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Risk factors for esophagogastric variceal-related poor outcomes in primary biliary cholangitis:A prospective cohort study

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iLIVER 2024年第1期3卷 30-37页

作者： Lin Han Huan Xie xue-mei ma Xiao-Long Lu Jun Zhao Qing-Sheng Liang Zheng-Sheng Zou Jing-Feng Bi Bo Jin Ying Sun Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China Graduate School Medical School of Chinese PLABeijing 100039China

Background and aims:Esophagogastric varices(EGV)are common complications of primary biliary cholangitis(PBC).We examined the risk factors for variceal bleeding-related liver transplantation(LT)or ***:This prospective observational cohort study involved PBC in our hospital from 1 January 2005 to 1 January *** clinical endpoints were variceal bleeding-related LT and *** analysis was performed using the Kaplan-meier estimate,cox regression analysis was performed to investigate risk ***:PBC with EGV had significantly shorter survival than those without(p?0.002).Endoscopic prophylaxis significantly improved poor outcomes in PBC with EGV(pmal(ULN),international normalized ratio(INR)of>1.2ULN at baseline,total bilirubin of>1.2ULN,aspartate aminotransferase(AST)of>2.3ULN after 1 year of ursodeoxycholic acid(UDCA)treatment,non-biochemical responders according to the Paris criteria,and no history of endoscopic *** PBC without EGV,risk factors included AST of>2.3ULN,INR of>1.2ULN at baseline,CHE of***:This study provides evidence that AST,INR and CHE are major risk factors for variceal bleedingrelated poor outcomes in *** PBC with EGV,a good biochemical response to UDCA and endoscopic prophylaxis may improve *** findings can aid for guiding initial PBC risk stratification and screening endoscopy in patients without EGV.

关键词： Primary biliary cholangitis Esophagogastric varices Ursodeoxycholic acid Liver transplant-free survival Endoscopic therapy Risk factors

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Large focal nodular hyperplasia is unresponsive to arterial embolization: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9977-9981页

作者： Hui Ren Yin-Jie Gao xue-mei ma Shao-Tang Zhou Department of Hepatobiliary and Liver Transplant Center The Fifth Medical CenterChinese People’s Liberation Army General HospitalBeijing 100039China

BACKGROUND Focal nodular hyperplasia(FNH)commonly occurs in women;it is usually asymptomatic and sometimes difficult to differentiate from hepatocellular carcinoma(HCC).CASE SUMmaRY A large space-occupying lesion in the right lobe of the liver was incidentally detected in an adult man and diagnosed as *** arterial chemoembolization was applied once monthly for 2 years,but the lesion did not decrease in *** was revealed by biopsy to be *** years later,the patient underwent liver resection due to hemorrhage and the pathological examination confirmed *** For a space-occupying lesion,it is prerequisite to pathologically confirm the diagnosis and the corresponding intervention can be effective.

关键词： Focal nodular hyperplasia Large focal nodular hyperplasia Transarterial embolization Hepatocellular carcinoma Case report

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Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 382-391页

作者： Ling ZHAO You-bin WANG Shi-rui QIN xue-mei ma xue-jun SUN Ming-lian WANG Ru-gang ZHONG College of Life Science and Bioengineering Beijing University of Technology Peking Union Medical College Hospital Department of Diving Medicine Faculty of Naval Medicinethe Second Military Medical University

Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R injury. Methods: Abdominal skin flaps of rats were elevated and ischemia was induced for 3 h; subsequently, HRS or physiological saline was administered intraperitoneally 10 min before reperfusion. On postoperative Day 5, flap survival, blood perfusion, the accumulation of reactive oxygen species (ROS), and levels of cytokines were evaluated. Histological examinations were performed to assess inflammatory cell infiltration. Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.

关键词： Hydrogen-rich saline Ischemia/reperfusion Skin flaps Oxidative damage Inflammation

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Association of the macrophage migration inhibitory factor promoter polymorphisms with benign lymphoepithelial lesion of lacrimal gland

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1229-1232页

作者： Qin-Jian Li Peng-Xiang Zhao Xu-Juan Zhang Yang Yi Dan-Ying Cheng Jian-Min ma xue-mei ma College of Life Science and Bio-engineering Beijing Universityof Technology Beijing 100124 China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical University Beijing 100015 China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology &VisionScience Key Lab Beijing 100730 China

AIM： To identify the association of the macrophage migration inhibitory factor （MIF） gene polymorphism with the susceptibility of benign lymphoepithelial lesions （BLEL） of the lacrimal gland. METHODS： A total of 40 BLEL of lacrimal gland cases were matched with 40 healthy subjects （HS）. Extraction the plasma and whole blood DNA of patients of lacrimal gland BLEL and HS. Elisa and polymerase chain reaction was used to determine in plasma contents of MIF and MIF gene SNP-173G〉C and STR -794 CATT（8） polymorphism, respectively. RESULTS： The MIF levels in plasma were significantly higher in patients with lacrimal gland *** versus HS （P〈0.001）. The -173 G〉C MIF polymorphism was significantly associated with lacrimal gland BLEL, with a significantly higher frequency of the C allele in lacrimal gland BLEL patients compared with HS （OR=2.38, 95% C1=1.07-5.31, P=0.032）, and the -173 C/x is more frequent in patients than in HS, P=0.037. Besides, we found that the carriage rate of the MIF -173C/x is associated with higher plasma levels of MIF in the BLEI. of lacrimal gland. CONCLUSION： MIF -173G/C variants play an insidious role in susceptibility of BLEL of lacrimal gland. Otherwise,there is no statistically significant correlation exists between MIF-794 CATT （） and BLEL of lacrimal gland.

关键词： benign lymphoepithelial lesion lacrimal gland macrophage migration inhibitory factor gene polymorphism

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Association analysis of BclI with benign lymphoepithelial lesions of the lacrimal gland and glucocorticoids resistance

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1734-1745页

作者： Xu-Juan Zhang Peng-Xiang Zhao Ming-Shen ma Hao Wu Rui Liu Hui Wang Meng-Yu Liu Fei Xie xue-mei ma Faculty of Environment and Life Beijing University of TechnologyBeijing 100124China Beijing International Science and Technology Cooperation Base of Antivirus Drug Beijing 100124China Beijing Tongren Hospital Capital Medical UniversityBeijing 100730China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Department of General Dentistry and EmergencySchool of StomatologyAir Force MedicalXi’an 710032Shaanxi ProvinceChina

AIM:To evaluate the relationship between gene polymorphism(BclI,ER22/23EK,N363S)and the occurrence,progression and sensitivity to glucocorticoid of lacrimal gland benign lymphoepithelial lesion(LGBLEL).METHODS:Clinical peripheral blood samples of 52 LGBLEL patients and 10 normal volunteers were collected for DNA extraction and polymerase chain reaction sequencing to analyze single nucleotide polymorphism(SNP)*** lacrimal tissues of LGBLEL were surgically removed and made into paraffin sections for subsequent hematoxylin-eosin(HE)and masson staining *** duration of disease and hormone use of LGBLEL patients from diagnosis to surgery were also *** Meta-analysis follows PRISma guidelines to conducted a systematic review of human studies investigating the relationship between the NR3C1 BclI polymorphism and glucocorticoids(GCs)***:There was no association between ER22/23EK or N363S and the occurrence of LGBLEL or GCs sensitivity(P>0.05);BclI GC genotype was closely related to GCs resistance(P=0.03)as is the minor allele C(P=0.0017).The HE staining and masson staining showed that the GC genotype of BclI remarkably slowed down the disease progression and reduced fibrosis(Pmay be more sensitive to GCs and associated with lower fibrosis and slower disease *** results may guide the clinical treatment strategy for the LGBLEL patients.

关键词： lacrimal gland benign lymphoepithelial lesion Bcll single nucleotide polymorphisms glucocorticoids resistance fibrosis

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CDX2 Inhibits Invasion and Migration of Gastric Cancer Cells by Phosphatase and Tensin Homologue Deleted from Chromosome 10/Akt Signaling Pathway

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Chinese Medical Journal 2015年第8期128卷 1065-1071页

作者： Yong-Qiang Liu Zhi-Gang Bai xue-mei ma Zhong-Tao Zhang Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Background： Gastric cancer （GC） is one of the most prevalent malignancies in the world today, with a high mortality rate. CDX2 is a Drosophila caudal-related homeobox transcription factor that plays an important role in GC. Phosphatase and tensin homologue deleted from chromosome 10 （PTEN） is an important tumor suppressor which is widely expressed in normal human tissues. The aim of the study was to determine the relationship and mechanism between CDX2 and PTEN in invasion and migration of GC ***： pcDNA3-CDX2 plasr^lids were transfected into MGC-803 cells to up-regulate CDX2 protein, and small interfering RNA-CDX2 was transfected to down-regulate CDX2. The influence of CDX2 or PTEN on cell migration and invasion was measured by invasion, migration and wound healing assays. Western blotting assay and immunofluorescence were used to detect the expression ofCDX2, PTEN, phosphorylation ofAkt, E-cadherin and N-cadherin. Statistical significance was determined by one-way analysis of ***： The results showed that CDX2 reduced the migration and invasion of GC cells （P 〈 0.05）, and inhibited the activity of Akt through down-regulating PTEN expression （P 〈 0.05）. CDX2 also restrained epithelial-mesenchymal transition of GC ***： CDX2 inhibited invasion andmigration of GC cells by PTEN/Akt signaling pathway, and that may be used for potential therapeutic target.

关键词： CDX2 Epithelial-mesenchymal Transition Gastric Cancer PTEN

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IgG4 and IgE co-positive group found in idiopathic orbital inflammatory disease

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 36-42页

作者： Peng-Xiang Zhao Yao mawulikplimi Adzavon Jian-Min ma Lei Shang Dan-Ying Chen Fei Xie Meng-Yu Liu Xin Zhang Bao-Bei Lyu Ming-Zi Zhang Lin-Qi Yang xue-mei ma College of Life Science and Bio-engineering Beijing University of Technology Beijing Ophthalmology & Vision Science Key Lab Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Institute of Infectious Diseases Beijing Ditan Hospital Capital Medical University Department of Plastic Surgery Peking Union Medical College Hospital

AIM： To reveal the cytokines involved in idiopathic orbital inflammatory disease（IOID） and the relationship between Th17 cells, IgE and IOID ***： Whole blood samples were processed immediately after collection and serological IgG4, IgG, and IgE antibodies were tested using ELISA. IOID and orbital cavernous hemangioma（CH） tissue samples underwent Bio-Plex multiplex cytokine detection. Hematoxylin-Eosin（HE） staining of all paraffin samples suggested the histological features of IOIDs, and expressions of IgG4 and IL-17 A in affected tissues were detected by immunohistochemistry. RESULTS： Among 40 IOID plasma samples, 52.5%（21/40） were positive for IgG4 and 25%（10/40） were positive for IgE. Overlapped IgG4 or IgE positive samples accounted for 22.5%（9/40）. Therefore, IOID samples were separated into three groups. The IgE＋/IgG4＋ group had a relevantly lower level of pro-inflammatory cytokine expression. IL-4（Th2 cell related）, IL-10 and TGF-β1（Treg cell immunity related） were elevated in all three groups. Some of the Th17 cell related cytokines（i.e. IL-17 A/F, IL-25, IL-23, and IL-33） displayed higher expression levels in the IgE-/IgG4-group compared to the other two ***： We discovered an IgG4-IgE co-positive group as well as Th17 cell immune involvement in IgG4-IgE co-negative subgtroup in IOID for the first time. The pathogenesis of IOID could differ from different subgroups according to the IgG4 and IgE detection. Therefore, we recommend that, Treatment stratagy should be made according to the clinical assessment of IgG4-IgE and Th17 profile detection.

关键词： idiopathic orbital inflammatory disease IgE IgG4 Th17

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A review of vehicle detection methods based on computer vision

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第1期7卷 1-18页

作者： Changxi ma Fansong xue School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Railway Industry on Plateau Railway Transportation Intelligent management and Control Lanzhou 730070China

With the increasing number of vehicles,there has been an unprecedented pressure on the operation and maintenance of intelligent transportation systems and transportation *** order to achieve faster and more accurate identification of traffic vehicles,computer vision and deep learning technology play a vital role and have made significant *** study summarizes the current research status,latest findings,and future development trends of traditional detection algorithms and deep learning-based detection *** the detection algorithms based on deep learning,this study focuses on the representative convolutional neural network ***,it examines the two-stage and one-stage detection algorithms,which have been extensively utilized in the field of intelligent transportation *** to traditional detection algorithms,deep learning-based detection algorithms can achieve higher accuracy and *** single-stage detection algorithm is more efficient for real-time detection,while the two-stage detection algorithm is more accurate than the single-stage detection *** the follow-up research,it is important to consider the balance between detection efficiency and detection ***,vehicle missed detection and false detection in complex scenes,such as bad weather and vehicle overlap,should be taken into *** will ensure better application of the research findings in engineering practice.

关键词： intelligent transportation system computer vision deep learning vehicle detection object detection algorithm

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Effect of heat treatment on the microstructure,mechanical properties and fracture behaviors of ultra-high-strength SiC/Al-Zn-Mg-Cu composites

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International Journal of Minerals,Metallurgy and materials 2024年第10期31卷 2233-2243页

作者： Guonan ma Shize Zhu Dong Wang Peng xue BolüXiao Zongyi ma Shi-changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Centre of Excellence for Advanced materials Dongguan 523808China

A high-zinc composite,12vol%SiC/Al-13.3 Zn-3.27 Mg-1.07Cu(wt%),with an ultra-high-strength of 781 MPa was success-fully fabricated through a powder metallurgy method,followed by an extrusion *** effects of solid-solution and aging heat treat-ments on the microstructure and mechanical properties of the composite were extensively *** with a single-stage sol-id-solution treatment,a two-stage solid-solution treatment(470℃/1 h+480℃/1 h)exhibited a more effective solid-solution strengthen-ing owing to the higher degree of solid-solution and a more uniform *** to the aging hardness curves of the com-posite,the optimized aging parameter(100℃/22 h)was *** the aging temperature and time resulted in finer and more uniform nanoscale precipitates but only yielded a marginal increase in tensile *** fractography analysis revealed that intergranu-lar cracking and interface debonding were the main fracture mechanisms in the ultra-high-strength SiC/Al-Zn-Mg-Cu *** regions,such as the SiC/Al interface containing numerous compounds and the precipitate-free zones at the high-angle grain boundaries,were identified as significant factors limiting the strength enhancement of the *** compounds,including MgO,MgZn2,and Cu5Zn8,reduced the interfacial bonding strength,leading to interfacial debonding.

关键词： metal matrix composites heat treatment interfacial reaction mechanical properties fracture mechanism

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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU xue Xin ZHANG Xiao mei JIANG XIAO Lin SONG Qing HUANG xue Yong ma Hong Xia YU Peng Cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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