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A novel method for extracting and optimizing the complex permittivity of paper-based composites based on an artificial neural network model

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Science China Technological Sciences 2024年第10期67卷 3190-3204页

作者： XIA ChenBin SHEN JunYi LIAO ShaoWei WANG Yi HUANG ZhengSheng xue Quan TANG min LONG Jin HU Jian School of Light Industry and Engineering South China University of Technology School of Electronic and Information Engineering South China University of Technology

Measuring the complex permittivity of ultrathin, flexible materials with a high loss tangent poses a substantial challenge with precision using conventional methods, and verifying the accuracy of test results remains difficult. In this study, we introduce a methodology based on a back-propagation artificial neural network(ANN) to extract the complex permittivity of paper-based composites(PBCs). PBCs are ultrathin and flexible materials exhibiting considerable complex permittivity and dielectric loss tangent. Given the absence of mature measurement methods for PBCs and a lack of sufficient data for ANN training, a mapping relationship is initially established between the complex permittivity of honeycomb-structured microwave-absorbing materials(HMAMs, composed of PBCs) and that of PBCs using simulated data. Leveraging the ANN model, the complex permittivity of PBCs can be extracted from that of HMAMs obtained using standard measurement. Subsequently, two published methods are cited to illustrate the accuracy and advancement of the results obtained using the proposed approach. Additionally, specific error analysis is conducted, attributing discrepancies to the conductivity of PBCs, the homogenization of HMAMs, and differences between the simulation model and actual objects. Finally, the proposed method is applied to optimize the cell length parameters of HMAMs for enhanced absorption performance. The conclusion discusses further improvements and areas for extended research.

关键词： paper-based composite honeycomb complex permittivity artificial neural networks inverse modeling

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao xue Qiao Hang Yang min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2

Electroacupuncture induces acute changes in cerebral cortical mi RNA profile, improves cerebral blood flow and alleviates neurological deficits in a rat model of stroke

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Neural Regeneration Research 2016年第12期11卷 1940-1950页

作者： Hai-zhen Zheng Wei Jiang Xiao-feng Zhao Jing Du Pan-gong Liu Li-dan Chang Wen-bo Li Han-tong Hu xue-min shi VIP of Acupuncture Department First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China Tianjin University of Traditional Chinese Medicine Tianjin China Department of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China

Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters mi RNA expression in the cortex. In this study, we examined changes in the cerebral cortical mi RNA profile, cerebral blood flow and neurological function induced by electroacupuncture in a rat model of stroke. Electroacupuncture was performed at Renzhong（GV26） and Neiguan（PC6）, with a frequency of 2 Hz, continuous wave, current intensity of 3.0 m A, and stimulation time of 1 minute. Electroacupuncture increased cerebral blood flow and alleviated neurological impairment in the rats. mi RNA microarray profiling revealed that the vascular endothelial growth factor signaling pathway, which links cell proliferation with stroke, was most significantly affected by electroacupuncture. Electroacupuncture induced changes in expression of rno-mi R-206-3p, rno-mi R-3473, rno-mi R-6216 and rno-mi R-494-3p, and these changes were confirmed by quantitative real-time polymerase chain reaction. Our findings suggest that changes in cell proliferation-associated mi RNA expression induced by electroacupuncture might be associated with the improved cerebral blood supply and functional recovery following stroke.

关键词： nerve regeneration stroke middle cerebral artery occlusion electroacupuncture mi RNA cerebral blood flow Neiguan(PC6) Renzhong(GV26) neural regeneration

Magnetic Bistability in the Crystaline Fullerene Radical Salt

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Chinese Journal of Chemistry 2024年第17期42卷 2043-2048页

作者： Huapeng Ruan Ke Li Quanchun Sun min Liu Zhongtao Feng xue Dong Yue Zhao Xinping Wang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of AdvancedMicrostructuresNanjing UniversityNanjingJiangsu210023China Department College of Materials and Chemical Engineering Pingxiang UniversityPingxiangJiangxi 337055China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghai 200032China

Compounds with magnetic bistability is highly attractive for the construction of switches,thermal sensors,information-storage media and memory ***,we report a crystalline fullerene radical anion salt[Na(THF)_(5)]C_(60)(1),obtained by the reduction of C_(60) with Na in solution,which exhibits magnetic bistability accompanied with one magnetostructural transition,giving low temperature(LT),high temperature(HT)phases and a metastable phase.

关键词： Magnetic bistability Fullerene radical Structural transition Crystal structure Chain distortion Fullerene Magnetic materials π-πstacking

The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers

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Chinese Chemical Letters 2024年第6期35卷 312-315页

作者： Jiahui Li Qiao shi Ying xue mingde Zheng Long Liu Tuoyu Geng Daoqing Gong minmeng Zhao Jiangsu Key Laboratory of Animal genetic Breeding and Molecular Design College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of ministry of Education of China Yangzhou UniversityYangzhou 225009China

Selenium is an essential trace element for humans and *** the active center of selenoproteins,the addition of selenium is beneficial to enhance the antioxidant ***,the high cost limits the application of organic Se in agriculture animal *** glucose(SeGlu)is a newly invented organoselenium material with good stability,low toxicity and low *** assay found that SeGlu was able to increase selenium deposition in liver of newborn broilers,and enhance the antioxidant capacity of liver by elevating the activities of antioxidant enzymes such as total superoxide dismutase and glutathione *** paper as the first example clarifying the mechanism of SeGlu to enhance the antioxidant ability of chicks,shows that SeGlu can be used as an organic selenium enrichment additive for early nutrition of *** a cross-discipline study involving chemistry,biology and agriculture animal science,the work may be beneficial for studies in related fields and prompt the development of the selenium science.

关键词： Selenized glucose In ovo feeding Antioxidant capacity Selenium Broiler

数智技术赋能新时代思想政治教育话语创新论析

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思想教育研究 2024年第7期 27-32页

作者：闵雪石书臣上海师范大学马克思主义学院上海200234

作为驱动思想政治教育话语创新的重要动力,数智技术推动新时代思想政治教育话语从现实场域到虚实场域互嵌、从语言文字到视觉图像、从单一主体到一体多元的范式转型。受数智技术负面效应的影响,思想政治教育话语面临价值淡化、内容窄化... 详细信息

作为驱动思想政治教育话语创新的重要动力,数智技术推动新时代思想政治教育话语从现实场域到虚实场域互嵌、从语言文字到视觉图像、从单一主体到一体多元的范式转型。受数智技术负面效应的影响,思想政治教育话语面临价值淡化、内容窄化、效力弱化等风险挑战。为有效应对数智技术所带来的负面效应,推进新时代思想政治教育话语创新,需要探寻系列应对之策。具体而言,要推动技术理性与人文精神双轮驱动,凸显思想政治教育话语的人本价值;强化对算法的规制,丰富思想政治教育话语内容有效供给;超越数字资本的利益趋向,重塑思想政治教育话语权威。

关键词：数智技术思想政治教育话语创新

Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue Cai Weiming shi Zhao-Hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1482-1484页

作者： shi-Yan Zhang Xiong-Jian Ma xue-Xia Zhu Na Cai Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This letter to the editor addresses the study titled“Predictive value of NLR,Fib4,and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma”by Kuang et al in the World Journal of Gastrointestinal *** study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient *** letter recommends prospective studies for validation and considers the influence of confounding *** finding underscores the significance of this study in improving hepatocellular carcinoma management.

关键词： Neutrophil-to-lymphocyte ratio Hepatocellular carcinoma Liver failure Hepatectomy Letter to the Editor Commentary

A Hf-doped dual-phase high-entropy alloy: phase evolution and wear features

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Rare Metals 2024年第1期43卷 324-333页

作者： Hao Ren Rui-Run Chen xue-Feng Gao Tong Liu Gang Qin Yu-Lung Chiu shi-Ping Wu Jing-Jie Guo National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK

Initially defined high entropy alloys(HEAs)usually exhibit a single-phase solid-solution ***,two and/or more types of phases in HE As possibly induce the desired microstructure features,which contribute to improving the wear properties of HE ***,we prepare a series of(AlCoCrFeNi)_(100-x)Hf_(x)(x=0,2,4and 6;at%) HEAs and concern their phase compositions,micro structures and wear *** leads to the formation of(Ni,Co)_(2)Hf-type Laves phase and tailors the microstructure from a body-centered cubic(BCC) singlephase structure to a hypoeutectic *** increased hardness from~HV 512.3 to~HV 734.1 is due to solid-solution strengthening,grain refinement strengthening and precipitated phase *** a few oxides(Al_(2)O_(3)+Cr_(2)O_(3)) caused by the wear heating contribute to an 85.5% decrease in wear rate of the HEA system from6.71×10^(-5) to 0.97×10^(-5) m^(3)·N^(-1)·m^(-1).In addition,Hf addition changes the wear mechanism from abrasive wear,mild oxidative wear and adhesive wear to oxidative wear and adhesive wear.

关键词： High entropy alloy Laves phase Hardness Wear mechanism