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Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing shi Yu Song xue-xue Liang Ting Chen Huang-Yu Hao xue Han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： shi-Yan Sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

激光诱导荧光技术与地下水重金属原位检测应用进展

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岩矿测试 2025年第1期44卷 19-34页

作者：毛康薛家奇陈卓张华中国科学院地球化学研究所环境地球化学国家重点实验室贵州贵阳550081

对地下水重金属污染进行现场检测,是快速识别重金属种类和评价污染程度的重要手段。激光诱导荧光技术(LIF)利用特定荧光探针,在目标重金属存在下,通过激光诱导荧光探针产生/猝灭荧光,从而完成对重金属的识别和检测,具有快速甄别地下水... 详细信息

对地下水重金属污染进行现场检测,是快速识别重金属种类和评价污染程度的重要手段。激光诱导荧光技术(LIF)利用特定荧光探针,在目标重金属存在下,通过激光诱导荧光探针产生/猝灭荧光,从而完成对重金属的识别和检测,具有快速甄别地下水重金属污染特性和无损获取其价态的优势。本文在简述LIF检测重金属原理和LIF原位检测地下水重金属装备基础上,重点从荧光探针合成及其在重金属传感检测方法的构建上总结了基于不同荧光探针的LIF现场检测重金属的研究进展。目前可用于重金属检测的荧光探针包括以小分子探针、有机大分子和聚集诱导发光为主的有机荧光探针和以金纳米簇、量子点和金属有机框架材料为代表的纳米荧光探针。这些探针的合成及其对应的传感检测方法的构建表明LIF技术在地下水重金属检测中具有巨大优势。而针对地下水重金属检测的LIF设备研发方面的成果虽不如荧光传感检测方法丰富,但已研制出部分重金属的传感器和检测装备,表现出良好的应用前景。未来研究将会聚焦在地下水重金属主控因子识别和抗干扰技术研发、荧光探针合成与LIF检测方法构建、重金属传感部件和检测装备集成研制,以及检测技术标准化,为后续场地地下水典型重金属LIF检测技术的研究提供参考。

关键词：地下水重金属激光诱导荧光荧光探针现场检测

Integrative Medicine Intervention for Chronic Disease Management——Cardiovascular Disease

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Chinese Journal of Integrative Medicine 2018年第12期24卷 883-885页

作者： shi Da-zhuo Center of Cardiology Xiyuan HospitalChina Academy of Chinese Medical Sciences

Cardiovascular disease （CVD） is a leading life-threatening chronic disease in China. In the primary and secondary prevention, remarkable achievements have been made during past decades. In treating coronary artery disease （CAD）, for example, the advanced treatment approaches, suchas percutaneous coronary intervention （PCI） guided by intracoronary imaging, minimally-invasive coronary artery bypass graft （CABG）, and novel drugs for better control of the risk factors including hypertension, hyperglycemia and dyslipidemia, have been widely used in clinical practice.

关键词： ACS Cardiovascular Disease CVD PCI

Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury

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Neural Regeneration Research 2021年第4期16卷 721-726页

作者： zhuo Zhang xue Bao Dan Li Department of Human Anatomy College of Basic Medical SciencesChina Medical UniversityShenyangLiaoning ProvinceChina

Batroxobin is a thrombin-like serine protease from the venom of the Bothrops atrox and Bothrops moojeni snake *** 1(Sirt1)has been shown to play an important role in neuroprotection after traumatic brain ***,its underlying mechanism of action remains poorly *** purpose of this study was to investigate whether the mechanism by which batroxobin participates in the activation of astrocytes is associated with *** models of nigrostriatal pathway injury were *** after modeling,mice were intraperitoneally administered 39 U/kg *** significantly reduced the expression of cleaved caspase-3 in both the substantia nigra and striatum,inhibited neuronal apoptosis,and promoted the recovery of rat locomotor *** changes coincided with a remarkable reduction in astrocyte *** also reduced Sirt1 expression and extracellular signal-regulated kinase activation in brain *** administration of the Sirt1-specific inhibitor EX527(5 mg/kg)30 minutes prior to injury could inhibit the abovementioned *** mouse astrocyte cultures,1 ng/mL batroxobin attenuated interleukin-1β-induced activation of astrocytes and extracellular signal-regulated ***527 could also inhibit the effects of *** findings suggest that batroxobin inhibits astrocyte activation after nigrostriatal pathway injury through the Sirt1 *** study was approved by the Animal Ethics Committee of China Medical University,China(approval ***2020037)on July 19,2015.

关键词： astrocyte brain central nervous system factor injury pathway

Optimizing hemicelluloses pre-extraction in eucalyptus kraft pulping:A pathway towards enhancing pulp mill biorefineries

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Chinese Journal of Chemical Engineering 2024年第6期70卷 162-172页

作者： Yuhan Wang Danqi xue Jingjing zhuo Zhouyang Xiang State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

A critical pathway towards enhancing pulp mill biorefineries is to integrate the extraction and utilization of hemicelluloses into the pulping ***,an industrial pre-extraction strategy for hemicelluloses targeting eucalyptus kraft pulping process was *** solution or pulping white liquor was used to pre-extract hemicelluloses before the actual pulping *** response surface methodology(RSM)technique was applied to investigate the most suitable conditions to maximize the yield of these hemicelluloses while simultaneously minimizing the damage to pulp yields and ***(105 to 155℃),alkali concentration(3%to 8%),sulfidity(20%to 30%)and retention time(19 to 221 min)were combined to evaluate their effects on hemicellulose yields and chemical *** optimal pre-extraction conditions identified in this work(5.75%NaOH concentration,25%sulfidity at 135℃for 60 min)successfully allowed recovering 4.8%of hemicelluloses(based on the wood dry mass)and limited damages to pulp yields and *** cellulose content in pulp can even be increased by about 10%.Hemicellulose emulsification properties were also evaluated,which were comparable to synthetic *** study provides an industrial pathway to effectively separate and utilize wood hemicelluloses from the pulping process,which has the potential to improve the economy and material utilization of pulp and paper mills.

关键词： Hemicelluloses Xylan Pre-extraction Kraft pulping Emulsifying Response surface methodology(RSM)

A multiscale view in functional materials

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Progress in Natural Science:Materials International 2022年第6期32卷 674-683页

作者： Guoqiang shi Dongfeng xue Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

Functional materials show various highly demanded performances originating from intrinsic features related to degrees of freedom in a lattice ***,deep physical or chemical insights of quantum materials stimulate researchers to clarify multiscale processes within both materials and devices,which may be understood as functional materials that possess energy origin beyond electron *** is of great significance for the design of functional materials to understand the sources of properties of functional materials from the perspective of multi degrees of freedom via multiscale research *** short review illustrates the importance and explores the energy source of functional materials from multiple degrees of freedom ***,we analyzed the multiple degrees of freedom within lithium niobate single crystals to clarify their multiscale *** short review may,in some cases,provide a perspective for enhancing research scopes of functional materials and recommending some methodologies from multiple degrees of freedom perspectives.

关键词： Degrees of freedom Functional crystals Lithium niobate

Persymmetric adaptive polarimetric detection of subspace range-spread targets in compound Gaussian sea clutter

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Journal of Systems Engineering and Electronics 2024年第1期35卷 31-42页

作者： XU Shuwen HAO Yifan WANG zhuo xue Jian National Key Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China Xi’an Electronic Engineering Research Institute Xi’an 710100China Beijing Institute of Radio Measurement Beijing 100039China School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China

This paper focuses on the adaptive detection of range and Doppler dual-spread targets in non-homogeneous and nonGaussian sea *** sea clutter from two polarimetric channels is modeled as a compound-Gaussian model with different parameters,and the target is modeled as a subspace rangespread target *** persymmetric structure is used to model the clutter covariance matrix,in order to reduce the reliance on secondary data of the designed *** adaptive polarimetric persymmetric detectors are designed based on the generalized likelihood ratio test(GLRT),Rao test,and Wald *** the proposed detectors have constant falsealarm rate property with respect to the clutter texture,the speckle covariance *** results on simulated and measured data show that three adaptive detectors outperform the competitors in different clutter environments,and the proposed GLRT detector has the best detection performance under different parameters.

关键词： sea clutter adaptive polarimetric detection compound Gaussian model subspace range-spread target persymmetric structure

ContextAug:model-domain failing test augmentation with contextual information

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Frontiers of Computer Science 2024年第2期18卷 43-60页

作者： zhuo ZHANG Jianxin xue Deheng YANG Xiaoguang MAO School of Information Technology and Engineering Guangzhou College of CommerceGuangzhou 511363China School of Computer and Information Engineering Institute for Artificial IntelligenceShanghai Polytechnic UniversityShanghai 201209China College of Computer National University of Defense TechnologyChangsha 410073China

In the process of software development,the ability to localize faults is crucial for improving the efficiency of *** speaking,detecting and repairing errant behavior at an early stage of the development cycle considerably reduces costs and development *** have tried to utilize various methods to locate the faulty ***,failing test cases usually account for a small portion of the test suite,which inevitably leads to the class-imbalance phenomenon and hampers the effectiveness of fault ***,in this work,we propose a new fault localization approach named *** obtaining dynamic execution through test cases,ContextAug traces these executions to build an information model;subsequently,it constructs a failure context with propagation dependencies to intersect with new model-domain failing test samples synthesized by the minimum variability of the minority feature *** contrast to traditional test generation directly from the input domain,ContextAug seeks a new perspective to synthesize failing test samples from the model domain,which is much easier to augment test *** conducting empirical research on real large-sized programs with 13 state-of-the-art fault localization approaches,ContextAug could significantly improve fault localization effectiveness with up to 54.53%.Thus,ContextAug is verified as able to improve fault localization effectiveness.

关键词： context fault localization test cases