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A possible probe to neutron-skin thickness by fragment parallel momentum distribution in projectile fragmentation reactions

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Nuclear science and Techniques 2024年第6期35卷 114-119页

作者： Chun-Wang Ma Yi-Jie Duan ya-Fei Guo Chun-Yuan Qiao Yu-Ting Wang Jie Pu Kai-xuan Cheng Hui-ling Wei college of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear science and Technology Henan Academy of SciencesZhengzhou 450015China

Neutron-skin thickness is a key parameter for a neutron-rich nucleus;however,it is difficult to *** the framework of the Lanzhou Quantum Molecular Dynamics(LQMD)model,a possible probe for the neutron-skin thickness(δ_(np))of neutron-rich ^(48)Ca was studied in the 140A MeV ^(48)Ca+^(9)Be projectile fragmentation reaction based on the parallel momentum distribution(p∥)of the residual fragments.A Fermi-type density distribution was employed to initiate the neutron density distributions in the LQMD simulations.A combined Gaussian function with different width parameters for the left side(Γ_(L))and the right side(Γ_(R))in the distribution was used to describe the p∥of the residual *** neutron-rich sulfur isotopes as examples,Γ_(L) shows a sensitive correlation withδ_(np) of ^(48)Ca,and is proposed as a probe for determining the neutron skin thickness of the projectile nucleus.

关键词： Neutron-skin thickness Projectile fragmentation Parallel momentum distribution Neutron-rich nucleus Quantum molecular dynamics model

The regulatory mechanism of rapid lignification for timely anther dehiscence

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Journal of Integrative Plant Biology 2024年第8期66卷 1788-1800页

作者： Jing-Shi xue Yi-feng feng Ming-Qi Zhang Qin-Lin Xu ya-Min Xu Jun-Qin Shi Li-Fang Liu Xiao-feng Wu Shui Wang Zhong-Nan yang Shanghai Key Laboratory of Plant Molecular sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China university of the Chinese Academy of sciences Beijing 100049China Development Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234China

Anther dehiscence is a crucial event in plant reproduction,tightly regulated and dependent on the lignification of the anther *** this study,we investigated the rapid lignification process that ensures timely anther dehiscence in *** findings reveal that endothecium lignification can be divided into two distinct *** Phase Ⅰ,lignin precursors are synthesized without polymerization,while Phase Ⅱ involves simultaneous synthesis of lignin precursors and *** transcription factors MYB26,NST1/2,and ARF17 specifically regulate the pathway responsible for the synthesis and polymerization of lignin monomers in Phase Ⅱ.MYB26-NST1/2 is the key regulatory pathway responsible for endothecium lignification,while ARF17 facilitates this process by interacting with ***,our results demonstrate that the lignification of the endothecium,which occurs within approximately 26 h,is much faster than that of the vascular *** findings provide valuable insights into the regulation mechanism of rapid lignification in the endothecium,which enables timely anther dehiscence and successful pollen release during plant reproduction.

关键词： anther dehiscence ARF17 endothecium lignin MYB26 NST

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

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science china(life sciences) 2024年第4期67卷 765-777页

作者： Hui zhao Lin-Lin Liu Jian sun Lian Jin Hai-Bing Xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin Zhuang Min-Sheng Peng ya-Jun Guo Wei-Zhu Qian Newton OOtecko Wei-Jie sun Liang-Hu Qu Jie He zhao-Li Chen Rong Liu Ce-Shi Chen ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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science china(life sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia xue-feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin ya-Wei Zhang Wei-Guang Fu Lin zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu jiang yan-ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life sciences Institute Guangxi Medical UniversityNanning 530020China college of life sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen ling Su-Su Liu Yu-ya Wang Gui-Tao Huo yan-Wei yang Nan Xu Hong Wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei zhao Chang-Fa Fan college of life sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

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Zoological Research 2024年第3期45卷 451-463页

作者： Bin Hu Jia-Min Wang Qing-Xun Zhang Jing Xu ya-Nan Xing Bo Wang Shu-Yi Han Hong-xuan He CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China college of life sciences University of Chinese Academy of SciencesBeijing 100049China beijing Milu Ecological Research Center Beijing 102600China beijing capital International Airport Co. Ltd.Beijing 101300China

The gut microbiota significantly influences host physiology and provides essential ecosystem *** diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary *** carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging *** this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological *** present,however,the role of the gut microbiota remains incompletely *** this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in beijing,*** findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion ***,*** isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica *** showed that *** down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented *** colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory ***,*** exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets.

关键词： Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing

Metasurface-assisted low-frequency performance enhancement of ultra-broadband honeycomb absorber based on carbon nanotubes

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Nano Research 2024年第9期17卷 8542-8551页

作者： Cai-Liang Wang Shuang Bai Pei-yan zhao Tao Zhou Hui-ya Wang Jun-Peng Wang Luo-Xin Wang Guang-Sheng Wang School of Chemistry Beihang UniversityBeijing 100191China Aerospace science and Industry Corporation of Wuhan Magnetoelectricity Co. Ltd.Wuhan 430070China college of Materials science and Engineering Key Laboratory for New Textile Materials and Applications of Hubei ProvinceWuhan Textile UniversityWuhan 430200China School of Chemistry and Chemical Engineering Lingnan Normal UniversityZhanjiang 524048China School of Materials science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Here,we present a unique method to enhance the low-frequency absorption performance of a honeycomb absorber by integrating a *** geometrical dimensions of the proposed metasurface have been numerically *** introduction of the metasurface allows exploitation of its robust resonance and superior impedance matching in low-frequency bands,thereby improving microwave absorption *** incorporation of the metasurface does not impact the wave transmission performance of the honeycomb core absorber at high-frequency band,thus preserving its high-frequency *** broadens the absorption range,leading to an expanded *** results reveal that the composite absorber(CA)exhibits strong absorption performance with an incident angle stability up to 45°for both transverse electric(TE)and transverse magnetic(TM)*** absorption mechanism of the CA has been investigated by using an equivalent circuit model and electromagnetic field analysis.A prototype was designed,fabricated,and tested to validate the proposed *** simulation and measurement results demonstrate that the prototype can achieve an average absorption rate exceeding 90%across a 1.0-18.0 GHz *** study introduces an innovative technique for creating microwave absorbers for low-frequency wideband applications.

关键词： low frequency metasurface radar absorption impedance matching

Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu yang Zishan Jin Xiaolin Tong Jun Wang Linhua zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(china)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun university of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China university of Chinese Academy of sciences Beijing 100049China beijing university of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

壳寡糖通过调控SOCS3/STAT3信号通路改善脂多糖诱导的小鼠神经炎症

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食品安全质量检测学报 2024年第10期15卷 90-98页

作者：何悦陈红利孙雅煊戴雪伶北京联合大学生物化学工程学院北京100023

目的探讨壳寡糖(chitosan oligosaccharide,COS)对脂多糖(lipopolysaccharide,LPS)诱导小鼠神经炎症的改善作用及机制。方法通过对10周龄C57BL/6N小鼠腹腔注射LPS建立神经炎症模型。动物随机分为5组,分别是:对照(CON)组、LPS组、LPS+CO... 详细信息

目的探讨壳寡糖(chitosan oligosaccharide,COS)对脂多糖(lipopolysaccharide,LPS)诱导小鼠神经炎症的改善作用及机制。方法通过对10周龄C57BL/6N小鼠腹腔注射LPS建立神经炎症模型。动物随机分为5组,分别是:对照(CON)组、LPS组、LPS+COS低剂量(LPS+COS 50 mg/kg)组、LPS+COS中剂量(LPS+COS 100 mg/kg)组、LPS+COS高剂量(LPS+COS 200 mg/kg)组。LPS注射完毕后进行旷场实验、新物体识别、Morris水迷宫等行为学实验。处死动物后,收集脑组织,酶联免疫吸附实验(enzyme linked immunosorbent assay,ELISA)分析脑内促炎因子白细胞介素-2(interleukin-2,IL-2)、白细胞介素-6(interleukin-6,IL-6)和抗炎因子白细胞介素-4(interleukin-4,IL-4)的表达;Western blot分析脑内信号传导及转录激活蛋白(STAT3)、细胞因子信号抑制物(SOCS3)蛋白的表达水平。结果行为学实验结果表明,COS可以改善LPS诱发的小鼠认知障碍下降等表现。ELISA结果表明,LPS组小鼠的促炎细胞因子的释放量显著增加,抗炎细胞因子的释放量显著降低;而COS灌胃可逆转这一变化趋势。Western blot结果提示,与CON组相比,LPS的STAT3磷酸化水平显著升高,同时也促进SOCS3的蛋白表达升高;而COS则显著下调这两个蛋白的表达。结论COS可能通过抑制SOCS3/STAT3信号通路改善LPS引起的小鼠神经炎症。

关键词：壳寡糖脂多糖神经炎症 SOCS3/STAT3信号通路