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Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： Sheng-hao Li Ao Huang fan-bo Zeng Hui Peng Hao-ran Wei xue-chun Huang Sheng-qiang Song Hua-zhi gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical

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QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency

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World Journal of Pediatrics 2014年第3期10卷 219-226页

作者： De-Yun Lu Jun Ye Lian-Shu Han Wen-Juan Qiu Hui-Wen Zhang Jian-De Zhou Pei-Zhong Bao Ya-Fen Zhang xue-fan gu Department of Pediatric Endocrinology and Genetic Metabolism and Shanghai Institute for Pediatric Research Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

Background:This study aimed to investigate the mutation spectrum of the QDPR gene,to determine the effect of mutations on dihydropteridine reductase(DHPR)structure/function,to discuss the potential genotype-phenotype correlation,and to evaluate the clinical outcome of Chinese patients after ***:Nine DHPR-deficient patients were enrolled in this study and seven of them underwent neonatal *** gene mutations were analyzed and confi rmed by routine *** potential pathogenicity of missense variants was analyzed using Clustal X,PolyPhen program and Swiss-PDB Viewer 4.04_OSX software,*** clinical outcomes of the patients were evaluated after long-term ***:In 10 mutations of the 9 patients,4 were novel mutations(G20V,V86D,G130S and A175R),4 were reported by us previously,and 2 known mutations were identified.R221X was a hotspot mutation(27.7%)in our *** missense mutations probably had damage to *** patients in this series were treated with a good control of phenylalanine *** height and weight of the patients were normal at the age of 4 months to 7.5 *** patients,who underwent a neonatal screening and were treated early,showed a normal mental *** 2 patients diagnosed late,neurological symptoms were signifi cantly ***:The mutation spectrum of the QDPR gene is different in the Chinese *** mutations are related to severe *** determination of DHPR activity should be performed in patients with ***-defi cient patients who were treated below the age of 2 months may have a near normal mental development.

关键词： dihydropteridine reductase hyperphenylalaninaemia tetrahydrobiopterin

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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao Zhang Xin Ding Yushuo gu Qing Li Wei Jiang Kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion

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Protein & Cell 2024年第6期15卷 403-418页

作者： Song xue Yuru Han fan Wu Qiao Wang Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecurityShanghai Frontiers Science Center of Pathogenic Microorganisms and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation *** mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)***,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune *** single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding ***,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major *** predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two ***,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.

关键词： ACE2 affinity maintained

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Carbon sink response of terrestrial vegetation ecosystems in the Yangtze River Delta and its driving mechanism

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Journal of Geographical Sciences 2024年第1期34卷 112-130页

作者： ZHAO Haixia fan Jinding gu Binjie CHEN Yijiang Nanjing Institute of Geography and Limnology CASNanjing 210008China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Nanjing College University of Chinese Academy of SciencesNanjing 211135China School of Agricultural and Food Science The University of QueenslandQueensland 4072Australia

The carbon cycle of terrestrial ecosystems is influenced by global climate change and human *** remote sensing data and land cover products,the spatio-temporal variation characteristics and trends of NEP in the Yangtze River Delta from 2000 to 2020 were analyzed based on the soil respiration *** driving influences of ecosystem structure evolution,temperature,rainfall,and human activities on NEP were *** results show that the NEP shows an overall distribution pattern of high in the southeast and low in the *** area of carbon sinks is larger than that of the carbon *** spatial heterogeneity is *** change trend is basically unchanged or significantly *** future change trend in most areas will be continuous *** with temperature,NEP are more sensitive to *** positive influence of human activities on NEP is mainly observed in north-central Anhui and northern Jiangsu coastal areas,while the negative influence is mainly found in highly urbanized *** the process of ecosystem structure,the contribution of unchanged areas to NEP change is greater than that of changed areas.

关键词： carbon sinks terrestrial vegetation ecosystems driving mechanisms climate change human activities ecosystem structure Yangtze River Delta

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Comparison of the hygrothermal performance of two light-framed timber structure buildings under different operation modes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 18-35页

作者： Wanqing XU Yucong xue Jiang LU Yifan fan Xiaoyu LUO College of Civil Engineering and Architecture Zhejiang UniversityHangzhou310058China International Research Center for Green Building and Low-Carbon City International CampusZhejiang UniversityJiaxing314400China School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou310023China

Light-framed timber structure(LTS)buildings have been highly valued in recent years due to their low-carbon ***,the applicability of the building envelope is closely related to indoor and outdoor *** hot summer and cold winter(HSCW)climate zone in China has high humidity and great temperature variation throughout the year,resulting in distinct outdoor environments in different *** indoor environment is greatly affected by energy-consumption patterns and window-opening habits,which largely depend upon the regulation operations of *** these interrelated factors lead to extremely complex boundary conditions on each side of the building *** the structures of LTS buildings are applicable in this climate zone,therefore,needs to be carefully *** this study,two LTS buildings with different envelopes were established in Haining,China,situated in the HSCW climate zone,and selected as the study *** operation modes were adopted to create a variety of indoor *** each condition,the processes of heat and moisture transfer within the building envelopes and the indoor environment were monitored and *** comparison indicated that the building envelope with high moisture storage and insulation ability maintained a relatively stable indoor environment,especially when the environment changed ***,if the outdoor environment was equable(e.g.,relative humidity within the range of 30%–60%)or intermittent energy consumption modes were adopted,the building envelope with a low thermal inertia index and weak moisture-buffering ability performed better because it enabled a faster response of the indoor environment to air ***,a high risk of moisture accumulation between the thermal insulation layer and other materials with a large water vapour transfer resistance factor was also identified,suggesting a higher requirement for the vapour insulation of the env

关键词： Light-framed timber structure(LTS)buildings In-situ experiment Typical operation mode Indoor environment Heatand moisture transfer

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Big Data Application Simulation Platform Design for Onboard Distributed Processing of LEO Mega-Constellation Networks

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China Communications 2024年第7期21卷 334-345页

作者： Zhang Zhikai gu Shushi Zhang Qinyu xue Jiayin School of Electronics and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China guangdong Provincial Key Laboratory of Aerospace Communication and Networking Technology Shenzhen 518055China Broadband Communications Research Department Peng Cheng LaboratoryShenzhen 518000China

Due to the restricted satellite payloads in LEO mega-constellation networks(LMCNs),remote sensing image analysis,online learning and other big data services desirably need onboard distributed processing(OBDP).In existing technologies,the efficiency of big data applications(BDAs)in distributed systems hinges on the stable-state and low-latency links between worker ***,LMCNs with high-dynamic nodes and long-distance links can not provide the above conditions,which makes the performance of OBDP hard to be intuitively *** bridge this gap,a multidimensional simulation platform is indispensable that can simulate the network environment of LMCNs and put BDAs in it for performance *** STK's APIs and parallel computing framework,we achieve real-time simulation for thousands of satellite nodes,which are mapped as application nodes through software defined network(SDN)and container *** elaborate the architecture and mechanism of the simulation platform,and take the Starlink and Hadoop as realistic examples for *** results indicate that LMCNs have dynamic end-to-end latency which fluctuates periodically with the constellation *** to ground data center networks(GDCNs),LMCNs deteriorate the computing and storage job throughput,which can be alleviated by the utilization of erasure codes and data flow scheduling of worker nodes.

关键词： big data application Hadoop LEO mega-constellation multidimensional simulation onboard distributed processing

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Phenylalanine Hydroxylase Deficiency and Citrin Deficiency in a Chinese Infant

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Chinese Medical Journal 2015年第21期128卷 2979-2980页

作者： Jun Ye Wen-Juan Qiu Lian-Shu Han Hui-Wen Zhang xue-fan gu Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric Research Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

To the Editor： Tandem mass spectrometry （MS/MS）-based expanded newborn screening was first introduced in Pediatric Endocrinology/ Genetics of Xin Hua Hospital in 2003. The screening is expected to detect genetic disorders leading to a secondary increase in blood phenylalanine （Phe） in newborns. We reported a rare case in a Chinese infant with hyperphenylalaninemia （HPA） caused by phenylalanine hydroxylase （PAH） deficiency and neonatal intrahepatic cholestasis caused by citrin deficiency （NICCD）. This constellation of two different metabolic pathway defects in one patient has not been reported previously.

关键词： p-氨基马尿酸苯丙氨酸羟化酶串联质谱法胆汁淤积肝内内分泌学普查下丘脑-垂体系统亚洲大陆世系人群人类婴儿婴儿新生

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Revolutionary entrapment model of uniformly distributed swarm robots in morphogenetic formation

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Defence Technology（防务技术） 2024年第1期31卷 496-509页

作者： Chen Wang Zhaohui Shi Minqiang gu Weicheng Luo Xiaomin Zhu Zhun fan Shantou University ShantouGuangdongChina National University of Defense Technology ChangshaChina Key Lab of Digital Signal and Image Processing of guangdong Province China

This study proposes a method for uniformly revolving swarm robots to entrap multiple targets,which is based on a gene regulatory network,an adaptive decision mechanism,and an improved *** the gene regulatory network method,the robots can generate entrapping patterns according to the environmental input,including the positions of the targets and ***,an adaptive decision mechanism is proposed,allowing each robot to choose the most well-adapted capture point on the pattern,based on its *** robots employ an improved Vicsek-model to maneuver to the planned capture point smoothly,without colliding with other robots or *** proposed decision mechanism,combined with the improved Vicsek-model,can form a uniform entrapment shape and create a revolving effect around targets while entrapping *** study also enables swarm robots,with an adaptive pattern formation,to entrap multiple targets in complex *** robots can be deployed in the military field of unmanned aerial vehicles’(UAVs)entrapping multiple *** experiments demonstrate the feasibility and superiority of the proposed gene regulatory network method.

关键词： Swarm intelligence Revolutionary entrapment Flocking Robots Gene regulatory network Vicsek-model Entrapping multiple targets

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Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

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Bio-Design and Manufacturing 2024年第5期7卷 597-610页

作者： Minxuan Jia Tingting fan Tan Jia Xin Liu Heng Liu Qi gu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Orthopaedics Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

In the intricate skeletal muscle tissue,the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and *** study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization ofmuscle *** harnessing the capabilities of three-dimensional(3D)bioprinting and modeling,we developed a novel approach involving the co-construction of endothelial and muscle cells,followed by their subsequent *** findings highlight the importance of the interaction dynamics between these two cell ***,introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube ***,it stimulated the development of the vascular network,paving the way for the early stages of vascularized skeletal muscle *** methodology proposed in this study indicates the potential for constructing large-scale,physiologically aligned skeletal ***,it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial *** on the multicell-type interaction model,we can predict promising pathways for constructing even more intricate tissues or organs.

关键词： Skeletal muscle Vascularization 3D bioprinting Cell interaction

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