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Metallographic investigationof first full-sizehigh-Jc Nb_(3)Sn cable-in-conduit conductor aftercyclicloadingtests

Superconductivity 2024年第1期9卷 1-8页

作者： Chao Dai Yunhao Liu Zichuan Guo Yu Wu Arend Nijhuis Tianjun xue Zuojiafeng Wu Jinggang qin Huainan New Energy Research Center Huainan 232000People’s Republic of China University of Twente EnergyMaterials and SystemsFaculty of Science and TechnologyEnschede 7500AENetherlands University of Science and Technology of China Hefei 230026People’s Republic of China Baiyin Non-ferrous Changtong Wire&Cable Co.Ltd BaiyinGansu 730900People’s Republic of China Longteng Mechanical and Electrical Co. LtdYiChun 336000People’s Republic of China

In order to verify the feasibility of applying high-Jc Nb_(3)Sn strand in fusion magnet,a full-size cable-in-conduit conductor(CICC)with short twist pitch(STP)cable pattern was manufactured and tested in SULTAN facility at SPC,*** levels of cyclic electromagnetic(EM)load were applied on the sample stepwise,no visible decrease of current sharing temperature(TcsT was observed until the EM load increased to 80 kA×10.8 T,after that the Tcs decreased dramatically with the EM cycles,which suggested that irreversible deformation,causing a change in the strain state,or even damage has occurred in the superconducting *** investigating the reason which caused the conductor performance degradation,the tested conductor was dissected for metallographic *** segments which subjected to different EM loads were extracted from one of the legs,the geometric feature changes of the cable cross-sections were analyzed and compared.A good correlation was found between the decrease of the Tcs and deformation of the cable cross section.A mass of cracks were found on the sub-elements of strands in the segment which subjected to highest EM load,but the amount of crack is much lower in other *** the analyses,it is speculated that the critical EM load which causes irreversible degradation is between 850 kN/m and 870 kN/m for this *** results could be a reference in high-Jc Nb_(3)Sn CICC design.

关键词： High‐Jc Nb_(3)Sn Cable‐in‐conduit conductor Metallography

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Progress and current perspectives of diagnosis and treatment of hepatoid adenocarcinoma of the stomach

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Oncology and Translational Medicine 2024年第2期10卷 54-59页

作者： Kai qin Jing Zhang Chen gong Yi Cheng Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Hepatoid adenocarcinoma of the stomach(HAS)is a rare malignant gastric tumor exhibiting both hepatocellular and adenocarcinomatous *** are often diagnosed at an advanced stage,and their clinical symptoms closely resemble those of gastric *** of its rarity,misdiagnosis and missed diagnoses are *** with gastric adenocarcinoma,HAS typically exhibits higher invasiveness and amore unfavorable *** review aimed to elaborate on the pathological features,potential mechanisms,clinical characteristics,diagnosis,and prognosis of *** insights provided aimed to contribute robust guidance for the clinical management of patients with HAS.

关键词： Diagnosis Hepatoid adenocarcinoma of the stomach Progress

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Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

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Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong Pifang gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian ***,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the *** lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V ***,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the *** genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the *** occurs at an early time point in the dorsal region relative to that in the ventral region of the developing *** transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal ***,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle

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细节全方位护理对CT引导下肺穿刺并发症的护理效果及舒适度的影响

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医学信息 2024年第12期37卷 156-159页

作者：宫雪天津市胸科医院呼吸与危重症一科

目的探究细节全方位护理对CT引导下肺穿刺并发症的护理效果及舒适度的影响。方法以2021年6月-2022年6月于我院行CT引导下肺穿刺检测的64例受检者为研究对象，采用随机数字表法分为对照组（32例）和观察组（32例）。对照组给予常规护... 详细信息

目的探究细节全方位护理对CT引导下肺穿刺并发症的护理效果及舒适度的影响。方法以2021年6月-2022年6月于我院行CT引导下肺穿刺检测的64例受检者为研究对象，采用随机数字表法分为对照组（32例）和观察组（32例）。对照组给予常规护理，观察组在其基础上应用细节全方位护理，比较两组穿刺配合度、穿刺成功率、穿刺时间、肺穿刺并发症、舒适度及护理满意率。结果观察组穿刺配合优良率、穿刺成功率高于对照组，穿刺时间短于对照组（P<0.05）；观察组肺穿刺并发症发生率小于对照组（P<0.05）；观察组心理舒适度及躯体舒适度评分均高于对照组（P<0.05）；观察组护理满意率高于对照组（P<0.05）。结论细节全方位护理在CT引导下肺穿刺活检中具有积极应用价值，可改善受检者检测配合度，提高其穿刺成功率，缩短穿刺时间，有利于提升受检者舒适度及护理满意率。

关键词： CT引导下肺穿刺细节全方位护理并发症舒适度护理满意率

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微生物污染控制策略在无菌注射剂生产中的验证与优化

实验室检测

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实验室检测 2024年第5期2卷 131-134页

作者：龚雪齐鲁制药有限公司

目的本研究旨在验证并优化无菌注射剂生产过程中的微生物污染控制策略，以确保产品安全、提升生产质量。方法采用随机试验设计，于2022年1月至2023年12月期间进行研究，2022年1月至2022年12月之间采用传统控制策略，2023年1月至2023... 详细信息

目的本研究旨在验证并优化无菌注射剂生产过程中的微生物污染控制策略，以确保产品安全、提升生产质量。方法采用随机试验设计，于2022年1月至2023年12月期间进行研究，2022年1月至2022年12月之间采用传统控制策略，2023年1月至2023年12月之间采用优化后策略。通过对比不同策略下的微生物污染情况，结合生产环境监控、工艺流程分析以及操作员行为规范评估，综合评估控制策略的有效性，并针对性地进行策略优化。结果研究发现，与优化前相比，优化后的策略使得产品微生物污染风险大幅减少，提高了生产效率和产品质量。结论验证与优化后的微生物污染控制策略在无菌注射剂生产中具有显著效果，为确保注射剂产品的无菌性和安全性提供了有力保障。未来，将持续监控生产过程，并根据实际情况对控制策略进行动态调整，以适应不断变化的生产环境和法规要求。

关键词：无菌注射剂微生物污染控制策略

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Acupoint catgut-embedding therapy ameliorates DNCB-induced atopic dermatitis in BALB/c mice by regulating Th2 type immune response and reducing infiltration of CD4^(+)and CD8^(+)cells

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Traditional Medicine Research 2024年第9期9卷 14-20页

作者： Cheng qin Xiang-Yi Kong Fang Wang Jin Xu Zhuo Zhang xue-Song Yang Jian-Zhou Ye College of First Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 650500China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunming 650500China Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine Yunnan University of Chinese MedicineKunming 650500China Department of Dermatology The First Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021China

Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c *** also conducted an initial examination of the underlying molecular ***:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding *** DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day *** in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut *** was assessed using SCORAD on treatment days 1,10,and *** day 18,nine mice per group were euthanized,and the remaining on day *** changes were observed using hematoxylin-eosin and immunohistochemistry ***-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western ***:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like *** decreases occurred in serum IL-4,IL-6,IL-13,and TNF-α*** analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein ***:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.

关键词： atopic dermatitis acupoint catgut-embedding therapy Th2 type immune response

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Advances and perspectives in environmental health research in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 105-113页

作者： Tong Zhu Yingjun Liu Shunqing Xu Guanghui Dong Cunrui Huang Nan Sang Yunhui Zhang Guanyong Su Jingwen Chen Jicheng gong Guohua qin Xinghua Qiu Jing Shang Haobo Wang Pengpeng Wang Mei Zheng SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Center for Environment and Health Peking UniversityBeijing 100871China School of Life and Health Sciences Huainan UniversityHaikou 570228China Joint International Research Laboratory of Environment and Health(Ministry of Education) Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Research Center of Environment and Health College of Environment and ResourceShanxi UniversityTaiyuan 030006China Department of Environmental Health School of Public HealthFudan UniversityShanghai 200032China School of Environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention TechnologySchool of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Department of Occupational and Environmental Health College of Public HealthZhengzhou UniversityZhengzhou 450001China

Environmental health research aims to identify environmental conditions suitable for the healthy living and reproduction of human *** the interdisciplinary research bridging environmental sciences and health/medical sciences,the impacts of physical,chemical,and biological environmental factors on human health are *** includes identifying environmental factors detrimental to human health,evaluating human exposure characteristics to environmental factors,clarifying causal relationships between environmental exposure and health effects,analyzing the underlying biochemical mechanisms,linking environmental factors to the onset and progression of diseases,establishing exposure-response relationships,and determining effect ***,the results of environmental health research can serve as a scientific basis for formulating environmental management strategies and guiding prevention and intervention measures at both the public and individual *** paper summarizes the recent advances and future perspectives of environmental health research in China,as reported by a group of Chinese scientists who recently attended a workshop in Hainan,*** it is not intended to provide a comprehensive review of this expansive field,it offers a glimpse into the significant progress made in understanding the health impacts of environmental factors over the past *** ahead,it is imperative not only to sustain efforts in studying the health effects of traditional environmental pollution,but also to prioritize research on the health impacts of emerging pollutants and climate change.

关键词： Environmental pollution Emerging pollutants Climate change Exposure Mechanism

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胆道闭锁:序贯治疗和一期肝移植如何选择

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中华小儿外科杂志 2024年第5期45卷 472-477页

作者：任雪陈功复旦大学附属儿科医院普外科上海201102

所有的胆道闭锁患儿是否都应该进行肝门空肠吻合术(Hepatoportoenterostomy,HPE)以及前期的HPE手术是否会对肝移植产生不良影响是值得深思的问题。随着活体肝移植技术的进展,如何区分哪些患儿能从一期肝移植中获益,也是摆在儿外科医生... 详细信息

所有的胆道闭锁患儿是否都应该进行肝门空肠吻合术(Hepatoportoenterostomy,HPE)以及前期的HPE手术是否会对肝移植产生不良影响是值得深思的问题。随着活体肝移植技术的进展,如何区分哪些患儿能从一期肝移植中获益,也是摆在儿外科医生面前的挑战。本研究将从HPE手术术后自体肝长期生存状况、续贯治疗中前期HPE手术对后期肝移植的影响、术前判断HPE手术自体肝预后的指标等三个方面对胆道闭锁患儿两种手术治疗方案的选择依据进行综述。

关键词：胆道闭锁手术治疗肝门空肠吻合术肝移植

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Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy

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Nano Research 2024年第3期17卷 1804-1817页

作者： Fazhan Wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming Wang Rui xue Wenjing Deng Shuai Shao Zhihai qin Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Translational Medical Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Department of Neuro-Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China

Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA *** expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA *** by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered *** the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA *** mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in *** with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma *** natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy.

关键词： mRNA vaccine lipid nanoparticles spleen long-chain saturated fatty acid cancer immunotherapy

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A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

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The Crop Journal 2024年第2期12卷 569-582页

作者： Suting Wu Htin Kyaw Zhijun Tong Yirong Yang Zhiwei Wang Liying Zhang Lihua Deng Zhiguo Zhang Bingguang Xiao William Paul Quick Tiegang Lu Guoying Xiao Guannan qin xue'an Cui Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Biological Breeding for Fujian and Taiwan Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic *** available genome-editing tools have a limited number of targets,restricting their application in genetic *** this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software *** combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was *** plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

关键词： CRISPR/Cas9 Multiplex genome editing Assembly system Plant

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