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Chemical Research in Chinese Universities 2013年第2期29卷 196-200页

作者： li Yang-xue xue Ming GUO li-jia HUANG lin CHEN Si-ru QIU Shi-lun State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

Multifunctional lanthanide metal-organic frameworks（MOFs）, M（H4TCPS）（H20）l.5[M=Tb（JUC-95a）, Er（JUC-95b）, Dy（JUC-95c）, Tm（JUC-95d）, Y（JUC-95e） and Pr（JUC-95f）; H4TCPS=tetrakis（4-carboxyphenyl）silane] were synthesized via the reaction of the lanthanide metal ions（Ln3） with a rigid silicon-centered tetrahedral carbo- xylate ligand H4TCPS via a hydrothermal synthesis method. X-Ray diffraction（XRD） analyses reveal that they are extremely similar in structure and crystallized in a monoclinic system with space group C2/c. Two eight-coordinated metal centers and four tetrahedral H4TCPS groups constructed a paddle-wheel building block. The paddle-wheel buil- ding blocks assembled with each other via one oxygen bridge from a water molecule to lead to a 1D infinite inorganic rod-shaped chain, --Y--O--C--O--Y--, along the [001] direction. These 1D inorganic rod-shaped chains linked with the phenyl groups of the tetrahedral HaTCPS ligand to form a 3D framework. In addition, the luminescent and magnetic properties of these compounds show that they could be potential antiferromagnetic and fluorescent mate- rials.

关键词： Metal-organic framework Tetrakis(4-carboxyphenyl)silane Magnetic property Fluorescence

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Effects of body-resistance strengthening and tumor-suppressing granules on immune adhesion function of red blood cells and expression of metastasis protein CD44 in tumor cells of patients with esophageal carcinoma

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World Journal of Gastroenterology 2007年第32期13卷 4360-4364页

作者： Jian-Xiong Zhao xue-Feng li xue-Xi Wang Institute of Combined Western and Chinese Traditional Medicine Lanzhou University Medical School Lanzhou 730000 Gansu Province China

AIM： To investigate the effects of Fuzheng Yiliu granules （body-resistance strengthening and tumor-suppressing granules） in patients with esophageal carcinoma. METHODS： We compared the immune adherent properties of red blood cells （RBCs）, the expression of metastasis protein CD44, and the metastasis inhibition factor nm23, in esophageal carcinoma tumor cells of patients before and after radiotherapy in the presence and absence of orally administered Fuzheng Yiliu granules. Sixty-three hospitalized patients with esophageal carcinoma were treated with standard radiotherapy and randomly divided into treatment group （n = 30） treated with both radiotherapy and Fuzheng Yiliu granules and control group （n = 33） given radiotherapy only. Blood samples and tumor tissue were obtained before and after 21 d of treatment. The rosette rates for complement receptor type 3b （C3bRR） and immune complex receptor （ICRR） on RBCs were measured by erythrocyte immunological methods. Expression of CD44 and rim23 in tumor tissue sections was determined by immunohistochemical staining with monoclonal antibodies CD44v6 ad nm23H-1, respectively. RESULTS： The positivity of RBC-C3bRR before and after 21 d of treatment increased from 7.78% ± 1.59% to 10.03% ± 2.01% in the double treatment group, while it changed only slightly from 7.18% ± 1.29% to 7.46% ± 1.12% in the radiotherapy group. The positive rate for RBC-ICRR decreased from 37.68% ± 2.51% to 22.55% ± 1.65% after the double treatment, and from 37.28% ± 2.41% to 24.69% ± 1.91% in radiotherapy group at the same time points. The difference in erythrocyte immune adherent function between the two groups was significant （P 〈 0.01, t-test）. The CD44^± - cases were reduced from 21 （70.00%） to 12 （40.00%） after treatment with Fuzheng Yiliu granules, whereas the CD44^± -cases （69.70%） in the radiotherapy group remained unchanged. The difference between the treatment （40.00%） and control （69.70%） groups was significant （P 〈 0.05）. Although the nm23^±

关键词： Fuzheng Yiliu granule RBC immune function CD44 nm23 Esophageal carcinoma Metastasis protein CD44 controlled clinical trial

A Multi-Objective Particle Swarm Optimization Algorithm Based on Decomposition and Multi-Selection Strategy

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Computers, Materials & Continua 2025年第1期82卷 997-1026页

作者： li Ma Cai Dai Xingsi xue Cheng Peng School of Computer Science Shaanxi Normal UniversityXi’an710119China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou350118China Information Construction and Management Center and Institute of Artificial Intelligence and Educational New Productivity Ningxia Normal UniversityGuyuan756099China

The multi-objective particle swarm optimization algorithm(MOPSO)is widely used to solve multi-objective optimization *** the article,amulti-objective particle swarm optimization algorithmbased on decomposition and multi-selection strategy is proposed to improve the search ***,two update strategies based on decomposition are used to update the evolving population and external archive,***,a multiselection strategy is *** first strategy is for the subspace without a non-dominated *** the neighbor particles,the particle with the smallest penalty-based boundary intersection value is selected as the global optimal solution and the particle far away fromthe search particle and the global optimal solution is selected as the personal optimal solution to enhance global *** second strategy is for the subspace with a non-dominated *** the neighbor particles,two particles are randomly selected,one as the global optimal solution and the other as the personal optimal solution,to enhance local *** third strategy is for Pareto optimal front(PF)discontinuity,which is identified by the cumulative number of iterations of the subspace without non-dominated *** the subsequent iteration,a new probability distribution is used to select from the remaining subspaces to ***,an adaptive inertia weight update strategy based on the dominated degree is designed to further improve the search ***,the proposed algorithmis compared with fivemulti-objective particle swarm optimization algorithms and five multi-objective evolutionary algorithms on 22 test *** results show that the proposed algorithm has better performance.

关键词： Multi-objective optimization multi-objective particle swarm optimization decomposition multi-selection strategy

“互联网＋旅游”背景下旅游业新型监管模式研究

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中国行政管理 2018年第5期 59-62页

作者：薛丽黑龙江大学临沂大学

以"黑心雪乡"、"天价虾"为代表的旅游纠纷在互联网时代具有的放大负面效应,作为旅游升级换代产品的全域旅游,对旅游业监管模式提出了挑战和更高要求。旅游网络经营平台、行业协会和社会监督协同旅游主管部门对旅游市场进行监管,形成"四... 详细信息

以"黑心雪乡"、"天价虾"为代表的旅游纠纷在互联网时代具有的放大负面效应,作为旅游升级换代产品的全域旅游,对旅游业监管模式提出了挑战和更高要求。旅游网络经营平台、行业协会和社会监督协同旅游主管部门对旅游市场进行监管,形成"四位一体"的共治监管模式应该是"互联网+全域旅游"新型监管模式的选择。旅游主管部门更多地应该依靠旅游网络经营平台的直接监管并重点监管网络平台,制定法律法规、政策和标准,构筑以信用监管为核心的新型市场监管;旅游网络经营平台与涉旅企业相互选择和相互制约,对涉旅企业通过网规实现直接地"软法之治";行业协会通过代表绝大多数中小涉旅企业利益与旅游网络经营平台抗争,但又助力其发展;社会监督大大降低旅游市场治理成本,在互联网时代作用凸显。

关键词： “互联网+全域旅游” 监管模式监管体制机制协同共治

Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults： a retrospective study spanning 15 years

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Chinese Medical Journal 2011年第21期124卷 3490-3494页

作者： TAO Jian-ling liU li-li WEN Yu-bing GAO Rui-tong li Hang li Ming-xi li xue-mei li xue-wang Division of Nephrology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China

Background Cyclosporine is effective in treating nephrotic syndrome （NS） with idiopathic membranous nephropathy （IMN） in adults. But high relapse rate remains a major concern. The way to manipulate cyclosporine is inconclusive. The aim of this study was to introduce the way how to titrate the cyclosporine to maintain complete remission without relapse. Methods Patients with biopsy-proven IMN with NS treated with cyclosporine for at least 1 month from 1996 to 2011 at Peking Union Medical College Hospital were reviewed. Results Mean age of the 51 eligible patients was 52 years, with 39 men. Mean proteinuria was （7.47±3.14） g/d, serum albumin （24.50±6.29） g/L, and serum creatinine （82.62±21.18） μmol/L. Cyclosporine was commenced at a mean dose of （3.46±0.63） mg·kg^-1·d^-1. Oral prednisone （0.40±0.29） mg·kg^-1·d^-1 was given concomitantly in 38 patients. Cyclosporine was administered for a median of 16 months （range 1-93 months） and stopped in non-responders by month six. By month 3 （n=47）, the number in complete remission （CR） and partial remission （PR） was 3 and 24, which shifted to 12 and 17 by month 6 （n=41）. Male gender, heavy proteinuria, low serum albumin level, and high serum creatinine level were significant determinants in poor response by month six （P 〈0.05 in all variables compared with responders）. There was a significant reversible serum creatinine increase within 25% during month 3 to 12 （P 〈0.05 in all variables compared with baseline value）. Eleven patients maintained cyclosporine for more than 24 months with a cyclosporine dose of （1.04±1.06） mg·kg^-1·d^-1. Nine patients were in CR. Renal function, systolic and diastolic blood pressure remained stable. Renal impairment （〉30% rise of serum creatinine）, secondary infection, hypertension, gingival hyperplasia and liver impairment occurred in 6, 4, 10, 4, and 1 patients, respectively. Conclusions The observation time for cyclosporine to effectively induce CR of NS in IMN adults should be at least six month

关键词： cyclosporine idiopathic membranous nephropathy nephrotic syndrome treatment

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Detection of Shigella gyrA mutations and correlations between gyrA mutations and quinolones resistance

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Journal of Microbiology and Immunology 2005年第2期3卷 101-104页

作者： CHONG ZHEN WANG xue PING li xue QIN QIAN li SHaG QIAN Department of Microbiology and Parasitology Shanghai Medical College Fudan University ShanghaiP. R. China

118 clinical strains of Shigella were serotyped, in which 116 strains were tested to be S. flexneri. The susceptibilities of the S .flexneri strains to quinolones were measured by the disk-diffusion method. It was found that most S .flexneri strains were susceptible to norfloxacin and ciprofloxacin, but resistant to nalidixic acid. To study the correlation between gyrA mutations and quinolones resistance, a fragment within the gyrA gene was amplified by PCR. The SSCP （Single-Strand Conformation Polymorphism） analysis was applied to detect mutations in PCR products of different strains. The mutations were then confirmed by DNA sequencing. Altogether, two types of mutation were revealed, in which one type was single mutation （ C42-T）, and the other was double mutations （ C42-T and A54- G）. By statistical analysis, C42-T （encoding Ser83-keu substitution） was shown to have correlation with nalidixic-acid resistance in the clinical strains of Shigella, while A54-G （encoding Asp87-Gly substitution） was shown to have correlations with both norfloxacin resistance and ciprofloxacin resistance.

关键词： Shigella Quinolones resistance PCR-SSCP gyrA mutations

Expression and molecular mechanism of PCNA,Caspase-3,IL-6 and Survivin proteins in chorionic villi and decidual tissue of early embryo damage

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Precision Medicine Research 2021年第2期3卷 20-25页

作者： Xiu-Rong Wang Zu-Dong Teng xue-xue li Wen-Ming Cao Changle County People’s Hospital Shandong ProvinceWeifang 262400China Department of Gynecology People's HospitalShandong ProvinceWeifang 262400China.

Objective:This study aims to explore its role in embryo damage and the relationship between them by testing the expression of PCNA,Caspase-3,IL-6 and Survivin protein in the chorionic villi and decidual tissue of patients with unexplained early embryo damage and normal early pregnancy at the same time voluntarily requested uterine aspiration abortion in order to clarify the pathogenesis of early embryo damage from the cellular and molecular perspectives,and provide theoretical basis for the diagnosis and treatment of embryo ***:From July 2018 to July 2019,30 patients with unexplained embryo damage were selected as embryo damage group,thirty normal early pregnancy patients with aspiration abortion were selected as the normal early pregnancy *** decidual tissue and chorionic villi of the two groups were collected to observe the structural and pathological *** method was used to detect the distribution of PCNA,Caspase-3,IL-6 and Survivin in the chorionic villi and decidual tissue,as well as the expression changes of the above four ***:Compared with the normal early pregnancy group,the chorionic villi in the early embryo damage group were obviously dysplasia,degenerative changes,structural disorders,homogeneous destruction,obvious reduction or even disappearance of trophoblast cells,inflammatory cell infiltration,more neutrophils and lymphocytes,interstitial edema and cell atrophy,accompanied by hemorrhage;The decidual tissue of the intima was not good,most of the cells were spindle-shaped,the structure was disordered,the stroma has edema,inflammatory cells can be seen,and hemorrhage *** results of immunohistochemistry showed that the expression of PCNA protein in chorionic villi and decidual tissue of early embryo damage group decreased significantly(P<0.05),while the expression of Caspase-3 protein increased significantly(P<0.05).The expression of IL-6 protein decreased significantly(P<0.05),and the express

关键词： Decidual tissue chorionic villi PCNA caspase-3 IL-6 Survivin

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states