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野菊中一个新的吉马烷型倍半萜

天然产物研究与开发 2024年第6期36卷 963-967页

作者：潘浩薛金凤贾瑶瑶卢纪衡袁雨洁冯卫生吴亚薛贵民河南中医药大学药学院河南省中药开发工程技术研究中心郑州450046

研究野菊Chrysanthemum indicum L.地上部分中萜类成分及其抗炎活性。采用MCI、ODS、SephadexLH-20凝胶柱色谱和pre-HPLC等方法分离纯化,再通过对其波谱数据分析鉴定化合物的结构。从野菊二氯甲烷提取物中分离纯化得到6个单体化合物,分... 详细信息

研究野菊Chrysanthemum indicum L.地上部分中萜类成分及其抗炎活性。采用MCI、ODS、SephadexLH-20凝胶柱色谱和pre-HPLC等方法分离纯化,再通过对其波谱数据分析鉴定化合物的结构。从野菊二氯甲烷提取物中分离纯化得到6个单体化合物,分别是chrygermalide A(1)、3β-hydroxy-oxo-7α,11β-germacra-4 Z,10(14)-diene-12,6α-olide(2)、deacetylherbolide A(3)、9β-hydroxy costunolide(4)、3β-hydroxycostunolide(5)、3β-hydroxy-11α,13-dihydrocos-tunolide(6)。其中化合物1为新化合物,2~6为首次从该属植物中分离得到。采用LPS诱导RAW 264.7巨噬细胞的炎症模型测试了化合物1~6的抗炎活性,其NO抑制率IC 50值在17.9~33.9μmol/L之间。

关键词：野菊化学成分倍半萜类抗炎活性

sICAM-1和miR-155与miR-141对糖尿病肾病血液透析并发血流感染的预测价值

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中华医院感染学杂志 2024年第8期34卷 1168-1172页

作者：严文静曹小云彭俊琼薛金凤王若愚江南大学附属医院血液净化中心江苏无锡214122 江南大学附属医院肾脏内科江苏无锡214122

目的研究血清可溶性细胞间黏附分子-1(sICAM-1)、外周血微小核糖核酸-155(miR-155)、微小核糖核酸-141(miR-141)对糖尿病肾病(DN)血液透析并发血流感染的预测价值及患者感染病原菌分布情况。方法选取2018年6月-2022年9月江南大学附属医... 详细信息

目的研究血清可溶性细胞间黏附分子-1(sICAM-1)、外周血微小核糖核酸-155(miR-155)、微小核糖核酸-141(miR-141)对糖尿病肾病(DN)血液透析并发血流感染的预测价值及患者感染病原菌分布情况。方法选取2018年6月-2022年9月江南大学附属医院收治的119例DN血液透析并发血流感染患者作为B组,收集同期在医院接受治疗的132例DN血液透析未并发血流感染患者作为A组,统计两组一般资料,比较两组血清sICAM-1、外周血miR-155、miR-141表达情况,采用受试者工作特征(ROC)曲线分析血清sICAM-1、外周血miR-155、miR-141单独及联合对DN血液透析患者并发血流感染的预测价值,统计DN血液透析并发血流感染患者感染病原菌分布情况。结果B组血清sICAM-1、外周血miR-155、miR-141表达水平高于A组(P<0.05);血清sICAM-1、外周血miR-155、miR-141联合预测DN血液透析患者并发血流感染的曲线下面积(AUC)值高于三者单独预测(P<0.05),敏感度高于血清sICAM-1、外周血miR-141(P<0.05),特异度低于血清sICAM-1、外周血miR-141(P<0.05);DN血液透析并发血流感染患者革兰阴性菌占比63.71%,革兰阳性菌占比33.06%,真菌占比3.23%。结论血清sICAM-1、外周血miR-155、miR-141联合对DN血液透析患者并发血流感染具有较好的预测价值,同时DN血液透析并发血流感染患者主要感染病原菌种类较多。

关键词：糖尿病肾病血液透析血流感染可溶性细胞间黏附分子-1 微小核糖核酸-155 微小核糖核酸-141 病原菌

我国中部水网区茭白潜流湿地进出水质和净化性能时变特征

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环境生态学 2024年第2期6卷 107-112,152页

作者：马彦涛曾志武杜征宇薛金凤中国电力工程顾问集团中南电力设计院有限公司湖北武汉430071 武汉大学动力与机械学院湖北武汉430072

本研究从小集水区角度研究了茭白潜流湿地进出水氮、磷、COD_(Cr)污染和净化性能的时变特征,结果表明,茭白潜流湿地进水氮、磷、COD_(Cr)季节波动大,其中春节期间湿地进水总氮(TN)和总磷(TP)最高,其次是农田施用化肥后产生地表径流的首... 详细信息

本研究从小集水区角度研究了茭白潜流湿地进出水氮、磷、COD_(Cr)污染和净化性能的时变特征,结果表明,茭白潜流湿地进水氮、磷、COD_(Cr)季节波动大,其中春节期间湿地进水总氮(TN)和总磷(TP)最高,其次是农田施用化肥后产生地表径流的首月,中等降雨量下湿地进水COD_(Cr)浓度高于强暴雨下的浓度。受沉淀池的调节缓冲,湿地进水氨氮(NH_(3)-N)和硝态氮(NO_(x)^(-)-N)秋季最高,其次是春节后。湿地对小集水区氮、磷、COD_(Cr)冲击负荷均具有良好的缓冲能力和净化性能,TP、TN和COD_(Cr)平均去除率分别为(82.1±10.5)%、(72.9±8.1)%和(65.6±6.2)%;秋冬季过渡期间,因微生物降解和基质吸附的协同作用使得植物吸收氮磷的季节拐点不明显;冬季湿地具有耐受中部水网区低温的能力。不过冬季低温易于引起潜流湿地内有机氮分解转变为NH_(3)-N后被沸石等基质吸附而发生积聚,同时较长水力停留时间(HRT)下因有机质分解耗氧引起环境厌氧的加剧。此外,冬季出水溶解有机磷(DOP)比例增加。该潜流湿地可有效提升村镇面源污染排水水质,改善乡村水环境,但对上述受季节影响较大的时变因素应加强管控。

关键词：潜流湿地茭白氮磷 COD_(Cr) 降雨径流季节变化

Network Pharmacology Based Elucidation of Molecular Mechanisms of Laoke Formula for Treatment of Advanced Non-Small Cell Lung Cancer

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Chinese Journal of Integrative Medicine 2024年第11期30卷 984-992页

作者： feng Yu-yu LIU jin-feng xue Yang LIU Dan WU Xiong-zhi Department of Nursing Tangshan Vocational and Technical College School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Department of Oncology Tianjin Medical University General Hospital Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for China Tianjin Nankai Hospital Tianjin Medical University

Objective: To explore the specific pharmacological molecular mechanisms of Laoke Formula(LK)on treating advanced non-small cell lung cancer(NSCLC) based on clinical application, network pharmacology and experimental validation. Methods: Kaplan-Meier method and Cox regression analysis were used to evaluate the survival benefit of Chinese medicine(CM) treatment in 296 patients with NSCLC in Tianjin Medical University Cancer Institute and Hospital from January 2011 to December 2015. The compounds of LK were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and the corresponding targets were performed from Swiss Target Prediction. NSCLC-related targets were obtained from Therapeutic Target Database and Comparative Toxicogenomics Database. Key compounds and targets were identified from the compound-target-disease network and protein-protein interaction(PPI) network analysis, respectively. Kyoto Encyclopedia of Genes and Genomes(KEGG) and Gene Ontology(GO) enrichment analysis were used to predict the potential signaling pathways involved in the treatment of advanced NSCLC with LK. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, A549 cell proliferation and migration assay were used to evaluate the antitumor activity of LK. Western blot was used to further verify the expression of key target proteins related to the predicted pathways. Results: Kaplan-Meier survival analysis showed that the overall survival of the CM group was longer than that of the non-CM group(36 months vs.26 months), and COX regression analysis showed that LK treatment was an independent favorable prognostic factor(P=0.027). Next, 97 components and 86 potential targets were included in the network pharmacology, KEGG and GO analyses, and the results indicated that LK was associated with proliferation and apoptosis. Moreover,molecular docking revealed a good binding affinity between the key

关键词： Chinese medicine LaoKe Formula anti-tumor network pharmacology non-small cell lung cancer

Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

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Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： Yuan-Kai Du Zheng-xue Shi Shan Dong Hui jin xue Ke Pei Zhao Bing-Bing Jiang feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive ***, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

Visible-light-initiated tandem synthesis of difluoromethylated oxindoles in 2-MeTHF under additive-,metal catalyst-,external photosensitizer-free and mild conditions

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Chinese Chemical Letters 2021年第6期32卷 1907-1910页

作者： Qing-Wen Gui Fan Teng Zhou-Chao Li Zhi-Yuan Xiong xue-feng jin Ying-Wu Lin Zhong Cao Wei-Min He College of Chemistry and Materials Science Hunan Agricultural UniversityChangsha 410128China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation Changsha University of Science and TechnologyChangsha 410114China

An efficient and eco-friendly protocol for synthesizing difluoromethylated oxindoles through a visiblelight induced one-pot tandem reaction of N-arylacrylamides,difluoroacetic acid and Ph I(OAc)_(2)was *** reaction proceeded in the absence of any additive,base,metal-catalyst and external photosensitizer,using cheap and easily available CHF_(2)CO_(2)H as the difluoromethylation reagent and bulk biomass-derived 2-Me THF as the sole solvent.26 Examples of N-arylacrylamide substrates were investigated,and all of them successfully underwent difluoromethylation to deliver the target products in good to excellent yields.

关键词： Green chemistry Visible light External photosensitizer-free Tandem reaction 2-MeTHF

Single-atom catalysis for advanced oxidation and reduction systems in water decontamination

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Rare Metals 2024年第8期43卷 3576-3606页

作者： Jie Teng jin-Hui Xu Wen-Xin Sun xue-feng Liu Xia Xu Guo-Shuai Liu School of Urban Construction Changzhou UniversityChangzhou 213164China School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China

Water scarcity is an escalating global crisis,posing a severe threat to populations ***,exploring various materials to remove emerging contaminants from freshwater sources has garnered significant *** this regard,single-atom catalysis(SACs) has emerged as a catalyst of scientific progress in water purification and treatment methodologies during recent *** exhibit exceptional catalytic activity,selectivity and stability,due to their near-perfect atom utilization,highly unsaturated coordination environment and uniform reaction ***,a comprehensive and critical review encompassing the successful integration of SACs into water purification processes needs to be *** review aims to accentuate recent trends by presenting the synthesis,structure,and environment and energy application-relevant properties of *** results show that a comprehensive and multi-perspective summary of the advantages of SACs in environmental remediation can have significant benefits,such as fast kinetics,costeffectiveness,*** oxidation and reduction processes of SACs and functional SACs materials in water purification were ***,the last section is devoted to the current research gaps and further perspectives on the application of SACs in water treatment,which are summarized and analyzed.

关键词： Single-atom catalysis Water treatment Oxidation Reduction

Enhancing the Circularly Polarized Luminescence of Self-assembled Cyanostilbenes through Extended π-Conjugation

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Chinese Journal of Chemistry 2024年第2期42卷 135-141页

作者： Tongjin Lv Song Wu Yu jin Jianfei Ma Sixun Jiang Yuncong xue feng Wang Key Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiAnhui 230026China Department of Thoracic Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Chiral supramolecular assembly of π-conjugated luminophores provides a promising avenue for enhancing circularly polarized *** this study,we shed light on the impact of π-conjugation length on circularly polarized luminescent performance of the resulting supramolecular assemblies,by designing a tetra-cyanostilbene monomeric compound alongside two dicyanostilbene control *** cyanostilbene-based compounds possess the ability to form chiral supramolecular polymers in toluene,driven by a synergistic combination of intermolecular hydrogen bonding and π-stacking *** extended π π-aromatic skeleton brings bathochromic-shifted fluorescence and enhanced intermolecular stacking capability for the tetra-cyanostilbene ***,chiral supramolecular assemblies formed by the tetra-cyanostilbene compound demonstrate a remarkable two-fold increase in g_(lum) values relative to the assemblies formed by the dicyanostilbene ***,this study provides valuable insights into the relationship between-conjugation length and the circularly polarized luminescent performance of π-conjugatedsupramolecularassemblies.

关键词： Self-assembly Supramolecular polymer Supramolecular chirality Circularly polarized luminescence Cyanostilbene πInteractions Aggregation Nanostructures

Improved lower bound for the complexity of unique shortest vector problem

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Cybersecurity 2024年第3期7卷 102-110页

作者： Baolong jin Rui xue State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China

Unique shortest vector problem(uSVP)plays an important role in lattice based *** cryptographic schemes based their security on *** the cofidence of those applications,it is essential to clarify the complex-ity of uSVP with different ***,proving the NP-hardness of usVP appears quite *** the state of the art,we are even not able to prove the NP-hardness of usVP with constant *** this work,we gave a lower bound for the hardness of usVP with constant parameters,*** proved that uSVP is at least as hard as gap shortest vector problem(GapSVP)with gap of O(√n/log(n)),which is in NP n *** previous works,our reduction works for paramters in a bigger range,especially when the constant hidden by the big-O in GapsVP is smallerthan1.

关键词： Computational complexity Unique shortest vector problem Bounded distance decoding Complexity reduction