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Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis

Neural Regeneration Research 2020年第3期15卷 482-490页

作者： Bao-Ping Xu Min Yao Zhen-jun Li Zi-Rui Tian Jie Ye Yong-jun Wang xue-jun cui Spine Disease Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Lu’an Hospital of Traditional Chinese Medicine Lu’anAnhui ProvinceChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)ShanghaiChina Gansu Provincial Hospital of Traditional Chinese Medicine LanzhouGansu ProvinceChina Department of Orthopedics and Traumatology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord *** sources:Using“spinal cord injury”,“resveratrol”and“animal experiment”as the main search terms,all studies on the treatment of spinal cord injury in rats by resveratrol were searched for in PubMed,EMBASE,MEDLINE,Web of Science,Science Direct,China National Knowledge Infrastructure,Wanfang,VIP,and SinoMed databases by *** search was conducted from their inception date to April *** language restriction was used in the literature *** selection:The methodological quality of each study was assessed by the initial Stroke Therapy Academic Industry Roundtable *** reviewers independently selected studies according to the title,abstract and full *** risk of bias in the included studies was also ***-analyses were performed with Review Manager 5.3 *** measures:Neurological function was assessed by the Basso,Beattie,and Bresnahan scale score,inclined plane score and Gale’s motor function ***-biological analysis of antioxidative effects was conducted to determine superoxide dismutase levels,malondialdehyde levels,nitric oxide synthase activity,nitric oxide levels,xanthine oxidase and glutathione levels in spinal cord ***:The methodological quality of the 12 included studies was *** results of meta-analysis showed that compared with the control group,resveratrol significantly increased the Basso,Beattie,and Bresnahan scale scores after spinal cord injury(n=300,mean difference(MD)=3.85,95%confidence interval(CI)[2.10,5.59],P<0.0001).Compared with the control group,superoxide dismutase levels were significantly elevated(n=138,standardized mean difference(SMD)=5.22,95%CI[2.98,7.45],P<0.00001),but malondialdehyde levels were significantly diminished(n=84,SMD=–3.64,95%CI[–5.84,–1.43],P=0.001)in the spinal cord of the resveratrol treatment ***:Re

关键词： antioxidation meta-analysis neurological recovery pharmacotherapy rats resveratrol spinal cord injury systematic review

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Properties of polydimethylsiloxane hydrophobic modified duplex microarc oxidation/diamond-like carbon coatings on AZ31B Mg alloy

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Journal of Magnesium and Alloys 2021年第4期9卷 1291-1303页

作者： xue-jun cui Chuang-Ming Ning Guang-An Zhang Lun-Lin Shang Li-Ping Zhong Ying-jun Zhang School of Materials Science and Engineering Sichuan University of Science and EngineeringZigong 643000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities Zigong 643000China

A reliable,high-performance coating procedure was developed using PDMS to modify a duplex MAO/DLC coating on an AZ31B Mg ***,the duplex MAO/DLC coating was fabricated via a combined MAO and unbalanced magnetron sputter ***,a PDMS solution was used to modify the MAO/DLC coating via a conventional dip-coating *** surface characteristics,bond strength,hardness,tribological behaviour,and corrosion resistance of the coated samples were evaluated via SEM,CA,Raman spectroscopy,friction and wear behaviour,polarisation curve,and NSS *** PDMS modification reduced the HIT of MAO/DLC coating from 15.96 to 8.34GPa;this is ascribed to the penetration of PDMS,which has good rheological properties to form a viscoelastic Si-based organic polymer layer on the MAO/DLC ***,the PDMS-modified MAO/DLC coating was denser,hydrophobic,and had higher bond strength compared with MAO-and MAO/DLC-coated ***,the PDMS modification reduced the COF and wear rate of the duplex MAO/DLC *** indicates that the PDMS improved the tribological behaviour owing to the transferred Si oxide that originated from the Si-O network of the PDMS,as well as the low graphitisation of the DLC layer during ***,the corrosion current density of the MAO/DLC-coated sample modified by PDMS for 10min decreased by two order of magnitude compared with that of the MAO/DLC-coated sample but by five orders of magnitude compared with that of the bare *** NSS tests proved that the PDMS layer slowed the corrosion of the Mg alloy under long-term service,enhancing the corrosion protection *** results are attributed to the high bond strength and lubricant MAO/DLC layer,and the dual role of sealing and hydrophobicity of ***,PDMS modification is promising for the fabrication of protective materials for Mg alloys that require corrosion and wear resistance.

关键词： Magnesium alloy Microarc oxidation Diamond-like carbon Polydimethylsiloxane Tribological behaviour Corrosion resistance

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Effect of docosahexaenoic acid on the recovery of motor function in rats with spinal cord injury: a meta-analysis

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Neural Regeneration Research 2020年第3期15卷 537-547页

作者： Zi-Rui Tian Min Yao Long-Yun Zhou Yong-Jia Song Jie Ye Yong-jun Wang xue-jun cui Institute of Spine Disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)ShanghaiChina Shanghai University of Traditional Chinese Medicine ShanghaiChina Rehabilitation Medicine College Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Orthopedics and Traumatology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Objective:Studies have shown that docosahexaenoic acid(DHA)has a beneficial effect in the treatment of spinal cord injury.A meta-analysis was used to study the effect of DHA on the neurological recovery in the rat spinal cord injury model,and the relationship between the recovery of motor function after spinal cord injury and the time and method of administration and the dose of *** source:Published studies on the effect of DHA on spinal cord injury animal models from seven databases were searched from their inception to January 2019,including PubMed,MEDLINE,EMBASE,the China National Knowledge Infrastructure,Wanfang,VIP,and SinoMed *** search terms included“spinal cord injury”“docosahexaenoic acid”,and“rats”.Data selection:Studies that evaluated the influence of DHA in rat models of spinal cord injury for locomotor functional recovery were *** intervention group included any form of DHA treatment and the control group included treatment with normal saline,vehicle solution or no *** Systematic Review Centre for Laboratory animal Experimentation’s risk of bias assessment tool was used for the quality assessment of the included *** inclusion,quality evaluation and data extraction were performed by two ***-analysis was then conducted on all studies that met the inclusion *** analysis was performed on the data using RevMan *** measures:The primary outcome measure was the score on the Basso,Beattie,and Bresnahan *** outcome measures were the sloping plate test,balance beam test,stair test and grid exploration ***:A total of 12 related studies were included,3 of which were of higher quality and the remaining 9 were of lower *** highest mean Basso,Beattie,and Bresnahan scale score occurred at 42 days after DHA treatment in spinal cord injury *** 21 days after treatment,the mean difference in Basso,Beattie,Bresnahan scores between the DHA group a

关键词： DHA docosahexaenoic acid fatty acid meta-analysis motor function motor function recover polyunsaturated fatty acid PUFA spinal cord injury systematic review

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Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice

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Neural Regeneration Research 2023年第3期18卷 634-642页

作者： Zhuo-Yao Li Ai-Fang Zhou Gan Li Long-Yun Zhou Pei-Min Pu Ke Zhu Zhong Zheng Yong-jun Wang Qian-Qian Liang Min Yao xue-jun cui Spine Disease Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghaiChina Rehabilitation Medicine Center Jiangsu Province HospitalNanjingJiangsu ProvinceChina

Chronic spinal cord compression(CSCC)is induced by disc herniation and other reasons,leading to movement and sensation dysfunction,with a serious impact on quality of *** disc herniation rarely occurs in rodents,and therefore establishing a chronic spinal cord compression(CSCC)animal model is of crucial importance to explore the pathogenesis and treatment of *** absence of secreted protein,acidic,and rich in cysteine(SPARC)leads to spontaneous intervertebral disc degeneration in mice,which resembles human disc *** this study,we evaluated whether SPARC-null mice may serve as an animal model for *** performed rod rotation test,pain threshold test,gait analysis,and Basso Mouse Scale *** results showed that the motor function of SPARC-null mice was weakened,and magnetic resonance images revealed compression at different spinal cord levels,particularly in the lumbar *** staining and western blot assay showed that the absence of SPARC induced apoptosis of neurons and oligodendrocytes,activation of microglia/macrophages with M1/M2 phenotype and astrocytes with A1/A2 phenotype;it also activated the expression of the NOD-like receptor protein 3 inflammasome and inhibited brain-derived neurotrophic factor/tyrosine kinase B signaling ***,these findings are characteristics of ***,we propose that SPARC-null mice may be an animal model for studying CSCC caused by disc herniation.

关键词： apoptosis astrocytes chronic spinal cord compression disc degeneration disc herniation macrophages microglia neuroinflammation neurons NOD-like receptor protein 3 inflammasomes secreted protein,acidic,and rich in cysteine

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Neurological Recovery and Antioxidant Effects of Curcumin for Spinal Cord Injury in the Rat:A Network Meta-Analysis and Systematic Review

Neurological Recovery and Antioxidant Effects of Curcumin fo...

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第十四届全国中药和天然药物学术研讨会

作者： Min Yao Long Yang Jin Wang Yue-li Sun Rong-liang Dun Yong-jun Wang xue-jun cui Longhua Hospital Shanghai University of Traditional Chinese Medicine Institute of Spine Disease Shanghai University of Traditional Chinese Medicine Yueyang College of Clinical Medicine Shanghai University of Traditional Chinese Medicine

＜正＞Background Spinal cord injury（SCI）is a devastating condition affecting young,healthy individuals *** agents have inadequate therapeutic efficacy,and some are associated with side *** objective is to summarize and critically assess the neurological recovery and antioxidant effects of curcumin for treatment of SCI in rat models.

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Effects of Qishe Pill,a Compound Traditional Chinese Herbal Medicine,on Cervical Radiculopathy:a Multicenter,Double-blind,Randomized Placebo-controlled Trial

Effects of Qishe Pill,a Compound Traditional Chinese Herbal ...

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第十四届全国中药和天然药物学术研讨会

作者： Yue-Li Sun Min Yao Sheng-Fu You Wen Mo Sheng Lu Qi Shi xue-jun cui Yong-jun Wang Shanghai University of Traditional Chinese Medicine

Background Neck pain is a common symptom in most patients suffering from cervical ***,some conservative treatments are limited by their modest *** patients use complementary and alternative medicine,including traditional Chinese medicine,to address their *** purpose of the present study is to examine the efficacy and safety of Qishe Pill,a compound traditional Chinese herbal medicine,for neck pain and related disability in patients with cervical *** To determine the relative efficacy and safety of Qishe Pill for cervical radiculopathy by large scale and *** A multicenter,double-blind,randomized,placebo-controlled trial to evaluate the efficacy and safety of the Qishe Pill is *** study will include 144 patients from three sites across China and diagnosed with cervical radiculopathy,according to the following inclusion criteria:age 18 to 65 with pain or stiffness in the neck for at least 2 weeks（neck disability index score25 or more） and accompanying arm pain that radiates distally from the *** participants will be randomly allocated into two groups（1:1）:Qishe Pill group and placebo *** prescription of the trial medications（***/placebo） are 3.75 g each twice a day for 28 consecutive *** primary outcome is pain *** outcomes are functional status,patient satisfaction,and adverse events as reported in the *** was collectedafter 4 weeks in treatment and 5 months in *** For pain,self-reported disability and general health status（Short Form-36）,Qishe Pill had a statistically significant advantage over placebo after 4 weeks in treatment and 5 months in follow-up（P＜ 0.05）.There was no adverse event that reported in the *** The relative efficacy and safety of Qishe Pill for neck pain and related disability could be determined.

关键词： Cervical radiculopathy Qishe pill Traditional Chinese medicine RCT.

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Clinical Observation on Changes of Bone Turnover Secondary to Chronical Renal Insufficiency

Clinical Observation on Changes of Bone Turnover Secondary t...

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第十四届全国中药和天然药物学术研讨会

作者： Xiao-Feng Li Bing Shu Chun-Chun xue De-Zhi Tang Jing Wang jun-Li Chang Wei-Wei Da xue-jun cui Yong-Jian Zhao Qian-Qian Liang Qi Shi Yong-jun Wang Shanghai University of Traditional Chinese Medicine

＜正＞To evaluate the changes of bone mass and metabolism in patients with chronical renal insuffic（CRF）in different stages（chronic kidney diseases 1-5,CKD1-5）.Patients of CKD1-5（defined by endogenous creatinine clearance rate,GFR）and healthy volunteers were recruited and assigned to CRF group（n=95）and control group（n=35）.Serum

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Pharmacokinetics,Pharmacodynamics,Tolerability and Safety of Qishe Pill in Healthy Chinese Subjects:Study Protocol for a Phase Ⅰ Trial

Pharmacokinetics,Pharmacodynamics,Tolerability and Safety of...

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第十四届全国中药和天然药物学术研讨会

作者： Yue-li Sun Ting Hou Shu-fen Liu Zhong-liang Zhang Ning Zhang Min Yao Long Yang Qi Shi xue-jun cui Yong-jun Wang Shanghai University of Traditional Chinese Medicine

To assess pharmacokinetics,pharmacodynamics,tolerability and safety of oral medication of Qishe Pill,a compound traditional Chinese herbal medicine,in healthy Chinese ***/design The study will take place at the Phase I Unit of Longhua Hospital,Shanghai University of TCM in Shanghai from September 2014 to December ***,20 subjects will be equally and successively divided into 2 groups(7.5g;15g) in separate two *** the 7.5g and 15 g oral medication dose groups,samples will be collected at dosing(time 0) and at 15,30,45,60,90,120,150,180,240,360,480,600,720,1440,2160 and 2880 min after *** the PK analysis,5 ml blood samples will be *** Pharmacokinetic Parameters assessed include area under the plasma concentration-time curve(AUC

关键词： Cervical radiculopathy Neck pain Qishe pill Traditional Chinese medicine healthy Chinese subject Pharmacokinetics Pharmacodynamics Tolerability

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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang jun Zhan Yiyuan xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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