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Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients

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Asian Journal of Andrology 2018年第1期20卷 56-61页

作者： Qun-Xiong Huang Chu-Tian Xiao zheng Chen Min-Hua Lu Jun Pang Jin-Ming Di Zi-Huan Luo Xin gao Department of Urology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630 China

The present study analyzed the predictive value of combined analysis of collapsin response mediator protein 4 （CRMP4） methylation levels and the Cancer of the Prostate Risk Assessment （CAPRA-S） Postsurgical score of patients who required adjuvant hormone therapy （AHT） after radical prostatectomy （RP）, We retrospectively analyzed 305 patients with prostate cancer （PCa） who received RP and subsequent androgen deprivation therapy （ADT）. Two hundred and thirty patients with clinically high-risk PCa underwent immediate ADT, and 75 patients with intermediate risk PCa underwent deferred ADT. CRMP4 methylation levels in biopsies were determined, and CAPRA-S scores were calculated. In the deferred ADT group, the values of the hazard ratios for tumor progression and cancer-specific mortality （CSM） in patients with 〉15% CRMP4 methylation were 6.81 （95% CI, 2.34-19.80） and 12.83 （95% CI. 2.16-26.10）, respectively. Receiver-operating characteristic curve analysis indicated that CRMP4 methylation levels 〉15% served as a significant prognostic marker of tumor progression and CSM. In the immediate ADT group, CAPRA-S scores ：〉6 and CRMP4 methylation levels ：〉15% were independent predictors of these outcomes （uni- and multi-variable Cox regression analyses）. The differences in the 5-year progression-free survival between each combination were statistically significant. Combining CAPRA-S score and CRMP4 methylation levels improved the area under the curve compared with the CRMP4 or CAPRA-S model. Therefore, CRMP4 methylation levels ：〉15% were significantly associated with a poor prognosis and their combination with CAPRA-S score accurately predicted tumor progression and metastasis for patients requiring AHT after RP.

关键词： adjuvant hormone therapy CAPRA-S CRMP4 methylation levels prostatic neoplasms

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Identification and expression patterns of alcohol dehydrogenase genes involving in ester volatile biosynthesis in pear fruit

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Journal of Integrative Agriculture 2017年第8期16卷 1742-1750页

作者： QIN Gai-hua QI Xiao-xiao QI Yong-jie gao zheng-hui YI Xing-kai PAN Hai-fa XU Yi-liu Horticultural Research Institute Anhui Academy of Agricultural SciencesHefei 230031P.R.China Anhui Key Laboratory of Genetic Improvement and Ecophysiology of Horticultural Crop Hefei 230031P.R.China College of Agriculture Medicine and HealthAnhui Radio and Television UniversityHefei 230022P.R.China

Alcohol dehydrogenase （ADH） catalyzes the interconversion of aldehydes and their corresponding alcohols, and is a key enzyme in volatile ester biosynthesis. However, little is known regarding ADH and ADH encoding genes （ADHs） in pear. We identified 8 ADHs in the pear＇s genome （PbrADHs） by multiple sequences alignment. The PbrADHs were highly ho- mologous in their coding regions, while were diversiform in structure. 9 introns were predicted in PbrADH3-PbrADH8, while 8 introns, generated through exon fusion and intron loss, were predicted in PbrADH1 and PbrADH2. To study the genetic regulation underlying aroma biogenesis in pear fruit, we determined the PbrADH transcripts, ADH activities and volatile contents of fruits during ripening stage for Nanguoli and Dangshansuli, two cultivars having different aroma characteristics. ADH activity was strongly associated with the transcription of ADH~ in the two cultivars during fruit ripening stage. The higher ester content paralleling to a higher ADH activity was detected in Nanguoli than in Dangshansuli, so it is induced that the lower ester content in Dangshansuli fruit may be the result of weak ADH activity. The present study revealed that total ADH activity and volatile ester production correlated with increased PbrADHstranscript levels. PbrADH6 may contribute to ADH activity catalyzing aldehyde reduction and ester formation in pear fruit.

关键词： alcohol dehydrogenase ester volatile gene expression pear

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浅谈BIM技术在粮油工程设计中的优势、特点和展望

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粮食与饲料工业 2024年第4期 7-10页

作者：周娜鲁艳秋郜培官雪薇钟华周俊梅国粮武汉科学研究设计院有限公司湖北武汉430079

为应对粮油工程设计日趋激烈的竞争,寻求一种新的工程项目设计方式及管理模式日益迫切。BIM技术作为一种基于数字化建筑信息模型的技术,因其具有可视性、模拟性、协调性、优化性、可出图性等特点,已由国内建筑行业推广到粮油、食品等多... 详细信息

为应对粮油工程设计日趋激烈的竞争,寻求一种新的工程项目设计方式及管理模式日益迫切。BIM技术作为一种基于数字化建筑信息模型的技术,因其具有可视性、模拟性、协调性、优化性、可出图性等特点,已由国内建筑行业推广到粮油、食品等多个行业。通过简述BIM技术在粮油工程设计中的优势、特点和未来发展展望,旨在为在粮油工程设计中推广应用BIM技术提供参考。

关键词： BIM技术粮油工程三维数字模型项目设计

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The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 50-75页

作者： Patrick Kwabena Oduro Xianxian zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei gao Mei Du Qilong Wang Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Ministry of EducationTianjin 301617China Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular *** derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases.

关键词： STING cGAS Cardiovascular diseases Metabolic diseases Damage-associated molecular patterns Inflammation ER stress Mitochondria

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Dynamic Cantilever Magnetometry of Paramagnetism with Slow Relaxation

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Chinese Physics Letters 2022年第3期39卷 94-98页

作者： Zhiyu Ma Kun Fan Qi Li Feng Xu Lvkuan Zou Ning Wang Li-Min zheng Fei xue Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Dynamic cantilever magnetometry is a sensitive method that has been widely used in studying magnetic anisotropy in ferromagnetic materials and Fermi surface in quantum *** study a cobalt-iridium metal-metalloligand coordination polymer using dynamic cantilever *** experimental data of dynamic cantilever magnetometry are well explained using the proposed model for Langevin paramagnetism with slow *** on the proposed model,we calculate the magnetization and magnetic susceptibility of paramagnetic materials from frequency shifts of a *** extracted magnetization and magnetic susceptibility are consistent with those obtained from conventional DC and AC *** proposed slow relaxation picture is probably a general model for explaining dynamic cantilever magnetometry data of paramagnetic materials,including previously observed dynamic cantilever magnetometry data of paramagnetic metals[Gysin et al.2011 Nanotechnology22285715].

关键词： cantilever magnetization susceptibility

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放射性废物焚烧处理技术概述

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广东化工 2024年第17期51卷 86-89页

作者：袁永太徐卫郑博文高东亮白智杰张禹中国辐射防护研究院山西太原030006

本文重点研究了放射性废物处理中焚烧技术的应用,并分析了德国Karlsruhe焚烧炉、比利时CILVA焚烧炉、中辐院热解焚烧炉等五大代表性焚烧炉,尤其以第三代技术为重点,分析了中辐院早期热解焚烧工艺、瑞士的ZWILAG热等离子体焚烧工艺等,中... 详细信息

本文重点研究了放射性废物处理中焚烧技术的应用,并分析了德国Karlsruhe焚烧炉、比利时CILVA焚烧炉、中辐院热解焚烧炉等五大代表性焚烧炉,尤其以第三代技术为重点,分析了中辐院早期热解焚烧工艺、瑞士的ZWILAG热等离子体焚烧工艺等,中辐院热解焚烧工艺作为国内先进废物热处理工艺,具有减容效果优异、焚烧灰性质稳定、放射性核素截留率高等特点,瑞士ZWILAG作为第一个完全的等离子体焚烧工艺,具有处理速度快,不可燃废物玻璃化浸出率极低等特点,总结各工艺优缺点和适用场景,可为实际生产应用选择方法提供参考和依据。

关键词：放射性废物焚烧热解

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国家组织药品集中带量采购政策对某院门诊药房降压药物使用的影响分析

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中国药业 2024年第5期33卷 14-18页

作者：王茂郑明琳何璐璐王世燕高洋洋樊萍四川大学华西医院四川成都610041

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院... 详细信息

目的探讨国家组织药品集中带量采购(简称国家集采)政策对某院门诊患者降压药物使用情况的影响。方法以医院门诊药房国家集采政策实施前(2018年1月至12月)及实施后(2020年1月至12月)23种降压药物为目标药品,共涉及10种中选品种;利用医院信息系统收集目标药品的价格、销售数量和金额,比较用药频度(DDDs)、限定日费用(DDC)。结果国家集采政策实施后,其中11种降压药物的价格降幅为5.86%~89.70%,23种降压药物的销售金额累计减少2705.60万元。DDDs排名前3的目标药品未发生变化,为苯磺酸氨氯地平片(商品名洛活喜)、富马酸比索洛尔片(商品名康忻)、坎地沙坦酯片(商品名维尔亚);10种中选品种的DDDs排名均居前列。DDC排名前4的目标药品未发生变化,为厄贝沙坦氢氯噻嗪片(商品名安博诺)、厄贝沙坦片(商品名安博维)、缬沙坦胶囊(商品名代文)、氯沙坦钾片;10种中选品种的DDC相对较低,且非中选品种的DDC均降低。结论国家集采政策的实施促使药品价格趋于合理,减轻了患者用药的经济负担,优化了医保资金的使用,提高了医疗保障水平。

关键词：国家组织药品集中带量采购门诊药房降压药物用药频度限定日费用

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超短半径多分支井柔性钻具设计及应用

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石油矿场机械 2024年第3期53卷 70-75页

作者：高鹏阳关皓纶薛宪波张文博王伟军赵金永中海油田服务股份有限公司一体化和新能源事业部天津300459

利用超短半径多分支井可高效靶向挖潜中老油田局部富集剩余油和断块油田阁楼油,加大储层泄油面积,提高油田的采收率。柔性钻具是超短半径侧钻多分支井技术中的核心工具,在钻进过程中受力较为复杂,国内尚未形成完整的柔性钻具设计方法及... 详细信息

利用超短半径多分支井可高效靶向挖潜中老油田局部富集剩余油和断块油田阁楼油,加大储层泄油面积,提高油田的采收率。柔性钻具是超短半径侧钻多分支井技术中的核心工具,在钻进过程中受力较为复杂,国内尚未形成完整的柔性钻具设计方法及相应的力学分析。基于工艺特点和现场需求,对柔性钻具进行了受力分析和总体结构设计,给出了整体管柱的设计方法,建立了力学模型进行有限元分析,对不同载荷条件下的钻具强度进行校核。在南海某井的现场应用结果表明,该柔性钻具造斜钻进顺利,作业后与治理前相比日产量提升三倍,含水率降低53%。可为适用于超短半径多分支井的柔性钻具的设计与研究提供参考。

关键词：超短半径柔性钻具剩余油阁楼油设计方法力学分析

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Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

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Science China(Life Sciences) 2023年第1期66卷 152-164页

作者： Xiyue Jin xue Sun Yan Chai Yu Bai Ying Li Tianjiao Hao Jianxun Qi Hao Song Catherine CL Wong George F.gao School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University First Hospital Peking UniversityBeijing 100034China Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China Research Network of Immunity and Health(RNIH) Beijing Institutes of Life ScienceChinese Academy of SciencesBeijing 100101China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China School of Basic Medical Sciences Peking University Health Science CenterPeking UniversityBeijing 100191China

The constant emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants indicates the evolution and adaptation of the *** innate immune evasion through increased expression of viral antagonist proteins,including ORF9b,contributes to the improved transmission of the Alpha variant;hence,more attention should be paid to these viral ***9b is an accessory protein that suppresses innate immunity via a monomer conformation by binding to ***,we solved the dimeric structure of SARS-CoV-2 ORF9b with a long hydrophobic tunnel containing a lipid molecule that is crucial for the dimeric conformation and determined the specific lipid ligands as monoglycerides by conducting a liquid chromatography with tandem mass spectrometry analysis,suggesting an important role in the viral life ***,a long intertwined loop accessible for host factor binding was observed in the *** phosphorylated residues in ORF9b were identified,and residues S50 and S53 were found to contribute to the stabilization of dimeric ***,we proposed a model of multifunctional ORF9b with a distinct conformation,suggesting that ORF9b is a fold-switching protein,while both lipids and phosphorylation contribute to the ***,the ORF9b monomer interacts with Tom70 to suppress the innate immune response,whereas the ORF9b dimer binds to the membrane involving mature virion *** results provide a better understanding of the multiple functions of ORF9b.

关键词： SARS-CoV-2 ORF9b immune escape viral antagonist membrane association fold switch lipid binding

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高应变速率下铸态ZM6镁合金的力学行为研究

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铸造技术 2024年第2期45卷 187-190页

作者：郑兆博高景龙孙庆冀董旭光闫友军沈阳理工大学材料科学与工程学院辽宁沈阳110159 潍坊科技学院化工与环境学院山东寿光262700

利用分离式霍普金森压杆对铸态ZM6镁合金进行高应变速率的动态力学压缩实验,并对ZM6镁合金的力学性能和微观组织进行了研究分析。结果表明,在试样解体之前,随着冲击载荷的提高,试样的应变速率及最大应变不断提高。从真应力-真应变曲线... 详细信息

利用分离式霍普金森压杆对铸态ZM6镁合金进行高应变速率的动态力学压缩实验,并对ZM6镁合金的力学性能和微观组织进行了研究分析。结果表明,在试样解体之前,随着冲击载荷的提高,试样的应变速率及最大应变不断提高。从真应力-真应变曲线中发现,铸态ZM6镁合金表现出明显的正应变率强化现象,并且随着应变速率的提升,加工硬化效果显著,最高抗冲击强度达到328.1 MPa。通过微观组织分析,铸态ZM6镁合金在高应变速率下的断裂方式为脆性断裂。

关键词： ZM6镁合金高应变速率霍普金森杆力学性能断裂方式

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