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In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis

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Bioactive Materials 2023年第3期21卷 86-96页

作者： Shi-Xiong Chen Ji Zhang Fengfeng xue Wei liu Yichen Kuang Bingxin Gu Shaoli Song Hangrong Chen State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049PR China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesSub-lane Xiangshan Road 1Hangzhou310024PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai200032PR China Center for Biomedical Imaging Fudan UniversityShanghai200032PR China Shanghai Engineering Research Center of Molecular Imaging Probes Shanghai200032PR China

Though the development of the diverse hypoxia-activated prodrugs(HAPs)has made great progresses in the last several decades,current cancer therapy based on HAPs still suffers many obstacles,e.g.,poor therapeutic outcome owing to hard deep reaching to hypoxic region,and the occurrence of metastasis due to *** by engineered niches,a novel functional chitosan polymer(CS-FTP)is synthesized for construction of a hydrogel-based bio-niche(CS-FTP-gel)in aiming at remodeling tumor hypoxic *** CS-FTP polymers are crosslinked to form a niche-like hydrogel via enzyme-mediated oxygen-consumable dimerization after injected into tumor,in which a HAP(i.e.,AQ4N)could be physically encapsulated,resulting in enhanced tumor hypoxia to facilitate AQ4N-AQ4 toxic transformation for maximizing efficacy of ***,Pazopanib(PAZ)conjugated onto the CS backbone via ROS-sensitive linker undergoes a stimuli-responsive release behavior to promote antiangiogenesis for tumor starvation,eventually contributing to the inhibition of lung metastasis and synergistic action with AQ4N-based chemotherapy for an orthotopic 4T1 breast tumor *** study provides a promising strategy for hypoxia-based chemotherapy and demonstrates an encouraging clinical potential for multifunctional hydrogel applicable for antitumor treatment.

关键词： Hypoxia-activated prodrugs Bio-niches Hypoxia-inducible hydrogels Antimetastases

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Comparison of thermal shock resistance capabilities of the rotary swaged pure tungsten,potassium-doped tungsten,and W-La_(2)O_(3)alloys

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Tungsten 2024年第4期6卷 759-766页

作者： Tao Yang Hao Wang Fan Feng Xiang liu xue-Yu Gong You-Yun Lian Jian-Bao Wang School of Nuclear Science and Technology University of South ChinaHengyang421001China Southwestern Institute of Physics Chengdu610041China

Tungsten-based materials are one of the most important candidates for the plasma facing materials(PFMs)of future fusion reactors,and it is necessary to study the properties of tungsten-based materials under the service conditions of fusion devices to ensure the long-term steady-state operation of future fusion *** this paper,different tungsten-based materials made by the same rotary swaging process are selected to simulate the transient thermal loads on the PFMs of a fusion reactor using an electron beam,and thermal load experiments are carried out by changing the power density of a loading pulse and the pulse *** is found that different tungsten-based materials made by the same process have large differences in thermal shock resistance,and the doped tungsten materials(W-K and W-La_(2)O_(3))are significantly better than the pure tungsten materials with the increase in thermal shock power density and the number of cycles,especially the W-K materials,which have excellent performance.

关键词： Rotary swaging Tungsten materials Electron beam Thermal shock

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减小GCr15轴承套圈热处理变形的工艺研究

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热加工工艺 2007年第10期36卷 62-64页

作者：刘雪华福建工程学院材料科学与工程系福建福州350014

观察了采用铸链炉淬火热处理的GCr15钢轴承套圈淬火前后的金相组织,并观察了其锻造和球化退火后的组织,发现淬火前组织均匀,而淬火后的组织中存在部分屈氏体组织。考虑到生产成本,采用适当升高淬火加热温度、延长保温时间,同时采用压缩... 详细信息

观察了采用铸链炉淬火热处理的GCr15钢轴承套圈淬火前后的金相组织,并观察了其锻造和球化退火后的组织,发现淬火前组织均匀,而淬火后的组织中存在部分屈氏体组织。考虑到生产成本,采用适当升高淬火加热温度、延长保温时间,同时采用压缩空气搅拌冷却淬火介质的方法处理套圈零件,并对比不同方案处理的套圈变形量,发现此方法可以在一定程度上降低套圈的热处理变形,且成本增加很少。

关键词：压缩空气 GCr15 轴承套圈热处理变形

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Postulation of Leaf Rust Resistance Genes in Seven Chinese Spring Wheat Cultivars

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Journal of Integrative Agriculture 2013年第9期12卷 1580-1588页

作者： SHI Li-hong ZHANG Na HU Ya-ya WEI xue-jun YANG Wen-xiang liu Da-qun Department of Plant Pathology College of Plant Protection/Biological Control Center for Plant Diseases and Plant Pests of HebeiAgricultural University of Hebei

To detect the leaf rust resistance genes in the 7 Chinese spring wheat clultivars Shenmian 99025, Shenmia 99042, Shenmian 85, Shenmian 91, Shenmian 96, Shenmian 1167 and Shenmian 962, Thatcher, Thatcher backgrounded near-isogenic lines and 15 pathotypes of P. triticina were used for gene postulate at the seedling stage, and 9 of the 15 pathotypes were used in the field tests. Molecular markers closely linked to, or co-segregated with resistance genes Lrl, Lr9, LrlO, Lrl9, Lr20, Lr21, Lr24, Lr26, Lr28, Lr29, Lr32, Lr34, Lr35, Lr37, Lr38, and Lr47 were screened to assist detection of the resistance genes. As results, 4 known resistance genes, including Lrl, Lr9, Lr26, and Lr34, and other unknown resistance genes were postulated singly or in combination in the tested cultivars. Shenmian 85, Shenmian 91, Shenmian 96, Shenmian 962, Shenmian 1167, and Shenmian 99042 are potentially useful for wheat production and breeding programs. The result suggested that combining gene postulation, molecular markers and pedigrees is effective and more accuracy method to know the resistance genes in cultivars.

关键词： gene postulation molecular marker Triticum aestivum Puccinia triticina resistance gene

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Genome-wide identification and characterization of HSP gene superfamily in whitefly (Bemisia tabacl)and expression profiling analysis under temperature stress

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Insect Science 2019年第1期26卷 44-57页

作者： Xin-Ru Wang Chao Wang Fei-xue Ban Dan-Tong Zhu Shu-Sheng liu Xiao-Wei Wang Ministry of Agriculture Key Laboratory of Agricultural Entomology Institute of Insect SciencesZhejiang UniversityHangzhouChina

Heat shock proteins (HSP)are essential molecular chaperones that play important roles in the stress stimulation of *** tabaci,a phloem feeder and invasive species,can cause extensive crop damage through direct feeding and transmission of plant *** we employed comprehensive genomics approaches to identity HSP superfamily members in the Middle East Asia Minor 1 whitefly *** total,we identified 26 Hsp genes,including three Hsp90,17 Hsp70,one Hsp60 and five sHSP (small heat shock protein)*** HSP gene superfamily of whitefly is expanded compared with the other five insects surveyed *** gene structures among the same families are relatively ***,the motif compositions and secondary structures of BtHsp proteins were *** addition,quantitative polymerase chain reaction analysis showed that the expression patterns of BtHsp gene superfamily were diverse across different tissues of *** Hsp genes were induced or repressed by thermal stress (40℃)and cold treatment (4℃)in *** the expression of BtHsp70-6 significantly decreased the survival rate of whitefly under 45℃.All the results showed the Hsps conferred thermo-tolerance or cold-tolerance to whiteflies that protect them from being affected by detrimental temperature *** observations highlighted the molecular evolutionary properties and the response mechanism to temperature assaults of Hsp genes in whitefly.

关键词： cold stress comparative genomics HSP phylogenetic thermal stress whitefly

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Petrophysical parameters inversion for heavy oil reservoir based on a laboratory-calibrated frequency-variant rock-physics model

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Petroleum Science 2023年第6期20卷 3400-3410页

作者： Xu Han Shang-Xu Wang Zheng-Yu-Cheng Zhang Hao-Jie liu Guo-hua Wei Gen-Yang Tang CNPC Key Laboratory of Geophysical Prospecting China University of Petroleum(Beijing)Beijing102249China Engineering Research Center of the Ministry of Education for Exploration and Development of Complex Oil and Gas Reservoirs China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield Geophysical Exploration Research Institute SinopecDongying257000ShandongChina

Heavy oil has high density and viscosity, and exhibits viscoelasticity. Gassmann's theory is not suitable for materials saturated with viscoelastic fluids. Directly applying such model leads to unreliable results for seismic inversion of heavy oil reservoir. To describe the viscoelastic behavior of heavy oil, we modeled the elastic properties of heavy oil with varying viscosity and frequency using the Cole-Cole-Maxwell (CCM) model. Then, we used a CCoherent Potential Approximation (CPA) instead of the Gassmann equations to account for the fluid effect, by extending the single-phase fluid condition to two-phase fluid (heavy oil and water) condition, so that partial saturation of heavy oil can be considered. This rock physics model establishes the relationship between the elastic modulus of reservoir rock and viscosity, frequency and saturation. The viscosity of the heavy oil and the elastic moduli and porosity of typical reservoir rock samples were measured in laboratory, which were used for calibration of the rock physics model. The well-calibrated frequency-variant CPA model was applied to the prediction of the P- and S-wave velocities in the seismic frequency range (1–100 Hz) and the inversion of petrophysical parameters for a heavy oil reservoir. The pre-stack inversion results of elastic parameters are improved compared with those results using the CPA model in the sonic logging frequency (∼10 kHz), or conventional rock physics model such as the Xu-Payne model. In addition, the inversion of the porosity of the reservoir was conducted with the simulated annealing method, and the result fits reasonably well with the logging curve and depicts the location of the heavy oil reservoir on the time slice. The application of the laboratory-calibrated CPA model provides better results with the velocity dispersion correction, suggesting the important role of accurate frequency dependent rock physics models in the seismic prediction of heavy oil reservoirs.

关键词： Heavy oil Rock physics Velocity dispersion Pre-stack inversion Reservoir prediction

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Rietveld refinement,microstructure,mechanical properties and oxidation characteristics of Fe-28Mn-xAl-1C(x=10 and 12 wt.%)low-density steels

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Journal of Iron and Steel Research International 2017年第12期24卷 1190-1198页

作者： Zhen-yi huang A-long Hou Yue-shan Jiang Ping Wang Qi Shi Qing-yu Hou Xiang-hua liu School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Key Laboratory of Metallurgical Emission Reduction&Resources Recycling Ministry of EducationAnhui University of TechnologyMaranshan 243002AnhuiChina Industrial&Commercial College Anhui University of TechnologyMa'anshan 243002AnhuiChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The quantitative relationship between microstructure and properties of austenitic Fe-28Mn-xAl-1C（x=10 and 12 wt.%）low-density steels was evaluated using Rietveld method to refine X-ray diffraction（XRD）*** results showed that a typical three-phase austenitic steel was obtained in the forged Mn28Al10（***-28Mn-10Al-1C）steel,which included about 92.85 wt.% γ-Fe（Mn,Al,C）（austenite）,5.28 wt.%（Fe,Mn）_3AlC_（0.5）（κ-carbide）,and 1.87 wt.% α-Fe（Al,Mn）（ferrite）.For the forged Mn28Al12（***-28Mn-12Al-1C）steel,nevertheless,only about 76.64 wt.% austenite,9.63 wt.%κ-carbide,9.14 wt.%ferrite and 4.59 wt.% Fe_3Al（DO_3）could be ***κ-carbide and DO_3 were mainly distributed in austenite grains and at the interface between austenite and ferrite,*** forged Mn28Al10 steel had a better combination of strength,ductility and specific strength as compared with the forged Mn28Al12 *** ductility of the forged Mn28Al12 steel was far lower than that of the forged Mn28Al10 *** oxidation kinetics of Mn28Al10 steel oxidized at 1323 Kfor 5-25 h had two-stage linear rate laws,and the oxidation rate of the second stage was faster than that of the first *** the oxidation kinetics of Mn28Al12 steel under this condition also had two-stage linear rate laws,the oxidation rate of the second stage was slower than that of the first *** the oxidation temperature increased to 1373K,the oxidation kinetics of the two steels at 5-25 hhad only onestage linear rate law,and the oxidation rates of the two steels were far faster than those at 1323K for5-25 *** oxidation resistance of Mn28Al12 steel was much better than that of Mn28Al10 *** layer formed between the austenite matrix and the oxidation layer of the two Fe-Mn-Al-C steels oxidized at high temperature.

关键词： Low-density steel Rietveld method Microstructure Mechanical property Oxidation characteristics

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多点激励下多跨斜拉桥缩尺模型的地震响应研究.部分2:数值分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第6期15卷 405-418页

作者： Rui ZHOU Zhou-hong ZONG xue-yang huaNG Zhang-hua XIA State Key Lab for Disaster Reduction in Civil Engineering Tongji University School of Civil Engineering Southeast University School of Civil Engineering Fuzhou University

研究目的:通过非线性动力有限元分析,模拟多塔斜拉桥在多点激励下的地震响应以及揭示其在强震下的倒塌破坏模式。创新要点:解决了多塔斜拉桥的非线性动力数值模拟技术,并首次模拟了多塔斜拉桥在强震下的破坏模式。研究方法:首先采用隐式... 详细信息

研究目的:通过非线性动力有限元分析,模拟多塔斜拉桥在多点激励下的地震响应以及揭示其在强震下的倒塌破坏模式。创新要点:解决了多塔斜拉桥的非线性动力数值模拟技术,并首次模拟了多塔斜拉桥在强震下的破坏模式。研究方法:首先采用隐式的Newmark-β法求解多点地震激励下的非线性动力方程(图3),随后采用显式的中心差分格式对强震作用下桥梁的倒塌破坏过程进行数值仿真(图4)。重要结论:1.单主梁模型的数值结果可以很好地反映地震模拟振动台试验的地震响应结果;2.在加速度峰值为4.0 m/s2的El-Centro波时,多塔斜拉桥模型只出现了中塔支座的破坏;3.在加速度峰值为4.0 m/s2的江心波时,多塔斜拉桥模型先后出现了支座破坏、拉索与塔的连接破坏以及中塔上塔柱段的单元失效。

关键词：多塔斜拉桥非线性有限元分析多点激励破坏模式

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Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization

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Virologica Sinica 2017年第5期32卷 387-395页

作者： Wei Wang Wenkun Fu Dequan Pan Linli Cai Jianghui Ye Jian liu Che liu Yuqiong Que Ningshao Xia hua Zhu Tong Cheng State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public Health Xiamen University Department of Microbiology Biochemistry and Molecular Genetics New Jersey Medical SchoolRutgers University

Varicella-zoster virus(VZV) is a neurotropic alphaherpesvirus that causes chickenpox and shingles. ORF7 is an important virulence determinant of VZV in both human skin and nerve tissues,however, its specific function and involved molecular mechanism in VZV pathogenesis remain largely elusive. Previous yeast two-hybrid studies on intraviral protein-protein interaction network in herpesviruses have revealed that VZV ORF7 may interact with ORF53, which is a virtually unstudied but essential viral protein. The aim of this study is to identify and characterize VZV ORF53, and to investigate its relationship with ORF7. For this purpose, we prepared monoclonal antibodies against ORF53 and, for the first time, characterized it as a ~40 k Da viral protein predominantly localizing to the trans-Golgi network of the infected host cell. Next, we further confirmed the interaction between ORF7 and ORF53 by co-immunoprecipitation and co-localization studies in both plasmid-transfected and VZV-infected cells. Moreover, interestingly, we found that ORF53 lost its trans-Golgi network localization and became dispersed in the cytoplasm of host cells infected with an ORF7-deleted recombinant VZV, and thus ORF7 seems to play a role in normal subcellular localization of ORF53. Collectively, these results suggested that ORF7 and ORF53 may function as a complex during infection, which may be implicated in VZV pathogenesis.

关键词： varicella-zoster virus(VZV) ORF7 ORF53 protein-protein interaction trans-Golgi network

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Transcript and Sequence Analysis of S-RNases in Self-Compatible Tetraploid Chinese Cherry (Prunus pseudocerasus L.)

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Agricultural Sciences in China 2010年第6期9卷 792-798页

作者： ZHANG Xiao-yan CHEN xue-sen MENG Qing-wei JIANG Yuan-mao ZHENG Yang CHEN Xiao-liu Institute of Horticulture Science and Engineering/State Key Laboratory of Crop Biology Shandong Agricultural University Tai＇an 271018 P.R.China Life Science Shandong Agricultural University Tai＇an 271018 PR.China

Chinese cherry （Prunus pseudocerasus L.） is an allotetraploid species and exhibits natural ***,the full-length cDNA sequences,functional analysis and the transcripts of S-RNase alleles in Chinese cherry cultivars are not *** the two cultivars Taixiaohongying and Laiyang Short Cherry with S1S2S3S4 genotypes,two S-RNases were transcribed in Northern blotting,and the two full-length cDNAs of S-RNase were cloned and *** the result,the transcribed S-RNases were S1-RNase and *** two complete cDNA sequences of S1-RNase and S2-RNase were registered as EU073938 and EU073939,respectively,and had characteristic structure of rosaceous S-RNases based on their sequences indicating that they had normal function for S-RNase in the *** S3-RNase and S4-RNase were not transcribed in the style and were nonfunctional for S-RNase,so S3m and S4m could be used to represent the nonfunctional S3-RNase and *** phylogenetic analysis implied that the S-RNases of Prunus,including Chinese cherry,had lower intra-specific similarity and diverged earlier than the divergence of species in Prunus.

关键词： Chinese cherry self-compatibility S-RNase Prunus tetraploid

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