检索结果-南通市图书馆

Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China： A Prospective, Multicenter, Noninterventional Study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第15期131卷 1767-1775页

作者： Jian-Qiu Wu Yong-Ping Song Li-Ping Su Ming-Zhi Zhang Wei Li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru FengTM Wei Wang Jie-Wen Peng Xiao-Lin Li xue-nong ouyang Chang-Ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang Yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng Department of Oncology Jiangsu Cancer Hospital ＆ Jiangsu Institute of Cancer Research ＆ Nanjing Medical University Affiliated Cancer HospitalNanjing Jiangsu 210008China Department of Hematology Henan Cancer HospitalZhengzhouHenan 450000China Department of Hematology Shanxi Cancer HospitalTaiyuanShanxi 030013China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130000China Department of Hematology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430072China Department of Hematology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Oncology Affiliated Hospital of Shandong Academy of Medical SciencesJinanShandong 250000China Department of Hematology Medical University Nanfang HospitalGuangzhouGuangdong 510000China Department of Oncology Guangdong Foshan First HospitalFoshanGuangdong 528000China Department of Oncology Guangdong Zhongshan People＇s HospitalZhongshanGuangdong 528403China Department of Hematology Xiangya Hospital Central South UniversityChangshaHunan 410008China Department of Oncology Fuzhou General Hospital of Nanjing Military CommandFuzhouFujian 350001China Department of Oncology Changzhou First People＇s HospitalChangzhouJiangsu 213000China Department of Oncology 307 Hospital of Chinese People＇s Liberation ArmyBeijing 100070China TDepartment of Hematology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650221China Department of Hematology Affiliated Hospital of Neimenggu Medical CollegeHohhotHuhehaoteInner Mongolia 010050China Department of Hematology The Fourth Military Medical University Affiliated Tangdu HospitalXi＇anShaanxi 710038China Department of Oncology Daqing General Hospital Grou

Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in China was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in China, and that HBV reactivation during R-chemo is manageable with preventive measur

关键词： Asian Hematopoietic Malignancy Hepatitis B Virus Observational Study Rituximab

在线全文

学校读者我要写书评

暂无评论

Her-2蛋白在胃癌中的表达及其临床意义

世界华人消化杂志 2010年第13期18卷 1375-1379页

作者：陈娟李东石余英豪王烈欧阳学农谢飞来熊喜生福建医科大学福总临床医学院病理科中国人民解放军南京军区福州总医院病理科福建省福州市350025 中国人民解放军南京军区福州总医院放疗科福建省福州市350025 中国人民解放军南京军区福州总医院普外科福建省福州市350025 中国人民解放军南京军区福州总医院肿瘤科福建省福州市350025

目的:评价Her-2过表达与胃癌患者临床病理参数间的相关性及其临床意义.方法:采用EliVisionTMplus免疫组织化学染色方法检测778例胃腺癌标本中Her-2蛋白的表达.结果:Her-2阳性率(+++)为11.35%,Her-2阳性与性别、年龄、肿瘤部位、浸润深... 详细信息

目的:评价Her-2过表达与胃癌患者临床病理参数间的相关性及其临床意义.方法:采用EliVisionTMplus免疫组织化学染色方法检测778例胃腺癌标本中Her-2蛋白的表达.结果:Her-2阳性率(+++)为11.35%,Her-2阳性与性别、年龄、肿瘤部位、浸润深度及淋巴结转移无相关性(均P>0.05),而与组织类型、分化程度、TNM分期及远处转移相关(P<0.05).经多因素分析,组织类型、分化程度、TNM分期及远处转移均会影响Her-2的表达(P<0.05).Her-2(++)表达率为5.68%.结论:Her-2检测可以作为评估胃癌恶性生物学行为及预后的指标,并为靶向治疗提供了理论依据.

关键词：胃癌表皮生长因子受体-2 免疫组织化学临床病理参数靶向治疗

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大肠癌患者外周血循环癌细胞检测的临床意义

世界华人消化杂志 2000年第2期8卷 187-189页

作者：杨家辉饶本强王瑶涂小煌张连阳陈少华欧阳学农戴西湖中国人民解放军南京军区福州总医院中医肿瘤研究所检验科福建省福州市350025 中国人民解放军第三军医大学大坪医院普外科重庆市400042 中国人民解放军空军476医院普外科福建省福州市350002

目的探讨肠癌外周血循环癌细胞检测的临床意义。方法以ＣＫ－２０ｍＲＮＡ为靶分子，ＲＴ－ＰＣＲ技术检测３种癌细胞株（结脾性腺癌株ＷＳ－４８０、胃癌细胞株ＳＧＣ－７９０１、食管癌细胞株ＴＥ－１１）和６７例大肠癌患者外周... 详细信息

目的探讨肠癌外周血循环癌细胞检测的临床意义。方法以ＣＫ－２０ｍＲＮＡ为靶分子，ＲＴ－ＰＣＲ技术检测３种癌细胞株（结脾性腺癌株ＷＳ－４８０、胃癌细胞株ＳＧＣ－７９０１、食管癌细胞株ＴＥ－１１）和６７例大肠癌患者外周血细胞ＣＫ－２０ｍＲＮＡ的表达。结果三种癌细胞株中，只有结肠癌细胞表达ＣＫ－２０ｍＲＮＡ，ＲＴ－ＰＣＲ技术能检出１０＾７个单核细胞中的一个肿瘤细胞，６７例患者中。

关键词：核糖核酸大肠癌 PCR CK-20

中药复方肺泰胶囊对ⅢB/Ⅳ期非小细胞肺癌化疗患者化疗延迟率和化疗通过率影响的随机对照研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中西医结合学报 2012年第6期10卷 635-640页

作者：邓水秋欧阳学农余宗阳戴西湖陈曦房方铮王文武刘志臻南京军区福州总医院预防保健科福州福建350025 南京军区福州总医院肿瘤科福州福建350025

背景:化疗通过率可间接反映患者对化疗的耐受性和依从性。患者耐受性或依从性差,会影响整个综合治疗计划,从而影响肿瘤治疗的疗效。因此,如何提高化疗通过率及减少延迟化疗率在肿瘤治疗领域中越来越引起人们的重视。中医药联合化疗在减... 详细信息

背景:化疗通过率可间接反映患者对化疗的耐受性和依从性。患者耐受性或依从性差,会影响整个综合治疗计划,从而影响肿瘤治疗的疗效。因此,如何提高化疗通过率及减少延迟化疗率在肿瘤治疗领域中越来越引起人们的重视。中医药联合化疗在减毒增效、提高中晚期非小细胞肺癌(non-small-celllungcancer,NSCLC)患者的生存质量方面有一定优势。目的:观察中药复方肺泰胶囊对ⅢB/Ⅳ期NSCLC化疗患者化疗延迟率和化疗通过率的影响。设计、场所、对象和干预措施:采用前瞻性、随机、对照的临床研究方法,收集南京军区福州总医院肿瘤科的NSCLC患者60例。将60例ⅢB/Ⅳ期NSCLC患者随机分为治疗组(肺泰胶囊联合化疗)和对照组(单纯化疗),治疗4个周期。主要结局指标:观察每个周期化疗通过率、化疗延迟率和4个周期后的治疗效果。结果:入组60例,其中5例被剔除(治疗组2例,对照组3例),55例可评价疗效。治疗前,两组基线资料分布均衡(P>0.05)。治疗组和对照组第4周期的化疗通过率分别为96.42%和74.07%,化疗延迟率分别为3.57%和14.8%(P=0.007)。4个周期后治疗组疾病控制率为78.6%,对照组疾病控制率为59.3%,两组比较,差异无统计学意义(P=0.1739)。结论:中药复方肺泰胶囊可提高ⅢB/Ⅳ期NSCLC化疗患者化疗通过率,增强化疗疗效。

关键词：癌,非小细胞肺中草药抗肿瘤联合化疗方案随机对照试验

Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao You Huiying ouyang Ruixiang Deng Qiuqi Zhang Zhenzhong Xing Xiaowu Chen Qingliang Shan Jinshan Yang Shaoming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

中药复方肺泰胶囊维持治疗对中晚期非小细胞肺癌生存质量的影响:随机对照试验

在线全文

学校读者我要写书评

暂无评论

中西医结合学报 2009年第7期7卷 611-615页

作者：刘志臻余宗阳欧阳学农戴西湖陈曦赵忠全王文武李捷涂华叶磊颜艳南京军区福州总医院肿瘤科福建福州350025

背景:近年关于已完成治疗周期的瘤灶稳定的非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的维持治疗问题,引起医学界普遍兴趣。开展中医药在中晚期恶性肿瘤维持治疗领域的研究可能是目前综合治疗措施有益的补充。目的:观察中药... 详细信息

背景:近年关于已完成治疗周期的瘤灶稳定的非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的维持治疗问题,引起医学界普遍兴趣。开展中医药在中晚期恶性肿瘤维持治疗领域的研究可能是目前综合治疗措施有益的补充。目的:观察中药复方肺泰胶囊维持治疗对NSCLC患者生存质量的影响,并评价其安全性。设计、场所、受试者和干预措施:按标准入选南京军区福州总医院中晚期NSCLC患者62例,按信封法随机分为治疗组和对照组,每组各31例。治疗组给予肺泰胶囊维持治疗,对照组不给予任何干预。两组患者均定期随访。主要结局指标:定期评估临床证候疗效、体力状况、生存质量和安全性。组间临床特征、症状缓解率、体力状况和生活质量评分分别采用方差分析、非参数检验和协方差分析进行统计。安全性评价采用描述性统计。结果:入组62例,治疗组和对照组各1例出组,可评价疗效病例60例。治疗前两组基线资料分布均衡(P>0.05)。治疗组治疗后临床证候评估以及体力状况改善率分别提高了36.6%(Z=-2.632,P=0.008)和26.7%(Z=-2.182,P=0.029),两指标间存在显著正相关(r=0.917,P<0.001);治疗组生活质量得以改善,治疗期间未见明显药物相关的不良反应。结论:中药复方肺泰胶囊维持治疗可改善中晚期非小细胞肺癌患者的生存质量。

关键词：非小细胞肺癌复方(中药) 生活质量随机对照试验

First-principles kinetics study of carbon monoxide promoted Ostwald ripening of Au particles on FeO/Pt(111)

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第3期28卷 108-113页

作者： Sulei Hu Runhai ouyang Wei-xue Li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Department of Chemical Physics School of Chemistry and Materials ScienceiCHeMCAS Excellence Center for NanoscienceUniversity of Science and Technology of ChinaHefei 230026AnhuiChina Hefei National Laboratory for Physical Sciences at the Microscale Hefei 230026AnhuiChina University of Chinese Academy of Sciences Beijing 100049China

The dynamic and kinetic evolution of supported metal particles in the presence of reactants is decisive in shaping the nature of the catalytic active sites and the deactivation process. Ostwald ripening of FeO/Pt(111) supported Au particles in the presence of carbon monoxide is addressed here by firstprinciples kinetics. It is found that CO stabilizes the ripening monomer(Au atom) by forming favorable Au carbonyls with lower total activation energy, and corresponding phase diagram at wide range of temperature and CO pressures is constructed. Evolution of particle number, dispersion and particle size distribution of supported Au particles are explored. Great influence of CO promotion on ripening kinetics is revealed and explored in details, and mbar range of CO can lower the onset temperature of ripening by a few hundred kelvins. The present work reveals the crucial role of the metal-reactant complexes formed under reaction conditions on ripening of metal catalysts.

关键词： Carbon monoxide Au particles Ostwald ripening First-principles kinetics FeO/Pt(111)

Class numbers of cyclic 2-extensions and Gross conjecture over Q

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2010年第9期53卷 2447-2462页

作者： ouyang Yi xue Hang Univ Sci & Technol China Dept Math Hefei 230026 Peoples R China

The Gross conjecture over Q was first claimed by Aoki in ***,the original proof contains too many mistakes and false claims to be considered as a serious *** paper is an attempt to find a sound proof of the Gross conjecture under the outline of *** reduce the conjecture to an elementary conjecture concerning the class numbers of cyclic 2-extensions of Q.

关键词： Gross conjecture class number cyclic 2-extension

Effect of thermo-mechanical processing parameters on the dynamic restoration mechanism in an Mg-4Y-2Nd-1Sm-0.5Zr alloy during hot compression

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第31期90卷 205-224页

作者： Yunwei Gui Lingxiao ouyang Yibei xue Quanan Li School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal New Materials and Advanced Processing Technology Luoyang 471023China Department of Materials Processing Graduate School of EngineeringTohoku University6-6-11 AobaAramakiAoba-kuSendai980-8579Japan School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

Microstructure evolution and dynamic restoration mechanism of solution-treated Mg-4Y-2Nd-1Sm-0.5Zr alloy have been studied under three TMP parameters consisting of deformation temperatures(350-500℃),strain rates(0.01-5 s^(-1)),and strains(0.2,0.4,and 0.8).A strong dynamic softening is observed in all stress-strain curves,even at higher strain rates(1 and 5 s^(-1))due to an adiabatic heating *** stress-strain curves are applied to construct a processing map and develop an Arrhenius-type constitutive *** the prediction of the processing map,an optimal processing domain has been determined to be the temperature range 450-500℃and strain rate range 0.01-0.1 s^(-1)at a strain of *** volume fraction of DRX grains is the largest in the corresponding domain of high temperature and low strain *** the effect of TMP parameters on the dynamic restoration,the discontinuous dynamic recrystallization(DDRX)and continuous DRX(CDRX)synergistic effect occur throughout the whole process at high temperature and high strain *** terms of high temperature and low strain rate,DDRX characteristics at a low strain and then the DDRX+CDRX synergistic effect is observed at a higher *** the DRX process is weak at low temperature and low strain rate,deformation twins have occurred and provided nucleation sites for DRX grains.

关键词： Mg-RE alloy TMP parameters Processing map prediction Constitutive analysis Dynamic restoration mechanism