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Joint Sample Position Based Noise Filtering and Mean Shift Clustering for Imbalanced Classification Learning

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Tsinghua Science and Technology 2024年第1期29卷 216-231页

作者： Lilong Duan Wei xue Jun Huang Xiao zheng School of Computer Science and Technology Anhui University of TechnologyMaanshan 243032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

The problem of imbalanced data classification learning has received much *** classification algorithms are susceptible to data skew to favor majority samples and ignore minority *** weighted minority oversampling technique(MWMOTE)is an effective approach to solve this problem,however,it may suffer from the shortcomings of inadequate noise filtering and synthesizing the same samples as the original minority *** this end,we propose an improved MWMOTE method named joint sample position based noise filtering and mean shift clustering(SPMSC)to solve these ***,in order to effectively eliminate the effect of noisy samples,SPMsC uses a new noise filtering mechanism to determine whether a minority sample is noisy or not based on its position and distribution relative to the majority *** that MWMOTE may generate duplicate samples,we then employ the mean shift algorithm to cluster minority samples to reduce synthetic replicate ***,data cleaning is performed on the processed data to further eliminate class *** on extensive benchmark datasets demonstrate the effectiveness of SPMsC compared with other sampling methods.

关键词： imbalanced data classification oversampling noise filtering clustering

Rupture of sigmoid colon caused by compressed air

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World Journal of Gastroenterology 2016年第10期22卷 3062-3065页

作者： Wan-Bin Yin Ji-Lin Hu Yuan Gao Xian-Xiang Zhang Mao-Shen Zhang Guang-Wei Liu xue-feng zheng Yun Lu Department of General Surgery Affiliated Hospital of Qingdao University

Compressed air has been generally used since the beginning of the 20 th century for various applications. However, rupture of the colon caused by compressed air is uncommon. We report a case of pneumatic rupture of the sigmoid colon. The patient was admitted to the emergency room complaining of abdominal pain and distention. His colleague triggered a compressed air nozzle against his anus as a practical joke 2 h previously. On arrival, his pulse rate was 126 beats/min, respiratory rate was 42 breaths/min and blood pressure was 86/54 mm Hg. Physical examination revealed peritoneal irritation and the abdomen was markedly distended. Computed tomography of the abdomen showed a large volume of air in the abdominal cavity. Peritoneocentesis was performed to relieve the tension pneumoperitoneum. Emergency laparotomy was done after controlling shock. Laparotomy revealed a 2-cm perforation in the sigmoid colon. The perforation was sutured and temporary ileostomy was performed as well as thorough drainage and irrigation of the abdominopelvic cavity. Reversal of ileostomy was performed successfully after 3 mo. Follow-up was uneventful. We also present a brief literature review.

关键词： Colon Rectum Colon rupture Intestinal perforation Compressed air

Dimension by Dimension Finite Volume HWENO Method for Hyperbolic Conservation Laws

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Communications on Applied Mathematics and Computation 2024年第1期6卷 605-624页

作者： feng zheng Jianxian Qiu College of Mathematics and Statistics Fujian Normal UniversityFuzhou350117FujianChina School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling&High-Performance Scientific Computing Xiamen UniversityXiamen361005FujianChina

In this paper,we propose a finite volume Hermite weighted essentially non-oscillatory(HWENO)method based on the dimension by dimension framework to solve hyperbolic conservation *** can maintain the high accuracy in the smooth region and obtain the high resolution solution when the discontinuity appears,and it is compact which will be good for giving the numerical boundary ***,it avoids complicated least square procedure when we implement the genuine two dimensional(2D)finite volume HWENO reconstruction,and it can be regarded as a generalization of the one dimensional(1D)HWENO *** numerical tests are performed to verify the high resolution and high accuracy of the scheme.

关键词： Finite volume Dimension by dimension HWENO Hyperbolic conservation laws

Inactivated Sendai Virus Suppresses Murine Melanoma Growth by Inducing Host Immune Responses and Down-regulating β-catenin Expression

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Biomedical and Environmental Sciences 2012年第5期25卷 509-516页

作者： ZHANG Quan YUAN Wei feng ZHAI Guo Qin xue zheng feng ZHU Hong Fei XU Xiang Ming College of Veterinary Medicine Yangzhou UniversRyYangzhou 225009JiangsuChina Institute of Animal Science and Veterinary Medicine Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Animal-used High-tech Biopharmaceutical of Jiangsu Province Taizhou 225300JiangsuChina

Abstract Objective This paper aims to investigate the anti-tumor mechanism of inactivated Sendai virus （Hemagglutinating virus of Japan envelope, HVJ-E） for murine melanoma （B16F10）. Methods The murine dendritic cells （DCs） were treated with HVJ-E, and then the cytokines secreted from DCs and costimulation-related molecules on DCs were measured. Meanwhile, the expression of 13-catenin in HVJ-E treated murine melanoma cells was detected. In addition, HVJ-E was intratumorally injected into the melanoma on C57BL/6 mice, and the immune cells, CTL response and tumor volume were analyzed. Results HVJ-E injected into B16F10 melanoma obviously inhibited the growth of the tumor and prolonged the survival time of the tumor-bearing mice. Profiles of cytokines secreted by dendritic cells （DCs） after HVJ-E stimulation showed that the number of cytokines released was significantly higher than that elicited by PBS （P〈O.05）. The co-stimulation-related molecules on DCs were comparable to those stimulated by LPS. Immunohistochemical examinations demonstrated the repression of 13-catenin in B16F10 melanoma cells after HVJ-E treatment. Meanwhile, real-time reverse transcription PCR revealed that HVJ-E induced a remarkable infiltration of CDllc positive cells, chemokine ligand 10 （CXCL10） molecules, interleukin-2 （IL-2） molecule, CD4^＋ and CD8^＋ T cells into HVJ-E injected tumors. Furthermore, the mRNA expression level of 13-catenin in the HVJ-E injected tumors was also down-regulated. In addition, B16F10-specific CTLs were induced significantly after HVJ-E was injected into the tumor-bearing mice. Conclusion This is the first report to show the effective inhibition of melanoma tumors by HVJ-E alone and the mechanism through which it induces antitumor immune responses and regulates important signal pathways for melanoma invasion. Therefore, HVJ-E shows its prospect as a novel therapeutic for melanoma therapy.

关键词： HVJ-E Dendritic cell Melanoma β-catenin

Vertical polarization-induced doping InN/InGaN heterojunction tunnel FET with hetero T-shaped gate

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Chinese Physics B 2021年第5期30卷 687-693页

作者： Yuan-Hao He Wei Mao Ming Du Zi-Ling Peng Hai-Yong Wang xue-feng zheng Chong Wang Jin-Cheng Zhang Yue Hao Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi'an 710071China

A novel vertical InN/InGaN heterojunction tunnel FET with hetero T-shaped gate as well as polarization-doped source and drain region(InN-Hetero-TG-TFET)is proposed and investigated by Silvaco-Atlas simulations for the first *** with the conventional physical doping TFET devices,the proposed device can realize the P-type source and N-type drain region by means of the polarization effect near the top InN/InGaN and bottom InGaN/InN heterojunctions respectively,which could provide an effective solution of random dopant fluctuation(RDF)and the related problems about the high thermal budget and expensive annealing techniques due to ion-implantation physical ***,due to the hetero T-shaped gate,the improvement of the on-state performance can be achieved in the proposed *** simulations of the device proposed here in this work show ION of 4.45×10^(-5)A/μm,ION/IOFF ratio of 10^(13),and SS_(avg)of 7.5 mV/dec in InN-Hetero-TG-TFET,which are better than the counterparts of the device with a homo T-shaped gate(InN-Homo-TG-TFET)and our reported lateral polarization-induced InN-based TFET(PI-InN-TFET).These results can provide useful reference for further developing the TFETs without physical doping process in low power electronics applications.

关键词： InGaN TFET hetero T-shaped gate polarization-doped source and drain

Stimulating Start-up Investment Through Government-Sponsored Venture Capital:Theory and Chinese Evidence

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Journal of Systems Science & Complexity 2024年第5期37卷 2021-2053页

作者： NI Xuanming zheng Tiantian GAO feng ZHAO Huimin School of Software and Microelectronics Peking UniversityBeijing 100871China School of Economics and Management Tsinghua UniversityBeijing 100084China School of Business Sun Yat-sen UniversityGuangzhou 510275China

Government-sponsored venture capital(GVC)has been used to support financially constrained start-ups as an important policy tool in ***,to motivate the social capital to invest in start-ups,GVC provides subsidies for them to bridge the funding gap in the early-stage venture capital ***,the effect and mechanism of GVC affecting social capital investment have not been clearly *** this paper,the authors not only develop a game model to analyze this issue in theory,but conduct an empirical study by analyzing the 14741 records matched by propensity score matching(PSM)of Chinese venture capital market data from 2011 to *** proposed findings are as the ***,the subsidies offered by GVC will simultaneously increase the returns and risks of investments in start-ups of social capital with more volatile incentive effect of *** incentive effect of GVC is only effective when the returns resulting from the subsidies outweigh the risks they *** the context of the Chinese venture capital market,the incentive effect of GVC is ***,the incentive effect of GVC is more pronounced in high-tech industries,which can be attributed to the signaling effect facilitated by *** this context,the subsidy mainly helps social capital to bear the costs associated with screening potential ***,the incentive effect of GVC is more significant in underdeveloped venture capital markets,which can be explained by the“virtuous cycle”effect,in which GVC plays a pioneering role in establishing a more robust early-stage market trading *** examining these three points,this study contributes to a better understanding of how GVC can effectively guide social capital investment,especially in the Chinese landscape.

关键词： Government-sponsored venture capital fund incentive effect social capital subsidy venture capital

Baicalin Prevents Colon Cancer by Suppressing CDKN2A Protein Expression

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1007-1017页

作者： LI Gang-gang CHU Xiu-feng XING Ya-min xue Xia Ihtisham Bukhari LIANG Xin-feng XU Ji-xuan MI Yang zheng Peng-yuan Henan Key Laboratory of Helicobacter pylori Microbiota and Gastrointestinal Cancers Marshall Medical Research Center Fifth Affiliated Hospital of Zhengzhou University

Objective:To observe the therapeutic effects and underlying mechanism of baicalin against colon ***:The effects of baicalin on the proliferation and growth of colon cancer cells MC38 and *** were observed and predicted potential molecular targets of baicalin for colon cancer therapy were studied by network ***,molecular docking and drug affinity responsive target stability（DARTS）analysis were performed to confirm the interaction between potential targets and ***,the mechanisms predicted by in silico analyses were experimentally verified in-vitro and ***:Baicalin significantly inhibited proliferation,invasion,migration,and induced apoptosis in MC38 and CT26 cells（all P<0.01）.Additionally,baicalin caused cell cycle arrest at the S phase,while the G0/G1phase was detected in the tiny portion of the *** network pharmacology analysis identified 6 therapeutic targets associated with baicalin,which potentially affect various pathways including 39 biological processes and 99 sugnaling *** addition,molecular docking and DARTS predicted the potential binding of baicalin with cyclin dependent kinase inhibitor 2A（CDKN2A）,protein kinase B（AKT）,caspase 3,and mitogen-activated protein kinase（MAPK）.In vitro,the expressions of CDKN2A,MAPK,and p-AKT were suppressed by baicalin in MC38 and CT26 *** vivo,baicalin significantly reduced the tumor size and weight（all P<0.01） in the colon cancer mouse model via inactivating p-AKT,CDKN2A,cyclin dependent kinase 4,cyclin dependent kinase 2,interleukin-1,tumor necrosis factor α,and activating caspase 3 and mouse double minute 2 homolog signaling（all P<0.05）.Conclusion:Baicalin suppressed the CDKN2A protein level to prevent colon cancer and could be used as a therapeutic target for colon cancer.

关键词： CDKN2A apoptosis baicalin cell cycle colon cancer network pharmacology

Effect of pre-transplantation hemoglobin concentration on prognosis of renal transplant recipients

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Chinese Medical Journal 2011年第8期124卷 1213-1216页

作者： NA Ning HONG Liang-qing MIAO Bin HUA xue-feng HUANG zheng-yu Department of Renal Transplantation Third Affiliated Hospital ofSun Yat-sen University Guangzhou Guangdong 510630 China

Background For the renal transplant recipients, anemia is one of the common complications and becomes a major medical issue before transplantation. Haemoglobin （Hb） is used as a prognostic indicator, although the optimal pre-transplantation Hb concentration associated with positive prognosis is still controversial. The aim of this study was to detect the optimal Hb concentration on predicting the graft survival and *** A retrospective cohort study was conducted by reviewing the medical records of the patients who received renal transplantations at our center from January 2004 to June 2008. Patients were divided into two groups： high Hb group （＞100 g/L, n=79） and low Hb group （＜100 g/L, n=63）. There was no significant difference between the two groups regarding sex, age, blood type and tissue types. Renal function among the two groups was measured and *** reacting antigens （PRA） of all the recipients were negative. The effect of preoperative hemoglobin concentration on the postoperative renal function recovery in both groups was further *** A total of 14 acute rejection episodes occurred, including 5 patients in the high Hb group （7.9%） and 9 in the low Hb group （11.4%, P ＞0.05）. The serum creatinine level at one-year post-transplantation of the low Hb group was significantly higher than that of the high Hb group （（117.8±36.3） μmol/L vs. （103.1±35.5） μmol/L, P ＜0.05）. For one-year actuarial patient and graft survival, incidence of delayed graft function （DGF）, serum creatinine concentrations at 1, 3, 6 months post-transplantation, the incidence of cytomegalovirus （CMV） infection, post-transplantation anemia （PTA） and post-transplantation diabetes mellitus （PTDM） of both groups, there were no statistically significant *** Pre-transplantation Hb concentration has significant effect on one-year creatinine concentration, but can not significantly affect acute rejection episodes, DGF, PTA, CMV infection and PTDM.

关键词： renal transplantation hemoglobin concentration prognosis

Ellagic acid inhibits gastric cancer cells by modulating oxidative stress and inducing apoptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 162-169页

作者： Jian zheng Chun-feng Li Department of Diagnostic Radiology Division Harbin Medical University Cancer HospitalHeilongjiangChina Department of Gastrointestinal Surgical Ward Harbin Medical University Cancer HospitalHeilongjiangChina

Objective:To evaluate the anticancer effect of ellagic acid on gastric cancer ***:MTT assay was used to evaluate the effect of ellagic acid at different concentrations(0.5-100μg/mL)on gastric cancer AGS ***-qPCR and Western blot analyses were applied to assess apoptosis(BCL-2,CASP-3,and BAX)and autophagy(LC3,ATG5,and BECN1)in AGS cells treated with ellagic *** expression of invasion-related markers including TP53,CDKN2A,and PTEN was *** addition,cell cycle markers including cyclin A,B,D,and E were measured by *** stress markers were evaluated using ***:Ellagic acid inhibited the proliferation of AGS cells in a concentration-and time-dependent *** expression of BCL-2 was significantly decreased(P0.05).Moreover,the oxidative stress markers including SOD,TAC,and MDA were increased by ellagic acid(P<0.01).Conclusions:Ellagic acid can inhibit cell proliferation,induce apoptosis,and modulate oxidative stress in AGS ***,further in vivo and molecular studies are needed to verify its anticancer efficacy.

关键词： Ellagic acid Gastric cancer Apoptosis Autophagy Metastasis Proliferation