检索结果-南通市图书馆

Comprehensive radiomics nomogram for predicting survival of patients with combined hepatocellular carcinoma and cholangiocarcinoma

引用

World Journal of Gastroenterology 2021年第41期27卷 7173-7189页

作者： You-Yin Tang Yu-Nuo Zhao Tao Zhang Zhe-Yu Chen xue-lei ma Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Biotherapy West China Hospital and State Key Laboratory of BiotherapySichuan UniversityWest China HospitalChengdu 610041Sichuan ProvinceChina West China School of Medicine of Sichuan University Chengdu 610041Sichuan ProvinceChina

BACKGROUND Combined hepatocellular carcinoma(HCC)and cholangiocarcinoma(cHCCCCA)is defined as a single nodule showing differentiation into HCC and intrahepatic cholangiocarcinoma and has a poor *** To develop a radiomics nomogram for predicting post-resection survival of patients with *** Patients with pathologically diagnosed cHCC-CCA were randomly divided into training and validation *** features were extracted from portal venous phase computed tomography(CT)images using the least absolute shrinkage and selection operator Cox regression and random forest analysis.A nomogram integrating the radiomics score and clinical factors was developed using univariate analysis and multivariate Cox *** performance was assessed in terms of the C-index as well as calibration,decision,and survival *** CT and clinical data of 118 patients were included in the *** radiomics score,vascular invasion,anatomical resection,total bilirubin level,and satellite lesions were found to be independent predictors of overall survival(OS)and were therefore included in an integrative *** nomogram was more strongly associated with OS(hazard ratio:8.155,95%confidence interval:4.498-14.785,Pmay predict survival of cHCC-CCA patients after hepatectomy and therefore help identify those more likely to benefit from surgery.

关键词： Radiomics Nomogram Combined hepatocellular carcinoma and cholangiocarcinoma Risk strata Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapeutic targets and interventional strategies in COVID-19:mechanisms and clinical studies

引用

Signal Transduction and Targeted Therapy 2021年第9期6卷 2723-2747页

作者： Yu-Wen Zhou Yao Xie Lian-Sha Tang Dan Pu Ya-Juan Zhu Ji-Yan Liu xue-lei ma Department of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Dermatovenerology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Lung Cancer Center West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Owing to the limitations of the present efforts on drug discovery against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the lack of the understanding of the biological regulation mechanisms underlying COVID-19,alternative or novel therapeutic targets for COVID-19 treatment are still urgently ***-CoV-2 infection and immunity dysfunction are the two main courses driving the pathogenesis of *** the virus and host factors are potential targets for antiviral ***,in this study,the current therapeutic strategies of COVID-19 have been classified into"target virus"and"target host" *** drugs,emerging approaches,and promising potential targets are the implementations of the above two ***,a comprehensive review of the highly acclaimed old drugs was performed according to evidence-based medicine to provide recommendations for ***,their unavailability in the fight against COVID-19 was ***,a profound analysis of the emerging approaches was conducted,particularly all licensed vaccines and monoclonal antibodies(mabs)enrolled in clinical trials against primary SARS-CoV-2 and mutant ***,the pros and cons of the present licensed vaccines were compared from different ***,the most promising potential targets were reviewed,and the update of the progress of treatments has been summarized based on these reviews.

关键词： drugs clinical immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune checkpoint inhibitor-associated ophthalmic adverse events: current understanding of its mechanisms,diagnosis, and management

引用

International Journal of Ophthalmology(English edition) 2022年第4期15卷 646-656页

作者： Yu-Wen Zhou Qian Xu Yan Wang Ruo-Lan Xia Ji-Yan Liu xue-lei ma Department of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Medical Publishers West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospitalthe First People’s Hospital of Long Quan Yi DistrictChengdu 610041Sichuan ProvinceChina

Immune checkpoint inhibitors(ICIs) targeting cytotoxic T-lymphocyte antigen 4 and programmed cell death protein 1 receptor/ligand have revolutionized cancer treatment, achieving unprecedented efficacy in numerous malignancies. Despite the excellent therapeutic effects of ICIs, medications, such as pembrolizumab, ipilimumab, nivolumab, atezolizumab, avelumab, and durvalumab, typically cause a broad spectrum of toxicity events termed as immune-related adverse events(ir AEs). Out of all ir AEs, ophthalmic adverse events occur infrequently and are not comprehensively recognized. The current understanding of ophthalmic ir AEs is mainly derived from case reports and case series. In this review, based on relevant articles in the literature and current evidence, we summarize the incidences, manifestations, diagnoses, underlying mechanisms, treatments, and outcomes of ophthalmic ir AEs and discuss possible management strategies. A better understanding of these features is critical for managing patients with ICI-associated ophthalmic adverse events.

关键词： immune checkpoint inhibitor ophthalmological adverse events uveitis neuro-ophthalmic toxicity retinopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review of vehicle detection methods based on computer vision

Journal of Intelligent and Connected Vehicles

引用

Journal of Intelligent and Connected Vehicles 2024年第1期7卷 1-18页

作者： Changxi ma Fansong xue School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Railway Industry on Plateau Railway Transportation Intelligent management and Control Lanzhou 730070China

With the increasing number of vehicles,there has been an unprecedented pressure on the operation and maintenance of intelligent transportation systems and transportation *** order to achieve faster and more accurate identification of traffic vehicles,computer vision and deep learning technology play a vital role and have made significant *** study summarizes the current research status,latest findings,and future development trends of traditional detection algorithms and deep learning-based detection *** the detection algorithms based on deep learning,this study focuses on the representative convolutional neural network ***,it examines the two-stage and one-stage detection algorithms,which have been extensively utilized in the field of intelligent transportation *** to traditional detection algorithms,deep learning-based detection algorithms can achieve higher accuracy and *** single-stage detection algorithm is more efficient for real-time detection,while the two-stage detection algorithm is more accurate than the single-stage detection *** the follow-up research,it is important to consider the balance between detection efficiency and detection ***,vehicle missed detection and false detection in complex scenes,such as bad weather and vehicle overlap,should be taken into *** will ensure better application of the research findings in engineering practice.

关键词： intelligent transportation system computer vision deep learning vehicle detection object detection algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Based Waterborne Poly(Vanillin-Butyl Acrylate)/MXene Coatings for Leather with Desired Warmth Retention and Antibacterial Properties

引用

Engineering 2024年第5期36卷 250-263页

作者： Jianzhong ma Li ma lei Zhang Wenbo Zhang Qianqian Fan Buxing Han College of Bioresources Chemical and materials Engineering Shaanxi University of Science and TechnologyXi’an 710021China Xi’an Key Laboratory of Green Chemicals and Functional materials Xi’an 710021China College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi’an 710021China Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology Shaanxi University of Science and TechnologyXi’an 710021China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

This study presents a solvent-free,facile synthesis of a bio-based green antibacterial agent and aromatic monomer methacrylated vanillin(MV)using *** resulting MV not only imparted antibacterial properties to coatings layered on leather,but could also be employed as a green alternative to petroleum-based carcinogen styrene(St).Herein,MV was copolymerized with butyl acrylate(BA)to obtain waterborne bio-based P(MV-BA)miniemulsion via miniemulsion ***,MXene nanosheets with excellent photothermal conversion performance and antibacterial properties,were introduced into the P(MV-BA)miniemulsion by ultrasonic *** the gradual solidification of P(MV-BA)/MXene nanocomposite miniemulsion on the leather surface,MXene gradually migrated to the surface of leather coatings due to the cavitation effect of ultrasonication and amphiphilicity of MXene,which prompted its full exposure to light and bacteria,exerting the maximum photothermal conversion efficiency and significant antibacterial *** particular,when the dosage of MXene nanosheets was 1.4 wt%,the surface temperature of P(MV-BA)/MXene nanocomposite miniemulsioncoated leather(PML)increased by about 15℃ in an outdoor environment during winter,and the antibacterial rate against Escherichia coli and Staphylococcus aureus was nearly 100%under the simulated sunlight treatment for 30 ***,the introduction of MXene nanosheets increased the air permeability,water vapor permeability,and thermal stability of these *** study provides a new insight into the preparation of novel,green,and waterborne bio-based nanocomposite coatings for leather,with desired warmth retention and antibacterial *** can not only realize zerocarbon heating based on sunlight in winter,reducing the use of fossil fuels and greenhouse gas emissions,but also improve ability to fight off invasion by harmful bacteria,viruses,and other microorganisms.

关键词： MXene nanosheets Vanillin Styrene substitute Leather coating Photothermal conversion Warmth retention Antibacterial properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Density EV Integrated Fast Battery Chargers Based on the General Torque Cancelation Law for Three-Phase Motors

引用

CSEE Journal of Power and Energy Systems 2024年第2期10卷 756-766页

作者： Yanxiong lei Guiping Du Tuhuan Li Wenjie ma xueyi Wang School of Electric Power South China University of TechnologyGuangzhou 510641China

Integrated battery chargers are highly effective for saving costs and improving the power density of on-board chargers in electric vehicles (EVs), However, achieving torque elimination of the commonly used three-phase (3p) motors during the fast-charging process is challenging. In this paper, the general torque cancelation law applied in 3p permanent magnet synchronous motors (PMSMs) and induction motors (IMs) is derived to design high power density integrated fast battery chargers. Two novel integrated systems with fast-charging and vehicle-to-grid (V2G) capabilities are proposed based on this law. The main advantages of the proposed systems are: (1) Two filter inductors are constituted by the stator windings while charging, and only one external inductor and several contactors are supplemented to the motor-drive circuit. Therefore, the proposed integrated systems possess high power density;(2) The 3p open-winding (OW) motor is employed, with no need to modify the propulsion system or redesign the interior structure of the motor;(3) Employing an individual controller for each phase of the inner current loop control, the proposed systems realize unity power factors and low current harmonics in the fast-charging and V2G mode. Simulation and experimental results verify the feasibility of the proposed topologies and control strategies.

关键词： Electric vehicles(EVs) fast charging integrated battery charger 3p PMSM/IM torque cancelation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-Superelasticity NiTi Shape Memory Alloy by Directed Energy Deposition-Arc and Solution Heat Treatment

引用

Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 132-144页

作者： Junyi ma Lin Yu Qing Yang Jie Liu lei Yang State Key Laboratory of materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430070China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan430074China

Directed energy deposition-arc(DED-Arc)technology has the advantages of simple equipment,low manufacturing cost and high deposition rate,while the use of DED-Arc has problems of microstructure inhomogeneity,position dependence of macroscopic mechanical properties and ***,it is necessary to carry out a subsequent heat treatment to improve its microstructure uniformity,mechanical properties and *** this investigation,the DED-Arc 15-layer NiTi alloy thin-walled parts with the solution treatment at different process parameters were studied to analyze the effects of solution heat treatment on microstructure,phase composition,phase transformation,microhardness,tensile and *** temperature range of solution treatment is 800-1050℃,and the treatment time range is 1-5.5 *** results show that after solution treatment at 800℃/1 h,the content of precipitated phase decreases,the grain is refined,the microhardness increases,and the mechanical properties in the 0°direction are *** strain recovery rate after 10 tensile cycles has increased from 37.13%(as-built)to 49.25%(solid solution treatment).This research provides an effective post treatment method for high-performance DED-Arc NiTi shape memory alloys.

关键词： Directed energy deposition-arc(DED-Arc) Cold metal transfer(CMT) NiTi shape memory alloys Microstructure Phase transformation Solution heat treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Generation and Optimization of Molecular Properties Using a Transformer Model

引用

Big Data Mining and Analytics 2024年第1期7卷 142-155页

作者： Zhongyin Xu Xiujuan lei Mei ma Yi Pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Generating novel molecules to satisfy specific properties is a challenging task in modern drug discovery,which requires the optimization of a specific objective based on satisfying chemical ***,we aim to optimize the properties of a specific molecule to satisfy the specific properties of the generated *** matched Molecular Pairs(MMPs),which contain the source and target molecules,are used herein,and logD and solubility are selected as the optimization *** main innovative work lies in the calculation related to a specific transformer from the perspective of a matrix *** intervals and state changes are then used to encode logD and solubility for subsequent *** the experiments,we screen the data based on the proportion of heavy atoms to all atoms in the groups and select 12365,1503,and 1570 MMPs as the training,validation,and test sets,*** models are compared with the baseline models with respect to their abilities to generate molecules with specific *** show that the transformer model can accurately optimize the source molecules to satisfy specific properties.

关键词： molecular optimization transformer matched Molecular Pairs(MMPs) logD solubility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diverse foraging strategies of breeding Swinhoe's Storm-petrel in the productive marginal sea of the Northwest Pacific

引用

Avian Research 2024年第1期15卷 27-34页

作者： Yachang Cheng lei Zhu Lin xue Shisheng ma Nan Jia Shaoping Zang Zhihai Cao Jing Yuan Yang Liu State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityShenzhen 518107China Guangxi mangrove Research Center Guangxi Marine Academy of SciencesNanning 530021China Qingdao Bird Watch Society Qingdao 266121China Jiangsu Provincial Environmental Monitoring Center Nanjing 210019China marine Science and Engineering Qingdao Agricultural UniversityQingdao 266109China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Fudan UniversityShanghai 200433China Qingdao marine management and Support Centre Qingdao 266555China management Committee of Lingshan Island Provincial Nature Reserve Qingdao 266428China

Understanding the foraging behavior is essential for investigating seabird ecology and conservation,as well as monitoring the well-being of the marine *** seabirds adopt diverse foraging strategies to maximize energy gains and cope with the intensified challenges of parenting and *** tradeoff may stem from the heterogeneity of food resources and the constraints of central place ***,abundant marine productivity could alleviate the energy limitation for seabirds,resulting in a consistent foraging ***,we investigated the foraging strategy during the breeding season of a cryptic small-sized seabird,Swinhoe’s Storm-petrel(Hydrobates monorhis),in the Yellow Sea,a productive marginal sea of the Northwest *** GPS tracking,we evaluated habitat preference,quantified the foraging strategy,and tested if environmental conditions and individual traits influence foraging *** found that Swinhoe’s Storm-petrels preferred nearshore areas with shallow water and engaged in primarily short foraging *** southeastward and southwestward strategies emerged when combining trip metrics,including foraging direction,duration,and maximum *** bathymetry,proximity to the coastline,and sea surface temperature differed in two foraging *** strategies exhibited flexibility between individuals,potentially explained by wing morphology,in which longer-winged birds are more likely to embark on longer-distance foraging *** findings highlight the impact of environmental factors and individual traits on seabirds’foraging decisions in productive marginal sea *** study also provides valuable insights into the foraging ecology of this Asian endemic storm-petrel.

关键词： Behavioral strategy Biologging Central place foraging marine primary productivity Seabird Sea surface temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Covalent triazine frameworks materials for photo-and electrocatalysis

引用

Nano Research 2024年第9期17卷 7830-7839页

作者： Aoji Liang Wenbin Li Anbai Li Hui Peng Guofu ma lei Zhu Ziqiang lei Yuxi Xu Key Laboratory of Eco-functional Polymer materials of the Ministry of Education Key Laboratory of Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China School of Chemistry and materials Science Hubei Key Laboratory of Quality Control of Characteristic Fruits and VegetablesHubei Engineering UniversityXiaogan 432000China School of Engineering Westlake UniversityHangzhou 310024China

Covalent triazine frameworks(CTFs)are a class of unique two-dimensional nitrogen-rich triazine framework with adjustable chemical and electronic structures,rich porosity,good stability and excellent semiconductivity,which enable great various applications in efficient gas/molecular adsorption and separation,energy storage and conversion,especially photo-and *** synthesis strategies strongly affect the morphology of CTFs and play an important role in their structure and *** this concept,we provide a comprehensive and systematic review of the synthesis methods such as ionothermal synthesis,phosphorus pentoxide catalytic method,polycondensation and ultra-strong acid catalyzed method,and applications of CTFs in photo-and *** we offer some insights into the future development progress of CTFs materials for catalytic applications.

关键词： covalent triazine frameworks synthetic strategy photocatalysis electrocatalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：