检索结果-南通市图书馆

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO lei DOU Renjie CHEN xueming CAO Yu DAI Zhen HU Ziyan ma Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Status and developmental trends in recombinant collagen preparation technology

引用

Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： Xiaolei Guo Yuan ma Hang Wang Hongping Yin Xinli Shi Yiqin Chen Guobiao Gao lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device Evaluation National Medical Products AdministrationBeijing 100081China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research Institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing *** technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and ***,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product *** article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this ***,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

引用

Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong ma Hai-Shan CHEN Yao-Ming SONG Bo-Tao ZHOU Shan-lei SUN Xin-Guan DU Yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Short-term displacement prediction for newly established monitoring slopes based on transfer learning

引用

China Geology 2024年第2期7卷 351-364页

作者： Yuan Tian Yang-landuo Deng Ming-zhi Zhang Xiao Pang Rui-ping ma Jian-xue Zhang Institute of Remote Sensing and Geographical Information Systems Peking UniversityBeijing 100871China Beijing Key Laboratory of Spatial Information Integration and Its Applications Beijing 100871China Institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China China Institute of Geo-Environment Monitoring Beijing 100081China Technology Innovation Center for Geohazard Monitoring and Risk Early Warning Ministry of Natural ResourcesBeijing 100081China

This study makes a significant progress in addressing the challenges of short-term slope displacement prediction in the Universal Landslide Monitoring Program,an unprecedented disaster mitigation program in China,where lots of newly established monitoring slopes lack sufficient historical deformation data,making it difficult to extract deformation patterns and provide effective predictions which plays a crucial role in the early warning and forecasting of landslide hazards.A slope displacement prediction method based on transfer learning is therefore ***,the method transfers the deformation patterns learned from slopes with relatively rich deformation data by a pre-trained model based on a multi-slope integrated dataset to newly established monitoring slopes with limited or even no useful data,thus enabling rapid and efficient predictions for these ***,as time goes on and monitoring data accumulates,fine-tuning of the pre-trained model for individual slopes can further improve prediction accuracy,enabling continuous optimization of prediction results.A case study indicates that,after being trained on a multi-slope integrated dataset,the TCN-Transformer model can efficiently serve as a pretrained model for displacement prediction at newly established monitoring *** three-day average RMSE is significantly reduced by 34.6%compared to models trained only on individual slope data,and it also successfully predicts the majority of deformation *** fine-tuned model based on accumulated data on the target newly established monitoring slope further reduced the three-day RMSE by 37.2%,demonstrating a considerable predictive *** conclusion,taking advantage of transfer learning,the proposed slope displacement prediction method effectively utilizes the available data,which enables the rapid deployment and continual refinement of displacement predictions on newly established monitoring slopes.

关键词： Landslide Slope displacement prediction Transfer learning Integrated dataset Transformer Pre-trained model Universal Landslide Monitoring Program(ULMP) Geological hazards survey engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

引用

Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong xue Xiaoyong WANG Zhixing ma Zhi JIA Kexin LI Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei ZHAO Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H19 remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H19 in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

引用

Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo ma Li-Na Sheng xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 mass measurement Lifetime

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柔性多功能Fe_(2)O_(3)/CC正极宿主实现高效吸附与催化多硫化物的锂硫电池

引用

新型炭材料（中英文） 2024年第2期39卷 345-353页

作者：田真薛磊磊丁红元中北大学材料科学与工程学院山西太原030051 中北大学先进能源材料与系统研究院山西太原030051 武汉第二船舶设计研究所湖北武汉430205

锂硫电池因其高能量密度和低成本而成为最有发展前景的电化学储能器件之一。然而,多硫化物的“穿梭效应”、硫导电率低是锂硫电池商业化面临的主要挑战。本工作中,以Fe(NO)_(3)·9H_(2)O为铁源,NH4F为表面活性剂,通过简单的水热及煅烧... 详细信息

锂硫电池因其高能量密度和低成本而成为最有发展前景的电化学储能器件之一。然而,多硫化物的“穿梭效应”、硫导电率低是锂硫电池商业化面临的主要挑战。本工作中,以Fe(NO)_(3)·9H_(2)O为铁源,NH4F为表面活性剂,通过简单的水热及煅烧处理制备了Fe_(2)O_(3)纳米棒修饰炭布(CC)的柔性Fe_(2)O_(3)/CC复合材料。其中,Fe_(2)O_(3)中介孔的存在有利于电解质的渗透和充放电过程中锂离子的传输和扩散,同时其密集阵列暴露出的丰富活性位点可以实现多硫化物的高效吸附和快速转化,降低多硫化物的穿梭效应。电化学分析显示:Fe_(2)O_(3)/CC正极在0.1 C(1 C=1672 ma g^(−1))的电流密度下具有1250 mah g^(-1)的高放电比容量,经100圈循环后比容量保持在789 mah g^(-1)。在2 C的倍率下循环1000圈后仍能达到576 mah g^(-1)的放电比容量,容量保持率为70%,明显优于对比样品。因此,Fe_(2)O_(3)/CC能够很好地抑制多硫化物的穿梭,提高电池倍率性能和循环稳定性。

关键词：锂硫电池 Fe_(2)O_(3) 正极材料纳米棒

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Sequence-Controlled Synthesis of Alternating Poly(ester amide)s using Water as Control Agent in One-Pot

引用

Chinese Journal of Polymer Science 2024年第8期42卷 1015-1020页

作者： Tao Liu Fang-Fang Niu Kan Cheng Yu-Min Xia Bo-Mou ma xue-Li Wang Jian-Yong Yu Yong He State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Poly(ester amide)s(PEAs)attract much attention as a new kind of biodegradable ***,the synthesis of PEAs with sequence-regulated chain structures is still complicated due to the multistep polymerization,high monomer purity,as well as the usage of organic solvents,which greatly inhibits its development and ***,a one-pot strategy without solvent was developed to synthesize the alternating PEA fromα,ω-amino alcohol and dicarboxylic acid by sequential polycondensation,where water was used as the controlling agent for amidation and ***,the amidation and esterification were controlled to proceed in turn by adding or removing water,realizing the one-pot preparation of alternating *** resultant PEA is characterized by^1H-and^(13)C-NMR,and its chain structure is confirmed to be highly quasi-alternating similar to alternating PEAs prepared by classical methods The evaluations from DSC and Dma demonstrate that the properties of quasi-alternating PEA(T_(m)=102℃,ΔH_(m)=30J·g^(-1))are far superior to those of random PEA(T_(m)=72℃,ΔH_(m)<1 J·g^(-1)).

关键词： Biodegradable macromolecules Polymer architectures Sequence-controlled synthesis One-pot polymerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Reclamation on the Groundwater-Lake Water Interaction in Chen Lake

引用

Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun lei Teng ma Liuzhu Chen Zhenxing Li Yu Chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bearing Fault Diagnosis Based on Deep Discriminative Adversarial Domain Adaptation Neural Networks

引用

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2619-2640页

作者： Jinxi Guo Kai Chen Jiehui Liu Yuhao ma Jie Wu Yaochun Wu Xiaofeng xue Jianshen Li School of Mechanical and Equipment Engineering Hebei University of EngineeringHandan056000China College of Mechanical Engineering Anyang Institute of TechnologyAnyang455000China Department of Mechanical and Electrical Engineering Yuncheng UniversityYuncheng044000China

Intelligent diagnosis driven by big data for mechanical fault is an important means to ensure the safe operation ofequipment. In these methods, deep learning-based machinery fault diagnosis approaches have received increasingattention and achieved some results. It might lead to insufficient performance for using transfer learning alone andcause misclassification of target samples for domain bias when building deep models to learn domain-invariantfeatures. To address the above problems, a deep discriminative adversarial domain adaptation neural networkfor the bearing fault diagnosis model is proposed (DDADAN). In this method, the raw vibration data are firstlyconverted into frequency domain data by Fast Fourier Transform, and an improved deep convolutional neuralnetwork with wide first-layer kernels is used as a feature extractor to extract deep fault features. Then, domaininvariant features are learned from the fault data with correlation alignment-based domain adversarial ***, to enhance the discriminative property of features, discriminative feature learning is embeddedinto this network to make the features compact, as well as separable between classes within the class. Finally, theperformance and anti-noise capability of the proposedmethod are evaluated using two sets of bearing fault *** results demonstrate that the proposed method is capable of handling domain offset caused by differentworkingconditions and maintaining more than 97.53% accuracy on various transfer tasks. Furthermore, the proposedmethod can achieve high diagnostic accuracy under varying noise levels.

关键词： Fault diagnosis transfer learning domain adaptation discriminative feature learning correlation alignment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：