检索结果-南通市图书馆

Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第12期15卷 2344-2352页

作者： xue-song mi Qian Feng Amy Cheuk Yin Lo Raymond Chuen-Chung Chang Sookja Kim Chung Kwok-Fai So Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Changsha Academician Expert Workstation Aier Eye Hospital GroupChangshaHunan ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina Department of Ophthalmology The University of Hong KongHong Kong Special Administrative RegionChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administrative RegionChina School of Biomedical Science LKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)*** investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 *** LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 *** AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation *** intervention with LBP,the above changes were significantly ***,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also *** results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH *** study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval ***-#1664-08).

关键词： astrocyte blood-retinal barrier glial cell Lycium barbarum microglia model plasticity remodel retina

Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第10期16卷 2109-2120页

作者： Xiao-Bin Liu Feng Liu Yi-Yao Liang Gang Yin Hui-Jun Zhang xue-song mi Zai-Jun Zhang Kwok-Fai So Ang Li Ying Xu Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardiocerebrovascular Diseases Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury,whereby it can inhibit microglial ***,luteolin holds the potential to be useful for treatment of retinal *** purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice,a slow photoreceptor-degenerative model of retinitis ***(100 mg/kg)intraperitoneally injected daily from postnatal day 14(P14)to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at ***,it increased the survival of photoreceptors and improved retinal ***,luteolin treatment attenuated increases in reactive oxygen species,photoreceptor apoptosis,and reactive gliosis;increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines;and lowered the ratio of phospho-JNK/*** of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin,suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK ***,luteolin may be useful as a supplementary treatment for retinitis *** study was approved by the Qualified Ethics Committee of Jinan University,China(approval ***-20181217-02)on December 17,2018.

关键词： anti-inflammation apoptosis flavonoid JNK pathway luteolin photoreceptor reactive gliosis reactive oxygen species retinal degeneration retinitis pigmentosa

Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第7期17卷 1596-1603页

作者： Hui-Jun Zhang Xiao-Bin Liu Xiong-min Chen Qi-Hang Kong Yu-Sang Liu Kwok-Fai So Jian-Su Chen Ying Xu xue-song mi Shi-Bo Tang Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology Guangzhou Panyu Central HospitalGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Laboratory of Retinal Cell Biology Aier Eye InstituteChangshaHunan ProvinceChina Aier Academician Station ChangshaHunan ProvinceChina Key Laboratory of CNS Regeneration(Jinan University) Ministry of EducationGuangzhouGuangdong ProvinceChina CoInnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Retinitis pigmentosa is a retinal disease characterized by photoreceptor *** is currently no effective treatment for retinitis *** a mixture of lutein and other antioxidant agents has shown promising effects in protecting the retina from degeneration,the role of lutein alone remains *** this study,we administered intragastric lutein to Pde6brd10 model mice,which display degeneration of retinal photoreceptors,on postnatal days 17(P17)to P25,when rod apoptosis reaches *** at the optimal protective dose of 200 mg/kg promoted the survival of photoreceptors compared with vehicle *** increased rhodopsin expression in rod cells and opsin expression in cone cells,in line with an increased survival rate of ***,lutein improved visual behavior,visual acuity,and retinal electroretinogram responses in Pde6brd10 ***,lutein reduced the expression of glial fibrillary acidic protein in Müller glial *** results of this study confirm the ability of lutein to postpone photoreceptor degeneration by reducing reactive gliosis of Müller cells in the retina and exerting anti-inflammatory *** study was approved by the Laboratory Animal Ethics Committee of Jinan University(approval ***-20181217-02)on December 17,2018.

关键词： anti-inflammation glial fibrillary acidic protein lutein microglia Pde6brd10(rd10)mouse photoreceptor reactive gliosis retinal degeneration retinal disease retinitis pigmentosa

Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2013年第4期11卷 233-240页

作者： xue-song mi Jing-xiang Zhong Raymond Chuen-Chung Chang Kwok-Fai So Department of Ophthalmology the First Affiliated Hospital Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of Medicine The University of Hong Kong Guangdong-Hong Kong-Macao Institute of Central Neural System Regeneration Jinan University

Progressive loss of retinal ganglion cells （RGCs） and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/ reperfusion insult. In order to target these mechanisms, multiple neuroprotective interventions have been investigated to prevent the death of RGCs. Of note are some tonic herbs from the traditional Chinese medicine （TCM） pharmacopeia that have shown neuroprotective effects in glaucoma. TCM differs from Western medicine in that TCM exhibits complicated bioactive com- ponents, triggering many signaling pathways and extensive actions on vital organs. Modern scientific approaches have demonstrated some of their underlying mechanisms. In this review, we used Lycium barbarum and Ginkgo biloba as examples to elaborate the characteristics of TCM and their potential applications in neuroprotection in glaucoma.

关键词： neuroprotection neuroprotective agents traditional Chinese medicine glaucoma review

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第9期7卷 645-651页

作者： xue-song mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Centre of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina The Joint Laboratory for Brain Function and Health （BFAH） Jinan University and The University of Hong Kong Guangzhou 510632Guangdong Province China

Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells （RGCs） in a rat chronic ocular hypertension （COH） model. Here, we investigated the expression of endothelin-1 （ET-1）, a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure （IOP） was induced in the right eye of SD rats using argon laser photocoagulation. （1） The expression of ET-1, ETA and ETB in normal and COH retinas was studied. （2） Some COH rats were fed daily with Lycium barbarum Polysaccharides （LBP） using 1 mg/kg or phosphate-buffered saline （PBS） for 3 weeks （started 1 week before photocoagulation）. The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that （1） Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. （2） After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. （3） By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature.

关键词： retinal ganglion cell Lycium barbarum Polysaccharides glaucoma endothelin-1

In-situ liquid-phase transmission electron microscopy for two-dimensional energy materials

在线全文

学校读者我要写书评

暂无评论

SCIENCE CHINA-CHEmiSTRY 2025年第2期68卷 414-429页

作者： Zhang, Junyu Xiao, Liangping Lu, mi Xiamen Univ Technol Sch Mat Sci & Engn Xiamen 361024 Peoples R China Huaqiao Univ Instrumental Anal Ctr Lab & Equipment Management Dept Xiamen 361021 Peoples R China Xiamen Univ Res Inst Biomimet & Soft Matter Jiujiang Res Inst Dept PhysFujian Prov Key Lab Soft Funct Mat Xiamen 361005 Peoples R China

Two-dimensional (2D) materials are vital for the development of advanced materials in the next-generation energy conversion and storage devices. In-situ liquid-phase transmission electron microscopy (LP-TEM) acts as a powerful tool for characterizing the dynamic evolution of materials under work condition in real time and in operando. Herein, this mini-review highlights the considerable advances in the utilization of in-situ LP-TEM for studying the physical and chemical process dynamics of 2D materials, such as their nucleation growth and phase transformation. The electrocatalytic water splitting reactions and CO2 electroreduction of 2D energy materials are highlighted. The underlying electrochemical reaction mechanisms of the 2D electrode materials in rechargeable batteries are discussed and summarized. Finally, the current challenges and perspectives for future research are proposed. This min-review aims to inspire and stimulate further innovation and encourage the broader adoption of LP-TEM in exploring the fascinating dynamics of 2D energy materials.

关键词： two-dimensional (2D) materials liquid-phase transmission electron microscopy electrochemical reaction electrode materials

Ingenious construction of a magnetic-recyclable photo-Fenton catalyst ZnFe_(2)O_(4)@miL-88A(Fe)and its adsorption-degradation activity toward levofloxacin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第5期151卷 677-691页

作者： Xichen mi Tingwei Wang Yitong Chen Dan Cao Na Ma Wei Dai Key Laboratory of the ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China Jinhua Customs Comprehensive Technology Service Center Jinhua 321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China

Monotonic pore size and particles inseparability of metal-organic frameworks(MOFs)caused serious effects on its light absorption ability and charge separation,restricting its application for antibiotic such as levofloxacin(LEV)degradation in *** this study,a magnetically detachable nano-photocatalyst(ZnFe_(2)O_(4)@miL-88A(Fe))was synthesized using a simple two-step hydrothermal *** morphology and microstructure analyses showed that n-type ZnFe_(2)O_(4)catalyst particleswere efficiently assembled onto the surface of miL-88A(Fe)*** activity studies indicated that the ZnFe_(2)O_(4)@miL-88A(Fe)plus H_(2)O_(2)exhibiting a significantly boosted photo-Fenton activity toward LEV at visible light irradiation,compared to the pure ZnFe_(2)O_(4)and miL-88A(Fe),the degradation efficiency accordingly reached up to nearly 82%and 25%within 60 *** excellent photocatalytic performance was ascribed to the synergistic effects of the heterogeneous structure of ZnFe_(2)O_(4)and miL-88A(Fe),whereby the efficient separation of charge carriers in the catalytic system is mutually reinforced with the efficient reduction of Fe^(3+)and Fe^(2+).Meanwhile,the degradationmechanism and intermediates of LEV during the photo-Fenton reaction process were also studied in depth through free radical burst,electron paramagnetic resonance,and mass spectrometry analyses,***,the ZnFe_(2)O_(4)@miL-88A(Fe)composite catalyst displayed significant stability and ease of separation,indicating potential for the photooxidative degradation of organic pollutants.

关键词： ZnFe_(2)O_(4) miL-88A(Fe) Magnetism Photo-Fenton Levofloxacin

Interfacial electron rearrangement of 3D Fe_(3)O_(4)/h-YFeO_(3)composites for efficient electromagnetic wave absorption

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of minerals,Metallurgy and Materials 2025年第3期32卷 609-618页

作者： Yi Sui Yingde Zhang Guang Liu Lei Ji Junyu Yue Chen Wu mi Yan School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Key Laboratory of Rare Earths Chinese Academy of SciencesGanzhou 341119China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Interface modulation is an important pathway for highly efficient electromagnetic wave ***,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructed via facile *** resulting interfa-cial electron rearrangement at the heterojunction led to enhanced dielectric and magnetic loss *** results and density function theory(DFT)simulations demonstrate a transition in electrical properties from a half-metallic monophase to metallic Fe_(3)O_(4)/h-YFeO_(3)composites,emphasizing the advantages of the formed *** transformation of electron behavior is also accompan-ied by a redistribution of electrons at the Fe_(3)O_(4)/h-YFeO_(3)heterojunction,leading to the accumulation of localized electrons around the Y-O-Fe band bridge,consequently enhancing the polarization.A minimum reflection loss of-34.0 dB can be achieved at 12.0 GHz and 2.0 mm thickness with an effective bandwidth of 3.3 GHz due to the abundant interfaces,enhanced polarization,and rational ***,the synergistic effects endow the Fe_(3)O_(4)/h-YFeO_(3)composites with high performance and tunable functional properties for efficient electromagnetic absorption.

关键词： self-assembling heterojunction electron rearrangement interface modulation electromagnetic wave absorption

Distribution and Hydrogeochemical Characteristic of High Iodine Groundwater in Oasis Zone in the Tarim Basin in Xinjiang,China

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2025年第1期36卷 173-183页

作者： Ying Sun Yinzhu Zhou Jinlong Zhou Yanyan Zeng Yuanyuan Ji mi Lei College of Hydraulic and Civil Engineering Xinjiang Agricultural UniversityUrumqi 830052China Xinjiang Hydrology and Water Resources Engineering Research Center Urumqi 830052China Xinjiang Key Laboratory of Hydraulic Engineering Security and Water Disasters Prevention Urumqi 830052China Center for Hydrogeology and Environmental Geology China Geological SurveyTianjin 300304China Xinjiang Agricultural Professional Technological College Changji 831100China

Groundwater is the main water supply source in the Tarim Basin in *** disease caused by high iodine(I)groundwater in the Tarim Basin was reported ***,it is crucial to systematically identify the distribution and genesis of groundwater *** on hydrochemical analysis of 717 groundwater samples collected in 2015–2018,spatial distribution and hydrogeochemistry characteristic of high I groundwater in different aquifers were *** showed that groundwater I ranged between100.00μg/L)accounted for 7.25%of the total ***,groundwater I significantly increased from recharge zone(RZ)to transition zone(TZ)and to evaporation zone(EZ).Vertically,groundwater in shallow confined aquifer(SCA)had the greatest I concentration,followed by single-structure phreatic aquifer(SSPA),phreatic aquifer in confined groundwater area(PACGA),while groundwater in deep confined aquifer(DCA)generally had low I *** I enrichment in SSPA was mainly affected by organic matter(OM)decomposition and that in SCA was mainly affected by evaporite mineral dissolution,OM decomposition under alkaline *** I enrichment in groundwater of PACGA was restrained under neutral *** sedimentary environment was crucial for I enrichment in ***,fine-grained lithology of aquifer,smooth topographic slope,shallow buried depth of groundwater,weak alkaline and reducing environment,reductive dissolution of iron oxide/hydroxide minerals and OM decomposition were advantageous to I enrichment in groundwater.

关键词： high iodine groundwater hydrogeochemical processes depositional environment hydrogeological condition Tarim Basin