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Association of age at diagnosis of diabetes with subsequent risk of age-related ocular diseases and vision acuity

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World Journal of Diabetes 2024年第4期15卷 697-711页

作者： Si-Ting Ye Xian-Wen Shang Yu Huang Susan Zhu Zhuo-Ting Zhu xue-li zhang Wei Wang Shu-lin Tang Zong-Yuan Ge Xiao-Hong Yang Ming-Guang He The Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Ultrasound The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Eye Institute Department of OphthalmologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Austin Hospital University of MelbourneMelbourne 3084VictoriaAustralia State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Monash e-Research Center Faculty of EngineeringAirdoc ResearchNvidia AI Technology Research CenterMonash UniversityMelbourne 3080VictoriaAustralia Department of Ophthalmic Epidemiology Centre for Eye Research AustraliaMelbourne 3002VictoriaAustralia

BACKGROUND The importance of age on the development of ocular conditions has been reported by numerous *** may have different associations with different stages of ocular conditions,and the duration of diabetes may affect the development of diabetic eye *** there is a dose-response relationship between the age at diagnosis of diabetes and the risk of cardiovascular disease and mortality,whether the age at diagnosis of diabetes is associated with incident ocular conditions remains to be *** is unclear which types of diabetes are more predictive of ocular *** To examine associations between the age of diabetes diagnosis and the incidence of cataract,glaucoma,age-related macular degeneration(AMD),and vision *** Our analysis was using the UK *** cohort included 8709 diabetic participants and 17418 controls for ocular condition analysis,and 6689 diabetic participants and 13378 controls for vision *** diseases were identified using inpatient records until January *** acuity was assessed using a *** During a median follow-up of 11.0 years,3874,665,and 616 new cases of cataract,glaucoma,and AMD,respectively,were identified.A stronger association between diabetes and incident ocular conditions was observed where diabetes was diagnosed at a younger *** with type 2 diabetes(T2D)diagnosed at<45 years[HR(95%CI):2.71(1.49-4.93)],45-49 years[2.57(1.17-5.65)],50-54 years[1.85(1.13-3.04)],or 50-59 years of age[1.53(1.00-2.34)]had a higher risk of AMD independent of glycated haemoglobin.T2D diagnosed<45 years[HR(95%CI):2.18(1.71-2.79)],45-49 years[1.54(1.19-2.01)],50-54 years[1.60(1.31-1.96)],or 55-59 years of age[1.21(1.02-1.43)]was associated with an increased cataract risk.T2D diagnosed<45 years of age only was associated with an increased risk of glaucoma[HR(95%CI):1.76(1.00-3.12)].HRs(95%CIs)for AMD,cataract,and glaucoma associated with type 1 diabetes(T1D)were 4.12(1.99-8.53),

关键词： Diabetes Age at diagnosis Cataract Glaucoma Age-related macular disease Vision acuity

Suppressing oxygen redox in layered oxide cathode of sodium-ion batteries with ribbon superstructure and solid-solution behavior

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Journal of Materials Science & Technology 2023年第29期160卷 9-17页

作者： Zhi-Xiong Huang xue-li zhang Xin-Xin Zhao Hong-Yan Lü Xin-Yi zhang Yong-li Heng Hongbo Geng Xing-Long Wu MOE Key Laboratory for UV light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin 130024China School of Materials Engineering Changshu Institute of TechnologyChangshuJiangsu 215500China Faculty of Chemistry Northeast Normal UniversityChangchunJilin 130024China

Sodium-ion batteries(SIBs)are proved as one of the most acceptable candidates for replacing lithium-ion batteries in some fields by virtue of a similar“rocking chair”mechanism and the abundance of *** voltage,rate performance,and energy density of these batteries are mainly determined by the ***,a li-Ni-Co co-substituted P2-Na_(0.67)[li_(0.1)(Mn_(0.7)Ni_(0.2)Co_(0.1))_(0.9)]O_(2)(NLMNC)with ribbon super-structure is prepared with the aim of multi-ion synergistic *** to the addition of Ni and Co,the Jahn-Teller distortion of Mn can be suppressed corresponding with the improved structural stability,and a little bit of oxygen redox activities is *** with the substitution of 10%li,the X-ray diffraction(XRD)peaks of NLMNC show the ribbon superstructure at about 21°and 22°.The smooth charge/discharge profiles of the NLMNC cathode exhibit the solid-solution *** addition,the platform at high voltage disappears corresponding with the existing oxygen redox activities being suppressed which may be related to the ribbon superstructure and the promotion of the Ni *** NLMNC cathode can deliver a reversible discharge capacity of 123.5 mA h g^(-1)at 10 mA g^(-1).Even if the current density increases to 500 mA g^(-1),a reversible discharge capacity of 112.8 mA h g^(-1)still can be *** distinguished cycling stability is related to the reversible migration of li+between the metal oxide layer and the interlayer and low volume change during *** is also needing to be mentioned that the capacity retention of NLMNC cathode is about 94.4%(based on the highest discharge capacity)after 100 *** work presents an effective route to develop high-performance cathodes for SIBs.

关键词： Sodium-ion batteries Layered oxides Ribbon superstructure Solid-solution reaction

Improving fault localization with pre-training

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Frontiers of Computer Science 2024年第1期18卷 247-249页

作者： Zhuo zhang Ya li Jianxin xue Xiaoguang MAO School of Information Technology and Engineering Guangzhou College of CommerceGuangzhou 511363China Ningbo Artificial Intelligence Institute Shanghai Jiao Tong UniversityNingbo 315000China Institute for Artificial Intelligence Shanghai Polytechnic UniversityShanghai 210209China College of Computer National University of Defense TechnologyChangsha 410073China

1 Introduction For developers,fault localization is the most tedious and time-consuming *** order to reduce the burden of developers,researchers have developed various techniques to help reduce the cost of locating faults based on possibility of containing a fault in program statements[1].Among them,coverage-based fault localization is one of the most studied automated fault localization ***-based fault localization methods utilize a type of preliminary information to localize the faults in programs,which is a matrix of statements’coverage *** value of each element is 1 or 0,in which 1 means a statement is executed and 0 denotes a statement is not executed[1].

关键词： fault statement utilize

Learning Epipolar line Window Attention for Stereo Image Super-Resolution Reconstruction

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Computers, Materials & Continua 2024年第2期78卷 2847-2864页

作者： xue li Hongying zhang Zixun Ye Xiaoru Huang School of Information Engineering Southwest University of Science and TechnologyMianyang621010China

Transformer-based stereo image super-resolution reconstruction(Stereo SR)methods have significantly improved image ***,existing methods have deficiencies in paying attention to detailed features and do not consider the offset of pixels along the epipolar lines in complementary views when integrating stereo *** address these challenges,this paper introduces a novel epipolar line window attention stereo image super-resolution network(EWASSR).For detail feature restoration,we design a feature extractor based on Transformer and convolutional neural network(CNN),which consists of(shifted)window-based self-attention((S)W-MSA)and feature distillation and enhancement blocks(FDEB).This combination effectively solves the problem of global image perception and local feature attention and captures more discriminative high-frequency features of the ***,to address the problem of offset of complementary pixels in stereo images,we propose an epipolar line window attention(EWA)mechanism,which divides windows along the epipolar direction to promote efficient matching of shifted pixels,even in pixel smooth *** accurate pixel matching can be achieved using adjacent pixels in the window as a *** experiments demonstrate that our EWASSR can reconstruct more realistic detailed *** quantitative results show that in the experimental results of our EWASSR on the Middlebury and Flickr1024 data sets for 2×SR,compared with the recent network,the Peak signal-to-noise ratio(PSNR)increased by 0.37 dB and 0.34 dB,respectively.

关键词： Stereo SR epipolar line window attention feature distillation

Intensified warming suppressed the snowmelt in the Tibetan Plateau

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Advances in Climate Change Research 2024年第3期15卷 452-463页

作者： Xiang li Peng CUI xue-Qin zhang Fang zhang Key Lab of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of Sciences and Higher Education CommissionIslamabad 45320Pakistan

Understanding how hydrological factors interrelate is crucial when examining the impact of climate warming on ***,these connections are often overlooked,leading to an unclear relationship between temperature and *** study investigates the complex interplay between temperature and snowmelt in the Tibetan Plateau from 1961 to 2020,focusing on how extreme high-temperature events affect the frequency of extreme *** a structural equation model,we detected three temperature-related factors that predominantly influenced snowmelt and extreme *** annual average temperature was found to have a significant indirect impact on snowmelt,mediated by changes in snowfall,snow depth and snow *** contrast,high-temperature days(daily maximum temperatures exceeding the 90th percentile)and heat waves(at least three consecutive high-temperature days)negatively affected extreme snowmelt directly or *** direct effect of increasing extreme temperature events was associated with an earlier onset of high-temperature periods,which accelerated snowmelt and shortened the duration of extreme snowmelt ***,the reduction in snow cover owing to warming emerged as a main factor suppressing snowmelt and extreme snowmelt *** also revealed spatiotemporal variations in the temperature‒snowmelt relationship that highly depended on changes in snowmelt *** study elucidated why warming suppresses snowmelt and extreme snowmelt events in the Tibetan Plateau,highlighting the mediating roles of snow-related and phenological *** findings will provide scientific support for climate simulation and water management policymaking in alpine regions worldwide.

关键词： Climate change Extreme temperature Snowmelt Structural equation model Tibetan Plateau

Can Industrial Structure Upgrading Restrain Industrial Land Expansion?Evidence from China

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Chinese Geographical Science 2024年第3期34卷 504-518页

作者： CHEN Wei li Qiao zhang Sun ZHOU xue College of Economics and Management Northwest A&F UniversityYangling Shaanxi 712100China Institute of Geographic Sciences&Natural Resources Research Chinese Academy of SciencesBeijing 100101China

China has made great achievements in industrial development and is transforming into a powerful manufacturing ***,the industrial land scale is also ***,whether industrial structure upgrading achieves the purpose of restraining industrial land expansion remains *** calculating the industrial land structure index(ILSI)and industrial land expansion scale(ILES),this study analyzed their temporal and spatial distribution characteristics at both regional and city levels from 2007to 2020 in *** show that industrial land expansion presents a different trend in the four regions,the ILES in the eastern region is the largest,and the speed of industrial land expansion has declined since 2013,but it has gradually increased since *** ILSI of the eastern and central regions is higher than that of the western and northeastern ***,a spatial Durbin model(SDM)has been established to estimate the spatial effect of industrial structure upgrading on industrial land expansion from 2007 ***,industrial structure upgrading has not slowed industrial land *** eastern and western regions require a greater amount of industrial land while upgrading the industrial *** improvement of the infrastructure level and international trade level has promoted industrial land expansion.

关键词： industrial development industrial structure upgrading industrial land expansion regional differences China

Compensated acceleration feedback based active disturbance rejection control for launch vehicles

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Chinese Journal of Aeronautics 2024年第4期37卷 464-478页

作者： Xiaoyan zhang Wenchao xue Zibo liU Ran zhang Huifeng li Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Astronautics Beihang UniversityBeijing 100191China

In this paper, the attitude tracking and load relief control problems against wind disturbances and uncertain aerodynamics as well as the engine thrust of launch vehicles are ***, a framework of Compensated Acceleration Feedback based Active Disturbance Rejection Control(CAF-ADRC) is established to achieve both desired attitude tracking and load relief performances. In particular, the total disturbance that includes the effects caused by both aerocoefficient perturbations and disturbances is estimated by constructing an Extended State Observer(ESO) to achieve attitude tracking. Furthermore, combined with the normal acceleration due to the engine thrust, the accelerometer measurement is also compensated to enhance the load relief ***, the quantitative analysis of ESO and the entire closed-loop system are studied. It can be concluded that the desired attitude tracking and load relief performances can be achieved simultaneously under the proposed approach. Besides, tuning laws of the proposed approach are systematically given, which are divided into ESO, Proportional Derivative(PD) and Compensated Acceleration Feedback(CAF) modules. Moreover, the performances under CAF-ADRC approach can be better than those under CAF based PD(CAF-PD) approach by tuning load relief ***, the approach presented is applied to a typical control problem of launch vehicles with wind disturbances and parameter uncertainties.

关键词： Launch vehicles Uncertainty analysis Active disturbance rejection control(ADRC) Load relief control Extended state observer(ESO)

High-throughput base editing KO screening of cellular factors for enhanced GBE

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遗传学报:英文版 2023年第8期50卷 611-614页

作者： Jie Yang Dongdong Zhao Xiagu Zhu Yuanzhao Yang Bo li Siwei li Chang-Hao Bi xue-li zhang College of Biotechnology Tianjin University of Science and TechnologyTianjin 300222China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China Key Laboratory of Systems Microbial Biotechnology Chinese Academy of SciencesTianjin 300308China National Technology Innovation Center of Synthetic Biology Tianjin 300308China University of Chinese Academy of Sciences Beijing 100049China

Base editor techniques have been developed as a means of precisely converting bases without the need for double-stranded DNA breaks(DSBs)or editing ***,these techniques can be used for cytosine(C)to thymine(T)conversions(cytosine base editors,CBEs)(Komor et al.,2016;Nishida et al.,2016),adenine(A)to guanine(G)conversions(adenine base editors,ABEs)(Gaudelli et al.,2017),and cytosine(C)to guanine(G)conversions(glycosylase base editors,GBEs)(Zhao et al.,2021)in mammalian ***,in particular,is a promising base editing technique capable of correcting up to 11%of the 32,044 pathogenic single nucleotide polymorphisms(SNPs)known to date(Gaudelli et al.,2017).Despite its potential,the performance of GBE is still not optimal,and its editing outcomes exhibit a wider variation range than those of CBEs due to the dependence on cellular DNA repair systems(Jiang et al.,2021),which implies that efficient GBE performance remains a challenge.

关键词： GBE base CBE

Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning

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Journal of Genetics and Genomics 2022年第3期49卷 254-257页

作者： Bo li Ya-Qiu li Dongdong Zhao Jie Yang Yan-He Ma Chang-Hao Bi xue-li zhang Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Systems Microbial Biotechnology Chinese Academy of SciencesTianjin 300308China National Technology Innovation Center of Synthetic Biology Tianjin 300308China

Base editor techniques were developed for precise base conversion without requiring double-stranded DNA breaks(DSBs) or an editing template(Komor et al., 2016;Nishida et al., 2016).

关键词： prediction editor