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论萧红小说的抒情性

北华大学学报（社会科学版） 2008年第4期9卷 97-99页

作者：薛丽敏吉林广播电视大学吉林长春130022

萧红的小说,不以情节叙事为重心,而是在小说创作中大胆引进抒情功能,散文化的抒情性成了她小说创作的主要特征。萧红的小说创作促进了现代小说观念的更新,使小说获得了另一种独特意义的存在。

关键词：萧红小说抒情性

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罗尔定理应用中辅助函数的构造

渭南师范学院学报 2008年第2期23卷 15-17页

作者：薛利敏渭南师范学院数学与信息科学系陕西渭南714000

探讨了在罗尔定理应用中如何通过积分构造辅助函数的方法,并得出了一些有用的结论.

关键词：罗尔定理辅助函数积分法构造法

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观察法在高等数学教学中的应用

渭南师范学院学报 2014年第19期29卷 9-13页

作者：薛利敏渭南师范学院数学与信息科学学院陕西渭南714099

观察就是仔细察看.观察是进行科学研究的出发点,是一切发明创造的源泉.文章通过实例从顺序观察法、解剖观察法、对比观察法、重点观察法和全面观察法等几个方面介绍了观察法在高等数学教学中的应用,阐明了在高等数学教学中如何培养学生... 详细信息

观察就是仔细察看.观察是进行科学研究的出发点,是一切发明创造的源泉.文章通过实例从顺序观察法、解剖观察法、对比观察法、重点观察法和全面观察法等几个方面介绍了观察法在高等数学教学中的应用,阐明了在高等数学教学中如何培养学生的观察能力.

关键词：观察观察法观察能力高等数学教学

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从一个极值问题到一类行列式的计算

北京机械工业学院学报 2000年第2期15卷 27-30页

作者：薛利敏陕西渭南师范专科学院数学系陕西渭南714000

在数学中及工程技术中 ,对有关极值问题的讨论是一个非常重要的课题。对于这些问题的讨论有时可化为一些等式或一些行列式的计算。对一类极值问题进行了认真讨论和分析 ,给出了一类行列式的计算 ,并推广了阶乘的概念 ,且得到一类正定矩阵。

关键词：极值行列式阶乘正定矩阵

负性协同刺激分子PD-1在重症肌无力患者外周血中的表达

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中华神经科杂志 2011年第10期44卷 694-697页

作者：薛群鲍民强蒋觉安陈永井薛利敏方琪王明元顾国浩董万利张学光苏州大学附属第一医院神经内科 215006 苏州大学临床免疫研究所、医学生物技术研究所苏州市红十字中心血站

目的观察重症肌无力（MG）患者外周血中负性协同刺激分子programmed death-1（ PD-1）的表达情况，并探讨其与MG发病的关系。方法采用免疫荧光标记、流式细胞仪检测45例MG患者和33名健康对照者外周血单个核细胞中PD-1及其配体PD-L1的... 详细信息

目的观察重症肌无力（MG）患者外周血中负性协同刺激分子programmed death-1（ PD-1）的表达情况，并探讨其与MG发病的关系。方法采用免疫荧光标记、流式细胞仪检测45例MG患者和33名健康对照者外周血单个核细胞中PD-1及其配体PD-L1的表达，用EliSA法检测各组血浆中可溶性PD-1的水平。结果（1）MG患者表达PD-1的CD4^＋T淋巴细胞比例增加，CD14^＋PD-L1^＋的单核细胞比例增加，但在不同性别及眼肌型与全身型间差异无统计学意义；在胸腺异常MG患者中CD4^＋PD-1^＋T细胞增加，CD14^＋ PD-L1^＋的单核细胞比例减少；早发型MG患者（年龄＜40岁）CD4^＋PD-1^＋T淋巴细胞比例明显低于晚发型（年龄≥40岁）。（2）MG患者血浆中sPD-1浓度为（6.92 ＋0.72） ng/ml，明显高于健康对照组的（3.28±0.42） ng/ml，但在性别、MG眼肌型与全身型不同类型间和有无胸腺异常各组间差异无统计学意义，且sPD-1与发病年龄呈负相关（r=-0.526，P=0.000）。结论 PD-1及PD-L1途径参与了MG的发病，异常升高的sPD-1可能干扰了正常的细胞膜上PD-1与PD-L1的结合，从而促使疾病进展。

关键词：重症肌无力抗原,CD 凋亡调节蛋白质类

Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging

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Nano Research 2025年第1期18卷 675-683页

作者： xue li Yanan Guo Guoying Tan Qingyi liu Nan Song Yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China

Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and ***,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical *** this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic *** from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in ***,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)***,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell ***,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关键词： aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen li Hui Ye xue-Zhi Zhang Jian-Xiang liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly