检索结果-南通市图书馆

唇样骨切除术治疗儿童股骨头坏死的短期疗效观察

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

临床小儿外科杂志 2013年第3期12卷 184-186页

作者：王继孟张敏刚闫学翔山东大学附属省立医院小儿骨科山东省济南市250021 山东省阳谷县人民医院小儿外科山东省阳谷县252300

目的观察股骨头坏死唇样骨切除术后患儿的短期临床疗效，探讨儿童股骨头坏死的治疗方法。方法我们收治4例（4髋）股骨头坏死患儿，男、女各2例。均曾因发育性髋关节脱位（DDH）接受保守治疗，后遗留髋关节半脱位伴股骨头坏死，手术治疗... 详细信息

目的观察股骨头坏死唇样骨切除术后患儿的短期临床疗效，探讨儿童股骨头坏死的治疗方法。方法我们收治4例（4髋）股骨头坏死患儿，男、女各2例。均曾因发育性髋关节脱位（DDH）接受保守治疗，后遗留髋关节半脱位伴股骨头坏死，手术治疗中因股骨头畸形使复位困难，遂用刀切除外翻的唇样骨及向外突出的赘骨部分，修整股骨头，达到满意的中心性复位。结果4例患儿均随访2～3年，疼痛均明显减轻或消失；3例无跛行，1例跛行改善；4例术前髋外展仅5°～10°，术后3例恢复至正常，1例获改善。头臼指数（AHI）术后平均达84．3％，CE角术后改善到25°。Sharp角恢复到31．5°。短期疗效评估：3例为优；1例为良。结论唇样骨切除术治疗儿童股骨头坏死短期疗效较好，髋部疼痛减轻，活动范围受限改善显著。

关键词：髋脱位,先天性并发症股骨头坏死外科学治疗结果

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 67-81页

作者： xiang LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

Metal–air batteries: A review on current status and future applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2023年第2期33卷 151-171页

作者： Tao Li Meng Huang xue Bai yan-xiang Wang Key Laboratory of Liquid-Solid Structural Evolution and Processing of Materials of Ministry of Education Shandong University School of Materials Science and Engineering Shandong University of Science and Technology

Metal–air batteries(MABs) have been paid much more attention owing to their greater energy density than the most advanced lithium-ion batteries(LIBs). Rechargeable MABs are considered as promising candidates for the next-generation of energy storage techniques for applications ranging from large-scale energy storage systems to electric vehicles and portable devices. However, there are still numerous scientific problems that must be overcome before their commercial application. With the aim of providing a comprehensive understanding of this new electrochemical system particularly Li–air batteries, this review paper provides an overview of the current status including corresponding strategies from the perspective of various battery components, including air cathode,metal anode and electrolyte. In addition, other promising MABs such as Zn–air, Mg–air and Al–air batteries are also introduced briefly for comparison. Finally, the applications and prospects of these four types of MABs are discussed and some perspectives for this research field are also provided.

关键词： Metal–air batteries Air cathode Metal anode Electrocatalyst Electrolyte

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie Jia-Lin Li Ling Gong xiang-Li Zhong Hong-Jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

Grounded-source short offset transient electromagnetic method:Theory and applications in deep mineral exploration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年

作者： Guoqiang xue Xin WU Weiying CHEN Nannan ZHOU Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Abstract The Transient Electromagnetic (TEM) method is a critical geophysical technique for subsurface exploration of metal ore bodies, primarily utilizing either loop or grounded transmitters. The Long Offset Transient Electromagnetic(LOTEM) method employs a grounded-source transmitter, relying on a far-source observation mode and plane wave approximation for detection. However, LOTEM’s far-source configuration weakens signal strength, and the plane wave approximation reduces precision, limiting effective detection depth to approximately 1000 m with a comprehensive error of about 15%. Recently, we have developed the grounded-source Short Offset Transient Electromagnetic (SOTEM) method,achieving greater detection depth and accuracy within the 500–2000 m depth range, a crucial interval for mineral resource exploration. This study explores the theoretical framework, instrumentation, data processing, and field applications of SOTEM. Based on a point charge element model, SOTEM accurately computes surface wave effects in EM field calculations,optimized for near-source observation. High-power, high-resolution, wide-bandwidth exploration equipment and an advanced three-dimensional hybrid inversion technique were also developed to enhance the method’s effectiveness. Application of SOTEM to the deep exploration of the Zhou’an Ni-Cu-PGE deposit in Henan Province yielded high-resolution imaging of conductivity structures to about 2.5 km depth. These results, consistent with existing drill data, delineated mineralized ore bodies from surrounding formations, identified zones of mineralization potential, and suggested extensive resource prospects in the region.

关键词：

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

维普期刊数据库

On the existence of solutions for prescribing fractional Q-curvature problem on S~n

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2025年

作者： yan LI Zhongwei TANG College of Science China University of Petroleum(Beijing) School of Mathematical Sciences Laboratory of Mathematics and Complex Systems MOEBeijing Normal University

The aim of this paper is to investigate the existence of solutions to the prescribing fractional Q-curvature problem on S~n under some reasonable assumption of the Laplacian sign at the critical point of prescribing curvature function K. Due to the lack of compactness, we choose to return to the basic elements of variational theory and study the deformation along the flow lines. The novelty of the paper is that we obtain the existence without assuming any symmetry and periodicity on K. In addition,to overcome the loss of compactness for high-order operator problem, we need more delicate estimates with the second order cases.

关键词：

Twist monomials of binary delta-matroids

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2025年

作者： Qi yan Xian'an JIN School of Mathematics and Statistics Lanzhou University School of Mathematical Sciences Xiamen University

Recently, we introduced the twist polynomials of delta-matroids and gave a characterization of even normal binary delta-matroids whose twist polynomials have only one term and posed a problem:what would happen for odd binary delta-matroids? In this paper, we show that a normal binary deltamatroid whose twist polynomials have only one term if and only if each connected component of the intersection graph of the delta-matroid is either a complete graph of odd order or a single vertex with a loop.

关键词：

The renaissance of oxo synthesis: heterogeneous Rh-catalyzed hydroformylation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Tao yan Zhi Cao State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences National Energy Center for Coal to Clean Fuels Synfuels China Technology Co. Ltd.

Hydroformylation could convert olefins and syngas （mixture of H2and CO） into aldehydes with a great atomic *** transformation serves as one of the most prominent processes in modern chemical industry, as it provides over 10million tons of aldehydes as feedstock for our daily essential products such as plasticizers, paints, solvents, and pharmaceuticals. This process generally requires efficient yet robust catalyst to realize decent efficacy. Compared with metals such as Co, Ru, and Pd, rhodium （Rh）-based catalysts stand out due to its superior activity even under mild reaction conditions, and dominate over 70%of global hydroformylation processes.

关键词：