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DNA Damage,Apoptosis and C-myc,C-fos,and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

Biomedical and Environmental Sciences 2006年第3期19卷 197-204页

作者： RI-AN YU chenG-FENG yang xue-MIN chen Department of Occupational and Environmental Health MOE Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China

Objective To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes. Methods Sodium selenite at the doses of 5, 10, and 20 μmol/kg was given to rats by i.p. and there were 5 male SD rats in each group. Hepatocellular DNA damage was detected by single cell gel electrophoresis （or comet assay）. Hepatocellular apoptosis was determined by TUNEL （TdT-mediated dUTP nick end labelling） and flow cytometry. C-myc, c-fos, and c-jun expression in rat bepatocytes were assayed by Northern dot hybridization. C-myc, c-fos, and c-jun protein were detected by immunohistochemical method. Results At the doses of 5, 10, and 20μmol/kg, DNA damage was induced by sodium selenite in rat hepatocytes and the rates of comet cells were 34.40%, 74.80%, and 91.40% respectively. Results also showed an obvious dose-response relationship between the rates of comet cells and the doses of sodium selenite （r=0.9501, P〈0.01）. Sodium selenite at the doses of 5, 10, and 20μmol/kg caused c-myc, c-fos, and c-jun overexpression obviously. The positive brown-yellow signal for proteins of c-myc, c-fos, and c-jun was mainly located in the cytoplasm of bepatocytes with immunohistocbemical method. TUNEL-positive cells were detected in selenium-treated rat livers. Apoptotic rates （%） of selenium-treated liver cells at the doses of 5, 10, and 20 μmol/kg were （3.72±1.76）, （5.82±1.42）, and （11.76±1.87） respectively, being much higher than those in the control. Besides an obvious dose-response relationship between apoptotic rates and the doses of sodium selenite （r=0.9897, P〈0.01）, these results displayed a close relationship between DNA damage rates and apoptotic rates, and the relative coefficient was 0.9021, P〈0.01. Conclusion Selenium at 5-20μmol/kg can induce DNA damage, apoptosis, and overexpression of c-myc, c-fos, and c-jun in rat hepatocytes.

关键词： Selenium DNA damage Apoptosis C-myc C-fos C-jun

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Fully Biodegradable Poly(lactic acid)/Poly(propylene carbonate)Shape Memory Materials with Low Recovery Temperature Based on in situ Compatibilization by Dicumyl Peroxide

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Chinese Journal of Polymer Science 2018年第6期36卷 783-790页

作者： Sheng-xue Qin Cui-Xiang Yu xue-yang chen Hai-Ping Zhou Li-Fen Zhao College of Mechanical and Electric Engineering College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China Qingdao Reinforced Thermoplastic Pipes Engineering Technology Center Qingdao 266590China

Fully biodegradable blends with low shape memory recovery temperature were obtained based on poly（lactic acid）（PLA） and poly（propylene carbonate）（PPC）. By virtue of their similar chemical structures, in situ cross-linking reaction initiated by dicumyl peroxide（DCP） between PLA and PPC chains was realized in PLA/PPC blends. Therefore, the compatibility between PLA and PPC was increased, which obviously changed the phase structures and increased the elongation at break of the blends. The compatibilized blends had a recovery performance at 45 °C. Combining the changes of phase structures, the mechanism of the shape memory was discussed. It was demonstrated that in situ compatibilization by dicumyl peroxide was effective to obtain eco-friendly PLA/PPC blends with good mechanical and shape memory properties.

关键词： Polylactide Poly(propylene carbonate) Dicumyl peroxide Compatibilization Shape memory

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Snow algal blooms in Antarctic King George Island in 2017-2022 and their future trend based on CMIP6 projection

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Advances in Climate Change Research 2023年第5期14卷 732-745页

作者： xue-yang chen Shuang-Lin LI Chao ZHANG Dong-Yan LIU Institute of Atmospheric Physics/Climate Change Research Center Chinese Academy of SciencesBeijing 100029China Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China College of Earth and Planetary Sciences University of the Chinese Academy of SciencesBeijing 100029China College of Marine Sciences Beibu Gulf UniversityQinzhou 535011China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 20062China

Snow algal blooms have a remarkable climatic or environmental effect through influencing the snow-albedo feedback,accelerating the melting of surface snow,and amplifying global *** algal blooms occurred frequently on King George Island,Antarctic,during the recent six austral summers(December to next February)through *** on an assessment of satellite images,this study found that the range and amount of snow algal blooms in the summers of 2018,2020,2021 and 2022 are relatively larger than in the summers of 2017 and *** meteorological conditions have shaped the year-to-year variation of algal bloom intensities is analyzed through observational *** results suggest that during the strong bloom summers there exist prevailing northerly or northwesterly wind anomalies which advect warm and humid airmass from the southern ocean into the island,increasing surface air temperature and humidity;the warmer and more humid surface favors melting of snow and an increase of low cloud cover,subsequently enhancing the atmospheric downward long-wave radiation and amplifying surface warmth;the increased low cloud cover reflects more ultraviolet rays back to space and weakens the short-wave radiation reaching the *** these factors together favor to a stronger *** comparison,during 2017 and 2019 there exist weak southerly wind anomalies which induce the northward advection of cold and dry air from the Antarctic Continent and favor the cooler ***,it is unfavorable for the snow algal *** on these results,a snow algal bloom potential index(API)integrating the meteorological conditions is constructed,and its future trend is projected based on the EC-Earth3 run attending the CMIP6 under SSP245 and SSP585.A significant increasing trend is projected especially under *** snow algal bloom on King George Island will become more frequent and stronger in *** implies a potential accelerate melting of ice shelf

关键词： Antarctic Peninsula Snow algal bloom Meteorological conditions Satellite images Future projection

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Enhancing the Robustness of the Microcavity Coupling System

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Chinese Physics Letters 2011年第3期28卷 100-103页

作者： YAN Ying-Zhan JI Zhe YAN Shu-Bin LIU Jun xue chen-yang ZHANG Wen-Doug XIONG Ji-Jun Key Laboratory of Instrumentation Science and Dynamic Measurement North University of ChinaTaiyuan 030051 Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051

A novel method to enhance the robustness of the microcavity coupling system(MCS)is presented by encapsulating and solidifying the MCS with a low refractive index(RI)curable UV *** encapsulating process is illustrated in detail for a typical microsphere with a radius of R about 240μ*** differences of the resonant characteristics before and after the package are observed and *** first two differences refer to the enhancement of the coupling strength and the shift of the resonant spectrum to the longer wavelength,which are both mainly because of the microsphere surrounding RI *** difference is the quality factor(Q-factor)which decreases from 7.8×10^(7)to 8.7×10^(6)after the package due to the polymer ***,rotation testing experiments have been carried out to verify the robustness of the package *** results demonstrate that the packaged MCR has much better robust performance than the un-package *** enhancement of the robustness greatly promotes the microcavity research from fundamental investigations to application fields.

关键词： resonant coupling rotation

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LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

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World Journal of Gastroenterology 2019年第45期25卷 6607-6618页

作者： xue-yang chen Chang-Zhou Cai Meng-Li Yu Ze-Min Feng Yu-Wei Zhang Pei-Hao Liu Hang Zeng Chao-Hui Yu Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Clinical Research Center for Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina

BACKGROUND It is well known that nonalcoholic fatty liver disease(NAFLD)is associated with insulin resistance(IR).LB100,a serine/threonine protein phosphatase 2A(PP2A)inhibitor,is closely related to ***,there is little data regarding its direct influence on *** To elucidate the effect and underlying mechanism of LB100 in *** After 10 wk of high fat diet(HFD)feeding,male C57BL/6 mice were injected intraperitoneally with vehicle or LB100 for an additional 6 wk(three times a week).The L02 cell line was treated with LB100 and free fatty acids(FFAs)for 24 *** and eosin and oil red O staining were performed for histological *** blot analysis was used to detect the protein expression of Sirtuin 1(Sirt1),total and phosphorylated AMP-activated protein kinaseα(AMPKα),and the proteins involved in lipogenesis and fatty acid *** mRNA levels were determined by *** inhibition of AMPK was performed to further examine the exact mechanism of LB100 in *** LB100 significantly ameliorated HFD-induced obesity,hepatic lipid accumulation and hepatic injury in *** addition,LB100 significantly downregulated the protein levels of acetyl-CoA carboxylase,sterol regulatory element-binding protein 1 and its lipogenesis target genes,including stearoyl-CoA desaturase-1 and fatty acid synthase,and upregulated the levels of proteins involved in fatty acidβ-oxidation,such as peroxisome proliferator-activated receptorα(PPARα),peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α),carnitine palmitoyltransferase 1α,acyl-CoA oxidase 1 and uncoupling protein 2,as well as the upstream mediators Sirt1 and AMPKαin the livers of HFD-fed *** vitro,LB100 alleviated FFA-induced lipid accumulation in L02 cells through the AMPK/Sirt1 signaling *** studies showed that the curative effect of LB100 on lipid accumulation was abolished by inhibiting AMPKαin L02 *** PP2A inhibition by LB

关键词： LB100 Nonalcoholic fatty liver disease Serine/threonine-protein phosphatase 2A Lipid metabolism AMP-activated protein kinaseα Sirtuin 1

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Assessing food security performance from the One Health concept:an evaluation tool based on the Global One Health Index

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Infectious Diseases of Poverty 2023年第5期12卷 98-99页

作者： Si-Yu Gu Fu-Min chen chen-Sheng Zhang Yi-Bin Zhou Tian-Yun Li Ne Qiang Xiao-Xi Zhang Jing-Shu Liu Shu-Xun Wang xue-chen yang Xiao-Kui Guo Qin-Qin Hu Xiao-Bei Deng Le-Fei Han School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University-The University of Edinburgh Shanghai China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) Shanghai China Minhang District Center for Disease Control and Prevention Shanghai China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China

Background Food systems instantiate the complex interdependencies across humans,physical environments,and other *** One Health approaches for agri-food system transformation,which adopts integrated and unifying approaches to optimize the overall health of humans,animals,plants,and environments,is crucial to enhance the sustainability of food *** study develops a potential assessment tool,named the global One Health index-Food Security(GOHI-FS),aiming to evaluate food security performance across countries/territories from One Health perspective and identify relevant gaps that need to be improved for sustainable food *** We comprehensively reviewed existing frameworks and elements of food *** indicator framework of GOHI-FS was conceptualized following the structure-process-outcome model and confirmed by expert *** available data in 2020 was collected for each *** weighting strategy was determined by the Fuzzy Analytical Hierarchy *** data for each indicator was normalized and aggregated by weighted arithmetic *** regressions were performed to evaluate the associations of GOHI-FS with health and social-economic *** The GOHI-FS includes 5 first-level indicators,19 second-level indicators and 45 third-level *** were 146 countries/territories enrolled for *** highest average score of first-level indicators was Nutrition(69.8)and the lowest was Government Support and Response(31.3).There was regional heterogeneity of GOHI-FS *** median scores with interquartile range(IQR)were shown in North America(median:76.1,IQR:75.5-76.7),followed by Europe and Central Asia(median:66.9,IQR:60.1-74.3),East Asia and the Pacific(median:60.6,IQR:55.5-68.7),Latin America and the Caribbean(median:60.2,IQR:57.8-65.0),Middle East and North Africa(median:56.6,IQR:52.0-62.8),South Asia(median:51.1,IQR:46.7-53.8),and sub-Saharan Africa(median:41.4,IQR:37.2-46.5).We

关键词： Food security One Health Index Indicator framework Assessment

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Wireless contactless pressure measurement of an LC passive pressure sensor with a novel antenna for high-temperature applications

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Chinese Physics B 2015年第4期24卷 540-545页

作者：李晨谭秋林薛晨阳张文栋李运芝熊继军 Science and Technology on Electronic Test and Measurement Laboratory North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of China

In this paper, a novel antenna is proposed for high-temperature testing, which can make the high-temperature pressure characteristics of a wireless passive ceramic pressure sensor demonstrated at up to a temperature of 600℃. The design parameters of the antenna are similar to those of the sensor, which will increase the coupling strength between the sensor and testing antenna. The antenna is fabricated in thick film integrated technology, and the properties of the alumina ceramic and silver ensure the feasibility of the antenna in high-temperature environments. The sensor, coupled with the ceramic antenna, is investigated using a high-temperature pressure testing platform. The experimental measurement results show that the pressure signal in a harsh environment can be detected by the frequency diversity of the sensor.

关键词： ceramic antenna contactless pressure measurement high-temperature application wireless passive pressure sensor

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang Liu Huopo chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan Yao Xinyue Xu yang Li Junhui xue Zuoming Zhang Tao chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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