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The 96-week clinical outcomes after cessation of nucleos(t)ide analog treatment in chronic hepatitis B patients

Gastroenterology Report 2021年第4期9卷 313-322,I0002页

作者： Wen-Xiong Xu Yang-Mei li Jian-Guo li Yong-Yu Mei You-Ming Chen xue-jun li Chao-Shuang lin Hong Deng Zhi-Xin Zhao Dong-Ying Xie Zhi-liang Gao liang Peng Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Key Laboratory of liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Prevention and Health Care The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Chronic hepatitis B(CHB)patients have a high virological relapse rate after cessation of nucleos(t)ide analog(NA)treatment,but the clinical outcome remains *** study aimed to investigate the 96-week clinical outcomes and the risk factors for relapse in CHB after cessation of ***:This study was a prospective trial;74 eligible patients were *** patients underwent NA cessation and follow-up according to the 2012 Asian Pacific Association for the Study of the liver ***,biochemical(aspartate aminotransferase[AST],alanine aminotransferase[ALT],total bilirubin,urea nitrogen,creatinine),virological data(hepatitis B surface antigen[HBsAg],hepatitis B e antigen[HBeAg],hepatitis B e antibody[HBeAb],hepatitis B virus[HBV]DNA levels),and color Doppler ultrasound examination results were recorded and ***:After NA cessation,19 cases were HBsAg-negative without relapse during the 96-week *** the 55 cases of HBsAg-positive after cessation,four types of clinical outcomes were *** patients had no relapse during the 96-week follow-up(type A,21.8%),7 patients underwent virological relapses but spontaneously had a non-virological relapse(type B,12.7%),10 patients maintained virological relapse(type C,18.2%),and 26 patients turned to clinical relapse,received NA retreatment,and achieved ALT normalization and negative conversion of HBV DNA within 12 months(type D,47.3%).The 2-year overall cumulative rates of virological and clinical relapses were 58.1%and 24.3%,*** factors associated with virological relapse were duration of negative HBV DNA,EOT(end of treatment)HBsAg,and original status of *** EOT HBsAg was also an independent factor for clinical ***:There are four types of clinical outcomes in patients with CHB after cessation of NA *** research is needed to explore the mechanism of different clinical *** EOT HBsAg level is an independent

关键词： chronic hepatitis B nucleos(t)ide analogs cessation relapse hepatitis B virus

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Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： jun Zhu Dan Cheng xue-Ying Zhu Fen-Fen li Ye Yang Yu-Feng Ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surger... 详细信息

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(linical outcomes were compared between the two *** relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating ***:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

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Oxidative Stress and Diabetic Wound Healing

Oxidative Stress and Diabetic Wound Healing

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第十五届中国中西医结合学会微循环专业委员会暨第二届中国微循环学会痰瘀专业委员会学术会议

作者： Lu Tie xue-jun li Department of Pharmacology School of Basic Medical SciencesPeking University

Objectives:Refractory wounds in diabetic patients constitute a serious complication that often leads to amputation with limited treatment *** stress has been proposed as an important pathogenic factor in diabetic wound *** present study was designed to determine the protective effect of the GTP cyclohydrolaseⅠ(GTPCH),the rate-limiting enzyme of BH4 synthesis;soy isoflavone genistein and Ganoderma lucidum polysaccharide(Gl-PS)on diabetic wound healing.

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Application of DNA barcoding to the identification of Hymenoptera parasitoids from the soybean aphid （Aphis glycines） in China

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Insect Science 2014年第3期21卷 363-373页

作者： Qing-Song Zhou Yu-Qiang Xi Fang Yu Xu Zhang xue-jun li Chun-Lai liu Ze-Qing Niu Chao-Dong Zhu Ge-Xia Qiao Yan-Zhou Zhang Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing School of life Science Anhui University Hefei College of Chemistry and life Sciences Shenyang Normal University Shenyang plant Protection Institute Heilongjiang Academy of Agricultural Sciences Harbin China

Aphis glycines Matsumura is an important pest of soybean in Asia and North America. Hymenoptera parasitoids play a key role in the control of the soybean aphid. Thecorrect identification of parasitoids is a critical step that precedes the assessment of their potential biological control agents. Accurate identification of the majority of the speciesattacking the soybean aphid often requires elaborate specimen preparation and expert taxonomic knowledge. In this study, we facilitated the identification of soybean aphidparasitoids by applying a DNA barcoding approach following a preliminary morphological identification. We generated DNA sequence data from the mitochondrial COI gene andthe D2 region of 28S rDNA to assess the genetic variation within and between parasitoid species emerging from the soybean aphid in China. Fifteen Hymenoptera parasitoid speciesbelonging to 10 genera of five families were identified with little intra-specific variation （0.09% ± 0.06% for 28S and 0.36% ± 0. 18% for COI） and large inter-specific divergence（30.46% ± 3.42% for 28S and 20.4% ± 1.20% for COI）.

关键词： biological control COl 28S-D2 molecular identification species delimitation

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Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

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World Journal of Gastroenterology 2010年第48期16卷 6145-6150页

作者： Ji Chen,Yan Wang,xue-Jie Wu,jun li,Feng-Qin Hou,Gui-Qiang Wang,Department of Infectious Diseases,Center for liver Diseases,Peking University First Hospital,Beijing 100034,China Department of Infectious Diseases Center for Liver Diseases Peking University First Hospital No. 8 Xishiku Street Xicheng District Beijing 10034 China. wanggq@***

AIM:To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS:Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density:1.077 g/L,Pharmingen) at weeks 0,4,8,12,and 24,respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS:The frequency of circulating HBV core or env-specific CD8 T cells was higher (P lization of ALT in CHB patients (positive predict value = 56%,negative predict value = 92%). CONCLUSION:Pegylated IFN α-2b can enhance the immune response of CHB patients by increasing the frequency of HBV specific CD8+ T cells and regulating the Th1/Th2 cytokines.

关键词： Chronic hepatitis B Pegylated interferon α-2b therapy Immune response Cytokine

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Depositional Environment and Origin of Inertinite-rich Coal in the Ordos Basin

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1064-1085页

作者： SHI Qingmin ZHAO jun JI Ruijun xue Weifeng HAN Bo CAI Yue li Chunhao CUI Shidong College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710199China China National Logging Corporation Geological Research InstituteXi’an 710077China

Inertinite-rich coal is widely distributed in the Ordos Basin,represented by the No.2 coal seam of the Middle Jurassic Yan'an *** paper combined coal petrology and geochemistry to analyze the origin of inertinite,changes in the coal-forming environment and control characteristics of *** has shown that there are two forms of inertinite sources in the study *** typical fusinization,wildfire events also play a substantial role in inertinite *** are significant fluctuations in the coal-forming environment of samples at different *** samples were formed in dry forest swamp with low water levels and strong oxidation,which have a high inertinite content,and the samples formed in wet forest swamp and limnic showed low inertinite ***,the inertinite content of different origins does not fully correspond to the depositional environment characterized by dryness and *** inertinites were significantly influenced by climatic conditions,while pyrofusinite was not entirely controlled by climatic conditions but rather directly impacted by wildfire *** high oxygen level was the main factor causing widespread wildfire ***,the combination of wildfire activity and oxidation generates a high content of inertinite in the Middle Jurassic coal of the Ordos Basin.

关键词： inertinite-rich coal wildfire coal petrology geochemistry biomarkers depositional environment

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Random Forest-Based Fatigue Reliability-Based Design Optimization for Aeroengine Structures

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 665-684页

作者： xue-Qin li Lu-Kai Song School of Energy and Power Engineering Beihang UniversityBeijing100191China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityKowloonHong Kong999077China Research Institute of Aero-Engine Beihang UniversityBeijing100191China

Fatigue reliability-based design optimization of aeroengine structures involves multiple repeated calculations of reliability degree and large-scale calls of implicit high-nonlinearity limit state function,leading to the traditional direct Monte Claro and surrogate methods prone to unacceptable computing efficiency and *** this case,by fusing the random subspace strategy and weight allocation technology into bagging ensemble theory,a random forest(RF)model is presented to enhance the computing efficiency of reliability degree;moreover,by embedding the RF model into multilevel optimization model,an efficient RF-assisted fatigue reliability-based design optimization framework is *** the low-cycle fatigue reliability-based design optimization of aeroengine turbine disc as a case,the effectiveness of the presented framework is *** reliabilitybased design optimization results exhibit that the proposed framework holds high computing accuracy and computing *** current efforts shed a light on the theory/method development of reliability-based design optimization of complex engineering structures.

关键词： Random forest reliability-based design optimization ensemble learning machine learning

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FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2440-2453页

作者： Jing-Ya Yin Tian-Yuan Yang Bing-Qing Yang Chen-xue Hou jun-Nan li Yue li Qi Wang Center of liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing institute of infectious disease Beijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),*** high-risk MASH have rarely been studied and compared in *** To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk *** A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December *** screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH *** threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were *** operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with *** MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and ***,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively *** the sub

关键词： Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis Non-invasive models liver biopsy Diagnostic value

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Manipulating d-d orbital hybridization induced by Mo-doped Co_(9)S_(8) nanorod arrays for high-efficiency water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 592-600,I0015页

作者： xue Zhou Jing li Guangyao Zhou Weiran Huang Yucan Zhang jun Yang Huan Pang Mingyi Zhang Dongmei Sun Yawen Tang lin Xu Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina 'College of Science Jinling Institute of TechnologyNanjing 211169JiangsuChina State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100JiangsuChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009JiangsuChina Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina

Precisely refining the electronic structure of electrocatalysts represents a powerful approach to further optimize the electrocatalytic ***,we demonstrate an ingenious d-d orbital hybridization concept to construct Mo-doped Co_(9)S_(8) nanorod arrays aligned on carbon cloth(CC)substrate(abbreviated as Mo-Co_(9)S_(8)@CC hereafter)as a high-efficiency bifunctional electrocatalyst toward water *** has experimentally and theoretically validated that the 4d-3d orbital coupling between Mo dopant and Co site can effectively optimize the H_(2)O activation energy and lower H^(*)adsorption energy barrier,thereby leading to enhanced hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)*** to the unique electronic and geometrical advantages,the optimized Mo-Co_(9)S_(8)@CC with appropriate Mo content exhibits outstanding bifunctional performance in alkaline solution,with the overpotentials of 75 and 234 mV for the delivery of a current density of 10 mA cm^(-2),small Tafel slopes of 53.8 and 39.9 mV dec~(-1)and long-term stabilities for at least 32 and 30 h for HER and OER,*** impressively,a water splitting electrolylzer assembled by the self-supported Mo-Co_(9)S_(8)@CC electrode requires a low cell voltage of 1.53 V at 10 mA cm^(-2)and shows excellent stability and splendid reversibility,demonstrating a huge potential for affordable and scalable electrochemical H_(2) *** innovational orbital hybridization strategy for electronic regulation herein provides an inspirable avenue for developing progressive electrocatalysts toward new energy systems.

关键词： d-d orbital hybridization Transition metal sulfides Nanorods arrays Water electrolysis

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Mechanism of microarc oxidation on AZ91D Mg alloy induced byβ-Mg_(17)Al_(12) phase

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 712-724页

作者： Dajun Zhai Xiaoping li jun Shen College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

This work proposed a strategy of indirectly inducing uniform microarc discharge by controlling the content and distribution ofβ-Mg_(17)Al_(12)phase in AZ91D Mg *** kinds of nano-particles(ZrO_(2)and TiO_(2))were designed to be added into the substrate of Mg alloy by friction stir processing(FSP).Then,Mg alloy sample designed with different precipitated morphology ofβ-Mg_(17)Al_(12)phase was treated by microarc oxidation(MAO)in Na_(3)PO_(4)/*** characteristics and performance of the MAO coating was analyzed using scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),contact angle meter,and potentiodynamic *** was found that the coarseα-Mg grains in extruded AZ91D Mg alloy were refined by FSP,and theβ-Mg_(17)Al_(12)phase with reticular structure was broken and *** nano-ZrO_(2)particles were pinned at the grain boundary by FSP,which refined theα-Mg grain and promoted the precipitation ofβ-Mg_(17)Al_(12)phase in *** effectively inhibited the“cascade”phenomenon of microarcs,which induced the uniform distribution of discharge *** MAO coating on Zr-FSP sample had good wettability and corrosion ***,TiO_(2)particles were hardly detected in the coating on TiFSP sample.

关键词： AZ91D Mg alloy microarc oxidation friction stir processing ZrO_(2) TiO_(2) β-Mg_(17)Al_(12)

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