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Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer

Chinese Journal of Cancer Research 2023年第3期35卷 299-315页

作者： qi Cao Ruidong xue Ning zhang Translational Cancer Research Center Peking University First HospitalBeijing 100034China International Cancer Institute Peking University Health Science CenterBeijing 100191China Yunnan Baiyao Group Kunming 650500China

Objective: Cancer immunotherapy has made remarkable advances in recent years, but its effectiveness in treating gastric cancer is often limited by the complexity of the tumor microenvironment and the lack of effective biomarkers. This study aimed to identify effective biomarkers for immunotherapy treatment by characterizing the tumor microenvironment.Methods: We retrieved the RNA-seq data from gastric cancer patients treated with the programmed death 1(PD-1) blockade pembrolizumab. Differentially expressed genes associated with clinical outcomes were identified and further analyzed using gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis. Gene signature scores were calculated by single sample Gene Set Enrichment Analysis(ssGSEA). The infiltration levels of immune cells were quantified using the xCell website. Cell type enrichment analysis was performed to compare treatment response and non-response groups, and regression analysis was used to investigate the relationship between interferon gamma(IFNγ) immune response and immune cell infiltration. Biomarkers were identified using least absolute shrinkage and selection operator(LASSO) analysis.Results: Compared to normal tissues, cytokine activity and interleukin-6 production were highly activated in gastric tumors. Responders to pembrolizumab showed significantly up-regulated expression of IFNγ responserelated genes. Cell type enrichment analysis revealed that Th1 cells were significantly enriched in the tumor microenvironment of responders. Regression analysis indicated that Th1 cells induced IFNγ response more efficiently than other cell types. Using signatures of Th1 cells, stromal cells and IFNγ response, a set of eight genes were identified that effectively predicted the efficacy of immunotherapy treatment and patient prognosis.Conclusions: Th1 cells promote therapeutic efficacy of PD-1 blockade by promoting IFNγ immune response in gastric cancer. The identified biomarkers have the potential to improve the effectiveness of imm

关键词： Gastric cancer immunotherapy Th1 cells IFNγresponse biomarkers

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Bright future of polymerizing small-molecule acceptors in realizing high performance all-polymer solar cells

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Frontiers of Chemical Science and Engineering 2022年第10期16卷 1526-1529页

作者： qi Chen Cen zhang Lingwei xue Zhi-Guo zhang State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China School of Chemical and Environmental Engineering Pingdingshan UniversityPingdingshan 467000China

All-polymer solar cells(all-PSCs)are prepared with a sandwich device structure based on a binary blend of a polymer donor and a polymer acceptor(Fig.1),and have attracted intensive research attention as a potential renewable photovoltaic technology[1,2].As compared to the PSCs with small molecule acceptors(SMAs),allPSCs show pronounced advantages of superior mechanical flexibility/stretchability and improved device stability[3,4].Thus,they are more attractive for the applications in wearable and portable electronics.After the first report of the all-PSCs in 1995 using cyano-substituted polyphenylenevinylene as the polymer acceptor[5,6],researchers have focused their efforts on the design of new polymer acceptors,such as rylenediimide[7],B←N bridged bipyridine[8],and cyanobenzothiadiazole-based polymer acceptors[9].However,before 2017,the power conversion efficiency(PCE)of the all-PSCs was limited by the weak absorbance of the polymer acceptors in the nearinfrared region[10].

关键词： polymer acceptor substituted

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A novel MgF2/PDA/S-HA coating on the bio-degradable ZE21B alloy for better multi-functions on cardiovascular application

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Journal of Magnesium and Alloys 2023年第2期11卷 480-492页

作者： Yang Yu Shi-Jie Zhu Hao-Tian Dong Xue-Qi Zhang Jing-An Li Shao-Kang Guan School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China

Recently, functional molecules such as Polydopamine(PDA), Hyaluronic Acid(HA) and heparin have been widely studied in the field of surface modification of magnesium(Mg) alloy stents for better degradation behavior and biocompatibility, but their further application is limited by undesirable anticoagulant function, uncontrollable degradation and easy bleeding, respectively.Regarding to this consideration, a magnesium Fluoride/Polydopamine/Sulphonated hyaluronic acid(Mg F2/PDA/S-HA) composite coating was successfully prepared by applying S-HA with sulfur content of 9.71 wt% on the surface of ZE21B alloy in this study. The results showed that the composite coating with a unique mesh structure not only inherited the anticoagulant effect of sulfonic acid group and the excellent cyto-compatibility of S-HA with high sulfur content, but also significantly improved the corrosion performance of ZE21B alloy.These results indicate a great application potential of the composite coating in the field of cardiovascular biomaterials.

关键词： Bio-degradable magnesium alloy Cardio-vascular stents Composite coating Sulphonated hyaluronic acid

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A review on cell damage,viability,and functionality during 3D bioprinting

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Military Medical Research 2023年第5期10卷 620-635页

作者： He-qi Xu Jia-Chen Liu Zheng-Yi zhang Chang-xue Xu Department of Industrial Manufacturingand Systems EngineeringTexas Tech UniversityLubbockTX79409USA School of Naval Architecture and Ocean Engineering Huazhong University of Science and TechnologyWuhan430074China

Three-dimensional(3D)bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials and living cells.Even though 3D bioprinting techniques have experienced significant advancement over the past decades,it remains challenging for 3D bioprinting to artificially fabricate functional tissues/organs with high post-printing cell viability and functionality since cells endure various types of stress during the bioprinting process.Generally,cell viability which is affected by several factors including the stress and the environmental factors,such as pH and temperature,is mainly determined by the magnitude and duration of the stress imposed on the cells with poorer cell viability under a higher stress and a longer duration condition.The maintenance of high cell viability especially for those vulnerable cells,such as stem cells which are more sensitive to multiple stresses,is a key initial step to ensure the functionality of the artificial tissues/organs.In addition,maintaining the pluripotency of the cells such as proliferation and differentiation abilities is also essential for the 3D-bioprinted tissues/organs to be similar to native tissues/organs.This review discusses various pathways triggering cell damage and the major factors affecting cell viability during different bioprinting processes,summarizes the studies on cell viabilities and functionalities in different bioprinting processes,and presents several potential approaches to protect cells from injuries to ensure high cell viability and functionality.

关键词： Three-dimensional bioprinting Cell damage Shear stress Cell viability Cell functionality

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N/S codoping modification based on the metal organic frameworkderived carbon to improve the electrochemical performance of different energy storage devices

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Journal of Energy Chemistry 2022年第11期31卷 394-403,I0011页

作者： Ziyi Zhu xue Li Zhong zhang qi Meng Wenjia zhang Peng Dong Yingjie zhang National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Fabrication Technology Yunnan Provincial Laboratory for Advanced Materials and Batteries ApplicationKunming University of Science and TechnologyKunming 650093YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina School of Applied Sciences and Engineering Fuzhou Institute of TechnologyFuzhou 350118FujianChina

Carbon-based materials have become a research hotspot in the field of energy storage devices in recent years due to their abundant resources,low cost,and environmental friendliness.However,the low capacity and poor high rate performance still constitute great challenges.Metal organic framework-derived carbon has been widely researched because of its high porosity,tunable structure,and good conductivity.In this work,N/S codoped hierarchical porous carbon microspheres were prepared by a high-temperature heat treatment and atomic doping process using a zinc-based organic framework as the precursor.When used as a potassium-ion battery anode,it has a high reversible specific capacity(435.7 mAh g^(-1)),good rate performance(133.5 mAh g^(-1)at 10,000 m A g^(-1)),and long-term cycling stability(73.2%capacity retention after the 2500th cycle).The potassium storage mechanism of the derived carbon was explained by various electrochemical analysis methods and microstructure characterization techniques,and the relationship between the structural characteristics and electrochemical properties was researched.In a supercapacitor,the porous carbon material exhibits a specific capacitance of 307.2 F g^(-1)at a current density of 0.2 A g^(-1)in a KOH aqueous solution and achieves a retention rate of 99.88%after 10,000 cycles.The assembled symmetric supercapacitor device delivers a high energy density of 6.69 Wh kg^(-1),with a corresponding power density of 2500 W kg^(-1).In addition,density functional theory calculations further confirmed that N/S codoping can improve the adsorption capacities of potassium and hydroxyl ions in the derived carbon.

关键词： N/S codoped Carbon microspheres Metal organic frameworks Potassium-ion batteries Supercapacitors

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Fe_(3)O_(4)@C 3D foam for strong low-frequency microwave absorption

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Journal of Materiomics 2023年第1期9卷 148-156页

作者： Li Wang zhang Chen xue Wang Liying zhang Zongtao zhang qi Zhao Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai200444China Shanghai Collaborative Innovation Center for High Performance Fiber Composites Center for Civil Aviation CompositesDonghua UniversityShanghai201620China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450066China

Low-frequency microwave absorbing materials have been challenging for many years.Three-dimensional dielectric/magnetic porous materials are beneficial for improving the low-frequency microwave absorbing performance because of natural resonance and improved impedance matching.In this study,Fe_(3)O_(4)@C 3D foam was prepared by carbothermal reduction method and the microwave attenuation performances and mechanisms were studied.By adjusting the content of Fe_(3)O_(4)@C 3D foam in paraffin composites,the low-frequency microwave attenuation capacity could be effectively optimized.The minimum reflection loss(RLmin)of paraffin composite with 40%(in mass fraction)loading exhibits-54.7 dB at 4.1 GHz for a thickness of 4.0 mm.Surprisingly,the paraffin composite with 50%(in mass fraction)loading could almost cover 2–4 GHz(S-band)in the thickness range of 3.5–5.5 mm.The strong low-frequency microwave attenuation property of Fe_(3)O_(4)@C 3D foam is mainly attributed to excellent low-frequency impedance matching,natural resonance,interfacial/dipole polarization,multiple reflection and scattering.This method provides a new perspective for preparing lightweight and high performance low-frequency microwave absorbing materials.

关键词： Fe_(3)O_(4)@C 3D foam Low-frequency microwave absorption

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Responsive changes of rumen microbiome and metabolome in dairy cows with different susceptibility to subacute ruminal acidosis

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Animal Nutrition 2022年第1期8卷 331-340页

作者： Tao zhang Yingyu Mu Ruiyang zhang Yanfeng xue Changzheng Guo Wangpan qi Jiyou zhang Shengyong Mao National Center for International Research on Animal Gut Nutrition National Experimental Teaching Demonstration Center of Animal ScienceCentre for Ruminant Nutrition and Feed Technology ResearchCollege of Animal Science and TechnologyNanjing Agricultural UniversityNanjing210095China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang110866China College of Animal Science and Technology Shihezi UniversityShihezi832000China

Subacute ruminal acidosis(SARA)represents one of the most important digestive disorders in intensive dairy farms,and dairy cows are individually different in the severity of SARA risk.The objectives of the current study were to investigate differences in the ruminal bacterial community and metabolome in dairy cattle with different susceptibility to SARA.In the present study,12 cows were initially enrolled in the experiment.Based on average ruminal pH,4 cows with the lowest ruminal pH were assigned to the susceptible group(SUS,pH=5.76,n=4)and 4 cows with the highest ruminal pH assigned to the tolerant group(TOL,pH=6.10,n=4).Rumen contents from susceptible(SUS,n=4)and tolerant(TOL,n=4)dairy cows were collected through rumen fistula to systematically reveal the rumen microbial and metabolic alterations of dairy cows with different susceptibility to SARA using multi-omics approaches(16S and 18S rRNA gene sequencing and metabolome).The results showed that despite being fed the same diet,SUS cows had lower ruminal pH and higher concentrations of total volatile fatty acids(VFA)and propionate than TOL cows(P0.05).The principal coordinates analysis based on the analysis of molecular variance indicated a significant difference in bacterial composition between the two groups(P=0.01).More specifically,the relative abundance of starch-degrading bacteria(Prevotella spp.)was greater(P0.05).Metabolomics analysis revealed that the concentrations of organic acids(such as lactic acid),biogenic amines(such as histamine),and bacterial degradation prod

关键词： Subacute ruminal acidosis Microbiome Metabolome Dairy cows

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Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway

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当代医学科学(英文) 2023年第4期43卷 696-707页

作者： Tian-qi ZHAO Yuan LI Miao zhang Meng-chao ZHAO xue CAO Shao-zhang HOU School of Basic Medicine Ningxia Medical UniversityYinchuan 750004China School of Nursing Ningxia Medical UniversityYinchuan 750004China Department of Pathology People's Hospital of Ningxia Hui Autonomous RegionYinchuan 750004China Department of Pharmacy General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective:Diabetic nephropathy is one of the most important microvascular complications of diabetes,which mainly refers to glomerular capillary sclerosis.Podocytes are an important part of glomerular capillaries.Previous clinical and basic studies have shown that fibrosis is the main factor of diabetic nephropathy.This study aimed to assess the protective mechanism of glycyrrhizic acid(GA)on glomerular podocytes induced by high glucose as we hypothesized that GA may have antifibrotic and anti-inflammatory effects on podocytes through regulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/sucrose nonfermenting AMPK-related kinase(SNARK)signaling pathway.Methods:SNARK siRNA was used to transfect podocytes.Real-time quantitative polymerase chain reaction and immunofluorescence staining assays were used for molecular and pathological analysis.The expression levels of key pathway proteins(including TGF-β1,α-SMA,SITR1,AMPKα,LKB1,PGC-1α,NF-κB,IL-6,and TNF-α)were verified by Western blotting.The expression of inflammatory factors in podocytes was detected by ELISA.Results:We demonstrated that GA decreased the expression of podocyte fibrosis signaling pathway-related factors by upregulating the AMPK pathway and its related factors.However,after transfection of podocytes with SNARK siRNA,there was an increased expression of fibrosis-related factors and inflammation-related factors.Conclusion:GA can protect podocytes and alleviate fibrosis and inflammation induced by high glucose,which is related to the AMPK signaling pathway.Meanwhile,knockdown of SNARK protein can inhibit the AMPK signaling pathway,aggravate fibrosis,and increase inflammation.

关键词： podocyte glomerular fibrosis glycyrrhizic acid diabetic nephropathy AMPK SNARK

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Dynamic characteristics of the pipeline inspection gauge under girth weld excitation in submarine pipeline

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Petroleum Science 2022年第2期19卷 774-788页

作者： Hang zhang Meng-qi Gao Biao Tang Can Cui xue-Feng Xu College of Mechanical and Storage and Transportation Engineering China University of Petroleum-BeijingBeijing102249China CNPC offshore Engineering Co.Ltd Beijing102200China

Pipeline inner inspection technology based on Pipeline Inspection Gauge(PIG),is the primary means for ensuring the safety of submarine pipelines.The dynamic characteristics of a PIG can change abruptly with the excitation of obstacles such as girth welds inside the pipeline,which would result in failure or inaccuracy of the inspection results.This study establishes a dynamic model of the PIG sealing disc based on Kelvin spring damping in the circumferentially confined space.The axial vibration differential equations of the PIG is examined in detail.MSC/ADAMS is used to conduct the dynamic simulation of the PIG at different motion velocities and center of mass positions while passing through the girth weld process.Results indicate that the axial vibration caused by the girth weld intensifies substantially as the speed of the PIG increases,while the pitch and vertical vibrations exhibit a significant decline with an increase in the motion velocity.The change in the PIG’s center of mass positions has little effect on its axial vibration,while the pitch and vertical vibration conditions are significantly different in the same circumstances.

关键词： Pipeline inspection gauge Multi-system model Dynamic response Shock vibration Girth weld Submarine pipeline

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Effectiveness of resilience-promoting interventions in adolescents with diabetes mellitus:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第4期19卷 323-339页

作者： Yi Wu Yi-Yun zhang Ya-Ting zhang Hui-Jing zhang Tian-xue Long qi zhang Jing Huang Ming-Zi Li Peking University Health Science Center 38 Huayuan RoadHaidian DistrictBeijing100191China School of Nursing Peking UniversityBeijingChina Peking University Health Science Centre for Evidence-Based Nursing A Joanna Briggs Institute Affiliated GroupBeijingChina School of Nursing Jilin UniversityChangchunChina

Background This study aimed to analyze the efficacy of resilience-promoting interventions among adolescents and youth aged 10-24 years with any type of diabetes.Methods A systematic literature search was performed using the PubMed,Web of Science,Embase,Cochrane Library,CINAHL,and PsycINFO databases from inception to May 25,2022.The Cochrane risk of bias tool(version 2)was used to assess the quality of the included studies.A meta-analysis was performed to calculate the pooled effects of resilience-promoting interventions.Results Nineteen articles were included covering an overall sample of 2048 adolescents with diabetes.When analyzing the effectiveness of resilience-promoting interventions,hemoglobin A1c(HbA1c)at six months[mean difference=-0.47,95%confidence interval(CI)=-0.83 to-0.12,P=0.009]after the intervention was improved.However,long-term(≥12 months)improvement in HbA1c was not significant.In addition,comparing the control group,there were significant differences in the effect size for stress[standardized mean difference(SMD)=-0.87,95%CI=-1.25 to-0.48,P<0.05],self-efficacy(SMD=0.50,95%CI=0.02-0.98,P=0.04)and quality of life(SMD=0.27,95%CI=0.03-0.51,P=0.03).Conclusions Resilience-promoting intervention is a promising way for adolescent diabetes management to improve HbA1c,stress,self-efficacy,and quality of life.Incorporating resilience-promoting components into diabetes education and re-enforcing these contents every six months are recommended for implementation in clinical practice.

关键词： Adolescents Diabetes mellitus Intervention Meta-analysis Resilience

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