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Rare Metals 2024年第11期 6006-6022页

作者： xue-yu man Ze-Wen Sun Shan-He Li Gang Xu Wen-Juan Li Zhen-Lei Zhang Hong Liang Feng Yang State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) School of Chemistry and Pharmaceutical SciencesCollaborative Innovation Center for Guangxi Ethnic MedicineGuangxi Normal University

Cisplatin resistance is the main cause for the failure of cancer *** solve the problem,we proposed to develop a novel human serum albumin(HSA)nanoplatform to integrate chemotherapy,photothermal therapy(PTT) and *** this end,we obtained a platinum compound(C5) with significant cytotoxicity in the cisplatin-resistant SKOV-3 cells(SKOV-3/DDP),and then innovatively constructed photosensitizer(indocyanine green(ICG))-encapsulated HSAC5 complex nanoparticles(ICG@HSA-C5 NPs).The ICG@HSA-C5 NPs exhibited excellent photothermal performances in vitro and in ***,the in vivo results revealed that HSA enhanced the antitumor effect of C5 and that the combination of chemotherapy and PTT could significantly inhibit cisplatin-resistant tumor growth and improved the targeting abilities of C5 and ICG,and reduced their side *** also confirmed that ICG@HSA-C5 NPs killed the SKOV-3/DDP cells via gasdermin E(GSDME)-mediated pyroptosis and pyroptosis-induced immune responses,thereby synergistically leading to the death of the SKOV-3/DDP cells.

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腹部摩法结合颈椎旋转定位扳法治疗痰湿阻络型椎动脉型颈椎病患者的疗效观察

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世界中西医结合杂志 2024年第3期19卷 550-555页

作者：许嘉犇刘士硕陈柏臻薛玉满黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001 黑龙江中医药大学附属第三医院黑龙江哈尔滨150001

目的探讨腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证的效果。方法选取2022年1月—2022年12月期间黑龙江中医药大学附属第二医院收治的90例椎动脉型痰湿阻络证患者,采用随机数字表法分为腹摩组、扳法组、联合组,每组各3... 详细信息

目的探讨腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证的效果。方法选取2022年1月—2022年12月期间黑龙江中医药大学附属第二医院收治的90例椎动脉型痰湿阻络证患者,采用随机数字表法分为腹摩组、扳法组、联合组,每组各30例。3组患者均给予西药与常规推拿治疗,在此基础上,腹摩组施以腹部摩法,扳法组施以颈椎旋转定位扳法,联合组给予腹部摩法+颈椎旋转定位扳法,3组患者均治疗2周。观察比较3组患者临床疗效、安全性以及治疗前后中医证候积分、眩晕症状评分(Evaluation scale for cervical vertigo,ESCV评分)、颈椎功能评分[颈椎功能障碍指数(Neck disability index,NDI)及日本骨科协会(Japanese orthopaedic association scores,JOA)]、椎-基底动脉血流动力学[平均血流速度(Velocitymean,Vm)、收缩期峰值血流速度(Velocity systolic,Vs)、舒张期末血流速度(Vend of diastolic velocity,Vd)、阻力指数(Resistance index,RI)、搏动指数(Pulsation index,PI)值]。结果治疗后联合组临床总有效率96.67%(29/30)高于腹摩组70.00%(21/30)与扳法组80.00%(24/30),差异有统计学意义(P0.05)。结论腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证安全、有效,有利于改善颈椎功能,调节椎-基底动脉血流动力学,进而缓解眩晕症状。

关键词：椎动脉型颈椎病痰湿阻络证腹部摩法颈椎旋转定位扳法血流动力学

The in vitro proliferation and cytokine production of Vα24＋Vβ11＋ natural killer T cells in patients with systemic lupus erythematosus

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Chinese Medical Journal 2011年第1期124卷 61-65页

作者： yu xue-man WANG Xiao-fei Department of Rheumatology Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China

Background Activation in vitro of natural killer T （NKT） cells in systemic lupus erythematosus （SLE） with a-galactosylceramide （a-GalCer） and dendritic cells （DC） may affect the immunoregulatory role of NKT cells. This study was designed to compare the number of NKT cells in patients with SLE to the number in healthy volunteers and measure the cytokines secreted from these NKT cells in vitro. Methods Three sets of culture conditions using （i） a-GalCer, （ii） DC, or （iii） both a-GalCer and DC （a-GalCer＋DC） were adopted to expand NKT cells from peripheral blood mononuclear cells （PBMC） of patients with SLE and healthy volunteers. Flow cytometry was used to assess the levels of interleukin （IL）-4, IL-10, interferon （IFN）-y and tumor necrosis factor （TNF）-a produced by the Vα24＋Vβ11＋ NKT cells. Results After 14 days in culture, the total cell count and percentage of Vα24＋Vβ11＋ NKT cells were increased under all conditions but were highest in the a-GalCer＋DC group. The level of IL-4 and IL-10 secreted by Vα24＋Vβ11＋ NKT cells from patients with active SLE was found to be higher than that of inactive patients and the control group （P 〈0.05）, while the levels of IFN-y and TNF-a were lower than those found in the inactive and control groups （P 〈0.05）. Conclusions Va24＋V^11＋ NKT cells showed the greatest expansion in vitro with a-GalCer and DC. Th2-type cytokines from Vα24＋Vβ11＋ NKT cells are the predominant type in patients with SLE, while Th 1 cytokines predominate in the control group. This evolution of NKT cell function during the progression of the disease may have important implications in understanding the mechanism of SLE and for the development of possible therapies using NKT cell agonists.

关键词： natural killer T cell, systemic lupus erythematosus α-galactosylceramide cytokine dendritic cells

The in vitro proliferation and cytokine production of Vα24+Vβ11+ natural killer T cells in patients with systemic lupus erythematosus

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中华医学杂志(英文版) 2011年第1期124卷 61-65页

作者： yu xue-man WANG Xiao-fei Department of Rheumatology Shengjing Hospital of China Medical University

Background Activation in vitro of natural killer T （NKT） cells in systemic lupus erythematosus （SLE） with a-galactosylceramide （a-GalCer） and dendritic cells （DC） may affect the immunoregulatory role of NKT cells. This study was designed to compare the number of NKT cells in patients with SLE to the number in healthy volunteers and measure the cytokines secreted from these NKT cells in vitro. Methods Three sets of culture conditions using （i） a-GalCer, （ii） DC, or （iii） both a-GalCer and DC （a-GalCer+DC） were adopted to expand NKT cells from peripheral blood mononuclear cells （PBMC） of patients with SLE and healthy volunteers. Flow cytometry was used to assess the levels of interleukin （IL）-4, IL-10, interferon （IFN）-γ and tumor necrosis factor （TNF）-a produced by the Vα24+Vβ11+NKT cells. Results After 14 days in culture, the total cell count and percentage of Vα24+Vβ11+NKT cells were increased under all conditions but were highest in the a-GalCer+DC group. The level of IL-4 and IL-10 secreted by Vα24+Vβ11+NKT cells from patients with active SLE was found to be higher than that of inactive patients and the control group （P<0.05）, while the levels of IFN-γ and TNF-α were lower than those found in the inactive and control groups （P<0.05）. Conclusions Vα24+Vβ11+NKT cells showed the greatest expansion in vitro with a-GalCer and DC. Th2-type cytokines from Vα24+Vβ11+NKT cells are the predominant type in patients with SLE, while Th1 cytokines predominate in the control group. This evolution of NKT cell function during the progression of the disease may have important implications in understanding the mechanism of SLE and for the development of possible therapies using NKT cell agonists.

关键词： natural killer T cell systemic lupus erythematosus α-galactosylceramide cytokine dendritic cells

Effects of proton pump inhibitors on inflammatory bowel disease:An updated review

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World Journal of Gastroenterology 2024年第21期30卷 2751-2762页

作者： yu Liang Zhen Meng xue-Li Ding man Jiang Department of Pharmacy The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Intervention The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal *** pump inhibitors(PPIs)are the primary drugs used to treat acid-related *** are also commonly prescribed to patients with *** studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of *** this review,we summarize the potential impact of PPIs on IBD and analyze the underlying *** findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.

关键词： Drug safety Proton pump inhibitor Inflammatory bowel disease Ulcerative colitis Crohn’s disease

Analysis of destructive effect of Zn on carbon brick and way of Zn into carbon brick

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Journal of Iron and Steel Research International 2024年第6期31卷 1344-1354页

作者： Peng-bo Liu Shu-sen Cheng yu-qing xue Xiao-man Cheng Zhao Liu University of Science and Technology Beijing Beijing 100083China Ministry of Ironmaking Shangdong Taishan Steel Group Co.Ltd.Taian 271000ShandongChina

The service life of a blast furnace depends largely on the degree of damage to the carbon brick in the *** brick and ramming material in the hearth of a 1780 m3 blast furnace after shutdown were sampled and *** was found that the substances in the cracks of the carbon brick near and above the taphole were ZnO and Zn_(2)SiO_(4),whereas the substances in the cracks of the carbon brick below the taphole were *** reaction of Zn with CO,SiO_(2),and Fes generates ZnO,Zn_(2)SiO_(4),and ZnS,resulting in volume expansion,which is an important reason for the cracking of carbon ***,several obvious Zn vapor flow channels were found in the ramming material,through which Zn vapor could enter the carbon brick,causing damage to the carbon *** the compactness of the ramming material is beneficial to preventing Zn vapor from entering the carbon brick through the voids in the ramming material,reducing the destructive effect of Zn on the carbon brick and further extending the service life of the blast furnace.

关键词： Zn Blast furnace Carbon brick Ramming material Crack

A phylogenetic approach identifies patterns of beta diversity and floristic subregions of the Qinghai-Tibet Plateau

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Plant Diversity 2024年第1期46卷 59-69页

作者： Haibin yu man Yang Zixin Lu Weitao Wang Fangyuan yu Yonghua Zhang xue Yin Hongjun yu Junjie Hu David C.Deane Key Laboratory of Conservation and Application in Biodiversity of South China School of Life SciencesGuangzhou UniversityGuangzhou 510006China School of Ecology Sun Yat-Sen UniversityShenzhen 510275China School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Centre for Future Landscapes and Department of Environment and Genetics La Trobe UniversityBundooraVIC 3083Australia

Patterns of taxonomic and phylogenetic beta diversity and their relationships with environmental correlates can help reveal the origin and evolutionary history of regional *** Qinghai-Tibet Plateau(QTP)harbors an exceptionally diverse flora,however,a phylogenetic perspective has rarely been used to investigate its beta diversity and floristic *** this study,we used a phylogenetic approach to identify patterns of beta diversity and quantitatively delimit floristic regions on the Qinghai-Tibet *** also examined the relationships between multifaceted beta diversity,geographical distance,and climatic difference,and evaluated the relative importance of various factors(i.e.,climate,topography and history)in shaping patterns of beta diversity.Sørensen dissimilarity indices indicated that patterns of species turnover among sites dominated the *** also found that patterns of both taxonomic and phylogenetic beta diversity were significantly related to geographical distance and climatic *** environmental factors that contributed most to these patterns of beta diversity include annual precipitation,mean annual temperature,climatic gradients and climatic *** dendrograms of dissimilarity and non-metric multidimensional scaling ordination based on phylogenetic beta diversity data identified ten floristic subregions in the *** results suggest that the contemporary environment and historical climate changes have filtered species composition among sites and eventually determined beta diversity patterns of plants in the QTP.

关键词： Biogeographical regionalization Phylogenetic beta diversity Seed plants Sørensen dissimilarity Qinghai-Tibet Plateau

Evaluating the historical,clinical,and cultural value of the Tian Hui Yi Jian

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Journal of Traditional Chinese Medicine 2024年第1期44卷 220-221页

作者： yu Linyong GU man China Academy of Chinese Medical Sciences Beijing 100700China Institute for History of Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China

Tian Hui Yi Jian was compiled by the Tianhui Medical manuscripts Compilation Group,which includes scholars from the Institute for History of Medicine and Medical Literature of the China Academy of Chinese Medical Sciences(CACMS),Chengdu University of Traditional Chinese Medicine,Chengdu Institute of Cultural Relics and Archaeology,and Jingzhou Cultural Relics Protection *** was published by the Cultural Relics Press in November *** volume includes images of eight medical manuscripts,along with the Team's annotations,and photographs of a lacquered figurine with meridian-channels and words on its surface.

关键词： surface Chengdu Tian

Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative Medicine 2024年第3期22卷 286-294页

作者： Jia-jia Liu xue Zhang Bang-lan Cai man-man Qi Yong-bin Chi Bin Peng Deng-hai Zhang School of Medicine Shanghai UniversityShanghai 200444China Shanghai Health Commission Key Lab of Artificial Intelligence-Based management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China School of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid Molecular docking

Spreadsheet quality assurance:a literature review

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Frontiers of Computer Science 2024年第2期18卷 61-82页

作者： Pak-Lok POON man Fai LAU yuen Tak yu Sau-Fun TANG School of Engineering and Technology Central Queensland UniversityMelbourne 3000Australia Department of Computing Technologies Swinburne University of TechnologyHawthorn 3122Australia Department of Computer Science City University of Hong KongHong Kong SAR 999077China The Royal Victorian Eye and Ear Hospital East Melbourne 3002Australia

Spreadsheets are very common for information processing to support decision making by both professional developers and non-technical end ***,business intelligence and artificial intelligence are increasingly popular in the industry nowadays,where spreadsheets have been used as,or integrated into,intelligent or expert systems in various application ***,it has been repeatedly reported that faults often exist in operational spreadsheets,which could severely compromise the quality of conclusions and decisions based on the *** a view to systematically examining this problem via survey of existing work,we have conducted a comprehensive literature review on the quality issues and related techniques of spreadsheets over a 35.5-year period(from January 1987 to June 2022)for target journals and a 10.5-year period(from January 2012 to June 2022)for target *** other findings,two major ones are:(a)Spreadsheet quality is best addressed throughout the whole spreadsheet life cycle,rather than just focusing on a few specific stages of the life cycle.(b)Relatively more studies focus on spreadsheet testing and debugging(related to fault detection and removal)when compared with spreadsheet specification,modeling,and design(related to development).As prevention is better than cure,more research should be performed on the early stages of the spreadsheet life *** by our comprehensive review,we have identified the major research gaps as well as highlighted key research directions for future work in the area.

关键词： decision support system end-user computing end-user programming Excel spreadsheet