Bcl-2 expression in Schwann cells. These effects were most pronounced with 100 μM ginsenoside Rbl. These results indicate that ginsenoside Rbl inhibits intermittent high glucose-induced oxidative stress and apoptosis in Schwann cells.

关键词： ginsenoside Rbt diabetic peripheral neuropathy Schwann ceils oxidative stress apoptosis glucose fluctuation Chinese herb neuroprotection neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new analytical model for the low-velocity perforation of thin steel plates by hemispherical-nosed projectiles

引用

Defence Technology（防务技术） 2017年第5期13卷 327-337页

作者： Chang-hai CHEN Xi ZHU Hai-liang HOU xue-bing TIAN Xiao-le SHEN Department of Naval Architecture Engineering Naval University of EngineeringWuhanHubeiPR China Lvshun Proving Ground Naval Unit No.91439Dalian 116041PR China

Ballistic experiments were conducted on thin steel plates that are normally impacted by hemisphericalnosed projectiles at velocities higher than their ballistic limits. The deformation and failure modes of the thin steel plates were analyzed. A new method was proposed according to the experimental results and the perforation phenomenon of the thin steel plates to determine the radius of the bulging region. In establishing this new method, a dynamic method combined with the plastic wave propagation concept based on the rigid plastic assumption was adopted. The whole perforation process was divided into four consecutive stages, namely, bulging deformation, dishing deformation, ductile hole enlargement, and projectile exit. On the basis of the energy conservation principle, a new model was developed to predict the residual velocities of hemispherical-nosed projectiles that perforate thin steel plates at low *** results obtained from the theoretical calculations by the present model were compared with the experimental results. Theoretical predictions were in good agreement with the experimental results in terms of both the radius of the bulging region and the residual velocity of the projectile when the strain rate effects of the target material during each stage were considered.

关键词： Ballistic impact Thin steel plate Perforation Low velocity Hemispherical-nosed projectile

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent progress in single-atom nanozymes research

引用

Nano Research 2023年第2期16卷 1878-1889页

作者： bing Jiang Zhanjun Guo Minmin liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom nanozyme(SAzyme)is the hot topic of the current nanozyme *** intrinsic properties,such as high activity,stability,and low cost,present great substitutes to natural ***,its fundamental characteristics,i.e.,maximized atom utilizations and well-defined geometric and electronic structures,lead to higher catalytic activities and specificity than traditional *** have been applied in many biomedical areas,such as anti-tumor therapy,biosensing,antibiosis,and anti-oxidation ***,we will discuss a series of representative examples of SAzymes categorized by their biomedical applications in this *** the end,we will address the future opportunities and challenges SAzymes facing in their designs and applications.

关键词： single-atom nanozymes natural enzymes enzyme-like activity biomedical applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-Bo Jin Cong-Feng Qiao Yue-liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

引用

Chinese Journal of Cancer 2012年第2期31卷 100-109页

作者： xue, xue liang, Xing-Jie Natl Ctr Nanosci & Technol China CAS Key Lab Biomed Effects Nanomat & Nanosafety Beijing 100190 Peoples R China

Multidrug resistance(MDR),which significantly decreases the efficacy of anticancer drugs and causes tumor recurrence,has been a major challenge in clinical cancer treatment with chemotherapeutic drugs for *** mechanisms of overcoming drug resistance have been *** known P-glycoprotein(P-gp) and other drug efflux transporters are considered to be critical in pumping anticancer drugs out of cells and causing chemotherapy *** theranostic(therapeutic and diagnostic) strategies with nanoparticles are rapidly evolving and are anticipated to offer opportunities to overcome these *** this review,we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome.

关键词：抗癌药物多药耐药纳米技术外排癌症 P-糖蛋白临床治疗化疗药物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction and evaluation of anti-gastrin immunogen based on P64K protein

引用

World Journal of Gastroenterology 2006年第13期12卷 2040-2046页

作者： Xiang-Hua Xiong Hong-liang Zhao Chong xue Wei Zhang bing-Fen Yang xue-Qin Yao Zhi-Min Liu Department of Microbiologic Engineering Beijing Institute of Biotechnology Beijing 100071 China

AIM： To construct two kinds of anti-gastrin immunogen based on P64K protein from Neisseria rneningitids and to compare their immunogenic effect. METHODS： G17P64K gene was cloned and ligated into pET28a plasmid, then transformed into BL21（DE3）. After inoculation of LB medium and IPTG induction, the recombinant protein was solubly expressed at a high level. The purification of G17P64K fusion protein was similar to that of P64K. An initial step of purification consisting of 30% saturated ammonium sulfate precipitation was done, Additional fine optimizations included phenyl-sepharose, G200 Sephadex gel filtration and Q-sepharose anion exchanger chromatography. Highly purified protein was obtained and sequenced at the N-terminal amino acid residues. Polypeptide was synthesized by Fmoc solid phase chemical method and cross-linked to carrier protein P64K and DT mutant by MBS method and then the rabbit anti-gastrin 17 antibody was prepared by immunizing rabbit with cross-linked and fused protein. The titer and the activity in vitro of antibody were assessed. RESULTS： G17P64K gene and the recombinant bacteria were obtained. After four steps purification, protein sample that has the purity above 90% was achieved. At the 84^th day after the first immunization, the titer of antibody against cross-linked protein reached 51 200. Evaluation of the antibody in vitro manifested that it had a high inhibitory activity on the growth of tumor cell SW480. CONCLUSION： The P64K-polypeptide cross-linked immunogen immunized rabbit and achieved a higher titer antibody against gastrin 17 than the G17P64K fusion protein immunogen, which could inhibit the growth of the tumor cell SW480.

关键词： Gastrin P64K protein therapeutic vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：