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Evaluation of efficacy of resin hemoperfusion in patients with acute 2,4-dinitrophenol poisoning by dynamic monitoring of plasma toxin concentration

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第8期16卷 720-726页

作者： xue-hong zhao Jiu-kun JIANG Yuan-qiang LU Department of Emergency Medicine the First Affiliated Hospital School of Medicine Zhejiang University

Objective： The intoxications caused by 2,4-dinitrophenol （2,4-DNP）, even death, have been frequently reported in recent years. This study aims to investigate the dynamic changes of plasma toxin concentration and explore the clinical value of resin hemoperfusion （HP） in the treatment of patients with acute 2,4-DNP poisoning. Methods We reported 16 cases of acute 2,4-DNP poisoning through occupational exposure due to ignoring the risk of poisoning. The blood samples were collected from the 14 survivors. According to the different treatments of resin HP, the survivors were divided into routine HP （n=5） and intensive HP （n=9） groups. Ultra high performance liquid chromatography/ tandem mass spectroscopy （UPLC-MS/MS） was used to detect the 2,4-DNP concentration in plasma in this study. Results： The 14 survivors recovered very well after treatment. The initial plasma 2,4-DNP concentrations （C1） of survivors ranged from 0.25 to 41.88 pg/ml （mean （12.56＋13.93） pg/ml）. A positive correlation existed between initial plasma 2,4-DNP concentration （C1） and temperature. The elimination of 2,4-DNP was slow and persistent, and the total clearance rates of plasma toxin from the 1st to 3rd day （R3）, the 3rd to 7th day （R3-7）, and the 1st to 7th day （RT）, were only （53.03±14.04）%, （55.25±10.50）%, and （78.29±10.22）%, respectively. The plasma toxin was cleared up to 25 d after poisoning in most of the patients. The R3, R3-7, and R7 in the intensive HP group were all apparently higher than those in the routine HP group, with statistical significance （P〈0.05）. Simultaneously, the elimination half-life （tl/2） of 2,4-DNP in the intensive HP group was apparently shorter than that in the routine HP group, with statistical significance （P〈0.05）. Conclusions： The clinicians should be aware of this slow and persistent process in the elimination of plasma 2,4-DNP. Higher initial plasma toxin concentration resulted in a more severe fever for the patient. According to the limited data, longer and m

关键词： 2,4-Dinitrophenol Poisoning Hemoperfusion Pharmacokinetics Therapeutics

Predictive model for acute abdominal pain after transarterial chemoembolization for liver cancer

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World Journal of Gastroenterology 2020年第30期26卷 4442-4452页

作者： Li-Fang Bian xue-hong zhao Bei-Lei Gao Sheng Zhang Guo-Mei Ge Dong-Di Zhan Ting-Ting Ye Yan Zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Nursing The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Hospital Infection Control The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)is the first-line treatment for patients with unresectable liver cancer;however,TACE is associated with postembolization *** To analyze the risk factors for acute abdominal pain after TACE and establish a predictive model for postembolization *** From January 2018 to September 2018,all patients with liver cancer who underwent TACE at our hospital were *** characteristics;clinical,imaging,and procedural data;and postembolization pain were *** pain was defined as acute moderate-to-severe abdominal pain within 24 h after *** regression and a classification and regression tree were used to develop a predictive *** operating characteristic curve analysis was used to examine the efficacy of the predictive *** We analyzed 522 patients who underwent a total of 582 TACE ***-seven(16.70%)episodes of severe pain occurred.A predictive model built based on the dataset from classification and regression tree analysis identified known invasion of blood vessels as the strongest predictor of subsequent performance,followed by history of TACE,method of TACE,and history of abdominal pain after *** area under the receiver operating characteristic curve was 0.736[95%confidence interval(CI):0.682-0.789],the sensitivity was 73.2%,the specificity was 65.6%,and the negative predictive value was 92.4%.Logistic regression produced similar results by identifying age[odds ratio(OR)=0.971;95%CI:0.951-0.992;P=0.007),history of TACE(OR=0.378;95%CI:0.189-0.757;P=0.007),history of abdominal pain after TACE(OR=6.288;95%CI:2.963-13.342;P<0.001),tumor size(OR=1.978;95%CI:1.175-3.330;P=0.01),multiple tumors(OR=2.164;95%CI:1.243-3.769;P=0.006),invasion of blood vessels(OR=1.756;95%CI:1.045-2.950;P=0.034),and TACE with drug-eluting beads(DEBTACE)(OR=2.05;95%CI:1.260-3.334;P=0.004)as independent predictive factors for postembolization *** Blood vesse

关键词： Liver cancer Predictive model Pain Transarterial chemoembolization Postembolization syndrome

Regression of liver fibrosis after biliary drainage in patients with choledocholith: a preliminary report

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 104-107页

作者： Yuan Gao Zuo-Bing Chen Shu-Sen Zheng Guo-Zhi Hu Chen-Yan Ding Yun Zhang xue-hong zhao Lin-Mei Ni Department of Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: Choledocholith is prevalent in some Asian countries and may lead to liver fibrosis and portal vein hypertension. Biliary drainage is an effective treatment for choledocholith. The aim of this study was to assess the impact of biliary drainage on liver fibrosis due to choledocholith.METHODS: Eight patients with liver fibrosis caused by choledocholith were followed up by biochemical tests (aspartate aminotransferase, alanine aminotransferase) and liver biopsy before and after biliary drainage, respectively. The severity of the fibrosis was scored on a scale from 0 to 3 (0: denoting none; 1: portal and periportal fibrosis; 2: the presence of numerous fiber septa; and 3: cirrhosis). The results were analyzed statistically.RESULTS: The severity scores of liver fibrosis in the 8 patients were 2,1; 2,1; 1,0; 1,1; 2,1; 1,1; 2,1; 1,0 before and after biliary drainage, respectively. The results showed that the average severity of liver fibrosis decreased significantly after biliary drainage (n=8, t=4.573, P=0.003).CONCLUSION: Liver fibrosis due to choledocholith may regress after biliary drainage.

关键词： regression liver fibrosis choledocholith

Pre-existing cirrhosis is associated with increased mortality of traumatic patients: Analysis of cases from a trauma center in East China

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World Journal of Gastroenterology 2007年第42期13卷 5654-5658页

作者： Zuo-Bing Chen Lin-Mei Ni Yuan Gao Chen-Yan Ding Yun Zhang xue-hong zhao Yun-Qing Qiu Department of Emergency Surgery First Affiliated Hospital College ofMedicine Zhejiang University Hangzhou 310003 ZhejiangProvince China

AIM:To determine the impact of cirrhosis on trauma patients and define the factors predicting ***:The data on patients admitted to the trauma center from January 2000-2005 were studied *** clinical variables were recorded and compared to identify the factors differentiating cirrhotic trauma survivors from non ***'s classification criteria were derived from the reviewed charts of cirrhotic trauma patients to evaluate their predictive value in cirrhotic *** registry was also used to generate a trauma control group by matching for age,sex,abbreviated injury score(AIS)over the same period of *** outcome variables compared were mortality rate,time of ICU and hospital *** were expressed as mean ± *** data were analyzed by SPSS.11.0 statistical *** analysis was performed to identify significant medical factors for survivor and non survivors subjected to chi-square ***'s exact test and Student's t test were performed to determine the statistical difference between cirrhotic and control groups.P < 0.05 was considered statistically ***:Poor prognosis of traum patients was associated with one or more of the following findings:ascitcs,hyperbilirubinemia(more than 2 mg/dL),hypoalbuminemia(less than 3.5 mg/dL),and prolonged prothrombin time(more than 12.5 seconds).Although Child's classification was used to predict the outcome in cirrhotic patients undergoing portacaval shunt procedures,no significant difference was found in mortality rate as a function of Child's ***:Cirrhosis is associated with a highermortality,a longer time of ICU and hospital stay of trauma *** seems that treatment of trauma patients with pre-existing severe liver disease is a challenge to surgeons.

关键词： Pre-existing cirrhosis Trauma Mortality rate

Impact of right upper pulmonary vein isolation on atrial vagal innervation and vulnerability to atrial fibrillation

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Chinese Medical Journal 2006年第24期119卷 2049-2055页

作者： LIU Yuan ZHANG Shu-long DONG Ying-xue zhao hong-wei GAO Lian-jun YIN Xiao-meng LI Shi-jun LIN Zhi-hu YANG Yan-zong Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian 116011 China

Background Based on the hypothesis that pulmonary vein isolation could result in the damage of the epicardial fat pads, this study aimed to investigated the impact of right upper pulmonary vein （RUPV） isolation on vagal innervation to atria. Methods Bilateral cervical sympathovagal trunks were decentralized in 6 dogs. Metoprolol was given to block sympathetic effects. Multipolar catheters were placed into the right atrium （R.A） and coronary sinus （CS）. RUPV isolation was performed via transseptal procedure. Atrial effective refractory period （ERP）, vulnerability window （VW） of atrial fibrillation （AF）, and sinus rhythm cycle length （SCL） were measured at RA and distal coronary sinus （CSd） at baseline and vagal stimulation before and after RUPV isolation. Serial sections of underlying tissues before and after ablation were stained with haematoxylin and eosin. Results SCL decreased significantly during vagal stimulation before RUPV isolation （197±21 vs 13±32 beats per minute, P〈0.001）, but remained unchanged after RUPV isolation （162±29 vs 140±39 beats per minute, P〉0.05）. ERP increased significantly before RUPV isolation compared with that during vagal stimulation [（85.00±24.29） ms vs （21.67±9.83） ms at RA, P〈0.001; （90.00± 15.49） ms vs （33.33±25.03） ms at CSd P〈0.005], but ERP at baseline hardly changed after RUPV isolation compared with that during vagal stimulation [（103.33 ± 22.50） vs （95.00± 16.43） ms at RA, P = 0.09; （98.33±24.83） vs （75.00±29.50） ms at CSd, P=0.009]. The ERP shortening during vagal stimulation after RUPV isolation decreased significantly [（63.33 ±22.51） ms vs （8.33 ± 9.83） ms at RA, P〈0.005; （56.67±20.66） ms vs （23.33± 13.66） ms at CSd, P〈0.05]. AF was rarely induced at baseline before and after RUPV isolation （VW close to 0）, while VW of AF to vagal stimulation significantly decreased after RUPV isolation [（40.00± 10.95） vs 0 ms at RA, P〈0.001; （45.00±32.09） vs （15.00±23.45） ms at CS, P 〈0.05]. The architecture of individual ganglia was signi

关键词： atrial fibrillation pulmonary vein vagus

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用户画像视角下精准教学设计模式研究

陇东学院学报 2019年第2期30卷 133-138页

作者：薛赵红淮北师范大学教育学院安徽淮北235000

对当下教学设计模式研究进行了回顾,分析了现阶段教学设计理论研究和实践应用中的主要问题及其原因。采用用户画像的方法,探讨了在大数据环境下教学设计模式的构建,将数据科学研究成果与教学设计模式相融合,以期进一步拓展教学设计模式... 详细信息

对当下教学设计模式研究进行了回顾,分析了现阶段教学设计理论研究和实践应用中的主要问题及其原因。采用用户画像的方法,探讨了在大数据环境下教学设计模式的构建,将数据科学研究成果与教学设计模式相融合,以期进一步拓展教学设计模式的研究领域。

关键词：用户画像教学设计模式大数据

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基于微博平台上的信息礼仪问题研究

齐齐哈尔大学学报（哲学社会科学版） 2018年第8期 151-155页

作者：薛赵红淮北师范大学教育学院安徽淮北235000

与现实生活一样,人们在网络虚拟交往中的行为也需要进行约束、规范,如信息礼仪。信息礼仪的缺失,将导致人们信息行为异化、网络世界失序。在微博用户信息行为中也存在着信息礼仪规范化问题。立足于"听、说、读、写"的视角分析信息礼仪... 详细信息

与现实生活一样,人们在网络虚拟交往中的行为也需要进行约束、规范,如信息礼仪。信息礼仪的缺失,将导致人们信息行为异化、网络世界失序。在微博用户信息行为中也存在着信息礼仪规范化问题。立足于"听、说、读、写"的视角分析信息礼仪存在的问题,从微博用户自身信息礼仪意识薄弱、微博运营商重视娱乐技术开发以及过度依赖信息法律、道德三个角度分析原因。从净化网络信息环境、加大网络信息法律法规以及丰富信息课程设置等提出对策。

关键词：信息礼仪微博网络世界信息行为

利用模型预测和优化多相各向异性TiB_2增强钢复合材料的力学性能

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机械工程材料 2017年第1期41卷 90-95,106页

作者：李涵金学军赵洪山上海交通大学材料科学与工程学院上海200240 法国国立高等工艺学校巴黎75014

基于Mori-Tanaka均匀化方法及Eshelby等效夹杂理论建立了解析计算模型,用以预测多相各向异性TiB_2增强钢复合材料的力学性能,并系统研究了增强体的长径比、体积分数和取向对复合材料横向和纵向弹性模量的影响。结果表明:建立的模型可以... 详细信息

基于Mori-Tanaka均匀化方法及Eshelby等效夹杂理论建立了解析计算模型,用以预测多相各向异性TiB_2增强钢复合材料的力学性能,并系统研究了增强体的长径比、体积分数和取向对复合材料横向和纵向弹性模量的影响。结果表明:建立的模型可以准确预测多种不同金属基复合材料的弹性模量;大的长径比可以显著提高TiB_2增强钢复合材料的纵向弹性模量,且只造成横向弹性模量少量损失;增强相体积分数与弹性模量呈正相关;纵向弹性模量随着增强体排列方向与载荷方向之间夹角的增大而先增大后减小。

关键词： TiB2增强钢复合材料模型多相各向异性增强体体积分数

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation