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Chinese Chemical Letters 2019年第4期30卷 919-923页

作者： Xin-Rui Wang Hui-Min Cheng xue-wei gao wei Zhou Shu-Jing Li xue-Li Cao Dongpeng Yan Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business University Department of Chemistry Beijing Normal University

A melanin synthesis inhibitor and bacteriostatic agent, kojic acid(KA) has been intercalated into Zn-Ti layered double hydroxide(LDH) by an anion-exchange reaction. The structure and the thermal stability of the samples were characterized by XRD, FT-IR, TG-DTA and SEM. The study of KA release from ZnTi-KALDH in phosphate buffered solution(pH 5) implies that ZnTi-KA-LDH is a better controlled release system than pure KA. Meanwhile, the mechanisms of slow release were assessed by using four commonly kinetic models. The antimicrobial activity of ZnTi-KA-LDH was tested against three kinds of bacteria. The inhibition of L-dopa oxidation was tested to verify its skin whitening effect. The studies suggest that the kojic acid intercalated LDHs has the potential application as a safely functional composite in cosmetic.

关键词： Layered double hydroxide Kojic acid Intercalation Slow release Antimicrobial Tyrosinase

Multi-scale context-aware network for continuous sign language recognition

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虚拟现实与智能硬件（中英文） 2024年第4期6卷 323-337页

作者： Senhua xue Liqing gao Liang WAN wei FENG College of Intelligence and Computing Tianjin UniversityTianjin 300354China

The hands and face are the most important parts for expressing sign language morphemes in sign language ***,we find that existing Continuous Sign Language Recognition(CSLR)methods lack the mining of hand and face information in visual backbones or use expensive and time-consuming external extractors to explore this *** addition,the signs have different lengths,whereas previous CSLR methods typically use a fixed-length window to segment the video to capture sequential features and then perform global temporal modeling,which disturbs the perception of complete *** this study,we propose a Multi-Scale Context-Aware network(MSCA-Net)to solve the aforementioned *** MSCA-Net contains two main modules:(1)Multi-Scale Motion Attention(MSMA),which uses the differences among frames to perceive information of the hands and face in multiple spatial scales,replacing the heavy feature extractors;and(2)Multi-Scale Temporal Modeling(MSTM),which explores crucial temporal information in the sign language video from different temporal *** conduct extensive experiments using three widely used sign language datasets,i.e.,RWTH-PHOENIX-Weather-2014,RWTH-PHOENIX-Weather-2014T,and *** proposed MSCA-Net achieve state-of-the-art performance,demonstrating the effectiveness of our approach.

关键词： Continuous sign language recognition Multi-scale motion attention Multi-scale temporal modeling

A survey of composite robot for aviation intelligent manufacturing application

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High Technology Letters 2024年第1期30卷 85-98页

作者：陶永 xue Jiao wei Hongxing LIU Haitao gao He WANG Tianmiao School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191P.R.China Research Institute of Aero Engine Beihang UniversityBeijing 100191P.R.China

With the rapid development of the aviation industry,the development of intelligent manufacturing equipment represented by composite robots has been paid close attention by the aviation *** on the analysis of the background and main structure function of composite robots,this paper focuses on the analysis of key technologies such as composite robot hardware design,visual sensing and planning system,integrated control of‘hands,feet,and eyes',multi-robot collaborative operation,and *** typical applications of composite robots in aviation intelligent manufacturing such as automatic drilling and connection of aircraft,aircraft surface spraying and finishing,parts handling,aircraft measurement,and inspection are *** development trends such as standardization of composite robots,integration of‘5G+cloud computing+AI',and fusion of intelligent sensors are proposed.

关键词： aviation manufacturing composite robot key technology development trend safety

OnFractional(g,f,n′,m)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 446-460页

作者： wei gao wei-Fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming 650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

The main contribution in this article is threefold:(1)we show the necessary and sufficient condition for graphs to be fractional(g,f)-covered which can be expressed in different forms,and extended to fractional(g,f,m)-covered graphs;(2)the concept of fractional-critical covered graph is put forward and its necessary and sufficient condition is given;(3)we present the degree condition for a graph to be fractional(g,f,n′,m)-critical covered,and show that degree bound is sharp when m is ***,the related result in fractional(a,b,n′,m)-critical covered setting is also verified.

关键词： Network Fractional factor Data transmission Fractional covered graph Fractional critical covered graph

A novel cascaded H-bridge photovoltaic inverter with flexible arc suppression function

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Global Energy Interconnection 2024年第4期7卷 513-527页

作者： Junyi Tang wei gao College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108P.R.China

This paper presents a novel approach that simultaneously enables photovoltaic(PV)inversion and flexible arc suppression during single-phase grounding *** compensate for ground currents through an arc-elimination function,while outputting a PV direct current(DC)power *** method effectively reduces the residual grounding *** reduce the dependence of the arc-suppression performance on accurate compensation current-injection models,an adaptive fuzzy neural network imitating a sliding mode controller was *** online adaptive adjustment law for network parameters was developed,based on the Lyapunov stability theorem,to improve the robustness of the inverter to fault and connection ***,a new arc-suppression control exit strategy is proposed to allow a zerosequence voltage amplitude to quickly and smoothly track a target value by controlling the nonlinear decrease in current and reducing the regulation *** results showed that the proposed method can effectively achieve fast arc suppression and reduce the fault impact current in single-phase grounding *** to other methods,the proposed method can generate a lower residual grounding current and maintain good arc-suppression performance under different transition resistances and fault locations.

关键词： Photovoltaic inverter Flexible arc suppression Adaptive control Fuzzy neural network Sliding mode control Exit strategy

Research progress in CALPHAD assisted metal additive manufacturing

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China Foundry 2024年第4期21卷 295-310页

作者： Ya-qing Hou Xiao-qun Li wei-dong Cai Qing Chen wei-ce gao Du-peng He xue-hui Chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Royal Institute of Technology StockholmSE-100Sweden Central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation

Biomimetic design of highly flexible metal oxide nanofibrous membranes with exceptional mechanical performance for superior phosphopeptide enrichment

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Nano Research 2024年第5期17卷 4270-4278页

作者： xue Mao Zhen-Zhen Li Dong-Lian Hao wei-Dong Han gao-Peng Li Yao-Yu Wang Kun Zhang School of Textile Science and Engineering Key Laboratory of Functional Textile Material and Product(Ministry of Education)Xi’an Polytechnic UniversityXi’an 710048China Key Laboratory of Magnetic Molecules&Magnetic Information Materials of the Ministry of Education School of Chemistry&Material ScienceShanxi Normal UniversityTaiyuan 030031China Department of Clinical Laboratory The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Shanghai iProteome Biotechnology Co. LtdShanghai 201210China College of Chemistry&Materials Science Northwest UniversityXi'an 710127China

Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches,but still a significant challenge in materials *** this end,we firstly constructed highly flexible ZrTiO_(4) nanofibrous membranes(NFMs)with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination ***,to further increase the enrichment capacity of the phosphopeptide,the biomimetic TiO_(2)@ZrTiO_(4) NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO_(4) NFMs through growing unfurling TiO_(2) nanosheets onto the ZrTiO_(4) ***,remarkable flexibility and mechanical stability enable the resulting TiO_(2)@ZrTiO_(4) NFMs excellent practicability,while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer ***,6770 phosphopeptides can be enriched by TiO_(2)@ZrTiO_(4) NFMs(2205 corresponding phosphoproteins can be identified),and the value is much higher than that of ZrTiO_(4) NFMs(6399 phosphopeptides and 2132 identified phosphoproteins)and commercial high-performance TiO_(2) particles(4525 phosphopeptides and 1811 identified phosphoproteins).These results demonstrate the super ability of TiO_(2)@ZrTiO_(4) NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.

关键词： inorganic nanofibers flexible ceramic nanofibrous membranes biomimetic materials exceptional mechanical performance flexibility

Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice

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Journal of Environmental Sciences 2024年第4期138卷 531-542页

作者： Jinglong xue Xiangyang Li Yafei Chi Leqiang gao Yue Zhang Yan Wang Moxuan Zhao Jialiu wei Zhixiong Shi Xianqing Zhou Department of Toxicology and Hygienic Chemistry School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China Laboratory Animal Center Capital Medical UniversityBeijing 100069China Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

The environmental presence of decabromodiphenyl ether(BDE-209),which is toxic to the male reproductive system,is *** current study investigated its mechanism of toxicity in *** results showed,that BDE-209 induced DNA damage,decreased the expression of the promoter of meiosis spermatogenesis-and oogenesis-specific basic helix-loop-helix 1(Sohlh1),meiosis related-factors Lethal(3)malignant brain tumor like 2(L3MBTL2),PIWI-like protein 2(MILI),Cyclin-dependent kinase 2(CDK2),Cyclin A,synaptonemal complex protein 1(SYCP1)and synaptonemal complex protein 3(SYCP3),and caused spermatogenic cell apoptosis,resulting in a decrease in sperm quantity and ***,BDE-209 downregulated the levels of anaphase-promoting complex/cyclosome(APC/C),increased the expression of PIWI-like protein 1(MIWI)in the cytoplasm of elongating spermatids,and decreased the nuclear levels of RING finger protein 8(RNF8),ubiquitinated(ub)-H2A/ub-H2B,and Protamine 1(PRM1)/Protamine 2(PRM2),while increasing H2A/H2B nuclear levels in *** reproductive toxicity was persistent for 50 days following the withdrawal of BDE-209 *** results suggested that BDE-209 inhibits the initiation of meiosis by decreasing the expression of ***,the reduced expression of L3MBTL2 inhibited the formation of chromosomal synaptonemal complexes by depressing the expression of meiosis regulators affecting the meiotic progression and also inhibited histone ubiquitination preventing the replacement of histones by protamines,by preventing RNF8 from entering nuclei,which affected the evolution of spermatids into mature sperm.

关键词： BDE-209 Meiosis L3MBTL2 Sperm RNF8 Histone ubiquitination

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

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Journal of Pharmaceutical Analysis 2024年第1期14卷 86-99页

作者： Shengyou Li xue gao Yi Zheng Yujie Yang Jianbo gao Dan Geng Lingli Guo Teng Ma Yiming Hao Bin wei Liangliang Huang Yitao wei Bing Xia Zhuojing Luo Jinghui Huang Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi'an710032China

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid peroxidation. However, the molecular mechanisms of ferroptosis in the context of PNI and nerve regeneration remain unclear. Ferroportin (Fpn), the only known mammalian nonheme iron export protein, plays a pivotal part in inhibiting ferroptosis by maintaining intracellular iron homeostasis. Here, we explored in vitro and in vivo the involvement of Fpn in neuronal ferroptosis. We first delineated that reactive oxygen species at the injury site induces neuronal ferroptosis by increasing intracellular iron via accelerated UBA52-driven ubiquitination and degradation of Fpn, and stimulation of lipid peroxidation. Early administration of the potent arterial vasodilator, hydralazine (HYD), decreases the ubiquitination of Fpn after PNI by binding to UBA52, leading to suppression of neuronal cell death and significant acceleration of axon regeneration and motor function recovery. HYD targeting of ferroptosis is a promising strategy for clinical management of PNI.

关键词： Ferroptosis UBA52 Ferroportin Ubiquitination Hydralazine Peripheral nerve injury

Toward a fundamental understanding of the heterogeneous multiphysics behaviors of silicon monoxide/graphite composite anodes

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Carbon Energy 2024年第1期6卷 142-158页

作者： Xiang gao Suli Li Jiachen xue Dianyang Hu Jun Xu Department of Mechanical Engineering and Engineering Science University of North Carolina at CharlotteCharlotteNorth CarolinaUSA Vehicle Energy and Safety Laboratory(VESL) Battery ComplexityAutonomous Vehicleand Electrification(BATT CAVE)Research CenterUniversity of North Carolina at CharlotteCharlotteNorth CarolinaUSA Zhuhai CosMX Battery Co.Ltd. ZhuhaiGuangdongChina School of Data Science University of North Carolina at CharlotteCharlotteNorth CarolinaUSA

Silicon monoxide(SiO)(silicon[Si]mixed with silicon dioxide[SiO_(2)])/graphite(Gr)composite material is one of the most commercially promising anode materials for the next generation of high-energy-density lithium-ion *** major bottleneck for SiO/Gr composite anode is the poor cyclability arising from the stress/strain behaviors due to the mismatch between two heterogenous materials during the lithiation/delithiation *** date,a meticulous and quantitative understanding of the highly nonlinear coupling behaviors of such materials is still ***,an electro–chemo–mechanics-coupled detailed model containing particle geometries is *** underlying mechanism of the regulation between SiO and Gr components during electrochemical cycling is quantitatively *** discover that increasing the SiO weight percentage(wt%)reduces the utilization efficiency of the active materials at the same 1C rate charging and enhances the hindering effects of stress-driven flux on *** addition,the mechanical constraint demonstrates a balanced effect on the overall performance of cells and the local behaviors of *** study provides new insights into the fundamental interactions between SiO and Gr materials and advances the investigation methodology for the design and evaluation of next-generation high-energydensity batteries.

关键词： interactions lithium-ion batteries mechanical constraint multiphysics modeling Si-based anode