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Stem cell therapy: A promising treatment for COVID-19

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World Journal of Clinical Cases 2021年第36期9卷 11148-11155页

作者： Zhi-xue zheng Department of General Surgery Beijing Jishuitan HospitalBeijing 100035China

Novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a global ***-2 is an RNA virus and has a glycosylated spike(S)protein used for genome ***-19 can lead to a cytokine storm and patients usually have early respiratory signs and further secondary infections,which can be ***-19 has entered an emergency phase,but there are still no specific effective drugs for this *** stem cells(MSCs)are multipotent stromal cells,which cause antiapoptosis and can repair damaged epithelial *** clinical trials have proved that MSC therapy could be a potential feasible therapy for COVID-19 patients,especially those with acute respiratory distress syndrome,without serious adverse events or ***,more studies are needed in the future,in order to confirm the effect of this therapy.

关键词： COVID-19 SARS-CoV-2 Mesenchymal stem cells Pandemic Stem cell therapy

Solution-based Chemical Strategies to Purposely Control the Microstructure of Functional Materials

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Journal of Materials Science & Technology 2008年第4期24卷 641-648页

作者： fei LIU Congting SUN Chenglin YAN Dongfeng xue State Key Laboratory of Fine Chemicals Department of Materials Science and Chemical Engineering School of Chemical Engineering Dalian University of Technology Dalian 116012 China

Micro/nanostructured crystals with controlled architectures are desirable for many applications in optics, electronics, biology, medicine, and energy conversions. Low-temperature, aqueous chemical routes have been widely investigated for the synthesis of particles, and arrays of oriented nanorods and nanotubes. In this paper, based on the ideal crystal shapes predicted by the chemical bonding theory, we have developed some potential chemical strategies to tune the microstructure of functional materials, ZnS and Nb205 nanotube arrays, MgO wiskers and nestlike spheres, and cubic phase Cu2O microcrystals were synthesized here to elucidate these strategies. We describe their controlled crystallization processes and illustrate the detailed key factors controlling their growth by examining various reaction parameters. Current results demonstrate that our designed chemical strategies for tuning microstructure of functional materials are applicable to several technologically important materials, and therefore may be used as a versatile and effective route to the controllable synthesis of other inorganic functional materials.

关键词： Functional materials Chemical strategy Chemical bonding theory Microstructure

Effect of Working Position on Vertical Motion Straightness of Open Hydrostatic Guideways in Grinding Machine

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Chinese Journal of Mechanical Engineering 2017年第1期30卷 46-52页

作者： ZHA JUn WANG Zhiwei xue fei CHEN Yaolong State Key Laboratory for Manufacturing Systems Engineering Xi 'an Jiaotong University Xi 'an 710049 China College of Mechanical and Electronic Engineering Shandong University of Science and Technology Qingdao 266590 China

Hydrostatic guideways have various applications in precision machine tools due to their high motion accuracy. The analysis of motion straightness in hydrostatic guideways is generally ignoring the external load on the slider. A variation force also exists, caused by the different working positions, together with the dead load of the slider and that of other auxiliary devices. The effect of working position on vertical motion straightness is investigated based on the equivalent static model, considering the error averaging effort of pressured oil film in open hydrostatic guideways. Open hydrostatic guideways in LGF1000 are analyzed with this approach. The theoretical results show that the slider has maximum vertical motion straightness when the working position is closer the guiderail of Y axis. The vertical motion straightness reaches a minimum value as the working position is located at the center of the two guiderails on the Y axis. The difference between the maximum and minimum vertical motion straightness is 34.7%. The smaller vertical motion straightness is attributed to the smaller spacing of the two pads centers, along the Y direction. The experimental results show that the vertical motion straightness is 4.15 μm/1200 mm, when the working position is located in the middle of the Xbeam, and 5.08 pro/1200 mm, when the working position is approaching the Y guiderails, denoting an increase of 18.3%. The changing trends of the measured results validate the correctness of the theoretical model. The research work can be used to reveal the variation law of accuracy of the open hydrostatic guideways, under different working positions, to predict the machining precision, and provides the basis for an error compensation strategy for gantry type grinding machines.

关键词： open hydrostatic guideways error averaging vertical motion straightness working position

Intermodel Diversity of Simulated Long-term Changes in the Austral Winter Southern Annular Mode:Role of the Southern Ocean Dipole

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Advances in Atmospheric Sciences 2021年第3期38卷 375-386页

作者： fei zheng Jianping LI Shuailei YAO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 10029China Frontiers Science Center for Deep Ocean Multispheres and Earth System(FDOMES)/Key Laboratory of Physical Oceanography/Institute for Advanced Ocean Studies Ocean University of ChinaQingdao 266100China Laboratory for Ocean Dynamics and Climate Pilot Qingdao National Laboratory for Marine Science

The Southern Annular Mode(SAM)plays an important role in regulating Southern Hemisphere extratropical ***-of-the-art models exhibit intermodel spread in simulating long-term changes in the *** from Atmospheric Model Intercomparison Project(AMIP)experiments from 28 models archived in CMIP5 show that the intermodel spread in the linear trend in the austral winter(June−July−August)SAM is significant,with an intermodel standard deviation of 0.28(10 yr)−1,larger than the multimodel ensemble mean of 0.18(10 yr)−*** study explores potential factors underlying the model difference from the aspect of extratropical sea surface temperature(SST).Extratropical SST anomalies related to the SAM exhibit a dipole-like structure between middle and high latitudes,referred to as the Southern Ocean Dipole(SOD).The role of SOD-like SST anomalies in influencing the SAM is found in the AMIP *** performance in simulating the SAM trend is linked with model skill in reflecting the SOD−SAM *** with stronger linkage between the SOD and the SAM tend to simulate a stronger SAM *** explained variance is about 40%in the AMIP *** results suggest improved simulation of the SOD−SAM relationship may help reproduce long-term changes in the SAM.

关键词： Southern Annular Mode Southern Ocean Dipole intermodel spread air−sea interactions

VBMq： pursuit baremetal performance by embracing block I/O parallelism in virtualization

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Frontiers of Computer Science 2018年第5期12卷 873-886页

作者： Diming ZHANG fei xue Hao HUANG Shaodi YOU Faculty of Computer Science and Technology Nanjing University Nanjing 210023 China College of Computer Science and Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China College of Engineering and Computer Science Australian National University Canberra 2600 Australia Data61-CSIRO Australian National University Canberra 2600 Australia

Barely acceptable block I/O performance prevents virtualization from being widely used in the HighPerformance Computing field. Although the virtio paravirtual framework brings great I/O performance improvement, there is a sharp performance degradation when accessing high-performance NAND-flash-based devices in the virtual machine due to their data parallel design. The primary cause of this fact is the deficiency of block I/O parallelism in hypervisor, such as KVM and Xen. In this paper, we propose a novel design of block I/O layer for virtualization, named VBMq. VBMq is based on virtio paravirtual I/O model, aiming to solve the block I/O parallelism issue in virtualization. It uses multiple dedicated I/O threads to handle I/O requests in parallel. In the meanwhile, we use polling mechanism to alleviate overheads caused by the frequent context switches of the VM＇s notification to and from its hypervisor. Each dedicated I/O thread is assigned to a non-ovedapping core to improve performance by avoiding unnecessary scheduling. In addition, we configure CPU affinity to optimize I/O completion for each request. The CPU affinity setting is very helpful to reduce CPU cache miss rate and increase CPU efficiency. The prototype system is based on Linux 4.1 kernel and QEMU 2.3.1. Our measurements show that the proposed method scales graciously in the multi-core environment, and provides performance which is 39.6x better than the baseline at most, and approaches bare-metal performance.

关键词： high-performance parallelism paravirtual I/O

Active Collision Avoidance System Design Based on Model Predictive Control with Varying Sampling Time

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Automotive Innovation 2020年第1期3卷 62-72页

作者： Wanying xue Ling zheng Automobile Engineering Department Chongqing UniversityChongqing 400044China The State Key Laboratory of Mechanical Transmission Chongqing 400044China

In active collision avoidance,the trajectory tracking controller determines the deviation from the reference path and the vehicle *** main objective of this study was to reduce the tracking error and improve the tracking performance in collision *** the previously proposed model predictive control(MPC)strategies with constant sampling time,an improved MPC controller with varying sampling time based on the hierarchical control framework was proposed in this *** with the original MPC tracking controller,the improved MPC controller demonstrated better adaptive capability for the varying road adhesion coefficients and vehicle speed on a curved *** simulation results revealed that the hierarchical control framework generated an optimal trajectory for collision avoidance in real-time by minimizing the potential field energy.

关键词： Active collision avoidance Improved MPC controller Varying sampling time Tracking control

IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy

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Chinese Journal of Polymer Science 2023年第7期41卷 1059-1068页

作者： Xiao-Shuang Wang Zhao-Shi zheng Meng-fei zheng Di Wang Hong-Lei Zhang Zhen-Qian Zhang Zhi-Lin Liu Zhao-Hui Tang xue-Mei Han No.1 Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchun130033China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Jilin Biomedical Polymers Engineering Laboratory Changchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education and Key Laboratory of Polymeric Materials&Application Technology of Hunan Province Xiangtan UniversityXiangtan411105China

Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transient proliferation of the anti-cancer CD8+ T cells can be achieved, resulting in poor efficacy. Therefore, the aim of this work was to create a system that promotes CD8+ T cell proliferation at the tumor site using IL-2 persistently present and activates an anti-cancer immune response. This goal was achieved by the design of the IL-2-loaded polypeptide nanoparticles (P-IL-2) where methoxy poly(ethylene glycol) block poly-[(N-2-hydroxyethyl)-aspartamide] phenylboronic acid was used to encapsulate IL-2 through boron-nitrogen coordination with poly(L-lysine). P-IL-2 significantly prolonged the circulation time of IL-2 and achieved a selective drug release at the tumor site in the presence of high levels of reactive oxygen species, thus activating an anti-cancer immune response and exerting a better anti-cancer effect. The half-life of P-IL-2 was 3.15-fold higher than that of IL-2, and the quantity of CD8+ T cells after using P-IL-2 was 1.89-fold higher than that after using IL-2. In addition, the combination of P-IL-2 and anti-CTLA-4 monoclonal antibody resulted in an enhanced immune activation. Hence, this work provides a new approach to improve the efficacy of IL-2 in anti-cancer immunotherapy.

关键词： Polypeptide Phenylboronic acid Boron-nitrogen coordination Interleukin 2 ROS-responsive

Discovering the relationship of disasters from big scholar and social media news datasets

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International Journal of Digital Earth 2019年第11期12卷 1341-1363页

作者： Liang zheng fei Wang Xiaocui zheng Binbin Liu Institute of Safety Science and Technology Department of Engineering PhysicsShenzhen Graduate SchoolTsinghua UniversityShenzhenPeople’s Republic of China

The construction method for chains of disasters or events is still one of the core scientific questions in studying the common rules of disaster’s *** when dealing with the complexity and diversity of disasters,it is critical to make a further investigation on reducing the dependency of prior knowledge and supporting the comprehensive chains of *** paper tries to propose a novel approach,through collecting the big scholar and social news data with disasterrelated keywords,analysing the strength of their relationships with the co-word analysis method,and constructing a complex network of all defined disaster types,in order to finally intelligently extract the unique disaster chain of a specific disaster *** Scholar,Baidu Scholar and Sina News search engines are employed to acquire the needed data,and the respectively obtained disaster chains are compared with each other to show the robustness of our proposed *** achieved disaster chains are also compared with the ones concluded from existing research methods,and the very reasonable result is *** is a great potential to apply this novel method in disaster management domain to find more secrets about disasters.

关键词： Disaster chain co-occurrence analysis co-word analysis community division complex network data mining disaster management

A Fair Off-Line E-Cash System with Group Signature

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Wuhan University Journal of Natural Sciences 2004年第5期9卷 745-748页

作者： SUYun-xue ZHUYue-fei NetEngineeringDepartmentofPLAInformationEngineeringUniversity Zhengzhou450002HenanChina

This paper describes the research results and development of fair off-line e-cash systems so far, and points out that in these systems, the bank can compute the double-spender’s account secret key, thus the bank can impersonate the double-spender to withdraw from the double-spender’s account. This article utilizes anonymity control and group signature to address this shortcoming. Key words electronic cash - anonymity control - group signature CLC number TP 309 Foundation item: Supported by the National Natural Science Fundation of China (90204015)Biography: SU Yun-xue (1975-), male, Ph. D. research direction: the software and theory of computer and information security.

关键词： electronic cash anonymity control group signature