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Intraparenchymal hemorrhage after surgical decompression of an epencephalon arachnoid cyst: A case report

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World Journal of Clinical Cases 2021年第1期9卷 274-277页

作者： xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong University(Nantong First People's Hospital)Nantong 226001Jiangsu ProvinceChina

BACKGROUND This study reports the clinical presentation of intraparenchymal hemorrhage as a rare complication after surgical decompression of an intracranial epencephalon arachnoid cyst(IEAC)at the posterior cranial *** SUMMARY The clinical information of a patient with an IEAC was reported,and the related literature was reviewed.A female patient with nausea presented to our *** tomography demonstrated an IEAC located at the posterior cranial fossa,which was large and required surgical *** operation,postoperative intraparenchymal hemorrhage was *** had a good recovery with conservative treatment 1 mo *** Though postoperative intraparenchymal hemorrhage is rare after surgical decompression of an IEAC,more attention should be paid to such a complication.

关键词： Intracranial arachnoid cyst Surgical decompression Hemorrhage Complication Case report

Research status of hormone replacement therapy on mood and sleep quality in menopausal women

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World Journal of Psychiatry 2024年第9期14卷 1289-1293页

作者： xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Menopausal syndrome is a common disease of clinical women,which refers to a series of physical and mental symptoms caused by the fluctuation or reduction of sex hormones before and after *** of these patients have sleep and mood abnormalities that affect their health and quality of *** present,the understanding of it is gradually *** paper mainly analyzes its back-ground and current treatment.

关键词： Effects Hormone replacement therapy Menopause Women Mood states Sleep quality Sex hormones

Toxicity assessment of heavy metals and organic compounds using CellSense biosensor with ***

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Chinese Chemical Letters 2008年第2期19卷 211-214页

作者： Hong wang xue jiang wang jian Fu Zhao Ling Chen State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and Engineering ongji University Shanghai 200092 China

A new strategy using an arnperometric biosensor with Escherichia coli （E. coli） that provides a rapid toxicity determination of chemical compounds is described. The CellSense biosensor system comprises a biological component immobilized in intimate contact with a transducer which converts the biochemical signal into a quantifiable electrical signal. Toxicity assessment of heavy metals using *** biosensors could be finished within 30 min and the 50% effective concentrations （ECso） values of four heavy metals were determined. The results shows that inhibitory effects of four heavy metals to *** can be ranked in a decreasing order of Hg^2＋〉 Cu^2＋〉 Zn^2＋〉 Ni^2＋, which accords to the results of conventional bacterial counting method. The toxicity test of organic compounds by using CellSense biosensor was also demonstrated. The CellSense biosensor with E. coli shows a good, reproducible behavior and can be used for reproducible measurements.

关键词： Whole-cell biosensor Heavy metal Organic compounds Toxicity

Efficacy evaluation of neuroendoscopy vs burr hole drainage in the treatment of chronic subdural hematoma:An observational study

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World Journal of Clinical Cases 2022年第35期10卷 12920-12927页

作者： xue-jian wang Yu-Hua Yin Zhi-Feng wang Yi Zhang Cheng Sun Zhi-Ming Cui Department of Neurosurgery Affiliated Hospital 2 to Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Neurosurgery Renji HospitalShanghai Jiao Tong UniversityShanghai 200000China jiangsu Provincial Key Laboratory of Nerve Regeneration Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Orthopedic Affiliated Hospital 2 to Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Chronic subdural hematoma(CSDH)is a common disease in *** traditional treatment methods include burr hole drainage,bone flap craniectomy and other surgical methods,and there are certain complications such as recurrence,pneumocephalus,infection and so *** the promotion of neuroendoscopic technology,its treatment effect and advantages need to be further *** To study the clinical effect of endoscopic small-bone approach in *** A total of 122 patients with CSDH admitted to our hospital from August 2018 to August 2021 were randomly divided into two groups using the digital table method:the neuroendoscopy group(n=61 cases)and the burr hole drainage group(n=61 cases).The clinical treatment effect of the two groups of patients with CSDH was *** At the early postoperative stage(1 d and 3 d),the proportion of 1/2 re-expansion of brain tissue in the hematoma cavity and the proportion of complete reexpansion was higher in the neuroendoscopy group than in the burr hole drainage group,and the difference between the two groups was statistically significant(P<0.05).The recurrence rate of hematoma in the neuroendoscopy group was lower than that in the burr hole drainage group,and the difference between the two groups was statistically significant(P<0.05).No intracranial hematoma,low cranial pressure,tension pneumocephalus or other complications occurred in the neuroendoscopy *** The neuroendoscopic approach for the treatment of CSDH can clear the hematoma under direct vision and separate the mucosal *** surgical effect is apparent with few complications and definite curative effect,which is worthy of clinical promotion and application.

关键词： Neuroendoscopy Small bone window approach Chronic subdural hematoma Curative effect Burr hole drainage

“In situ bone flap” combined with vascular pedicled mucous flap to reconstruction of skull base defect

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World Journal of Clinical Cases 2023年第29期11卷 7053-7060页

作者： Ming Qian Xi Chen Long-Yao Zhang Zhi-Feng wang Yi Zhang xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Nursing Affiliated Hospital 2 of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Neurosurgery Nantong Clinical Medical CollegeKangda CollegeNanjing Medical UniversityNantong 226000Jiangsu ProvinceChina

BACKGROUND At present,neuroendoscopy technology has made rapid development,and great progress has been made in the operation of lesions in the saddle area of the skull ***,the complications of cerebrospinal fluid and intracranial infection after the operation are still important and life-threatening complications,which may lead to poor *** To investigate the method of in situ bone flap combined with nasal septum mucosal flap for reconstruction of enlarged skull base defect by endonasal sphenoidal approach and to discuss its application *** Clinical data of 24 patients undergoing transnasal sphenoidal endoscopic approach in the Department of Neurosurgery,Affiliated 2 Hospital of Nantong University from January 2019 to December 2022 were retrospectively *** patients underwent multi-layer reconstruction of skull base using in situ bone flap combined with nasal septum mucosa *** incidence of intraoperative and postoperative cerebrospinal fluid leakage and intracranial infection were analyzed,and the application effect and technical key points of in situ bone flap combined with nasal septum mucosa flap for skull base bone reconstruction were *** There were 5 cases of high flow cerebrospinal fluid(CSF)leakage and 7 cases of low flow CSF *** cerebrospinal fluid leakage occurred in 2 patients(8.3%)and intracranial infection in 2 patients(8.3%),which were cured after strict bed rest,continuous drainage of lumbar cistern combined with antibiotic treatment,and no secondary surgical repair was *** patients were followed up for 8 to 36 months after the operation,and no delayed cerebrospinal fluid leakage or intracranial infection occurred during the *** tomography reconstruction of skull base showed satisfactory reconstruction after *** The use of in situ bone flap combined with vascular pedicled mucous flap to reconstruction of skull base defect after endonasal sphe

关键词： In situ bone flap Nasal septum mucosa flap Multilayer reconstruction Skull base reconstruction Neuroendoscopy Endonasal sphenoidal approach

Positioning and design by computed tomography imaging in neuroendoscopic surgery of patients with chronic subdural hematoma

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World Journal of Clinical Cases 2023年第14期11卷 3204-3210页

作者： xue-jian wang Yu-Hua Yin Long-Yao Zhang Zhi-Feng wang Cheng Sun Zhi-Ming Cui Department of Neurosurgery Affiliated Hospital 2 to Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Neurosurgery Renji HospitalShanghai Jiao Tong UniversityShanghai 200000China jiangsu Provincial Key Laboratory of Nerve Regeneration Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Orthopedic Affiliate Hospital 2 to Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Neuroendoscopy is a very useful technique to Chronic Subdural Hematoma(CSH).But how to achieve the goal of treatment more minimally invasive?AIM To develop a simple,fast and accurate preoperative planning method in our way for endoscopic surgery of patients with *** From June 2018 to May 2020,forty-two patients with CSH,admitted to our hospital,were performed endoscopic minimally invasive surgery;computed tomography(CT)imaging was employed to locate the intracerebral hematoma and select the appropriate endoscopic approach before the endoscopic *** clinical data and treatment efficacy were *** According to the learning of CT scanning images,the surgeon can accurately design the best minimally invasive neuroendoscopic surgical approach and realize the precise positioning and design of the drilling site of the skull and the size of the bone window,so as to provide the most effective operation space with the smallest bone *** this group,the average operation time was only about 1 h,and the clearance rate of hematoma was about 95%.CONCLUSION Patients with CSH can achieve good therapeutic effect by using our way to positioning and design to assist the operation of CSH according to CT scan and image,and our way is very useful and necessary.

关键词： Chronic subdural hematoma Neurosurgery neuroendoscopy Positioning and design Bone window design

Imaging characteristics and treatment strategies for carotid artery occlusion caused by skull base fracture

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World Journal of Clinical Cases 2024年第31期12卷 6513-6516页

作者： xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

The internal carotid artery occlusion caused by head and neck trauma,also known as traumatic intracranial artery occlusion,is relatively rare *** skull base fracture is a common complication of traumatic brain *** skull base fracture is one of the causes of traumatic internal carotid artery *** not detected early and treated in time,the prognosis of patients is *** editorial makes a relevant analysis of this disease.

关键词： Skull base fracture Traumatic internal carotid artery occlusion Blunt cerebrovascular injury Imaging Imaging characteristics Treatment strategies

Traditional Chinese medicine treatment of insomnia based on microbial-gut-brain axis theory

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World Journal of Clinical Cases 2024年第36期12卷 6867-6870页

作者： xue-jian wang Department of Neurosurgery The Second Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Neurosurgery Lueyang People's HospitalHanzhong 723000Shaanxi ProvinceChina

In recent years,insomnia has gradually become a common disease in society,which seriously affects people's quality of *** present,with the deepening of research on intestinal microbiota-gut-brain axis in Western medicine,many studies suggest that regulating the gastrointestinal tract can treat brain-related *** is found that brain-gut-bacteria axis plays an important role in the prevention and treatment of primary *** present,although the clinical treatment of insomnia with Western medicine can improve the insomnia symptoms of patients to a certain extent,there are still obvious adverse reactions,such as anxiety and depression,drug addiction,etc.,so long-term oral drug therapy cannot be carried *** Chinese medicine(TCM)and acu-puncture techniques have certain therapeutic effects on *** believes that the brain and gastrointestinal system are connected through the meridian,and the pathophysiology is closely *** paper will discuss the theory and feasibility of TCM for the treatment of insomnia from the pathological relation-ship between brain-gut axis,intestinal flora and insomnia.

关键词： Insomnia Microorganism Microbial-gut-brain axis Traditional Chinese medicine Acupuncture and moxibustion

Pituitary metastasis from lung adenocarcinoma

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World Journal of Clinical Cases 2024年第28期12卷 6155-6158页

作者： xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

Pituitary tumor is a common neuroendocrine tumor,but there are also rare clinical metastases at this site,which are generally transferred from extrabellar *** the clinical incidence is low,the prognosis is *** purpose of this editorial is to discuss further the relevant knowledge of pituitary metas-tases and remind clinicians to prevent missed diagnosis and improve the prog-nosis of these patients.

关键词： Editorial Pituitary metastasis Metastatic tumor Diagnosis Treatment Missed diagnosis