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Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： shan-shan Li Yu-Shi Jiang xue-Ling Luo Xuming Ran Yuqiang Li Dong Wu Cheng-xue Pan Peng-Ju xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection

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Virologica Sinica 2019年第3期34卷 270-277页

作者： Shu-Wei Dong Ling-Shuai Jiao Ming Yang Ying-Liang Duan Yi-Bo Chen Fei Zhao A-Mei Zhang Li Liu Min-Hua Luo xue-shan xia Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500China The Key Laboratory of Tropical and Subtropical Animal Viral Diseases in Yunnan Province Kunming 650224China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China

As a universal pathogen leading to neonatal defects and transplant failure,human cytomegalovirus(HCMV)has strict species specificity and this has prevented the development of a suitable animal model for the pathogenesis *** mechanism of cross-species barrier remains elusive and there are so far no non-human cell culture models that support HCMV *** Chinese tree shrew(Tupaia belangeri chinensis)is a small laboratory animal and evolutionary closely related with *** investigated the susceptibility of primary tree shrew dermis fibroblasts(TSDF)to HCMV *** with a GFP-expressing HCMV virus resulted in green fluorescence in infected cells with the expression of IE1,UL44 and *** titers of cell-free viruses reached 10^3 PFU/mL at 96 hpi,compared to titers of 10^4 PFU/mL observed in primary human foreskin *** results suggested that TSDF was semi-permissive for HCMV *** TSDF model could be further used to investigate key factors influencing cross-species multiplication of HCMV.

关键词： Human cytomegalovirus(HCMV) Primary tree shrew dermis fibroblasts(TSDF) Cross-species infection Semi-permissiveness

Retinal ischemia-reperfusion injury and pretreatment with Lycium barbarum glycopeptide

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1599-1605页

作者： Yan-xia Wu Shuo Yin shan-shan Song xiang Liu Yu-Xuan Deng xue-Jing Lu Eye School of Chengdu University of Traditional Chinese Medicine Chengdu 610075Sichuan ProvinceChina Ineye Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610084Sichuan ProvinceChina School of Chinese Classics Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with Traditional Chinese Medicine Chengdu 610075Sichuan ProvinceChina Retinal Image Technology and Chronic Vascular Disease Prevention&Control and Collaborative Innovation Center Chengdu 610075Sichuan ProvinceChina

AIM:To investigate the antioxidant protective effect of Lycium barbarum glycopeptide(LbGP)pretreatment on retinal ischemia-reperfusion(I/R)injury(RIRI)in ***:RIRI was induced in Sprague Dawley rats through anterior chamber perfusion,and pretreatment involved administering LbGP via gavage for *** 24h of reperfusion,serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and creatinine(CREA)levels,retinal structure,expression of Caspase-3 and Caspase-8,superoxide dismutase(SOD)activity,and malondialdehyde(MDA)in the retina were ***:The pretreatment with LbGP effectively protected the retina and retinal tissue from edema and inflammation in the ganglion cell layer(GCL)and nerve fiber layer(NFL)of rats subjected to RIRI,as shown by light microscopy and optical coherence tomography(OCT).Serum AST was higher in the model group than in the blank group(P=0.042),but no difference was found in ALT,AST,and CREA across the LbGP groups and model ***-3 expression was higher in the model group than in the blank group(P=0.006),but no difference was found among LbGP groups and the model ***-8 expression was higher in the model group than in the blank group(P=0.000),and lower in the 400 mg/kg LbGP group than in the model group(P=0.016).SOD activity was lower in the model group than in the blank group(P=0.001),and the decrease was slower in the 400 mg/kg LbGP group than in the model group(P=0.003).MDA content was higher in the model group than in the blank group(P=0.001),and lower in the 400 mg/kg LbGP group than in the model group(P=0.016).The pretreatment with LbGP did not result in any observed liver or renal toxicity in the ***:LbGP pretreatment exhibits dosedependent anti-inflammatory,and antioxidative effects by reducing Caspase-8 expression,preventing declines of SOD activity,and decreasing MDA content in the RIRI rat model.

关键词： retinal ischemia-reperfusion Lycium barbarum glycopeptide pretreatment anti-inflammatory antioxidative rat

ControlService: a containerized solution for control-algorithm-as-a-service in cloud control systems

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Science China(Information Sciences) 2024年第8期67卷 172-189页

作者： Chenggang shan Runze GAO Zhen YANG Wei ZHANG Yuanqing xia School of Artificial Intelligence Zaozhuang University School of Automation Beijing Institute of Technology

As an extension of networked control systems, cloud control systems(CCSs) have emerged as a new control paradigm to improve the service quality of emerging control missions, such as data-driven modeling and automated vehicles. Existing studies have used the workflow-based restructured method to optimize the computation-intensive algorithms in the CCSs. However, the challenges here are how to define and submit these algorithms' workflows as cloud services and execute these algorithms' workflows in a containerized manner. Based on these challenges, we propose a containerized solution for the control-algorithm-as-a-service(C3aS) in the CCSs, namely Control Service. It offers the control algorithm as a cloud workflow service and uses a customized workflow engine to realize the containerized execution. First, we employ a cloud workflow representation method to define a control algorithm into an abstract cloud workflow form. Afterward, we provide a cloud service representation of the abstract cloud workflow. Next, we design a workflow engine and submit the cloud service to this workflow engine to implement containerized execution of this cloud service in the CCSs. In the experiment, we discuss the cloud service form and containerized implementation of the subspace identification method. Experimental results show that the proposed Control Service has significant performance advantages in computational time, reduction percentage, and speedup ratio compared with the baseline method.

关键词： cloud control systems control-algorithm-as-a-service containerization workflow engine cloud workflow service subspace identification

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In-situ measurement via the flow-through method and numerical simulations for radon exhalation during measurements of the radon exhalation rate

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Nuclear Science and Techniques 2024年第7期35卷 192-207页

作者： Ming xia Yong-Jun Ye shan-Wei shang Ting Yu Dai-Jia Chen School of Resources Environment and Safety Engineering University of South ChinaHengyang421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang421001China

Small-scale measurements of the radon exhalation rate using the flow-through and closed-loop methods were conducted on the surface of a uranium tailing pond to better understand the differences between the two *** abnormal radon exhalation behavior was observed,leading to computational fluid dynamics(CFD)-based simulations in which dynamic radon migration in a porous medium and accumulation chamber was *** on the in-situ experimental and numerical simulation results,variations in the radon exhalation rate subject to permeability,flow rate,and insertion depth were quantified and *** in-situ radon exhalation rates measured using the flow-through method were higher than those measured using the closed-loop method,which could be explained by the negative pressure difference between the inside and outside of the chamber during the *** consistency of the variations in the radon exhalation rate between the experiments and simulations suggests the reliability of CFD-based techniques in obtaining the dynamic evolution of transient radon exhalation rates for diffusion and convection at the porous medium-air *** synergistic effects of the three factors(insertion depth,flow rate,and permeability)on the negative pressure difference and measured exhalation rate were quantified,and multivariate regression models were established,with positive correlations in most cases;the exhalation rate decreased with increasing insertion depth at a permeability of 1×10^(−11) m^(2).CFD-based simulations can provide theoretical guidance for improving the flow-through method and thus achieve accurate measurements.

关键词： Radon exhalation Flow-through Numerical simulation Accumulation chamber Multivariate regression

Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

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Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： Yuan-Kai Du Zheng-xue Shi shan Dong Hui Jin xue Ke Pei Zhao Bing-Bing Jiang Feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive ***, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： shan-Hu Wang Yang-Yang Wu xiao-Jiao xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

Pleomorphic rhabdomyosarcoma of the vagina: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2396-2403页

作者： Pan Xu shan-shan Ling E Hu Bi-xia Yi Department of Gynecology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000Zhejiang ProvinceChina Zhejiang University School of Medicine Hangzhou 310006Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)of the vagina in postmenopausal women is an extre-mely rare malignant tumor that was originally described as a unique group of soft tissue sarcomas originating from primitive mesenchymal *** was first re-ported in postmenopausal women in 1970,and fewer than 50 postmenopausal patients have been reported to *** SUMMARY A 68-year-old multiparous female was admitted to the hospital on October 11,2023,with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 *** vaginal mass was approximately the size of a pigeon egg;after lying down,the vaginal mass *** resection was performed,and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining *** patient is currently undergoing *** present study also reviewed the clinical,histolo-gical,and immunohistochemical features and latest treatment recommendations for vaginal *** abnormal vaginal mass should be promptly investigated through pelvic examination and appropriate *** current initial treat-ment for vaginal RMS is biopsy and primary *** When surgery is planned for vaginal RMS,an organ-preserving approach should be considered.

关键词： Rhabdomyosarcoma Vagina Postmenopausal woman Pleomorphic Case report

Characteristic Study of Self-Powered Sensors Based on Native Protein Composite Film

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Energy & Environmental Materials 2024年第1期7卷 226-232页

作者： Jiehui xue Huijing xiang Yanrong Zhang Jun Yang xia Cao Zhonglin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences School of Resources Environment and Materials School of Physics Science and Technology Center on Nanoenergy Research Guangxi University Center for Green Innovation School of Mathematics and Physics University of Science and Technology Beijing Research Centre of Information Technology Shenzhen Institute of Information Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing School of Materials Science and Engineering Georgia Institute of Technology

Flexible electronic sensors composed of flexible film and conductive materials play an increasingly important role in wearable and internet information *** has received more and more attention and made some progress over the ***,it is still a great challenge to prepare biocompatible and highly transparent conductive *** white is a pure natural protein-rich material.

关键词： flexible sensors intelligent sensing natural protein-rich material triboelectric nanogenerators