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Case Fatality Rate of Severe Acute Respiratory Syndromes in Beijing

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Biomedical and Environmental Sciences 2005年第4期18卷 220-226页

作者： QI CHEN WAN-NIAN LIANG GAI-FEN LIU MIN LIU xue-qin xie JIANG WU XIONG HE ZE-JUN LIU School of Health Management and Education Capital University of Medical Sciences Beijing 100054 China School of Public Health Peking University Beijing 100083 China Capital University of Medical Sciences ＆ Beijing Municipal Health Bureau Beijing 100054 China Beijing Municipal Centers for Disease Prevention and Control Beijing 100013 China

To describe the case fatality rate of SARS in Beijing. Methods Data of SARS cases notified from Beijing Center for Disease Control and Prevention （BCDC） and supplemented by other channels were collected. The data were analyzed by rate calculation. Results The case fatality rate of SARS in Beijing was 7.66%, and had an ascending trend while the age of cases was getting older, and a descending trend while the epidemic developmem. The case fatality rate in Beijing was lower than that in other main epidemic countries or regions. Conclusions The risk of death increases with the increment of age of SARS patients. Beijing is successful in controlling and treating SARS.

关键词： SARS Case fatality rate Beijing

The Modulation of Trehalose Metabolism by 20-Hydroxyecdysone in Antheraea pernyi(Lepidoptera:Saturniidae) During Its Diapause Termination and Post-Termination Period

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The Modulation of Trehalose Metabolism by 20-Hydroxyecdysone...

Severe Acute Respiratory Syndrome-Retrospect and Lessons of 2004 Outbreak in China

中国生物化学与分子生物学会2020全国学术在线会议

作者： Ya-Na Li Yu-Bo Liu xue-qin xie Jia-Ning Zhang Wen-Li Li School of Bioengineering Dalian University of Technology School of Life Science and Medicine Dalian University of Technology

Trehalose plays a crucial role in the diapause process of many insects,serving as an energy source and a stress *** accumulation has been reported in diapause pupae of Antheraea pernyi;however,trehalose metabolic regulatory mechanisms associated with diapause termination remain ***,we showed that the enhanced trehalose catabolism was associated with an increase in endogenous 20-hydroxyecdysone(20 E) in hemolymph of *** pupae during their diapause termination and post-termination *** of 20 E increased the mRNA level of trehalase 1 A(ApTre-1 A) and trehalase 2(ApTre-2) of *** diapause pupae in a dose-dependent manner but did not affect the mRNA level of trehalase1 B(ApTre-1 B).Meanwhile,exogenous 20 E increased the enzyme activities of soluble and membrane-bound trehalase,leading to a decline in hemolymph ***,the expression of ApTre-1 A and ApTre-2 were down-regulated after the ecdysone receptor gene(ApEcRB1) was silenced by RNA interference or by injection of an ecdysone receptor antagonist cucurbitacin B(CucB),which inhibits the 20 E ***,CucB treatment delayed adult emergence,which suggests that ApEcRB1 might be involved in regulating pupal-adult development of *** by mediating ApTre-1 A and ApTre-2 *** study provides an overview of the changes in the expression and activity of different trehalase enzymes in *** in response to 20 E,confirming the important role of 20 E in controlling trehalose catabolism during *** diapause termination and post-termination period.

关键词： 20-hydroxyecdysone ecdysone receptor trehalase diapause termination post-termtation

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Biomedical and Environmental Sciences 2006年第6期19卷 445-451页

作者： WAN-NIAN LIANG TAO ZHAO ZE-JUN LIU BAO-YING GUAN XIONG HE MIN LIU QI CHEN GAI-FEN LIU JIANG WU RUO-GANG HUANG xue-qin xie ZHENG-LAI WU Beijing Municipal Health Bureau Beijing 100053 China Beijing Municipal Centers for Disease Control and Prevention Beijing 100013 China School of Public Health Peking University Health Science Center Beijing 100083 China School of Public Health Capital University of Medical Sciences Beijing 100069 China Department of Epidemiology Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 China

Objective To summarize lessons learned from an outbreak of severe acute respiratory syndrome （SARS） in China during the spring of 2004. Methods Data of SARS cases were officially reported by Beijing Municipal Center for Disease Control and Prevention （BCDC） and Anhui Provincial Center for Disease Control and Prevention （APCDC） and results of epidemiological investigations were collected and analyzed. Results Three generations of 11 cases of SARS were identified during the outbreak, Initial two cases were most likely to be infected in Diarrhea Virus Laboratory of National Institute of Virology, China Centers for Disease Control and Prevention and main mode of transmission was direct contact with SARS patients, Delay in detecting initial case resulted in spread of the illness at hospitals and communities with two generations of secondary cases, Conclusions SARS outbreak in 2004 has yielded following lessons for public health globally. （1） Lab bio-safety programs should be made and should be strictly abided by, Studies in highly pathogenic viruses such as SARS coronavirus should be utmost cautious, （2） Management systems of occupational exposure to virus and disease surveillance need to be strengthened to take all risk factors into account so as to detect potential patients with infectious disease as early as possible.

关键词： Severe acute respiratory syndrome (SARS) Outbreak Bio-safety Laboratory China

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多源水汽再分析资料在青藏高原的适用性评估

干旱区研究 2017年第2期34卷 300-308页

作者：赵洪宇张雪芹解承莹中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟重点实验室北京100101 中国科学院大学北京100049

评估多源水汽再分析资料在青藏高原的适用性,可为高原水汽分布及输送特征研究提供数据参考,并有利于提高高原地区气候变化研究结果的可靠性。以探空观测资料(简称"观测资料")为参照标准,对比分析JRA-25(J25)、JRA-55(J55)和ERA-interim(... 详细信息

评估多源水汽再分析资料在青藏高原的适用性,可为高原水汽分布及输送特征研究提供数据参考,并有利于提高高原地区气候变化研究结果的可靠性。以探空观测资料(简称"观测资料")为参照标准,对比分析JRA-25(J25)、JRA-55(J55)和ERA-interim(ERA)等再分析水汽资料在高原的适用性。结果表明:3种再分析资料均能揭示高原比湿的时空变化特征,但再分析资料与观测资料比湿偏差存在明显的季节和区域差异。水平方向上,J25与观测资料比湿均方根误差(RMSE)及相对偏差(PIC)总体较小,J55和ERA夏季及年平均比湿RMSE和PIC明显偏大,冬季较小。垂直方向上,与观测资料比湿垂直廓线相比,J25夏、冬季及年平均比湿垂直廓线一致性最好;J55和ERA比湿垂直廓线冬季一致性较好,夏季偏差较大,特别是高原主体及东南部站点偏差尤为显著。再分析资料与观测资料各层比湿RMSE低层大,高层小,且J25的RMSE最小。与观测资料相比,J25比湿数值小幅偏高,J55和ERA则整体偏低,且偏差较大。J55和ERA再分析资料比湿存在较大偏差的原因及其在我国其他区域的适用性还有待进一步检验。

关键词：多源水汽再分析资料比湿适用性评估青藏高原

Thermally activated delayed fuorescent small molecule sensitized fuorescent polymers with reduced concentration‑quenching for efcient electroluminescence

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Frontiers of Optoelectronics 2023年第1期16卷 41-48页

作者： qin xue Mingfang Huo Guohua xie Department of Physical Science and Technology Central China Normal UniversityWuhan 430079China Sauvage Center for Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic MaterialsDepartment of ChemistryWuhan UniversityWuhan 430072China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Thermally activated delayed fuorescence(TADF)small molecule bis-[3-(9,9-dimethyl-9,10-dihydroacridine)-phenyl]-sulfone(m-ACSO2)was used as a universal host to sensitize three conventional fuorescent polymers for maximizing the electroluminescent *** excitons were utilized via inter-molecular energy transfer and the non-radiative decays were successfully refrained in the condensed ***,the signifcant enhancement of the electroluminescent efciencies was *** instance,after doping poly(9,9-dioctylfuorene-co-benzothiadiazole)(F8BT)into m-ACSO2,the external quantum efciency(EQE)was improved by a factor of 17.0 in the solution-processed organic light-emitting device(OLED),as compared with the device with neat *** terms of the other well-known fuorescent polymers,i.e.,poly(para-phenylene vinylene)copolymer(Super Yellow,SY)and poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene](MEH-PPV),their EQEs in the devices were respectively enhanced by 70%and 270%,compared with the reference devices based on the conventional host 1,3-di(9H-carbazol-9-yl)benzene(mCP).Besides the improved charge balance in the bipolar TADF host,these were partially ascribed to reduced fuorescence quenching in the mixed flms.

关键词： Thermally activated delayed fuorescence(TADF) Organic light-emitting device(OLED) Sensitization Energy transfer Solution process

Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

Rectifying control of wire diameter during dieless drawing by a deformation measuring method of interframe displacement

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 615-621页

作者： Yong He xue-feng Liu Fang qin Jian-xin xie Key Laboratory for Advanced Materials Processing (Ministry of Education) University of Science and Technology Beijing Beijing 100083 China

A deformation measurement method of interframe displacement was proposed in this paper. By online monitoring the shape di- mensions of both the deformation zone and its adjacent zone by machine vision, the initial and terminative positions of deformation were dynamically identified during dieless drawing, and the global monitoring and online closed-loop control of the deformation zone were achieved. The dieless drawing process was systematically carried out on NiTi shape memory alloy wires. It is shown that the deformation measurement method of interframe displacement can track the axial displacement of the wires, but this cannot be achieved by traditional machine vision. The initial and terminative positions of deformation can be accurately identified by this method. The proposed rectifying control technology can effectively decrease the wire diameter fluctuation during dieless drawing, that is, the standard deviation of the wire diameter fluctuation could be decreased fi＇om 0.30 to 0.08 mm after three passes of dieless drawing, indicating that the control system has a good rectifying ability.

关键词： wire drawing rectification deformation machine vision closed loop control systems nickel alloys sha^oe memory effect

Effect of Sand Body Enrichment Under the Restriction of a Tectonic Transfer Zone: A Case Study on the Pinghu Formation in the Kongqueting Region on the Pinghu Slope

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Journal of Ocean University of China 2021年第4期20卷 765-776页

作者： LI Junjie HOU Guowei qin Lanzhi xie Jingjing JIANG xue CNOOC(China)Co. Ltd.Shanghai CompanyShanghai 200030China

Results of long-term explorations in the Kongqueting region,located in an East China Sea depression,suggest that the strong fault activity during the sedimentary period of the Pinghu formation significantly influenced the development of the sedimentary ***,the aggregation and enrichment of the sand body under a tectonic background has become a problem that requires an immediate *** research outcomes of previous studies,this study used three-dimensional seismic and logging data to identify Y-or H-type and the en echelon distribution patterns of the fault plane,as well as identify the locations wherein the fault growth index value is greater than 1 in the study region,indicating the tectonic background of the fault transfer zone in the ***,the development type of the fault transfer zone was studied,and the sand body enrichment site was identified based on seismic inversion data and the development position of the fault transfer *** helps clarify the evolution of sedimentary facies of the Pinghu formation combined with the sedimentary environment of the braided-river ***,after summarizing the coupling relationship between the synsedimentary fault systems and the sand body enrichment patterns,three sand-control models were determined,namely,the flexural-parallel,the en echelon collinear,and the torsional-reformed superimposed transfer *** findings of this study lay a foundation for the subsequent search of tectonic lithologic oil and gas reservoirs.

关键词： synsedimentary fault paleogeomorphology structural transfer zone sand body distribution Kongqueting

The Role of Mold Temperature on Morphology and Mechanical Properties of PE Pipe Produced by Rotational Shear

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Chinese Journal of Polymer Science 2020年第6期38卷 653-664页

作者： Zu-Chen Du Hao Yang xie-Huai Luo Ze-Xiang xie Qiang Fu xue-qin Gao College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China

The role of mold temperature on the morphology and properties of rotational shearing polyethylene(PE)pipes was studied via a self-.developed rotational shear system(RSS).The result indicated that when the mold temperature was 150℃,the hoop tensile strength and Vicat softening temperature were enhanced rapidly,which were 383.6%and 137.9%higher than those of the conventional PE pipes,*** and crystal structure studies by SEM and DSC revealed that once the rotational shear was applied,the shish-kebab structure began to *** the increase of the mold temperature,due to the relaxation of most of the oriented molecular chains,the preservation of shish-kebab structure became *** the mold temperature was 190℃,only the inner layer of the pipes,where the cooling rate was the largest,could preserve the shish-kebab *** to WAXD,there was less shish structure,and the growth of kebab was distorted in the inner layer of the pipes at 210℃.The result of SAXS suggested that the length of shish changed most within the temperature range from 170℃to 190。*** results of DSC and WAXD showed less change in crystallinity and degree of orientation between the two *** can be concluded that the reduction of shish length leads to a decrease in mechanical properties and heat-resistance.

关键词： Shish-kebab Rotational shear Mold temperature PE pipe