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基于耦合界面键合效应的石墨烯磨损研究

原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

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马立克病病毒单克隆抗体的制备

中国兽医科学 2018年第9期48卷 1102-1108页

作者：宋利娜滕蔓郑鹿平李会珍朱志坚薛正飞郅玉宝罗俊张改平河南农业大学牧医工程学院河南郑州450002 河南省农业科学院农业部动物免疫学重点实验室河南省动物免疫学重点实验室河南郑州450002 河南科技大学动物科技学院动物疫病与公共安全重点实验室河南洛阳471003 扬州大学江苏高校动物重要疫病与人兽共患病防控协同创新中心江苏扬州225009

以纯化的经鸡胚成纤维细胞（CEF）培养的马立克病病毒（MDV）超强毒株GX0101病毒粒子作为免疫原，制备特异性识别MDV的单克隆抗体。GX0101感染CEF后第96小时收集细胞并反复冻融3次，离心取上清，选用100ku的切向流超滤离心管浓缩，浓缩... 详细信息

以纯化的经鸡胚成纤维细胞（CEF）培养的马立克病病毒（MDV）超强毒株GX0101病毒粒子作为免疫原，制备特异性识别MDV的单克隆抗体。GX0101感染CEF后第96小时收集细胞并反复冻融3次，离心取上清，选用100ku的切向流超滤离心管浓缩，浓缩液通过Sepharose 4 Fast Flow（4FF）凝胶作为层析介质分离纯化MDV病毒粒子，聚合酶链反应（PCR）和实时荧光定量PCR分析不同收集峰MDv病毒含量，并经过透射电子显微镜观察到直径约100nm的MDV病毒粒子。进一步用100ku的切向流超滤离心管浓缩,制备峰尖病毒浓缩液，以此免疫雌性BALB／c小鼠制备单克隆抗体。通过免疫过氧化物酶单层细胞试验（IPMA）和Western—blot筛选,最终获得107个阳性克隆。由其中1株强阳性单克隆抗体杂交瘤细胞株1082制备的单克隆抗体腹水1PMA效价为1：2．56×10^6。本研究结果为后续MDV单克隆抗体的筛选、鉴定及诊断试剂研发奠定了重要基础。

关键词：马立克病马立克病病毒单克隆抗体 IPMA

Crystal Structure of a Novel Complex Na_4[Y(PDC)_2(BTC)]·5H_2O with One-Dimensional Helical Network Structure (H2PDC = 2,6-Pyridinedicarboxylic acid)( H_3BTC = 1,3,5-Benzenetricarboxylic acid )

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1181-1185页

作者： xue Xu-fei CHE Yun-Xia xue Lin zheng Ji-Min Department of Chemistry Nankai University Tianjin 300071 China

A novel title complex, C23H19N2O19Na4Y （Mr= 808.27）, has been synthesized by hydrothermal reaction and structurally characterized by X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 13.560（3）, b = 14.016（3）, c = 14.948（4） A, β = 99.492（4）°, Z = 4, V = 2802.2（12） A^3, Dc = 1.916 g/cm^3,μ（MoKα） = 2.241 mm^-1, F（000） = 1624, the final R = 0.0337 and wR = 0.0828 for 4044 observed reflections（I〉 2σ（I））. In the crystal, each eight- coordinated Y（Ⅲ） atom is linked by carboxyl groups of BTC to form a one-dimensional helical network structure.

关键词： 1,3,5-benzenetricarboxylic acid 2,6-pyridinedicarboxylic acid,hydrothermal synthesis crystal structure

Area-efficient analog decoder design for low density parity check codes in deep-space applications

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The Journal of China Universities of Posts and Telecommunications 2017年第4期24卷 69-75页

作者： Zhao Zhe Gao fei zheng Hao Yin xue School of Information and Electronics Beijing Institute of Technology Beijing 100081 China

Area-efficient design methodology is proposed for the analog decoding implementations of the rate-l/2 accumulate repeat-4 jagged-accumulate （AR4JA） low density parity check （LDPC） code. The proposed approach is designed using optimized decoding architecture and regularized routing network, in such a way that the overall wiring overhead is minimized and the silicon area utilization is significantly improved. The prototyping chip used to verily the approach is tully integrated in a four-metal double-poly 0.35 lam complementary metal oxide semiconductor （CMOS） technology, and includes an input-output interface that maximizes the decoder throughput. The decoding core area is 2.02 mm2 with a post-layout area utilization of 80%. The decoder was successfully tested at the maximum data rate of 10 Mbit/s, with a core power consumption of 6.78 mW at 3.3 V, which corresponds to an energy per decoded bit of 0.677 nJ. The proposed analog LDPC decoder with low processing power and high-reliability is suitable lbr space- and power-constrained spacecraft system.

关键词： low density parity check (LDPC) code analog decoding iterative message-passing algorithms hardware efficient area utilization

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

马立克病病毒miR-M4-5p宿主靶基因cDNA文库的构建及鉴定

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畜牧兽医学报 2018年第2期49卷 348-359页

作者：薛正飞滕蔓李会珍马圣明宋利娜张雅罗俊张改平河南农业大学生命科学学院郑州450002 河南省农业科学院动物免疫学重点实验室农业部动物免疫学重点实验室河南省动物免疫学重点实验室郑州450002 河南科技大学动物科技学院动物疫病与公共安全重点实验室洛阳471003

马立克病病毒(MDV)是少数感染自然宿主后可诱发淋巴瘤的疱疹病毒之一,是研究肿瘤发生及发展的理想动物模型。目前已报道MDV可编码数十种miRNA,其中MDV-1编码的miR-M4-5p被鉴定为宿主细胞miR-155的同源物,由于miR-155与人类多种肿瘤性疾... 详细信息

马立克病病毒(MDV)是少数感染自然宿主后可诱发淋巴瘤的疱疹病毒之一,是研究肿瘤发生及发展的理想动物模型。目前已报道MDV可编码数十种miRNA,其中MDV-1编码的miR-M4-5p被鉴定为宿主细胞miR-155的同源物,由于miR-155与人类多种肿瘤性疾病密切相关,这意味着miR-M4-5p可能在MDV的致瘤过程中扮演重要角色。本研究旨在构建miR-M4-5p的宿主靶基因文库并进行初步鉴定。提取鸡胚成纤维细胞(CEF)总RNA,反转录合成cDNA,用hybrid-PCR扩增候选靶基因片段连接到pMD19-T载体,转化大肠杆菌JM109感受态细胞后挑选单克隆进行PCR鉴定及测序,通过BLAST比对分析,共获得88个宿主候选靶基因序列。优先选择miRNA结合靶点位于mRNA 3′-UTR且与miR-M4-5p种子序列(2~7nt)完全互补配对的29个候选靶基因,构建报告基因载体进行双荧光素酶报告试验,通过三轮双荧光素酶报告试验最终初步鉴定5个宿主靶基因:PRICKLE1、COLA、BCAT1、ANTXR1和TECPR1,为进一步揭示miR-M4-5p的分子调控机制奠定了重要基础。

关键词：马立克病病毒 hybrid-PCR miR-M4-5p cDNA文库宿主靶基因肿瘤发生

Sea surface temperature anomaly in the tropical North Atlantic during El Nino decaying years

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Atmospheric and Oceanic Science Letters 2021年第6期14卷 14-19页

作者： Xinyu Duan Feng xue fei zheng International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Climate Center of Meteorological Bureau of Gansu Province LanzhouChina

Based on reanalysis data from 1979 to 2016,this study focuses on the sea surface temperature(SST)anomaly of the tropical North Atlantic(TNA)in El Nino decaying *** TNA SST exhibits a clear warm trend during this *** composite result for 10 El Nino events shows that the TNA SST anomaly reaches its maximum in spring after the peak of an El Nino event and persists until *** general,the anomaly is associated with three factors-namely,El Nino,the North Atlantic Oscillation(NAO),and a long-term trend,leading to an increase in local SST up to 0.4℃,0.3℃,and 0.35℃,respectively.A comparison between 1983 and 2005 indicates that the TNA SST in spring is affected by El Niño,as well as the local SST in the preceding winter,which may involve a long-term trend *** addition,the lead-lag correlation shows that the NAO leads the TNA SST by 2-3 *** comparing two years with an opposite phase of the NAO in winter(i.e.,1992 and 2010),the authors further demonstrate that the NAO is another important factor in regulating the TNA SST anomaly.A negative phase of the NAO in winter will reinforce the El Nino forcing substantially,and vise *** other words,the TNA SST anomaly in the decaying years is more evident if the NAO is negative with El ***,the combined effects of El Nino and the NAO must be considered in order to fully understand the TNA SST variability along with a long-term trend.

关键词： Tropical North Atlantic Sea surface temperature anomaly North Atlantic Oscillation El Nino

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Aerodynamic characteristics of store during lateral jet assisted separation from cavity using free drop technique

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Chinese Journal of Aeronautics 2023年第1期36卷 139-151页

作者： fei xue Yipeng REN zheng LI Cong XU Dechen WEI Xiaolu MAO Zenghui JIANG China Academy of Aerospace Aerodynamics Beijing 100074China Bejing Institute of Astronautical Systems Engineering Beijing 100076China China Academy of Launch Vehicle Technology Beijing 100076China Institute of Aeronautical Engineering and Technology Binzhou UniversityBinzhou 256600China Nanhang Jincheng College Nanjing 211156China

Aimed at the problem of store separation from internal cavity,this paper innovatively puts forward a separation scheme of using lateral jet to assist store safe *** jet ensures that the store is continuously subjected to down head moment during separation,so as to ensure safe *** wind tunnel free drop test technique with lateral jet is established,which can ensure that there is no support interference in the motion process of the store and more truly simulate the motion of the *** feasibility of the new separation scheme is proved by wind tunnel *** test shows that the new scheme can also change the more dangerous state into a safe *** the analysis of the test data,the pitching moment coefficients of the store under different pressures in the high-pressure cylinder are obtained,and the effects of aircraft and cavity on the pitching moment of the store are *** 3 stages of store passing through cavity shock wave are *** results show that the lateral jet provides the store with continuous head down moment,and makes the store overcome the head up moment caused by the shock wave in front of the cavity,so as to ensure the safety of separation.

关键词： Compressible flow Internal cavity Lateral jet Store separation Unsteady test Wind tunnel free drop test