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Cocktail effect of ionic patch driven by triboelectric nanogenerator for diabetic wound healing

Chinese Chemical Letters 2024年第8期35卷 460-465页

作者： Yixia Zhang Caili xue Yunpeng Zhang Qi Zhang Kai Zhang Yulin Liu Zhaohui shan Wu qiu Gang Chen Na Li Hulin Zhang Jiang Zhao Da-Peng Yang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Rehabilitation Science and Engineering University of Health and Rehabilitation SciencesQingdao 266024China School of Materials and Chemical Engineering Quanzhou Normal UniversityQuanzhou 362000China

There is increasing evidence shows that either electrical stimulation(ES)or metal ion is an effective way to accelerate ulcerative wound ***,less attention is paid to investigating the synergistic effect between ***,we explore the combined effects of ES and multiple metal ions on dia-betic wound healing assisted by a triboelectric nanogenerator(TENG).Firstly,the novel Eggshell@CuFe_(2)O_(4)nanocomposites(NCs)are prepared,which show unique structure and intrinsic antimicrobial ***,the as-prepared nanocomposites are embedded in oxidized starch hydrogel to form a mul-tifunctional composite gel,which is further assembled into a wearable ionic triboelectric nanogenerator(iTENG)patch with polydimethylsiloxane(PDMS).It can convert the mechanical energy produced by a human body motion to electric energy and mediate the sequential release of metal ions(Fe^(2+)/Ca^(2+)/Cu^(2+)),thereby resulting in the“cocktail effect”on impaired *** their effects,a satisfying healing re-sult in diabetic mouse is identified,which can effectively accelerate wound healing process by relieving inflammation,promoting angiogenesis and collagen *** work puts forward the cocktail effect of electric simulation coupled with the multiple metal ions,and opens up a new perspective in designing iTENG patch towards repair of hard-to-heal wounds.

关键词： iTENG Cocktail effect CuFe_(2)O_(4) Eggshell Diabetic wound

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Development and Deformation Characteristics of Large Ancient Landslides in the Intensely Hazardous Xiongba-Sela Section of the Jinsha River, Eastern Tibetan Plateau, China

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Journal of Earth Science 2024年第3期35卷 980-997页

作者： Yiqiu Yan Changbao Guo Yanan Zhang Zhendong qiu Caihong Li xue Li Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China

The upstream Jinsha River,located in the eastern Tibetan Plateau,has been experiencing intense geological hazards characterized by a high density of ancient landslides,significant deformation and reactivation *** this study,remote sensing interpretation,field investigations,and Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-InSAR)technologies have been *** a 17 km stretch of the Jinsha River,specifically in the Xiongba-Sela segment,16 large-scale ancient landslides were identified,9 of which are currently undergoing creeping ***,the Sela and Xiongba ancient landslides exhibit significant deformation,with a maximum deformation rate of-192 mm/yr,indicating a high level of sliding *** volume of the Sela ancient landslide is estimated to be 1.8×108 to 4.5×108 m3,and characterized by extensive fissures and long-term creeping *** SBAS-InSAR results revealed significant spatial variations in the deformation of the Sela ancient landslide,generally displaying two secondary zones of intense deformation,and landslide deformation exhibits nonlinear behavior with *** January 2016 and February 2022,Zone III1 on the southwest side of the Sela ancient landslide,experienced a maximum cumulative deformation of-857 mm,with a maximum deformation rate of-108 mm/*** III2,on the northeast side of the Sela ancient landslide,the maximum cumulative deformation was-456 mm,with a maximum deformation rate of-74 mm/yr;among these,the H2 and H4 secondary bodies on the south side of III1 are in the accelerative deformation stage and at the Warn warning *** propose that the large-scale flood and debris flow disasters triggered by the Baige landslide-dammed lake-dam broken disaster chain in Tibetan Plateau during October and November 2018 caused severe erosion at the foot of downstream *** far-field triggering effect accelerated the creep of the downstream ancient ***,the defo

关键词： Jinsha River SBAS-InSAR landslides surface deformation disasters.

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Predicting the Prognosis and Immunotherapeutic Response of Triple-Negative Breast Cancer by Constructing a Prognostic Model Based on CD8+T Cell-Related Immune Genes

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Biomedical and Environmental Sciences 2024年第6期37卷 581-593页

作者： Nani Li Xiaoting qiu Jingsong xue Limu Yi Mulan Chen Zhijian Huang Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina Department of Breast Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina Departmen of Pathology Shenzhen Longhua Maternity and Child Healthcare HospitalShenzhen 518109GuangdongChina

Objective Triple-negative breast cancer(TNBC)poses a significant challenge for treatment ***8+T cells,which are pivotal immune cells,can be effectively analyzed for differential gene expression across diverse cell populations owing to rapid advancements in sequencing *** leveraging these genes,our objective was to develop a prognostic model that accurately predicts the prognosis of patients with TNBC and their responsiveness to *** Sample information and clinical data of TNBC were sourced from The Cancer Genome Atlas and METABRIC *** the initial stage,we identified 67 differentially expressed genes associated with immune response in CD8+T ***,we narrowed our focus to three key genes,namely CXCL13,GBP2,and GZMB,which were used to construct a prognostic *** accuracy of the model was assessed using the validation set data and receiver operating characteristic(ROC)***,we employed various methods,including Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway,immune infiltration,and correlation analyses with CD274(PD-L1)to explore the model's predictive efficacy in immunotherapeutic ***,we investigated the potential underlying biological pathways that contribute to divergent treatment *** We successfully developed a model capable of predicting the prognosis of patients with *** areas under the curve(AUC)values for the 1-,3-,and 5-year survival predictions were 0.618,0.652,and 0.826,*** this risk model,we stratified the samples into high-and low-risk *** KEGG enrichment analysis,we observed that the high-risk group predominantly exhibited enrichment in metabolism-related pathways such as drug and chlorophyll metabolism,whereas the low-risk group demonstrated significant enrichment in cytokine ***,immune landscape analysis revealed noteworthy variations between(PD-L1)expression and risk scores,indicating that o

关键词： Breast Cancer Immunotherapy Prognosis CD8+T cells PD-L1

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Arbitrary acoustic orbital angular momentum detection using dual-layer metasurfaces

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 106-112页

作者： Zhanlei Hao Haojie Chen Yuhang Yin shan Zhu Yadong Xu Cheng-Wei qiu Huanyang Chen Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Department of Mechanical and Electrical Engineering Xiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China School of Physical Science and Technology and Jiangsu Key Laboratory of Thin Films Soochow UniversitySuzhou 215006China

Orbital angular momentum(OAM),with its unique physical properties and vast application prospects,has attracted widespread attention in various ***,the development of valid and practical acoustic OAM detection methods continues to be a challenging *** this paper,we propose a novel construction method of dual-layer metasurfaces to achieve a doubleconversion process for the waveform reshaping and differentiated focusing of two-dimensional vortex sources with different ***,by utilizing a concise formula,a one-to-one correspondence is established between the OAM of incident vortex waves and different imaging *** fundamental principle of this special conversion relationship is rigorously constrained by the directional compensation of phase and the material parameters of dual-layer metasurfaces with different quadratic phase *** importantly,the highly consistent results between numerical demonstrations and acoustic experiments further confirm the feasibility and effectiveness of the proposed OAM detection *** work provides a new perspective on the precise manipulation for the phase of vortex fields,holding potential applications in super-resolution imaging and the design of acoustic OAM-based devices.

关键词： arbitrary acoustic OAM detection vortex waves dual-layer metasurfaces waveform reshaping differentiated focusing acoustic experiments

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Two-dimensional precise figuring of 500 mm-long X-ray mirror using one-dimensional ion beam system

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Advances in Manufacturing 2024年第1期12卷 177-184页

作者： qiu-Shi Huang Han-Dan Huang Qiao-Yu Wu Jun Yu Zhong Zhang Zhan-shan Wang MOE Key Laboratory of Advanced Micro-Structured Materials Institute of Precision Optical Engineering(IPOE)School of Physics Science and EngineeringTongji UniversityShanghai200092People’s Republic of China shanghai Professional Technical Service Platform for Full-Spectrum and High-Performance Optical Thin Film Devices and Applications Tongji UniversityShanghai200092People’s Republic of China shanghai Frontiers Science Center of Digital Optics Tongji UniversityShanghai200092People’s Republic of China

In this study,a new method was developed to realize two-dimensional(2D)figure correction of grazing-incidence X-ray mirrors using a one-dimensional(1D)ion-beam figuring system.A mask of holes was specifically designed to generate removal functions at different widths and extend the figuring capability over a wide ***,a long mirror could be *** this method,the surface height root-mean-square(RMS)error of the center area of 484 mm×16 mm was reduced from 11.49 nm to 2.01 nm,and the 1D meridional RMS error reached 1.0 *** proposed method exhibits high precision and cost effectiveness for production of long X-ray mirrors.

关键词： Long-size mirrors Ion beam figuring Two-dimensional figure correction Mask

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Retinal ischemia-reperfusion injury and pretreatment with Lycium barbarum glycopeptide

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1599-1605页

作者： Yan-Xia Wu Shuo Yin shan-shan Song Xiang Liu Yu-Xuan Deng xue-Jing Lu Eye School of Chengdu University of Traditional Chinese Medicine Chengdu 610075Sichuan ProvinceChina Ineye Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610084Sichuan ProvinceChina School of Chinese Classics Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with Traditional Chinese Medicine Chengdu 610075Sichuan ProvinceChina Retinal Image Technology and Chronic Vascular Disease Prevention&Control and Collaborative Innovation Center Chengdu 610075Sichuan ProvinceChina

AIM:To investigate the antioxidant protective effect of Lycium barbarum glycopeptide(LbGP)pretreatment on retinal ischemia-reperfusion(I/R)injury(RIRI)in ***:RIRI was induced in Sprague Dawley rats through anterior chamber perfusion,and pretreatment involved administering LbGP via gavage for *** 24h of reperfusion,serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and creatinine(CREA)levels,retinal structure,expression of Caspase-3 and Caspase-8,superoxide dismutase(SOD)activity,and malondialdehyde(MDA)in the retina were ***:The pretreatment with LbGP effectively protected the retina and retinal tissue from edema and inflammation in the ganglion cell layer(GCL)and nerve fiber layer(NFL)of rats subjected to RIRI,as shown by light microscopy and optical coherence tomography(OCT).Serum AST was higher in the model group than in the blank group(P=0.042),but no difference was found in ALT,AST,and CREA across the LbGP groups and model ***-3 expression was higher in the model group than in the blank group(P=0.006),but no difference was found among LbGP groups and the model ***-8 expression was higher in the model group than in the blank group(P=0.000),and lower in the 400 mg/kg LbGP group than in the model group(P=0.016).SOD activity was lower in the model group than in the blank group(P=0.001),and the decrease was slower in the 400 mg/kg LbGP group than in the model group(P=0.003).MDA content was higher in the model group than in the blank group(P=0.001),and lower in the 400 mg/kg LbGP group than in the model group(P=0.016).The pretreatment with LbGP did not result in any observed liver or renal toxicity in the ***:LbGP pretreatment exhibits dosedependent anti-inflammatory,and antioxidative effects by reducing Caspase-8 expression,preventing declines of SOD activity,and decreasing MDA content in the RIRI rat model.

关键词： retinal ischemia-reperfusion Lycium barbarum glycopeptide pretreatment anti-inflammatory antioxidative rat

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Robust asymmetric Cherenkov radiation in tilted anisotropic medium

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 46-51页

作者： Shuwen xue Yadong Xu Linkang Han Zhi Ning Chen Qiaoliang Bao shan Zhu Huanyang Chen Institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyJiujiang Research InstituteXiamen UniversityXiamen 361005China School of Physical Science and Technology Institute of Theoretical and Applied PhysicsSoochow UniversitySuzhou 215006China Department of Electrical and Computer Engineering National University of SingaporeSingapore 8117583Singapore Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Cherenkov radiation(CR)is available for a wide variety of terahertz(THz)radiation sources,but its efficiency is deeply affected by intrinsic *** find that if the tilted angle(α)of anisotropic material and radiation angle(θ)meet the condition ofθ+α=π/2,the intensity of radiation fields for the charged particle bunch(CPB)moving from left to right cannot be influenced by intrinsic losses,which means long-distance radiation can be ***,we observe an asymmetric CR when the CPB moves from the opposite *** addition,we select natural van der Waals(vd W)materialα-MoO3as an example,further confirming that the radiation field can reach the far field and the asymmetric CR radiation can also be *** wonderful properties with long-distance radiation will extend the application of CR to a certain extent for future design and fabrication.

关键词： asymmetric Cherenkov radiation intrinsic losses long-distance radiation

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Locomotion control of a rigid-soft coupled snake robot in multiple environments

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Biomimetic Intelligence & Robotics 2024年第2期4卷 12-23页

作者： Xuanyi Zhou Yuqiu Zhang Zhiwei qiu Zhecheng shan Shibo Cai Guanjun Bao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China State Key Laboratory of Chemical Engineering College of Chemicaland Bioogical EngineringZhejiang UniverstyHangzhou 310027China College of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510000China

The versatile motion capability of snake robots offers themselves robust adaptability in varieties of challenging environments where traditional robots may be *** study reports a novel flexible snake robot featuring a rigid-flexible coupling structure and multiple motion *** better understand the robot's behavior,a bending model for the soft actuator is ***,a dynamic model is developed to map the relationship between the input air pressure and joint torque,which is the model base for controlling the robot *** on the wave motion generated by the joint coupling direction function in different planes,multiple motion gait planning methods of the snake-like robot are *** order to evaluate the adaptability and maneuverability of the developed snake robot,extensive experiments were conducted in complex *** results demonstrate the robot's effectiveness in navigating through intricate settings,underscoring its potential for applications in various fields.

关键词： Snake robot Rigid-flexible coupled Soft actuator Motion gait analysis

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Insider threat detection approach for tobacco industry based on heterogeneous graph embedding

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High Technology Letters 2024年第2期30卷 199-210页

作者：季琦 LI Wei PAN Bailin xue Hongkai qiu Xiang Hangzhou Cigarette Factory China Tobacco Zhejiang Industrial Co.Ltd.Hangzhou 310024P.R.China Information Center China Tobacco Zhejiang Industrial Co.Ltd.Hangzhou 310024P.R.China College of Information Engineering Zhejiang University of TechnologyHangzhou 310014P.R.China

In the tobacco industry,insider employee attack is a thorny problem that is difficult to *** solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph ***,the interrelationships between logs are fully considered,and log entries are converted into heterogeneous graphs based on these ***,the heterogeneous graph embedding is adopted and each log entry is represented as a low-dimensional feature ***,normal logs and malicious logs are classified into different clusters by clustering algorithm to identify malicious ***,the effectiveness and superiority of the method is verified through experiments on the CERT *** experimental results show that this method has better performance compared to some baseline methods.

关键词： insider threat detection advanced persistent threats graph construction heterogeneous graph embedding

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Influence of cutterhead opening ratio on soil arching effect and face stability during tunnelling through non-uniform soils

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Underground Space 2024年第4期17卷 45-59页

作者： xue-Jian Chen Pei-Pei Fang qiu-Nan Chen Jun Hu Kai Yao Yong Liu State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China Hubei Technology Innovation Center for Smart Hydropower Wuhan 430000China College of Civil Engineering Anhui Jianzhu UniversityHefei 230601China School of Civil Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Civil and Architectural Engineering Hainan UniversityHaikou 570228China School of Qilu Transportation Shandong UniversityJinan 250002China

Tunnelling has increasingly become an essential tool in the exploration of underground space.A typical construction problem is the face instability during tunnelling,posing a great threat to associated *** face instability often occurs with the soil arching *** study investigates the combined effect of cutterhead opening ratio and soil non-uniformity on soil arching effect and face stability,via conducting random finite-element analysis coupled with Monte–Carlo *** results underscore that the face stability is strongly associated with the evolution of stress *** obtained stability factors in the uniform soils can serve as a reference for the design of support pressure in practical tunnelling *** addition,non-uniform soils exhibit a lower stability factor than uniform soils,which implies that the latter likely yields an underestimated probability of face *** tunnel face is found to have a probability of failure more than 50%if the spatial non-uniformity of soil is *** the end,a practical framework is established to determine factor of safety(FOS)corresponding to different levels of probability of face failure considering various opening ratios in non-uniform *** required FOS is 1.70 to limit the probability of face instability no more than 0.1%.Our findings can facilitate the prediction of probability of instability in the conventionally deterministic design of face pressure.

关键词： Tunnel Face stability Soil arching effect Cutterhead opening ratio Non-uniform soil Random field

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