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Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

World Journal of Gastroenterology 2018年第43期24卷 4950-4958页

作者： Qi-Xiong Qin xue-min cheng Li-Zhi Lu Yun-Fei Wei Da-cheng Wang Hai-Hua Li Guo-Hui Li Hong-Bin Liang Sheng-Yu Li Li Chen Zhi-Jian Liang Department of Neurology The First Affiliated Hospital of Guangxi Medical University Department of Neurology The Second Affiliated Hospital of Guangxi Medical University Department of Neurology The Ninth Affiliated Hospital of Guangxi Medical University Department of Neurology Fusui County People’s Hospital Department of Neurology Wuzhou Red Cross Hospital Department of Neurology Cenxi People’s Hospital Department of Neurology Wuming County People’s Hospital

AIM To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke(CRCIS).METHODS A retrospective study was conducted on CRCIS patients(colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age-and sex-matched patients with colorectal cancer(CRC) without ischemic stroke that were admitted to the same hospital during the same period. Univariate and multivariate analyses were performed to analyze the independent risk factors for CRCIS. A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the products of the independent risk factors for CRCIS. RESULTS A total of 114 CRCIS patients and 114 CRC patients were included. Multiple lesions in multiple vascular territories were common in CRCIS patients(71, 62.28%). The levels of plasma D-dimer, carcinoembryonic antigen(CEA), cancer antigen 125, and neutrophil count were significantly higher in CRCIS patients than in CRC patients. Multiple logistic regression analysis revealed that plasma D-dimer levels [odds ratio(OR) = 1.002, 95% confidence interval(CI): 1.001-1.003, P < 0.001], CEA levels(OR = 1.011, 95%CI: 1.006-1.015, P < 0.001), and neutrophil count levels(OR = 1.626, 95%CI: 1.268-2.087, P < 0.001) were independent risk factors for CRCIS. In addition, receiver operator characteristic curve revealed that the area under curve for the products of plasma D-dimer, CEA, and neutrophil count was 0.889 ± 0.022(95%CI: 0.847-0.932, P < 0.001), and the optimal cut-off value for the product was 252.06, which was called the CRCIS Index, with a sensitivity of 86.0% and specificity of 79.8%.CONCLUSION Hypercoagulability induced by elevated CEA and neutrophils may be an important cause of CRCIS. The CRCIS index, which serves as a biomarker of CRCIS, needs further study.

关键词： Colorectal cancer Ischemic stroke Biomarker Pathogenesis

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Gastrointestinal toxicity induced by microcystins

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World Journal of Clinical Cases 2018年第10期6卷 344-354页

作者： Jin-Xia Wu Hui Huang Lei Yang Xiao-Feng Zhang Shen-Shen Zhang Hao-Hao Liu Yue-Qin Wang Le Yuan xue-min cheng Dong-Gang Zhuang Hui-Zhen Zhang Department of Environmental Hygiene College of Public Health Zhengzhou University Department of Nutriology College of Public Health Zhengzhou University

Microcystins(MCs) are produced by certain bloomforming cyanobacteria that can induce toxicity in various organs, including renal toxicity, reproductive toxicity, cardiotoxicity, and immunosuppressive effects. It has been a significant global environmental issue due to its harm to the aquatic environment and human health. Numerous investigators have demonstrated that MC exposure can induce a widespread epidemic of enterogastritis with symptoms similar to food poisoning in areas close to lakes. Both in vivo and in vitro studies have provided evidence of positive associations between MC exposure and gastrointestinal toxicity. The toxicity of MCs on the gastrointestinal tract is multidimensional. MCs can affect gastrointestinal barrier function and shift the structure of gut microbiota in different gut regions. Furthermore, MCs can inhibit the secretion of gastrointestinal digestive enzymes and the release of inflammatory cytokines, which affects the expression of immune-related genes in the intestine. The damage of the intestine is closely correlated to MC exposure because the intestine is the main site for the digestion and absorption of nutrients. The damage to the gastrointestinal tract due to MCs was summarized from different aspects, which can be used as a foundation for further exploration of molecular damage mechanisms.

关键词： Immunotoxicity Gastrointestinal toxicity Intestine Depuration Oxidative stress Microcystins

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低合金钢焊接热影响区的微观组织和韧性研究进展

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工程科学学报 2017年第5期39卷 643-654页

作者：李秀程李学达王学林夏佃秀王学敏尚成嘉北京科技大学钢铁共性技术协同创新中心北京100083 中国石油大学机电工程学院青岛266580 济南大学机械工程学院济南250022

对钢结构而言,诸如海洋平台、船舶、桥梁、建筑和油气管线等,焊接后的性能直接决定了其服役寿命和安全性,重要性不言而喻.在针对焊接相关问题的研究中,焊接热影响区的韧性提升一直是重点和难点.焊接热影响区会经历高达1400℃的高温,从... 详细信息

对钢结构而言,诸如海洋平台、船舶、桥梁、建筑和油气管线等,焊接后的性能直接决定了其服役寿命和安全性,重要性不言而喻.在针对焊接相关问题的研究中,焊接热影响区的韧性提升一直是重点和难点.焊接热影响区会经历高达1400℃的高温,从而形成粗大的奥氏体晶粒,如果焊接参数控制不当,不能通过后续冷却过程中的相变细化组织,就会造成韧性的降低.而多道次焊接的情况更为复杂,前一道次形成的粗晶区还会在后续焊接过程中经历二次热循环,从而形成链状M-A,造成韧性的急剧下降.本文旨在对一些现有焊接热影响区的相关研究结果进行总结,探讨母材的成分、第二相及焊接工艺等因素对热影响区微观组织和性能的影响,为低温环境服役的大型钢结构的焊接性能改善提供一些设计思路.

关键词：低合金钢焊接热影响区(HAZ) 显微组织 M-A 韧性

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Motion Control of Underwater Vehicle Based on Least Disturbance BP Algorithm

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Journal of Marine Science and Application 2002年第1期1卷 16-20页

作者： LIU xue-min, LIU Jian-cheng, XU Yu-ruCollege of Shipbuilding Engineering, Harbin Engineering University, Harbin 150001 , China Harbin Institute of Technology (China)

Up to now, some technology of neural networks are developed to solve the non-linearity of researched objects and to implement the adaptive control in many engineering fields, and some good results were achieved. Though it puts some questions over to design application structure with neural networks, it is really unknowable about the study mechanism of those. But, the importance of study ratio is widely realized by many scientists now, and some methods on the modification of that are provided. The main subject is how to improve the stability and how to increase the convergent rate of networks by defining a good form of the study ratio. Here a new algorithm named LDBP (least disturbance BP algorithm) is proposed to calculate the ratio online according to the output errors, the weights of network and the input values. The algorithm is applied to the control of an autonomous underwater vehicle designed by HEU. The experimental results show that the algorithm has good performance and the controller designed based on it is fine.

关键词： BP algorithm of neural networks dynamic ratio least disturbance autonomous underwater vehicle

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye xue-Zhi Zhang Jian-Xiang Liu Hong cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu Xiao Shangru Zhai Chuang xue Guangping Zheng Deqing Zhang Renchao Che Junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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教师将学生带离现场的立法依据、条件及启示

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教学与管理 2023年第11期 13-15页

作者：薛承民解立军山东省高密市招生考试研究院山东省高密市教科院

教师采取将学生带离现场的应急措施的立法依据是我国《教师法》第8条第(五)项之规定。将学生带离现场应具备的基本条件是,学生扰乱行为具有相当的危害性与紧迫性,且正在进行或者即将要发生。采取带离现场的应急措施前应先考虑劝阻,只有... 详细信息

教师采取将学生带离现场的应急措施的立法依据是我国《教师法》第8条第(五)项之规定。将学生带离现场应具备的基本条件是,学生扰乱行为具有相当的危害性与紧迫性,且正在进行或者即将要发生。采取带离现场的应急措施前应先考虑劝阻,只有劝阻无效方可带离,不能将带离现场作为惩戒手段;带离现场的措施不能损害学生的人格;要恰当把握隔离时间长短;要关注隔离场所的物理条件安全问题。

关键词：教师学生教育惩戒带离现场

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我国大宗农产品贸易格局及对外依存度研究——基于虚拟耕地资源的分析和评价

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自然资源学报 2017年第6期32卷 915-926页

作者：刘爱民薛莉成升魁强文丽杨晓贾盼娜中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049 兰州大学资源环境学院兰州730000

我国已成为农产品进口大国,而所有农产品中都隐含有一定的耕地资源,论文基于农产品虚拟耕地资源的分析和评价,系统研究了我国大宗农产品贸易格局及对外依存度。论文所涉及的大宗农产品及其制品主要是土地资源密集型产品,包括粮食、油料... 详细信息

我国已成为农产品进口大国,而所有农产品中都隐含有一定的耕地资源,论文基于农产品虚拟耕地资源的分析和评价,系统研究了我国大宗农产品贸易格局及对外依存度。论文所涉及的大宗农产品及其制品主要是土地资源密集型产品,包括粮食、油料、木薯、植物油、棉花、糖、饲料粕类等7大类,24个具体品种,以2000—2016年分国别的贸易数据为基础,从消费者的角度对大宗农产品虚拟耕地资源贸易量进行了分析和评价。研究结果显示,我国大宗农产品虚拟耕地资源净进口量由2000年的675×10~4 hm^2增加到2016年的5 928×10~4 hm^2,其中美国和巴西是中国农产品虚拟耕地进口量最大的国家,进口量分别由2000年的342×10~4 和146×10~4 hm^2,增加到2016年的2 101×10~4 和2 192×10~4 hm^2,占我国虚拟耕地进口总量比例超过70%;2016年农业耕地资源对外依存度达到30.5%,对巴西和美国的依存度分别为11.3%和10.8%。土地密集型农产品的大量进口,在一定程度上缓解了我国耕地资源紧张的压力,保证了粮食安全。

关键词：大宗农产品贸易虚拟耕地资源对外依存度

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LINEAR FINITE ELEMENT APPROXIMATIONS FOR THE TIMOSHENKO BEAM AND THE SHALLOW ARCH PROBLEMS

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Journal of Computational Mathematics 2002年第1期20卷 15-22页

作者： Xiao-liang cheng Wei-min xue Department of Mathematics Zhejiang UniversityXixi CampusHangzhou 310028China Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

Focuses on a study that discusses the linear finite element approximations for the Timoshenko beam and the shallow arch problems with shear dampening and reduced integration. Information on the Timoshenko beam; Detail... 详细信息

关键词： Timoshenko beam shallow arch shear dampening reduced integration

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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li cheng-Zhi Huang Jun-Jiang Wang xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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