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Turbulent Agglomeration of Microparticles in a Cylinder w.ke Flow.Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： w.NG Shuang MU Lin LI xue XIE Jun DONG Ming School of Energy and Pow.r Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is view.d as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,w. numerically explored these phenomena under cylindrical vortex w.ke influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach w.s verified by comparison w.th available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles w.th different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow.regimes w.re *** particles w.re concentrated at the vortex centers,w.ile larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanw.se（y-direction）.w.th increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow.field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Establishing the vector-meson-exchange dominance for the short range interactions of light quarks

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： bing-Song Zou Department of Physics Tsinghua University CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences Southern Center for Nuclear-Science Theory (SCNT) Institute of Modern Physics Chinese Academy of Sciences

Understanding the interactions betw.en constituent quarks is one of the fundamental and challenging problems in hadron physics. At present, the constituent quark models have achieved great success in describing the properties of hadrons, w.ereas some long-standing disputes remain, especially for the short range interactions betw.en constituent quarks. In exploring the dynamic mechanism betw.en u/d quarks, it is found that the one gluon exchange and/or vector meson exchange induced interactions may dominate the short range interactions [1].

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Mechanism by w.ich Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion w.th the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;how.ver, its role in axonal regeneration in the central nervous system remains unclear. In this study, w. established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and tw.-photon axotomy techniques. w. found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae w.th the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. w. also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin dow.stream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathw.y.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Secure beamforming and deployment design for rate-splitting multiple access-based UAV communications

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Science China(Information Sciences) 2025年第1期68卷 342-356页

作者： bing w.NG Xiaofeng TAO Shujun HAN Huici w. Kai YANG Zhu HAN National Engineering Research Center of Mobile Netw.rk Technologies Beijing University of Posts and Telecommunications Peng Cheng Laboratory Department of Electrical and Computer Engineering University of Houston

Rate-splitting multiple access(RSMA) has recently gained attention as a potential robust multiple access(MA)scheme for upcoming w.reless netw.rks. Given its ability to efficiently utilize w.reless resources and design interference management strategies, it can be applied to unmanned aerial vehicle(UAV) netw.rks to provide convenient services for large-scale access ground users. How.ver, due to the line-of-sight(LoS) broadcast nature of UAV transmission, information is susceptible to eavesdropping in RSMA-based UAV netw.rks. Moreover, the superposition of signals at the receiver in such netw.rks becomes complicated. To cope w.th the challenge, w. propose a tw.-user multi-input single-output(MISO) RSMA-based UAV secure transmission framew.rk in dow.link communication netw.rks. In a passive eavesdropping scenario, our goal is to maximize the sum secrecy rate by optimizing the transmit beamforming and deployment location of the UAV-base station(UAV-BS),w.ile considering quality-of-service(QoS) constraints, maximum transmit pow.r, and flight space limitations. To address the non-convexity of the proposed problem, the optimization problem is first decoupled into tw. subproblems. Then, the successive convex approximation(SCA) method is employed to solve each subproblem using different propositions. In addition, an alternating optimization(AO)-based location RSMA(L-RSMA) beamforming algorithm is developed to implement joint optimization to obtain the suboptimal solution. Numerical results demonstrate that(1) the proposed L-RSMA scheme yields a28.97% higher sum secrecy rate than the baseline L-space division multiple access(SDMA) scheme;(2) the proposed L-RSMA scheme improves the security performance by 42.61% compared to the L-non-orthogonal multiple access(NOMA) scheme.

关键词： rate-splitting multiple access UAV communication precoding optimization deployment location physical layer security

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A Multi-Objective Particle Sw.rm Optimization Algorithm Based on Decomposition and Multi-Selection Strategy

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Computers, Materials & Continua 2025年第1期82卷 997-1026页

作者： Li Ma Cai Dai Xingsi xue Cheng Peng School of Computer Science Shaanxi Normal UniversityXi’an710119China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou350118China Information Construction and Management Center and Institute of Artificial Intelligence and Educational New.Productivity Ningxia Normal UniversityGuyuan756099China

The multi-objective particle sw.rm optimization algorithm(MOPSO)is w.dely used to solve multi-objective optimization *** the article,amulti-objective particle sw.rm optimization algorithmbased on decomposition and multi-selection strategy is proposed to improve the search ***,tw. update strategies based on decomposition are used to update the evolving population and external archive,***,a multiselection strategy is *** first strategy is for the subspace w.thout a non-dominated *** the neighbor particles,the particle w.th the smallest penalty-based boundary intersection value is selected as the global optimal solution and the particle far aw.y fromthe search particle and the global optimal solution is selected as the personal optimal solution to enhance global *** second strategy is for the subspace w.th a non-dominated *** the neighbor particles,tw. particles are randomly selected,one as the global optimal solution and the other as the personal optimal solution,to enhance local *** third strategy is for Pareto optimal front(PF)discontinuity,w.ich is identified by the cumulative number of iterations of the subspace w.thout non-dominated *** the subsequent iteration,a new.probability distribution is used to select from the remaining subspaces to ***,an adaptive inertia w.ight update strategy based on the dominated degree is designed to further improve the search ***,the proposed algorithmis compared w.th fivemulti-objective particle sw.rm optimization algorithms and five multi-objective evolutionary algorithms on 22 test *** results show.that the proposed algorithm has better performance.

关键词： Multi-objective optimization multi-objective particle sw.rm optimization decomposition multi-selection strategy

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi bing-Sen Shi Tianqi Li Shan-Shan Su w.itao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang w.ng Dong-Sheng Guo xue xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow.treatment w.ndow.resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new.hopes for subacute stroke *** w. designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,w.ich utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed w.th glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system w.s validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** w.rk offers a precise and integrative strategy for stroke patients missing the acute therapy w.ndow.to improve functional recovery and enhance the effect of comprehensive treatment.

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renew.l and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong w.ng Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, w.ere it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as w.ll as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review.of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renew.l, as w.ll as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renew.l, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renew.l central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

维普期刊数据库

Bearing Fault Diagnosis Based on the Markov Transition Field and SE-IShufflenetV2 Model

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Structural Durability & Health Monitoring 2025年第1期19卷 125-144页

作者： Chaozhi Cai Tiexin Xu Jianhua Ren Yingfang xue School of Mechanical and Equipment Engineering Hebei University of EngineeringHandan056038China

A bearing fault diagnosis method based on the Markov transitionﬁeld(MTF)and SEnet(SE)-IShufﬂenetV2 model is proposed in this paper due to the problems of complex w.rking conditions,low.fault diagnosis accuracy,and poor generalization of rolling ***,MTF is used to encode one-dimensional time series vibration sig-nals and convert them into time-dependent and unique tw.-dimensional feature ***,the generated tw.-dimensional dataset is fed into the SE-IShufﬂenetV2 model for training to achieve fault feature extraction and classiﬁ*** paper selects the bearing fault datasets from Case w.stern Reserve University and Paderborn University to experimentally verify the effectiveness and superiority of the proposed *** generalization performance of the proposed method is tested under the variable load condition and different signal-to-noise ratios(SNRs).The experimental results show.that the average accuracy of the proposed method under different w.rking conditions is 99.2%w.thout adding *** accuracy under different w.rking conditions from 0 to 1 HP is 100%.w.en the SNR is 0 dB,the average accuracy of the proposed method can still reach 98.7%under varying w.rking ***,the bearing fault diagnosis method proposed in this paper is characterized by high accuracy,strong anti-noise ability,and ***,the proposed method can also overcome the inﬂuence of variable w.rking conditions on diagnosis accuracy,providing method support for the accurate diagnosis of bearing faults under strong noise and variable w.rking conditions.

关键词： Bearings Markov transitionﬁeld SE-IShufﬂenetV2

Design and Application of Turbine Cascade Partitioned Endw.ll Profiling

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Journal of Thermal Science 2025年第1期34卷 110-128页

作者： ZENG Fei JIANG Ruiqi xue Xingxu DU w.i LUO Lei ZHOU Xun AECC Hunan Aviation Pow.rplant Research Institute School of Energy Science and Technology Harbin Institute of Technology Science and Technology on Diesel Engine Turbocharging Laboratory China North Engine Research Institute

The influence of partitioned profiling design based on a large-pitch highly loaded cascade is studied by numerical *** partitioned profile is mainly composed of a pressure-side convex structure near the leading edge and a suction-side convex structure at the midstream and dow.stream sides of the *** influence of the change in the vertex axial position and peak value of the B-line on the secondary flow.control is *** this paper,air(ideal gas) is selected as the flow.*** average static pressure at the outlet and the average total temperature at the inlet are kept *** γ-θ is used as the turbulence *** results show.that the pressure-side convex structure suppresses the spanw.se and pitchw.se migration of the inlet flow.by adjusting the static pressure distribution of the flow.field,so the development of the pressure-side leg of the horseshoe vortex is effectively *** suction-side convex structure adjusts the static pressure distribution of the flow.field and increases the included angle betw.en the cross-flow.and suction surface,so the accumulation of low.momentum fluid,the development of a corner vortex and the flow.separation at the trailing edge of the suction-side surface are all suppressed near the endw.ll-suction ***,the energy loss coefficient of the large-pitch highly loaded cascade is decreased from 0.0564 to 0.0485,representing a 25% reduction in secondary flow.losses.

关键词： Vortex flow