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Oral absorption of hyaluronic acid and phospholipids complexes in rats

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World Journal of Gastroenterology 2007年第6期13卷 945-949页

作者： Si-Ling Huang Pei-xue Ling Tian-min zhang Working Station for Postdoctoral Scientific Research Institute of Biopharmaceuticals of Shandong Province Jinan 250108 Shandong Province China

AIM： To prepare a complex of hyaluronic acid （HA） and phospholipids （PL）, and study the improvement effect of PL on the oral absorption of HA. METHODS： The complex of HA-PL （named Haplex） was prepared by film dispersion and sonication method, its physico-chemical properties were identified by infrared spectra and differential scanning calorimetry （DSC）. The oral absorption of Haplex was studied. Thirty-two healthy rats were divided into 4 groups randomly：（1） a normal saline （NS） control group; （2） an HA group; （3） a mixture group and （4） a Haplex group. After intragastric administration, the concentration of HA in serum was determined. RESULTS： The physico-chemical properties of Haplex were different from HA or PL or their mixture. After Haplex was administered to rats orally, the serum concentration of HA was increased when compared with the mixture or HA control groups from 4 h to 10 h （P 〈 0.05）. The AAUCo-12, of Haplex was also greater than that of the other three groups （P 〈 0.05）. CONCLUSION： The method of film dispersion and sonication can prepare HA and PL complex, and PL can enhance the oral absorption of exogenous HA.

关键词： Hyaluronic acid Phospholipids Complex Oral absorption Infrared spectrum Thermochemistry

Constitutive equation and hot processing maps of Al-5Ti-1B master alloy

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Rare Metals 2018年第8期37卷 668-674页

作者： Fu-Wei Kang Jie Zhou Zhi-Wei Wang xue-min zhang Yi-Cheng Feng Er-Jun Guo School of Materials Science and Engineering Harbin Universityof Science and Technology Harbin 150040 China Harbin Dong An Engine Group Corporation Ltd. Aviation Industry Corporation of China Harbin 150066 China

The isothermal compression tests of A1-5Ti- 1B master alloy were conducted on the thermal mechanical simulator Gleeble-1500D at the deformation temperature range of 300-450 ℃,the strain rate range of 0.01- 10.00 s^-l, and the engineering strain of 50 %. The effects of deformation temperatures and strain rates on the flow stress were analyzed by the true stress-true strain curves. The result indicates that the flow stress increases with the increase of strain rate, while it decreases with the increase of temperature. The hot deformation activation energy of A1-5Ti-IB master alloy is calculated to be 250.9 ***^-1, and the constitutive equation is established as ε=1.97 x lO^19[sinh（O.O15δ）^11.14exp（-250.9/RT）, and the validity of this constitutive equation is verified. Based on dynamic material model （DMM） criterion, the hot processing map of AI-5Ti-1B master alloy is obtained. The optimum hot extrusion conditions are determined as deformation temperature of 400℃ and strain rate of 1.00 s^-1, and the flow instability only appears at the temperature range of 300-340℃ at the base of the hot processing map.

关键词： Al-5Ti-1B master alloy Flow stress Constitutive equation Hot processing map

Preparation and characterization of resistant starch type 3 from yam and its effect on the gut microbiota

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Traditional Medicine Research 2022年第2期7卷 11-19页

作者： xue-Qian zhang Di Liang Na Liu Ou Qiao xue-min zhang Wen-Yuan Gao Xia Li Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300193China. Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300410China.

Background:Yam(Dioscorea opposita Thunb.)has been consumed as a food and used in traditional Chinese medicine for thousands of *** starch(RS)3 is of particular interest because it is heat-resistant,safe and non-toxic,and retains good nutritional benefits;it is therefore used in a wide range of traditional and emerging foods as a heat-stable prebiotic *** our previous study,we found that yam RS includes strong lipid-lowering and anti-constipation ***:Yam RS3 was prepared by autoclaving-retrogradation and pullulanase debranching to yield autoclaving-retrogradation yam RS and pullulanase debranching yam RS,***,the physicochemical properties of both RS3s were ***,the structures of the RS3s were characterized by scanning electron microscopy,X-ray powder diffraction,and Fourier transform infrared ***,the regulatory effects of the RS3s on the gut microbiota were evaluated using an in vitro fecal fermentation ***:The RS content of the RS3s decreased after processing,but was higher in pullulanase debranching yam RS(35.67%)than in autoclaving-retrogradation yam RS(28.71%).Compared with native yam starch,RS3s lost their original granular shapes and instead exhibited irregularly shapes with continuous *** crystalline structure of the RS3s was completely altered,with pullulanase debranching yam RS exhibiting B-type *** RS3s,and especially pullulanase debranching yam RS,promoted a significant increase in short chain fatty acid content after in vitro fermentation(all P<0.05).Moreover,pullulanase debranching yam RS significantly increased the abundance of beneficial bacteria and decreased the abundance of harmful bacteria such as Escherichia and Shigella(all P<0.05).Conclusion:Our findings show that yam RS3s can regulate the composition of the gut microbiota and promote the production of short chain fatty acid,especially butyric *** debranching was a more effecti

关键词： Yam resistant starch type 3 physicochemical properties short chain fatty acids gut microbiota

Physical properties of WSTi3515S burn-resistant titanium alloy

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Rare Metals 2016年第5期35卷 361-366页

作者： Yun-Jin Lai Ping-Xiang zhang xue-min zhang Xiang-Hong Liu Yong Feng Hong-Chao Kou Fan-Jiao Ma Wei-Dong Zeng State Key Laboratory of Solidification Processing Northwestern Polytechnical University Western Superconducting Technologies Co. Ltd. School of Materials Science and Engineering Chang’an University

Development of burn-resistant titanium alloys is the most direct way of mitigating the ignition and propagation of titanium fires in jet engines. WSTi3515S alloy（Ti–35V–15Cr–0.3Si–0.1C） is a new high alloying beta type burn-resistant titanium alloy, belonging to Ti–V–Cr type alloys which have been made significant progress in engineering technology in the past 5 years. The physical properties of WSTi3515S burn-resistant titanium alloy such as the elastic properties and thermal properties were measured and analyzed in different conditions. The results show that both the Young＇s modulus and shear modulus of WSTi3515S alloy decrease slightly with the temperature increasing at the tested temperature range. The Poisson＇s ratio of WSTi3515S alloy is around 0.36. However, the thermal properties such as the specific heat, thermal diffusivity, thermal conductivity and thermal expansion increase with the temperature increasing, which results from the strengthening of lattice heat vibration at elevated temperature. And the room temperature density of WSTi3515S alloy is 5.295 gácm^（-3）.

关键词： Physical properties WSTi3515S alloy Extrusion Burn-resistant

Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第16期21卷 4864-4874页

作者： Ke-Qi Han xue-Qun He Meng-Yu Ma Xiao-Dong Guo xue-min zhang Jie Chen Hui Han Wei-Wei zhang Quan-Gang Zhu Hua Nian Li-Jun Ma Department of Oncology Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Department of Pharmacy Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Department of Oncology Tongren Hospital of Shanghai Jiaotong University School of Medicine

AIM:To study the inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma(HCC) in nude ***:CBRH-7919 HCC cells were injected into the subcutaneous region of nude *** two weeks after the challenge,tumor growth was measured every week for six *** stromal microenvironment and inflammatory cell infiltration was assessed by immunohistochemistry in paired tumor and adjacent peritumoral samples,and macrophage phenotype was assessed using double-stain immunohistochemistry incorporating expression of an intracellular enzyme.A chemokine PCR array,comprised of 98 genes,was used to screen differential gene expressions,which were validated by Western ***,expression of identified chemokines was knocked-down by RNA interference,and the effect on tumor growth was ***:Inflammatory cell infiltrates are a key feature of adjacent peritumoral tissues with increased macrophage,neutrophil,and T cell(specifically helperand activated subsets)*** within adjacent peritumoral tissues express inducible nitric oxide synthase,suggestive of a proinflammatory ***-one genes were identified in tumor tissues during the progression period,including 50that were overexpressed(including CXCL1,CXCL2 and CXCL3)and three that were underexpressed(CXCR1,Ifg and Actb).RNA interference of CXCL1 in the CBRH-7919 cells decreased the growth of tumors in nude mice and inhibited expression of CXCL2,CXCL3and interleukin-1β***:These findings suggest that CXCL1plays a critical role in tumor growth and may serve as a potential molecular target for use in HCC therapy.

关键词： Chemokines Gene expression profile Hepatocellular carcinoma PCR array RNA interference

A review on the extraction and separation of andrographolide from Andrographis paniculata:extraction selectivity,current challenges and strategies

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Traditional Medicine Research 2023年第7期8卷 11-23页

作者： Di Liang Wei-Mei zhang Xu Liang Hong-Yue Tian xue-min zhang Xia Li Wen-Yuan Gao Tianjin Key Laboratory for Advanced Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300193China Key Laboratory of Advanced Chinese Medicine Resources Research Enterprises Tianjin 300402China College of Pharmacy Qinghai Minzu UniversityQinghai 810007China

Andrographolide is the main active ingredient of Andrographis paniculata(Burm.f.)Nees,known as“natural antibiotic”.Here,for the purpose of discovering a more efficient,low-cost extraction and separation method,the research status of andrographolide was *** present,researches only take extraction rate as the only index to optimize extraction parameters,but ignores the importance of extraction *** is usually meaningless to blindly pursue the extraction rate without considering the difficulty and cost of subsequent ***,factors affecting extraction selectivity such as solvent choice,temperature and physicochemical effects caused by extraction technique itself,are first *** extraction techniques for andrographolide were discussed by comparing the selectivity,efficiency and cost of *** separation procedures of andrographolide such as decolorization,impurity removal,crystallization,membrane separation,solid-phase extraction and partition chromatography and their challenges and possible strategies are also *** is hoped that this review can provide guidance for researchers who are committed to advancing the field of andrographolide extraction and purification.

关键词： andrographolide extraction techniques extraction selectivity separation

Dynamic Proteome Changes of Shigella flexneri 2a During Transition from Exponential Growth to Stationary Phase

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Genomics, Proteomics & Bioinformatics 2007年第2期5卷 111-120页

作者： Li Zhu Xian-Kai Liu Ge Zhao Yi-Dan Zhi Xin Bu Tian-Yi Ying Er-Ling Feng Jie Wang xue-min zhang Pei-Tang Huang Heng-Liang Wang State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Biotechnology Beijing 100071 China National Center of Biomedical Analysis Beijing 100850 China

Shigella flexneri is an infectious pathogen that causes dysentery to human, which remains a serious threat to public health, particularly in developing countries. In this study, the global protein expression patterns of S. flexneri during transition from exponential growth to stationary phase in vitro were analyzed by using 2-D PAGE combined with MALDI-TOF MS. In a time-course experiment with five time points, the relative abundance of 49 protein spots varied significantly. Interestingly, a putative outer membrane protein YciD （OmpW） was almost not detected in the exponential growth phase but became one of the most abundant proteins in the whole stationary-phase proteome. Some proteins regulated by the global regulator FNR were also significantly induced （such as AnsB, AspA, FrdAB, and KatG） or repressed （such as AceEF, OmpX, SodA, and SucAB） during the growth phase transition. These proteins may be the key effectors of the bacterial cell cycle or play important roles in the cellular maintenance and stress responses. Our expression profile data provide valuable information for the study of bacterial physiology and form the basis for future proteomic analyses of this pathogen.

关键词： Shigella flexneri proteomics growth phase

The mechanism and clinical effectiveness of the six-step Chinese Daoyin technique on hemiplegic patients with drop-foot

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Journal of Biomedical Science and Engineering 2012年第11期5卷 652-656页

作者： Wen-Ru Zhao Hai-Hong Zhao xue-min zhang Xiao Cao Xin Li Neurological Training Rehabilitation Department Rehabilitation Hospital of National Research Center for Rehabilitation Technical Aids (NRRA) Beijing China

Objective: The aim of this study was to improve the Chinese Daoyin technique (physical and breathing exercises), which is an ancient rehabilitation method, to elevate its effect and to standardize its operational procedure. Methods: Based on the ancient Chinese Daoyin technique, a six-step method was developed including: 1) motion imagination and imitation;2) mental and breathing regulation;3) target point determination;4) motion percussion;5) motion persistence;6) relaxation. Sixty drop-foot patients who suffered from hemiparesis after a stroke were randomly divided into the experimental group and the control group. Functional evaluation including Fugl-Meyer assessment score, Lovett manual muscle test (MMT), active range of motion of the ankle joint and electromyography were performed before and after the training course. The data were analyzed using the statistical software SPSS 12.0. Results: The differences between the two groups were significant. The effectiveness of the six-step group was significantly better than the effectiveness of the control group. Conclusion: The six-step method of the Chinese Daoyin technique is an effective rehabilitation training method for drop-foot in stroke patients with hemiparesis.

关键词： Rehabilitation Chinese Daoyin Technique Six-Step Method Hemiparesis Drop-Foot

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China Life Sciences 2024年

作者： xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen xue xue-Qing Zhou Zhi-Hui Su Xin-Ran zhang Li-ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian Xia xue-min zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical Analysis School of Basic Medical Sciences Fudan University Department of Basic Medical Sciences School of Medicine Tsinghua University

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid （CSF） flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of Gprotein signaling 22 （RGS22） results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor （LPAR） signaling under Rgs22–/–condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22–/–rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

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