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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2563-2574页

作者： Li LI Yu-tong CHEN Lei-xin YUAN Fen luo Zhi-xue feng Xiao-qiang LI School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013China National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China

A novel micro-nano Ti−10Cu−10Ni−8Al−8Nb−4Zr−1.5Hf filler was used to vacuum braze Ti−47Al−2Nb−2Cr−0.15B alloy at 1160−1220℃ for 30 *** interfacial microstructure and formation mechanism of TiAl joints and the relationships among brazing temperature,interfacial microstructure and joint strength were emphatically *** show that the TiAl joints brazed at 1160 and 1180℃ possess three interfacial layers and mainly consist of α_(2)-Ti_(3)Al,τ_(3)-Al_(3)NiTi_(2) and Ti_(2)Ni,but the brazing seams are no longer layered and Ti_(2)Ni is completely replaced by the uniformly distributed τ_(3)-Al_(3)NiTi_(2) at 1200 and 1220℃ due to the destruction of α_(2)-Ti_(3)Al barrier *** transformation at 1200℃ obviously improves the tensile strength of the joint and obtains a maximum of 343 ***,the outward diffusion of Al atoms from the dissolution of TiAl substrate dominates the microstructure evolution and tensile strength of the TiAl joint at different brazing temperatures.

关键词： γ-TiAl alloy micro-nano filler vacuum brazing interfacial microstructure tensile strength

Grain boundary-induced drastic sensing performance enhancement of Fe2O3 gas sensors for acetone

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Rare Metals 2024年第9期43卷 4412-4424页

作者： Tian-Jun Hu Yi-Fan Li Yu-Zhu Tian Ying Wang Ya-Ru Chen Jun-Ming Zhang Er-Gui luo Jian-feng Jia Key Laboratory of Magnetic Molecules & Magnetic Information Materials Ministry of Education School of Chemical and Material ScienceShanxi Normal University

Exploring the structure-activity relationship between the performance of gas sensors and the structure of semiconductor metal oxide （SMO） nanomaterials is crucial for understanding and designing gas-sensing materials and overcoming the application limitations of SMO-based gas *** of a single SMO microstructure provides a promising solution to address this scientific problem due to its controllable *** this study,we control the grain boundary （GB） density of Fe2O3nanomaterials using a simple solvothermal *** have similar chemical compositions and crystal phases,providing an ideal platform for studying the influence of the GB density on the gas-sensing ***-sensing tests showed that the Fe2O3-1 sensor with medium GB density and the Fe2O3-2 sensor with high GB density had higher sensitivity and selectivity than the Fe2O3-0 sensors with low GB density before reaching the optimal operating ***,when the GB density increased,the response to acetone decreased slightly,whereas the optimal operating temperature *** work highlights the unique performance of the GB density in enhancing the gas sensitivity of a single SMO.

关键词： Charge transfer Gas sensors Grain boundary (GB) density Oxygen adsorption Semiconductor metal oxide (SMO)

Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury

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Chinese Chemical Letters 2024年第2期35卷 323-328页

作者： Qiu Wang Qikun Jiang Dan Li Zimeng Yang Lin Gao Fan Liu Chang Li Yao feng Zhonggui He Cong luo Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Kangya of Ningxia Pharmaceutical Co.Ltd. Yinchuan 750000China

Small interfering RNA(siRNA)-based gene silencing has been considered as a potential therapy modality against inflammatory ***,the effective delivery of siRNA to desired destination still remains challenging due to poor stability,high molecular weight and negative ***,ionizable lipid nanoparticle(LNP)has been extensively used as vector for effective delivery of ***,we report a mannose-modified LNP(M-MC_(3) LNP@TNFα)loading tumor necrosis factorα(TNFα)siRNA for targeting liver macrophages,achieving effectively inhibit acute liver *** M-MC_(3) LNP@TNFαnot only increases the internalization of LNP by macrophages,but also enhances the gene silencing efficiency of TNFαin ***,the M-MC_(3) LNP@TNFαexhibits higher accumulation in liver of healthy mice than that of MC_(3) LNP@TNFα(un-modified LNP)owing to the targeting effect of *** expected,the M-MC_(3) LNP@TNFαsignificantly suppresses the expression of TNFαand ameliorates liver damage in acute liver injury *** a LNP targeting siRNA delivery holds great potential for the treatment of diseases associated with liver in the future.

关键词： Lipid nanoparticle Targeting siRNA delivery Acute liver injury Gene silencing Tumor necrosis factorα

Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars

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Chinese Chemical Letters 2024年第10期35卷 511-515页

作者： xue-Zhi Wang Yi-Tong Liu Chuang-Wei Zhou Bei Wang Dong luo Mo Xie Meng-Ying Sun Yong-Liang Huang Jie luo Yan Wu Shuixing Zhang Xiao-Ping Zhou Dan Li Department of Radiology The First Affiliated Hospital Jinan University College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University Department of Medicinal Chemistry Shantou University Medical College Department of Anesthesiology The First Affiliated Hospital of Sun Yat-sen University

Post-synthetic installation strategy is an effective approach to improve the functions of metal-organic frameworks（MOFs）. Herein, a pair of chiral MOFs is successfully constructed through solvothermal subcomponent self-assembly and exhibit circularly polarized luminescence（CPL）. These MOFs contain coordinatively unsaturated Zn sites and channels, which allow the installation of pyridyl-terminated pillars into the original structure. Such a post-synthetic installation process reinforces the MOFs' rigidity and increases the photoluminescence quantum yields（PLQYs）. Furthermore, the luminescence dissymmetry factors(glum) of these post-modified MOFs are amplified after installing the pillars. This work provides an appealing strategy for boosting the CPL performance of chiral MOFs.

关键词： Chiral metal-organic frameworks Chirality transfer Circularly polarized luminescence Post-synthetic installation Pyridyl-terminated pillars

In Situ Polymer Gel Electrolyte in Boosting Scalable Fibre Lithium Battery Applications

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Nano-Micro Letters 2024年第11期16卷 170-173页

作者： Jie luo Qichong Zhang Key Laboratory of Multifunctional Nanomaterials and Smart Systems Chinese Academy of SciencesSuzhou Institute of Nano-Tech and Nano-Bionics398 Ruoshui RoadSuzhou 215123People’s Republic of China

The poor interfacial stability not only deteriorates fibre lithium-ion batteries(FLBs)performance but also impacts their scalable *** efficiently address these challenges,*** Peng team proposed a generalized channel structures strategy with optimized in situ polymerization technology in their recent *** resultant FLBs can be woven into different-sized powering textiles,providing a high energy density output of 128 Wh kg^(-1) and simultaneously demonstrating good durability even under harsh *** a promising strategy expands the horizon in developing FLB with particular polymer gel electrolytes,and significantly ever-deepening understanding of the scaled wearable energy textile system toward a sustainable future.

关键词： High-performance fibre lithium batteries Gel electrolytes Channel structures Stable interface Scalable application

The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang feng Chuanjia Zhai xuejiao Li Yulian Shi Xiang Li Miao Li Ying Wang Gan luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

Catalyst design and structure control for photocatalytic refineries of cellulosic biomass to fuels and chemicals

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Journal of Energy Chemistry 2024年第7期94卷 102-127页

作者： Lulu Sun Nengchao luo State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Lignocellulosic biomass is the largest renewable hydrocarbon resource on *** cellulose,one of the major components of lignocellulose,powered by solar energy is a promising way of providing lowcarbon-footprint energy chemicals such as H_(2),HCOOH,CO,and transportation ***-of-the-art biorefineries target the full use of biomass feedstocks as they have a maximum collection radius of 75-100 km,requesting efficient and selective photocatalysts that significantly influence the outcome of photocatalytic ***-performed photocatalysts can harvest a broad solar spectrum and are active in breaking the chemical bonds of cellulose,decreasing the capital investments of ***,photocatalysts should control the selectivity of cellulose conversion,originating target products to level down separation *** separation in photocatalysts and interfacial charge transfer between photocatalysts and cellulose affect the activity and selectivity of cellulose refineries to H2 and carbonaceous *** account for the challenges above,this review summarizes photocatalysts for the refineries of cellulose and downstream platform molecules based on the types of products,with the structure features of different types of photocatalysts discussed in relation to the targets of either improving the activity or product *** addition,this review also sheds light on the methods for designing and regulating photocatalyst structures to facilitate photocatalytic refineries of cellulose and platform molecules,meanwhile summarizing proposed future research challenges and opportunities for designing efficient photocatalysts.

关键词： Photocatalysts Biorefineries Cellulose Fuels Hydrogen

Ginsenoside modified lipid-coated perfluorocarbon nanodroplets: A novel approach to reduce complement protein adsorption and prolong in vivo circulation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1845-1863页

作者： Jie Zhou Binyang Gao Huan Zhang Rui Yang Jianbo Huang Xin Li Yi Zhong Yan Wang Xiaoxia Zhu Yan luo feng Yan Ultrasound Department of West China Hospital Sichuan UniversityChengdu 610041China Laboratory of Ultrasound Imaging of West China Hospital Sichuan UniversityChengdu 610041China West China Washington Mitochondria and Metabolism Research Center West China HospitalSichuan UniversityChengdu 610041China Research Core Facilities of West China Hospital Sichuan UniversityChengdu 610041China

Lipid-coated perfluorocarbon nanodroplets(lp-NDs)hold great promise in bio-medicine as vehicles for drug delivery,molecular imaging and vaccine ***,their clinical utility is restricted by limited targeted accumulation,attributed to the innate immune system(IIS),which acts as the initial defense mechanism in *** study aimed to optimize lp-ND formulations to mini-mize non-specific clearance by the ***(Gs),the principal components of Panax ginseng,possessing complement inhibition ability,structural similarity to cholesterol,and comparable fat solubi-lity to phospholipids,were used as promising candidate IIS *** different types of ginsenoside-based Ip-NDs(Gs Ip-NDs)were created,and their efficacy in reducing IS recognition was *** Gs p-NDs were observed to inhibit the adsorption of C3 in the protein corona(PC)and the generation of *** Gs to Ip-NDs reduced complement adsorption and phagocytosis,resulting in a longer blood circulation time in vivo compared to lp-NDs that did not contain *** results suggest that Gs can act as anti-complement and anti-phagocytosis adjuvants,potentially reducing non-specific clear-ance by the IS and improving lifespan.

关键词： Lipid-coated perfluorocarbon nanodroplets Protein corona Complement C3 Phagocytosis Ginsenosidelipid-coated perfluorocarbon nanodroplets Innate immune system Complement system Mononuclear phagocytic system

Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

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Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang xueying Huang Guoying Sun Jingwen Chen Bangguo Wu Jiahui luo Shuyan Tang Peng Dai feng Zhang Jinsong Li Lingbo Wang Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful *** deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental ***,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is ***,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are *** Ccdc38-KO sperm display acrosomal hypoplasia and typical MMAF *** find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-KO *** analyses reveal that Ccdc38 knockout causes a decreased level of TEKT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEKT3 in *** finally show that intracytoplasmic sperm injection overcomes Ccdc38-related *** study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng Li feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua luo Wenping Song Yong-Tang Zheng Tianlei Ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein