检索结果-南通市图书馆

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第6期15卷 403-418页

作者： song xue Yuru han Fan Wu Qiao Wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

A Facile Synthetic Route to L-Phosphinothricin

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第2期17卷 177-179页

作者： xue song XU han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU School of Pharmacy Wuhan University Wuhan 430072

A convenient and effective method for synthesis of L-phosphinothricin was described. The highlight was involved in a simple access to the key intermediate L-2-amino-4-chlorobutyric acid derivative from the inexpensive... 详细信息

关键词： Synthesis L-methionine L-phosphinothricin.

Site-specific and seasonal variation in habitat use of Eurasian otters(Lutra lutra)in western China:implications for conservation

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2021年第6期42卷 825-833页

作者： Qiao-Yun Wang Kai-Dan Zheng xue-song han Fang He Xiang Zhao Peng-Fei Fan Lu Zhang School of Life Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Shan Shui Conservation Center Beijing 100871China School of Life Sciences Peking UniversityBeijing 100871China Tangjiahe National Natural Reserve GuangyuanSichuan 628109China

As a top predator,the Eurasian otter(Lutra lutra)is an indicator of healthy freshwater ecosystems and a flagship species for *** widespread in China,the species is now distributed mainly in the upper reaches of the great rivers of western ***,a lack of knowledge on local otter populations continues to hinder their conservation in ***,we conducted a detailed study on habitat use of Eurasian otters in Yushu City and Tangjiahe National Nature Reserve in western China using transect *** both study sites,otters preferred to defecate on large rocks close to or protruding from the river and about 50 cm above the *** Yushu,no spraints were found along the 5 km river bank section in the downtown area,with otters preferring sprainting sites with natural banks,riparian zones,and lower human population ***,this pattern was not obvious at Tangjiahe,where river transformation and human disturbance are *** river use intensity was negatively correlated with elevation and human population density in Yushu in both *** Tangjiahe,otter river use intensity was positively correlated with prey mass and flow rate and negatively correlated with human population in spring,but positively correlated with human population and negatively correlated with flow rate in *** results reflect the flexible habitat use strategies of otters at different sites,underlining the necessity to study otters living in different regions and habitat *** provide suggestions for river modification and call for more site-specific studies to promote otter conservation in China.

关键词： Lutra lutra Sprainting site Habitat selection Conservation Local scale

Discovery of first active breeding den of Chinese mountain cat(Felis bieti)

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2020年第3期41卷 341-344页

作者： xue-song han Huai-Qing Chen Zheng-Yi Dong Ling-Yun Xiao Xiang Zhao Zhi Lu Shan Shui Conservation Center Peking UniversityBeijing 100871China Center for Nature and Society School of Life SciencesPeking UniversityBeijing 100871China

DEAR EDITOR,In mid-September 2018,during a field survey in Chiat'ung,Sanjiangyuan(Three-River-Source)Region,Tibetan Plateau,China,we discovered the first active breeding den of the Chinese mountain cat(Felis bieti),inhabited by one adult female and two *** on fieldwork over the following months,five breeding dens were discovered,and 33 sightings were recorded.

关键词： breeding Plateau den

Low-temperature graphitization of lignin via Co-assisted electrolysis in molten salt

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第9期9卷 1449-1458页

作者： Shijie Li Wei-Li song xue han Qingqing Cui Yan-li Zhu Shuqiang Jiao Institute of Advanced Structure Technology Beijing Institute of Technology State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

The ever-growing energy demand and environmental issues have stimulated the development of sustainable energy ***,an efficient and environmentally friendly electrochemical transformation technology was proposed to prepare highly graphitized carbon materials from an abundant natural resource-lignin （LG）.The preparation process mainly includes pyrolytic carbonization of raw LG material and electrochemical conversion of amorphous carbon ***,with the assistance of Co catalyst,the graphitization degree of the products was significantly improved,in which the mechanism was the removal of heteroatoms in LG and the rearrangement of carbon atoms into graphite ***,tunable microstructures （nanoflakes） under catalytic effects could also be observed by controlling the electrolytic *** with the products CN1 （without catalyst） and CN5 （with 10%catalyst）,the specific surface area are 158.957 and202.246 m2g-1,*** used as the electrode material for lithium-ion batteries,CN5 delivered a competitive specific capacity of～350 m Ah g-1（0.5 C） compared with commercial *** strategy proposed in this work provides an effective way to extract value-added graphite materials from lignin and can be extended to the graphitization conversion of any other amorphous carbon precursor materials.

关键词： Lignin Graphitic carbon Electrochemical conversion Lithium-ion batteries

Heterostructured Pt-Ni_(3)Mo_(3)N formed via ammonia-containing polyoxometalates for highly efficient electrocatalytic hydrogen evolution in acid medium

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 698-704页

作者： Bianqing Ren xue Gong Jing Cao Dezheng Zhang Zizhun Wang Ping song Ce han Weilin Xu State Key Laboratory of Electroanalytical Chemistry Jilin Province Key Laboratory of Low Carbon Chemical PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina Key Laboratory of Automobile Materials MOE School of Materials Science&EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012JilinChina

Constructing heterostructured nanohybrid is considered as a prominent route to fabricate alternative electrocatalysts to commercial Pt/C for hydrogen evolution reaction(HER).In this work,(NH_(4))_(4)[NiH_(6)Mo_(6)O_(4)]·5H_(2)O polyoxometalates(NiMo_(6))are adopted as the cluster precursors for simple fabrication of heterostructured Pt-Ni_(3)Mo_(3)N nanohybrids supported by carbon black(Pt-Ni_(3)Mo_(3)N/C)without using additional N *** improved porosity and enhanced electronic interaction of Pt-Ni_(3)Mo_(3)N/C should be attributed to the integration of Pt with NiMo_(6),which favors the mass transport,promotes the formation of exposed catalytic sites,and benefits the regulation of intrinsic ***,the as-obtained Pt-Ni_(3)Mo_(3)N/C exhibits impressive and durable HER performance as indicated by the low overpotential of 13.7 mV at the current density of 10 mA cm^(-2) and the stable overpotential during continuous working at 100 mA cm^(-2) for 100 *** work provides significant insights for the synthesis of new highly active heterostructured electrocatalysts for renewable energy devices.

关键词： Polyoxometalates Cluster precursors Heterostructured nanohybrids Hydrogen evolution reaction Electrocatalysis

Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 543-550页

作者： YU Qian SHU Shi JU Xin-yao PENG Wei REN xue-qi SI Shu-han song Shi-zhen XIE xue-yun FANG Bang-jiang ZHOU Shuang School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China College of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To observe the angiogenesis effect of electroacupuncture(EA)at Shuigou acupoint(GV 26)in the treatment of cerebral ischemia,and explore the value of miRNA-7(miR-7)in *** First,48 mice were randomly divided into sham operation,middle cerebral artery occlusion(MCAO)model,and EA treatment *** 9 mice were divided into carrier control group,miR-7 knockout group and miR-7 overexpression group(n=3 each group).Finally,20 mice were divided into model and carrier control group,model and miR-7 knockout group,EA treatment and carrier control group and EA treatment and miR-7 overexpression group,with 3–6 mice in each *** MCAO model was established in the MCAO and EA *** deficit score and 2,3,5-triphenyltetrazolium chloride(TTC)staining were used to evaluate the severity of cerebral ***-eosin staining was used to describe basic pathological *** was used to quantify cerebral microvessel ***-time PCR and Western blot were used to detect the expression of miR-7 and its downstream target genes Krüppel-like factor 4/vascular endothelial growth factor(KLF4/VEGF)and angiopoietin-2(ANG-2)in the ischemic cerebral *** After EA,neurological deficit scores and infarction volumes decreased,and the density of cerebral microvessels *** the MCAO group,miR-7 expression was higher than that in the sham group(P<0.01).After EA at GV 26,miR-7 expression decreased(P<0.01)and the expression of downstream target genes KLF4/VEGF and ANG-2 increased as compared with the MCAO group(P<0.01).After EA combined with overexpression of miR-7,the expression of downstream target genes KLF4/VEGF and ANG-2 decreased compared to the control EA group(P<0.01).After miR-7 knockdown,the expression of KLF4/VEGF and ANG-2 increased(P<0.05 or P<0.01).Conclusions EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEG

关键词： electroacupuncture cerebral ischemia miRNA-7 angiogenesis Shuigou(GV 26) acupuncture points

Experimental and Numerical Investigation on the Aerodynamic Characteristics of High-Speed Pantographs with Supporting Beam Wind Deflectors

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第1期20卷 127-145页

作者： Shiyang song Tongxin han Postgraduate Department China Academy of Railway SciencesBeijing100081China Locomotive&Car Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China

Aiming to mitigate the aerodynamic lift force imbalance between pantograph strips,which exacerbates wear and affects the current collection performance of the pantograph-catenary system,a study has been conducted to support the beam deflector optimization using a combination of experimental measurements and computational fluid dynamics(CFD)*** results demonstrate that the size,position,and installation orientation of the wind deflectors significantly influence the amount of force *** also indicate that the front strip deflectors should be installed downwards and the rear strip deflectors upwards,thereby forming a“π”***,the lift force compensation provided by the wind deflectors increases with the size of the *** wind compensation strategies,such as control circuits,are also discussed,putting emphasis on the pros and cons of various pantograph types and wind compensation approaches.

关键词： High-speed pantograph aerodynamic lift force supporting beam wind deflectors computational fluid dynamics(CFD)

Variability of the Pacific subtropical cells under global warming in CMIP6 models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第1期42卷 24-40页

作者： xue han Junqiao FENG Yunlong LU Dunxin HU Key Laboratory of Ocean Circulation and Waves Chinese Academy of SciencesQingdao 266071China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean Dynamics and Climate Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The Pacific subtropical cells(STCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal *** variability of STCs under global warming is investigated using multimodal outputs from the latest phase of the Coupled Model Inter-comparison Project(CMIP6)and ocean reanalysis ***,the volume transport diagnostic analysis is employed to evaluate how coupled models and ocean reanalysis products reproduce interior STC *** variation of heat transport by the interior STC under the high-emissions warming scenarios is also *** results show that the multimodal-mean linear trends of the interior STC transport along 9°S and 9°N are-0.02 Sv/a and 0.04 Sv/a under global warming,respectively,which is mainly due to the combined effect of the strengthened upper oceanic stratification and the weakening of wind *** is a compensation relationship between the interior STC and the western boundary transport in the future climate,and the compensation relationship of 9°S is more significant than that of 9°*** addition,compared with ocean reanalysis products,the coupled models tend to underestimate the variability of the interior STC transport convergence,and thus may lose some sea surface temperature(SST)driving force,which may be the reason for the low STC-SST correlation simulated by the *** future scenario simulation shows that the heat transport of interior STC is weakened under global warming,with a general agreement across models.

关键词： interior subtropical cell(STC) global warming Coupled Model Inter-comparison Project(CMIP6) western boundary transport