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c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway

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Acta Pharmacologica Sinica 2019年第8期40卷 1058-1066页

作者： Dan Xu Bao Wang Pan-pan Chen Yan-zhe Wang Nai-jun Miao Fan yin Qian Cheng Zhuan-li Zhou Hong-yan Xie Li Zhou Jun Liu Xiao-xia Wang Hong xue Wei Zhang Li-min Lu Department of Physiology and Pathophysiology School of Basic Medical SciencesShanghai Medical CollegeFudan University Department of Nephrology Shanghai Tong Ren HospitalShanghai Jiao Tong University School of Medicine

c-Myc plays an important role in cell proliferation,differentiation,and cell ***/Fas pathway is a key regulator of cell *** study was aimed to investigate the effects of c-Myc on the FasL/Fas pathway in ischemia-reperfusion(I/R)-induced renal *** were objected to bilateral renal ischemia for 60 min and reperfused for 24 or 48 ***-52 E cells were treated with hypoxia-reoxygenation(H/R)or *** was used to identify the distribution of *** apoptosis was assessed by TUNEL ***-c-Myc and recombinant pcDAN 3.0 were used to overexpress c-Myc and c-FLIP,*** assay and luciferase assay were used to detect the binding of c-Myc to c-FLIP *** I/R rats,c-Myc was increased significantly and mainly located in renal tubular epithelial cells;meanwhile,c-FLIP was decreased,cleaved caspase-8,cleaved caspase-3 and TUNEL-positive staining cells were *** of I/R rats with c-Myc inhibitor 10058-F4 significantly attenuated the decrease in c-FLIP,the increase in cleaved caspase-8,cleaved caspase-3,TUNEL-positive cells,Scr and BUN in I/R *** NRK-52 E cells,hypoxia and reoxygen induced the increase in c-Myc and decrease in *** and luciferase assay results indicated that cMyc binds to the promoter region of c-FLIP *** of c-Myc markedly decreased *** of c-FLIP inhibited the increase in cleaved caspase-8 and caspase-3 induced by *** indicated that c-Myc is increased in kidneys of I/R rats and negatively regulates the expression of c-FLIP,then enhanced FasL-induced cell apoptosis in I/R stress.

关键词： c-Myc c-FLIP Fas/Fas ischemia-reperfusion tubular cell apoptosis

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Enhancing the Robustness of the Microcavity Coupling System

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Chinese Physics Letters 2011年第3期28卷 100-103页

作者： YAN ying-Zhan JI zhe YAN Shu-Bin LIU Jun xue Chen-Yang ZHANG Wen-Doug XIONG Ji-Jun Key Laboratory of Instrumentation Science and Dynamic Measurement North University of ChinaTaiyuan 030051 Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051

A novel method to enhance the robustness of the microcavity coupling system(MCS)is presented by encapsulating and solidifying the MCS with a low refractive index(RI)curable UV *** encapsulating process is illustrated in detail for a typical microsphere with a radius of R about 240μ*** differences of the resonant characteristics before and after the package are observed and *** first two differences refer to the enhancement of the coupling strength and the shift of the resonant spectrum to the longer wavelength,which are both mainly because of the microsphere surrounding RI *** difference is the quality factor(Q-factor)which decreases from 7.8×10^(7)to 8.7×10^(6)after the package due to the polymer ***,rotation testing experiments have been carried out to verify the robustness of the package *** results demonstrate that the packaged MCR has much better robust performance than the un-package *** enhancement of the robustness greatly promotes the microcavity research from fundamental investigations to application fields.

关键词： resonant coupling rotation

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Synergistic anti-liver cancer effects of curcumin and total ginsenosides

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1091-1103页

作者： zhe Deng Xiao-Yan Xu Fenny Yunita Qing Zhou Yong-Rong Wu Yu-Xing Hu Zhi-Qi Wang xue-Fei Tian Department of Internal Medicine College of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Basic Chinese Medical Sciences Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Pharmaceutical Sciences Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Liver cancer is the sixth most frequently occurring cancer in the world and the fourth most common cause of cancer *** pathogenesis of liver cancer is closely associated with inflammation and immune response in the tumor *** therapeutic agents for liver cancer,which can control inflammation and restore cellular immunity,are ***(Cur)is a natural anti-inflammatory drug,and total ginsenosides(TG)are a commonly used immunoregulatory *** note,both Cur and TG have been shown to exert anti-liver cancer *** To determine the synergistic immunomodulatory and anti-inflammatory effects of Cur combined with TG in a mouse model of subcutaneous liver *** A subcutaneous liver cancer model was established in BALB/c mice by a subcutaneous injection of hepatoma cell *** were treated with Cur(200 mg/kg per day),TG(104 mg/kg per day or 520 mg/kg per day),the combination of Cur(200 mg/kg per day)and TG(104 mg/kg per day or 520 mg/kg per day),or 5-fluorouracil combined with cisplatin as a positive control for 21 *** volume was measured and the protein expression of programmed cell death 1 and programmed cell death 1 ligand 1(PD-L1),inflammatory indicators Toll like receptor 4(TLR4)and nuclear factor-κB(NF-κB),and vascular growth-related factors nitric oxide synthases(iNOS)and matrix metalloproteinase 9 were analyzed by Western blot ***4+CD25+Foxp3+regulatory T cells(Tregs)were counted by flow *** The combination therapy of Cur and TG significantly inhibited the growth of liver cancer,as compared to vehicle-treated animals,and TG showed dose *** combined with TG-520 markedly decreased the protein expression of PD-L1(P<0.0001),while CD4+CD25+Foxp3+Tregs regulated by the PD-L1 signaling pathway exhibited a positive correlation with *** combined with TG-520 also inhibited the cascade action mediated by NF-κB(P<0.0001),thus inhibiting the TLR4/NF-κB signalling pathway(

关键词： Total ginsenosides Curcumin Liver cancer Immune Inflammation Programmed cell death 1 ligand 1

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Charge density wave order and electron-boson coupling in ternary superconductor Bi_(2)Rh_(3)Se_(2)

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Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 120-126页

作者： Zi-Teng Liu Chen Zhang Qi-Yi Wu Hao Liu Bo Chen Zhi-Bo yin Sheng-Tao Cui zhe Sun Shuang-Xing Zhu Jiao-Jiao Song yin-Zou Zhao Hong-Yi Zhang xue-Qing Ye Fan-ying Wu Shu-Yu Liu Xiao-Fang Tang Ya-Hua Yuan Yun-Peng Wang Jun He Hai-Yun Liu Yu-Xia Duan Jian-Qiao Meng School of Physics and Electronics Central South UniversityChangsha 410083China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Department of Physics and Electronic Science Hunan University of Science and TechnologyXiangtan 411201China Beijing Academy of Quantum Information Sciences Beijing 100085China

The newly discovered ternary chalcogenide superconductor Bi_(2)Rh_(3)Se_(2) has attracted growing attention,which provides an opportunity to explore the interplay between charge density wave(CDW)order and ***,whether the phase transition around 240 K can be attributed to the formation of CDW remains *** help resolve the debate,we study the electronic structure of Bi_(2)Rh_(3)Se_(2) by angle-resolved photoemission spectroscopy,focusing on the nature of its high-temperature phase transition around 240 *** measurements demonstrate that the phase transition at 240 K is a second-order CDW phase *** results reveal(i)a 2×2 CDW order in Bi_(2)Rh_(3)Se_(2),accompanied by the reconstruction of electronic structure,such as band folding,band splitting,and opening of CDW gaps at and away from the Fermi level;(ii)the existence of electron-boson coupling,which is manifested as an apparent kink and peak-dip-hump structure in *** observations thus enable us to shed light on the nature of CDW order and superconductivity in Bi_(2)Rh_(3)Se_(2).

关键词： charge density wave electron-boson coupling angle-resolved photoemission spectroscopy electronic structure Chalcogenide

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Panaxadiol inhibits programmed cell deathligand 1 expression and tumor proliferation via hypoxia-inducible factor(HIF)-1a and STAT3 in human colon cancer cells

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中国药理学与毒理学杂志 2019年第10期 888-889页

作者： WANG zhe LI Ming-yue ZHANG Zhi-hong MA Juan JIN xue-jun Molecular Medicine Research Center Colege of PharmacyYanbian University

OBJECTIVE To investigate the potential anti-cancer activity of panaxadiol on PD-L1 expression and tumor proliferation in human colon cancer cells and to identify the underlying mechanism. METHODS HCT116, SW620, and HT29 cells were pretreated with panaxadiol(1, 3, 10, 30 μmol·L-1) for 48 h to verify cell viability by MTT assay. HCT-116 cells were pretreated with panaxadiol(1, 3, 10 μmol·L-1) for 12 h in Western blotting, flow cytometry analysis, and reverse transcription-PCR（RTPCR）. The interaction between panaxadiol and HIF-1α/STAT3 was studied by molecular docking and immunofluorescence. HCT-116/T-cell coculture model and T-cell killing assay were employed to investigated the immunosuppressive of HCT-116 cells. Colony cormation and Ed U labeling assay were performed to detect cell proliferation. Panaxadiol at a dose of 10 and 30 mg·kg-1were orally administered in xenografted assay and Immunohistochemical analysis. RESULTS Panaxadiol showed little cytotoxicity according to the result of MTT assay and exerted a potent inhibitory activity against PD-L1 expression both on cell surface and protein/m RNA level in a dose-dependent manner. It was subsequently shown that panaxadiol inhibited STAT3 activation through JAK1,JAK2, and Src pathways. Simultaneously panaxadiol promoted degradation and depressed synthesis of HIF-αprotein induced by hypoxia. Moreover, pretrement of panaxadiol could restore the activity of cytotoxic T lymphocyte（CTL） and regain their capacity of tumor cell killing in a T cell/tumor cell co-culture system. Colony formation and Ed U labeling assays Further demonstrated that panaxadiol inhibited tumor proliferation. The Proliferation inhibitory effect in vivo of panaxadiol was also proved by xenograft assay. CONCLUSION Taken together, these studies reveal previously unknown characteristics of panaxadiol provide new perspectives into the mechanism of cancer inhibition of the compound.

关键词： panaxadiol PD-L1 HIF-1α STAT3 proliferation

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Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3513-3527页

作者： xue Liang Kunpeng Liu Xin Jia Cuiqin Cheng Meiqi Zhang Lingdong Kong Qiqi Li zhe Liu Min Li Junliang Li Yao Wang Anlong Xu School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanning 530004China Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Bile acids(BAs)are natural metabolites in mammals and have the potential to function as drugs against viral ***,the limited understanding of chenodeoxycholic acid(CDCA)receptors and downstream signaling,along with its lower suppression efficiency in inhibiting virus infection limits its clinical *** this study,we demonstrate that farnesoid X receptor(FXR),the receptor of CDCA,negatively regulates interferon signaling,thereby contributing to the reduced effectiveness of CDCA against virus *** deficiency or pharmacological inhibition enhances interferon signaling activation to suppress virus ***,FXR impairs the DNA binding and transcriptional abilities of activated interferon regulatory factor 3(IRF3)through *** IRF3 transcriptional activity by FXReIRF3 interaction significantly undermines the expression of Interferon Beta 1(IFNB1)and the antiviral response of cells,especially upon the CDCA *** FXR-deficient cells,or when combined with Z-guggulsterone(GUGG)treatment,CDCA exhibits a more potent ability to restrict virus ***,these findings suggest that FXR serves as a limiting factor for CDCA in inhibiting virus replication,which can be attributed to the“signaling-brake”roles of FXR in interferon *** FXR inhibition represents a promising pharmaceutical strategy for the clinical application of BAs metabolites as antiviral drugs.

关键词： Bile acids FXR IRF3 Interferon transcription RNA virus Z-guggulsterone Broad-spectrum antiviral activity Synergistic inhibitory effect

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Variability of microphysical characteristics in the “21·7” Henan extremely heavy rainfall event

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Science China Earth Sciences 2022年第10期65卷 1861-1878页

作者： Gang CHEN Kun ZHAO yinghui LU Yuanyuan zheNG Ming xue zhe-Min TAN Xin XU Hao HUANG Haonan CHEN Fen XU Ji YANG Shushi ZHANG xueqi FAN Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Key Laboratory for Mesoscale Severe Weather/MOE and School of Atmospheric Science Nanjing UniversityNanjing 210023China State Key Laboratory of Severe Weather and Joint Center for Atmospheric Radar Research of CMA/NJU Chinese Academy of Meteorological SciencesBeijing 100081China Center for Analysis and Prediction of Storms and School of Meteorology University of OklahomaNormanOklahoma 73072USA Colorado State University Fort CollinsCO 80523USA

In this study, significant rainfall microphysical variability is revealed for the extremely heavy rainfall event over Henan Province in July 2021(the “21·7” Henan EHR event) using a dense network of disdrometers and two polarimetric *** broad distributions of specific drop size distribution(DSD) parameters are identified in heavy rainfall from the disdrometer observations, indicating obvious microphysical variability on the surface. A K-means clustering algorithm is adopted to objectively classify the disdrometer datasets into separate groups, and distinct DSD characteristics are found among these heavy rainfall groups. Combined with the supporting microphysical structures obtained through radar observations, comprehensive microphysical features of the DSD groups are derived. An extreme rainfall group is dominantly formed in the deep convection over the plain regions, where the high number of concentrations and large mean sizes of surface raindrops are underpinned by both active ice-phase processes and efficient warm-rain collision-coalescence processes in the vertical direction. Convection located near orographic regions is characterized by restricted ice-phase processes and high coalescence efficiency of liquid hydrometeors, causing the dominant DSD group to comprise negligible large raindrops. Multiple DSD groups can coexist within certain precipitation episodes at the disdrometer stations, indicating the potential microphysical variability during the passage of convective system on the plain regions.

关键词： The“21·7”Henan EHR event Microphysical characteristics Variability Disdrometer Polarimetric radar

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Strong and stiff Ag nanowire-chitosan composite films reinforced by Ag-S covalent bonds

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Nano Research 2018年第1期11卷 410-419页

作者： Xiao-Feng Pan Huai-Ling Gao Yang Su Ya-Dong Wu Xiang-ying Wang Jing-zhe xue Tao He Yang Lu Jian-Wei Liu Shu-Hong Yu School of Chemistry and Chemical Engineering Hefei University of Technology Hefei230009 China Division of Nanomatefials and Chemistry Hefei National Laboratory for Physical Sciences at Microscale Collaborative Innovation Center of Suzhou Nano Science and Technology CAS Center for Excellence in Nanoscience Department of Chemistry University of Science and Technology of China Hefei 230026 China

High-performance composites containing various kinds of nanofibers as reinforcing building blocks have recently received considerable attention, owing to their superior mechanical properties. One of the effective strategies to reinforce these composites involves strengthening interfacial interactions via covalent bonds. However, in contrast to nanosheets, covalent bonds have been rarely used in nanofiber-reinforced composites. Herein, we report the macroscale fabrication of a series of Ag nanowire （NW）-thiolated chitosan （TCS） composite films via spray induced self-assembly. The obtained films were significantly strengthened by Ag-S covalent bonds formed between the Ag NWs and the thiol groups of TCS. The tensile strength of the optimized Ag NW-TCS film was up to 3.9 and 1.5 times higher compared with that of pure TCS and Ag NW-chitosan （CS） films, respectively.

关键词： silver nanowire thiolated chitosan Ag-S covalent bond spraying reinforcement

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Response of runoff to climate change in the area of runoff yield in upstream Shiyang River Basin,Northwest China:A case study of the Xiying River

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Journal of Groundwater Science and Engineering 2023年第1期11卷 89-96页

作者： Shu-hong Song zhen-long Nie Xin-xin Geng xue Shen zhe Wang Pu-cheng Zhu Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of Natural ResourcesShijiazhuang 050061China China University of Geosciences Beijing 10083China

The objective of this study was to analyze the response of runoff in the area of runoff yield of the upstream Shiyang River basin to climate change and to promote sustainable development of regional water resources and ecological *** the biggest tributary of the Shiyang River,Xiying River is the only hydrological station(Jiutiaoling) that has provincial natural river and can achieve long time series monitoring data in the *** data obtained from this station is representative of natural conditions because it has little human *** study built a regression model through identifying the characteristics of runoff and climate change by using Mann-Kendall nonparametric statistical test,cumulative anomaly,and correlation *** results show that the average annual runoff is 320.6 million m3/a with the coefficient of variation of 0.18 and shows slightly decrease during *** has a significant positive correlation the average annual precipitation(P<0.01).Runoff is sensitive to climate change,and the climate has becoming warm and wet and annual runoff has entering wet period from *** to the earlier period(1955-2000),the increases of average annual temperature,precipitation and runoff in recent two decades were 15%,9.3%,and 7.8%,*** in the Shiyang River is affected by temperature and precipitation among climate factors,and the simulation results of the runoff-climate response model(R=0.0052P-0.1589T+2.373) indicate that higher temperature leads to a weakening of the ecological regulation of surface runoff in the flow-producing area.

关键词： Runoff Heating and wetting Mann-Kendall test Regression model Ecological function

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Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

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Neural Regeneration Research 2023年第12期18卷 2773-2780页

作者： zhe Liu Jingfei xue Canying Liu Jiahui Tang Siting Wu Jicheng Lin Jiaxu Han Qi Zhang Caiqing Wu Haishun Huang Ling Zhao Yehong Zhuo Yiqing Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong ProvinceChina

Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion *** mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision *** date,there is no clinical treatment that can regenerate the optic nerve and restore *** previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform ***,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term *** this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine *** also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision *** analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion *** results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal *** results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the com

关键词： axonal regeneration conditional knockout neurotransmitter optic nerve injury presynaptic neuron retinal network synaptic connection synaptic vesicles visual acuity zinc transporter 3

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