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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1128-1134页

作者： Ping Li Shuangwu Xia Junfu Dong Liangwei Dai Zhicheng luo Kemin xue School of Material Science and Engineering Hefei University of TechnologyHefei230009China

The Mg–Zn–Gd alloy with quasicrystal icosahedral phase was processed by high-pressure torsion (HPT). The effect of bimodal I-phase on the dynamic recrystallization was analyzed by transmission electron microscopy. The results showed that the block I-phase can stimulate obvious particle-stimulated nucleation and dynamic recrystallization (DRX) grains were preferentially formed after HPT for 5 turns, while the granular I-phase only promoted the generation of sub-grains. The orientation relationship was determined as twofold//[1210] and fivefold//(0002)_(Mg). Moreover, after HPT for 9 turns, the DRX grains induced by block I-phase appeared to grow up and coarsened. Compared with block I-phase, the grains induced by granular I-phase presented much smaller size and distributed more homogeneous due to the strong pinning effect.

关键词： High-pressure torsion(HPT)-Quasicrystal phase Dynamic recrystallization Particle-stimulated nucleation Orientation relationship

Ileal conduit stomal variceal bleeding managed by endovascular embolization

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World Journal of Gastroenterology 2013年第44期19卷 8156-8159页

作者： Deng-Hua Yao xue-feng luo Biao Zhou Xiao Li Department of Gastroenterology and Hepatology Institution of Intervention Radiology West China Hospital Sichuan University

Ileal conduit stomal varices are rare,and may result in *** standard treatment modality for management of this type of hemorrhage has not been *** present the case of a 70-year-old woman with progressive ileal conduit stomal variceal bleeding which was successfully managed by endovascular embolization via the transjugular transhepatic *** conclusion,transjugular transhepatic endovascular embolization is a good choice in patients with ileal conduit stomal variceal bleeding who have failed conservative therapy.

关键词： Ectopic variceal bleeding Ileal conduit Stomal bleeding Cirrhosis Hemostasis Transjugular transhepatic embolization

Multi-party privacy-preserving decision tree training with a privileged party

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Science China(Information Sciences) 2024年第8期67卷 253-268页

作者： Yiwen TONG Qi feng Min luo Debiao HE Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education School of Cyber Science and Engineering Wuhan University Shanghai Technology Innovation Centre of Distributed Privacy-Preserving Artificial Intelligence Matrix Elements Technologies Key Laboratory of Computing Power Network and Information Security Ministry of EducationShandong Computer Science Center Qilu University of Technology(Shandong Academy of Sciences)

Currently, a decision tree is the most commonly used data mining algorithm for classification tasks. While a significant number of studies have investigated privacy-preserving decision trees, the methods proposed in these studies often have shortcomings in terms of data privacy breach or efficiency. Additionally,these methods typically only apply to symmetric frameworks, which consist of two or more parties with equal privilege, and are not suitable for asymmetric scenarios where parties have unequal privilege. In this paper,we propose SecureCART, a three-party privacy-preserving decision tree training scheme with a privileged party. We adopt the existing pMPL framework and design novel secure interactive protocols for division,comparison, and asymmetric multiplication. Compared to similar schemes, our division protocol is 93.5–560.4× faster, with the communication overhead reduced by over 90%; further, our multiplication protocol is approximately 1.5× faster, with the communication overhead reduced by around 20%. Our comparison protocol based on function secret sharing maintains good performance when adapted to pMPL. Based on the proposed secure protocols, we implement SecureCART in C++ and analyze its performance using three real-world datasets in both LAN and WAN environments. he experimental results indicate that SecureCART is significantly faster than similar schemes proposed in past studies, and that the loss of accuracy while using SecureCART remains within an acceptable range.

关键词： privacy protection decision trees secure multi-party computation secret sharing privileged party

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Unlocking the potential of bispecific ADCs for targeted cancer therapy

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Frontiers of Medicine 2024年第4期18卷 597-621页

作者： Hongye Zeng Wenjing Ning xue Liu Wenxin luo Ningshao Xia State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for Industry-Education Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen361102China

Antibody–drug conjugates(ADCs)are biologically targeted drugs composed of antibodies and cytotoxic drugs connected by *** innovative compounds enable precise drug delivery to tumor cells,minimizing harm to normal tissues and offering excellent prospects for cancer ***,monoclonal antibody-based ADCs still present challenges,especially in terms of balancing efficacy and *** antibodies are alternatives to monoclonal antibodies and exhibit superior internalization and selectivity,producing ADCs with increased safety and therapeutic *** this review,we present available evidence and future prospects regarding the use of bispecific ADCs for cancer treatment,including a comprehensive overview of bispecific ADCs that are currently in clinical *** offer insights into the future development of bispecific ADCs to provide novel strategies for cancer treatment.

关键词： antibody-drug conjugate bispecific antibody bispecific ADC cancer

Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

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Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu Pan-Pan Zhou xue-Zhang Xiao Jia-Cheng Qi Jia-Peng Bi Tiao Ying Xing-Wen feng Yan Shi Wen-Hua luo Li-Xin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable *** this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation *** performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 ***,unique phase transition behaviors were presented in Zr_(2)Co-H ***,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and *** the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free ***,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li Yu-Shi Jiang xue-Ling luo Xuming Ran Yuqiang Li Dong Wu Cheng-xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-feng luo Wei-Hai Chen Xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy Drug carriers Biomaterials Nanotechnology

IP-Pealing: A Robust Network Flow Watermarking Method Based on IP Packet Sequence

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Chinese Journal of Electronics 2024年第3期33卷 694-707页

作者： Wangxin feng Xiangyang luo Tengyao LI Chunfang YANG State Key Laboratory of Mathematical Engineering and Advanced Computing Key Laboratory of Cyberspace Situation Awareness of Henan Province

Network flow watermarking(NFW) is usually used for flow *** actively modulating some features of the carrier traffic,NFW can establish the correspondence between different network *** the face of strict demands of network traffic tracing,current watermarking methods cannot work efficiently due to the dependence on specific protocols,demand for large quantities of packets,weakness on resisting network channel interferences and so *** this end,we propose a robust network flow watermarking method based on IP packet sequence,called as *** is designed to utilize the packet sequence as watermark carrier with IP identification field which is insensitive to time jitter and suitable for all IP based *** enhance the robustness against packet loss and packet reordering,the detection sequence set is constructed in terms of the variation range of packet sequence,correcting the possible errors caused by the network *** improve the detection accuracy,the long watermark information is divided into several short sequences to embed in turn and assembled during *** a large number of experiments on the Internet,the overall detection rate and accuracy of IP-Pealing reach 99.91% and 99.42%*** comparison with the classical network flow watermarking methods,such as PROFW,IBW,ICBW,WBIPD and SBTT,the accuracy of IP-Pealing is increased by 13.70% to 54.00%.

关键词： Protocols Packet loss Watermarking Telecommunication traffic Jitter Robustness Internet

Emerging delivery systems based on aqueous two-phase systems:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 110-132页

作者： Yaowen Zhang Yankun luo Jingqi Zhao Wenzhuo Zheng Jun Zhan Huaping Zheng feng luo State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China School of StomatologySichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Dermatology Rare Diseases CenterInstitutes for Systems GeneticsFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

The aqueous two-phase system(ATPS)is an all-aqueous system fabricated from two immiscible aqueous *** is spontaneously assembled through physical liquid-liquid phase separation(LLPS)and can create suitable templates like the multicompartment of the intracellular *** structures containing multiple compartments make it possible to endow materials with advanced *** to the properties of ATPSs,ATPS-based drug delivery systems exhibit excellent biocompatibility,extraordinary loading efficiency,and intelligently controlled content release,which are particularly advantageous for delivering drugs in ***,we will systematically review and evaluate ATPSs as an ideal drug delivery *** on the basic mechanisms and influencing factors in forming ATPSs,the transformation of ATPSs into valuable biomaterials is ***,we concentrate on the most recent cutting-edge research on ATPS-based delivery ***,the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treatment is also explored.

关键词： Aqueous two-phase systems Drug delivery systems Biomaterials Microcapsules Microparticles Cell therapy Cancer treatment Organ regeneration

Migration and distribution characteristics of soil heavy metal(loid)s at a lead smelting site

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Journal of Environmental Sciences 2024年第1期135卷 600-609页

作者： Chuxuan Li Mu Li Jiaqing Zeng Shanxin Yuan Xinghua luo Chuan Wu Shengguo xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution Central South UniversityChangsha 410083China

Heavy metal(loid)s contamination is a constant issue at smelting *** is essential to investigate the spatial distribution and migration characteristics of heavy metal(loid)s in the soil for environmental management and remediation strategies of non-ferrous smelting *** this study,203 soil samples from 57 sites were collected in a typical lead smelting *** findings demonstrated that there were significant Pb,Zn,Cd,and As contamination in soil *** spatial distribution of heavy metal(loid)s showed strong spatial heterogeneity,the contaminated soil areas of Pb,As,Cd,and Zn were 99.5%,98.9%,85.3%,and 72.4%,***,Cd,and As contamination of the soil reached a depth of 5 m,which migrated from the surface to deep soil *** leaching contents of Zn,Pb,and As decreased obviously in 3-4 m soil layer,but the leaching content of Cd was still high,which indicated the high migration of *** the increase of depth,the proportion of acid soluble fraction of heavy metal(loid)s decreased,and the residual fraction *** acid soluble fraction of Cd accounted for a higher proportion,and As mainly existed in reducible and residual fractions in *** to the calculation of the migration factor,the migration of heavy metal(loid)s in soils were ordered as Cd>Zn>Pb>*** outcomes are advantageous for risk reduction and site remediation for non-ferrous metal smelting sites.

关键词： Smelting sites Heavy metal(loid)s Spatial distribution Chemical speciation Migration characteristics