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蛤蜊岗不同贝龄四角蛤蜊数量性状的通径分析

渔业科学进展 2024年第1期45卷 185-193页

作者：李昂冯加岭李加琦唐玉泽薛素燕朱玲张秀梅毛玉泽中国水产科学研究院黄海水产研究所山东青岛266071 崂山实验室海洋生态与环境科学功能实验室山东青岛266071 浙江海洋大学水产学院浙江舟山316022 盘锦光合蟹业有限公司辽宁盘锦124200

为研究蛤蜊岗不同贝龄四角蛤蜊(Mactra veneriformis)形态性状与质量性状之间的相关性,采用相关分析、通径分析和多元回归分析等方法,对1~3龄四角蛤蜊的壳长(SL)、壳宽(SW)、壳高(SH)、活体湿重(BW)和软组织湿重(RW)等参数进行分析,建... 详细信息

为研究蛤蜊岗不同贝龄四角蛤蜊(Mactra veneriformis)形态性状与质量性状之间的相关性,采用相关分析、通径分析和多元回归分析等方法,对1~3龄四角蛤蜊的壳长(SL)、壳宽(SW)、壳高(SH)、活体湿重(BW)和软组织湿重(RW)等参数进行分析,建立形态性状与质量性状之间的回归方程。结果显示,不同生长阶段四角蛤蜊形态性状对质量性状的贡献存在极显著差异(P0.05)。以活体湿重为目标性状时,1~3龄贝均应以壳宽为主要选择性状,并以壳长作为辅助选择性状;以软组织湿重为目标性状时,1龄贝应以壳宽为主要选择性状,同时辅以壳长;2龄和3龄贝均应以壳长为主要选择性状,并分别以壳宽和壳高作为2龄贝和3龄贝的辅助选择性状。研究结果可为蛤蜊岗四角蛤蜊良种选育提供基础数据。

关键词：四角蛤蜊形态性状通径分析相关分析

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m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

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Frontiers of Medicine 2024年第3期18卷 499-515页

作者： Han Wu Weitao Jiang Ping Pang Wei Si xue Kong Xinyue z.ang Yuting Xiong Chunlei Wang Feng z.ang Jinglun Song Yang Yang Linghua zeng Kuiwu Liu Yingqiong Jia zhuo Wang Jiaming Ju Hongtao Diao Yu Bian Baofeng Yang Department of Pharmacology(National Key Laboratory of Frigid zone Cardiovascular Diseases the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart *** N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the occurrence and development of many *** investigating the biological function of the m^(6)A reader YTHDF1 in cardiac fibrosis,adeno-associated virus 9 was used to knock down or overexpress the YTHDF1 gene in mouse hearts,and MI surgery in vivo and transforming growth factor-β(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosis *** results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosis,whereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricular pathological remodeling and fibrotic ***,zinc finger BED-type containing 6 mediated the transcriptional function of the YTHDF1 gene ***1 augmented AXL translation and activated the TGF-β-Smad2/3 signaling pathway,thereby aggravating the occurrence and development of cardiac dysfunction and myocardial ***,our data indicated that YTHDF1 was involved in activation,proliferation,and migration to participate in cardiac fibrosis in *** results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis.

关键词： cardiac fibrosis YTHDF1 AXL zBED6 heart failure

The Bright Single Pulse Emission from PSR B1133+16

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Research in Astronomy and Astrophysics 2024年第4期24卷 253-261页

作者： Jun Tan zhi-Gang Wen zhen Wang xue-Feng Duan Hong-Guang Wang Na Wang Vishal Gajjar Jian-Ping Yuan Rai Yuen Wen-Ming Yan Jian-Ling Chen Wei Han Hui Wang Cheng-Bing Lyu Ai-Jun Dong Maths and Information Technology School Yuncheng UniversityYuncheng 044000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Space Science Laboratory University of CaliforniaBerkeley 94710USA Department of Physics and Electronic Engineering Yuncheng UniversityYuncheng 044000China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China

We have conducted a comprehensive investigation into the bright single pulse emission from PSR B1133+16using the Giant Metrewave Radio *** time resolution data(61μs)were obtained at a center frequency of 322 MHz with a bandwidth of 32 MHz over a continuous observation period of 7.45 hr.A total of 1082 bright pulses were sporadically detected with peak flux densities ranging from 10 to 23 times stronger than the average pulse ***,no giant pulse-like emission with a relative pulse energy larger than 10 and extremely short duration was detected,indicating that these bright pulses cannot be categorized as giant pulse *** majority of these bright pulses are concentrated in pulse phases at both the leading and trailing windows of the average pulse profile,with an occurrence ratio of approximately *** pulse energy distribution for all individual pulses can be described by a combination of two Gaussian components and a cutoff power-law with an index of α=-*** updated nulling fraction of 15.35%±0.45% was determined from the energy *** emission of individual pulses follows a log-normal distribution in peak flux density *** is imperative that regular phase drifting in bright pulse sequence is identified in both the leading and trailing components for the first *** physical mechanisms are discussed in detail to provide insights into these observations.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(PSR B1133+16) methods:observational methods:data analysis

拉林铁路沿线风积沙自由场及其加固地基动力特性分析

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铁道标准设计 2024年第3期68卷 49-55页

作者：薛春晓中铁西北科学研究院有限公司兰州730000

拉林铁路沿线风积沙地基液化是其面临的主要问题之一,利用振冲碎石桩法进行地基处理时存在局部沉降量大等一系列问题。为解决上述问题,借助振动台试验,分析了研究区风积沙自由场和水泥搅拌桩加固地基的动力响应特征。研究结果表明,当地... 详细信息

拉林铁路沿线风积沙地基液化是其面临的主要问题之一,利用振冲碎石桩法进行地基处理时存在局部沉降量大等一系列问题。为解决上述问题,借助振动台试验,分析了研究区风积沙自由场和水泥搅拌桩加固地基的动力响应特征。研究结果表明,当地震强度较小时(0.1g),地震动在风积沙自由场中有较为明显的自下而上不断放大的趋势,当地震强度较大时(0.3g),地震动在土层中从下而上呈现先增大后减小的趋势;风积沙自由场中的液化现象并非同时发生,而是具有明显的时间差,即从上到下逐渐发展;输入的地震动强度一定时,风积沙自由场表层沉降量和孔压比较加固地基明显偏大,前者的地表宏观反应也明显强于后者,这表明水泥搅拌桩对风积沙地基的液化具有较好的抑制作用,这种抑制作用与地震动强度呈负相关,但与土层的埋深呈正相关。该研究成果可为风积沙地基的液化处理提供借鉴和参考。

关键词：拉林铁路风积沙地基液化水泥搅拌桩振动台试验

基于多位移光谱遥感图像的空间引力模型亚像元定位

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哈尔滨工程大学学报 2024年第6期45卷 1179-1186页

作者：王鹏严昂陈永康赵春雷石立新中国测绘科学研究院测绘科学与地球空间信息技术自然资源部重点实验室北京100039 湖南省国土资源规划院自然资源部南方丘陵区自然资源监测监管重点实验室湖南长沙410114 南京航空航天大学电子信息工程学院江苏南京211106 河北省气象科学研究所河北省气象与生态环境重点实验室河北石家庄050022

目前基于多位移光谱遥感图像的亚像元定位方法通常很少考虑点扩散函数效应影响,本文提出了一种基于多位移光谱遥感图像的空间引力模型亚像元定位方法。为了生成粗糙丰度图像,首先对多个多位移光谱遥感图像进行解混;在点扩散函数效应被... 详细信息

目前基于多位移光谱遥感图像的亚像元定位方法通常很少考虑点扩散函数效应影响,本文提出了一种基于多位移光谱遥感图像的空间引力模型亚像元定位方法。为了生成粗糙丰度图像,首先对多个多位移光谱遥感图像进行解混;在点扩散函数效应被考虑的前提下,对粗糙丰度图像实施面积到点的克里插值处理,然后通过理想方波滤波进行滤波,最终获得改进后的粗糙丰度图像;利用空间引力模型对改进后的粗糙丰度图像进行上采样,从而得到上采样丰度图像,再对上采样丰度图像执行整合处理,以生成精细丰度图像;在完成上述所有图像处理步骤后,最终通过应用类别分配方法,将类别标签分发给各个亚像元,以此获得精确的定位结果。在2组实验数据集上的实验结果表明:本文提出的方法比现有的亚像元定位方法获得了更好的定位效果。

关键词：遥感图像高光谱图像亚像元定位点扩散函数空间引力模型多位移光谱遥感图像

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浙东沿海典型沉积盆地CO_(2)地质封存潜力与试点意义分析——以长河盆地为例

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海洋地质前沿 2024年第8期40卷 1-11页

作者：陈越杨娇娇李雪王建强曹珂李昂吕清陈俊兵韩国志浙江省水文地质工程地质大队宁波315100 中国地质调查局舟山海洋地质灾害野外科学观测研究站青岛266237 中国地质大学(武汉) 武汉430074 中国地质调查局青岛海洋地质研究所青岛266237 浙江省工程勘察设计院集团有限公司宁波315100 大庆油田有限责任公司第一采油厂大庆163000

碳捕集利用和封存(CCUS)技术是实现全球碳中和不可或缺的技术,开展CO_(2)地质封存(CCS)工作有助于实现碳中和的目标。中国东部沿海发达城市分布众多发电厂、炼化厂等CO_(2)大排放源,对CO_(2)封存需求较高。为缓解地区CO_(2)排放压力,挖... 详细信息

碳捕集利用和封存(CCUS)技术是实现全球碳中和不可或缺的技术,开展CO_(2)地质封存(CCS)工作有助于实现碳中和的目标。中国东部沿海发达城市分布众多发电厂、炼化厂等CO_(2)大排放源,对CO_(2)封存需求较高。为缓解地区CO_(2)排放压力,挖掘东部沿海地区周围具有封存潜力的中小型沉积盆地,在搜集区域地质资料的基础上,选取浙江省杭州湾南岸的长河盆地作为研究对象,计算盆地封存潜力,并分析中小盆地封存试点意义。根据沉积盆地CO_(2)地质储存潜力评价方法,计算盆地咸水层CO_(2)地质封存潜力,评价结果表明,长河盆地具有较好的咸水层CO_(2)地质封存潜力。盆地最具封存潜力的是古近系长河组二段(Ech^(2))中的第一砂岩层和长河组一段(Ech^(1))中的砂砾岩层,预期理论封存量为4.84亿t,有效封存量可以达到1 162.61万t。研究结果表明,开展中小沉积盆地CO_(2)地质封存工程试点,可在一定程度上缓解沿海地区和企业碳排放压力,为海域碳封存积累技术和经验。

关键词：东部沿海沉积盆地 CO_(2)地质封存咸水层碳中和

The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

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生物安全与健康(英文) 2024年第4期06卷 216-224页

作者： He Yihui z.ang Yang zhen Jiaxin Sun Guangqiang Li zhen Yang Bo Yang Bin Chang Keyi Chen xue z.ang Yulin Guo Caiping Wang Wen Wu Ping z.ang Tong Wang Lei Postgraduate Union Training Base of Jinzhou Medical University PLA Rocket Force Characteristic Medical Center Beijing China Department of Neurology PLA Rocket Force Characteristic Medical Center Beijing China Center for Infectious Disease Beijing Youan Hospital Capital Medical University Beijing China Beijing Key Laboratory for HIV/AIDS Research Beijing China Beijing Institute for Sexually Transmitted Disease Control Beijing China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders and National Center for Mental Disorders Beijing Anding Hospital Capital Medical University Beijing China Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China The Second Hospital of Beijing Beijing China Department of Respiratory and Critical Care Medicine Beijing Youan Hospital Capital Medical University Beijing China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking University Beijing China Key Discipline for Neuroscience of the Ministry of Education Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Beijing China

Integrase strand transfer inhibitors (INSTIs) have emerged as the first-line choice for treating human immunodeficiency virus (HIV) infection due to their superior efficacy and safety. However, the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV (PLWH) is not fully understood due to limited data. In this study, we conducted a cross-sectional examination of PLWH receiving antiretroviral therapy, with a specific focus on HIV-positive men who have sex with men (MSM) on INSTI-based regimens (n = 61) and efavirenz (EFV)-based regimens (n = 28). Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging (MRI) scans, including T1-weighted images and resting-state functional MRI. Compared to the EFV group, the INSTI group exhibited primarily reduced gray matter volume (GMV) in the right superior parietal gyrus, higher regional homogeneity (ReHo) in the left post-central gyrus, lower ReHo in the right orbital part of the inferior frontal gyrus, and increased voxel-wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right cuneus. Furthermore, the analysis revealed a main effect of antiretroviral drugs on GMV changes, but no main effect of neuropsychiatric disorders or their interaction. The repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group, validating the initial findings. Our study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI-based regimens compared to those on EFV-based regimens. These neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI-based regimens.

关键词： Human immunodeficiency virus (HIV) Multimodal magnetic resonance imaging (MRI) Integrase strand transfer inhibitors (INSTIs) Efavirenz (EFV)

Identification of Fucans from Four Species of Sea Cucumber by High Temperature ~1H NMR

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Journal of Ocean University of China 2014年第5期13卷 871-876页

作者： WU Nian CHEN Shiguo YE Xingqian LI Guoyun YIN Li'ang xue Changhu College of Biosystem Engineering and Food Science Zhejiang University College of Food Science and Engineering Ocean University of China

Acidic polysaccharide, which has various biological activities, is one of the most important components of sea cucumber. In the present study, crude polysaccharide was extracted from four species of sea cucumber from three different geographical zones, Pearsonothuria graeffei(Pg) from Indo-Pacific, Holothuria vagabunda(Hv) from Norwegian Coast, Stichopus tremulu(St) from Western Indian Ocean, and Isostichopus badionotu(Ib) from Western Atlantic. The polysaccharide extract was separated and purified with a cellulose DEAE anion-exchange column to obtain corresponding sea cucumber fucans(SC-Fucs). The chemical property of these SC-Fucs, including molecular weight, monosaccharide composition and sulfate content, was determined. Their structure was compared simply with fourier infrared spectrum analyzer and identified with high temperature 1H nuclear magnetic resonance spectrum analyzer(NMR) and room temperature 13 C NMR. The results indicated that Fuc-Pg obtained from the torrid zone mainly contained 2,4-O-disulfated and non-sulfated fucose residue, whereas Fuc-Ib from the temperate zone contained non-, 2-O- and 2,4-O-disulfated fucose residue; Fuc-St from the frigid zone and Fuc-Hv from the torrid zone contained mainly non-sulfated fucose residue. The proton of SC-Fucs was better resolved via high temperature 1H NMR than via room temperature 1H NMR. The fingerprint of sea cucumber in different sea regions was established based on the index of anomer hydrogen signal in SC-Fucs. Further work will help to understand whether there exists a close relationship between the geographical area of sea cucumber and the sulfation pattern of SC-Fucs.

关键词： sea cucumber sulfated fucan composition analysis 1H NMR identification

Hipbone Biomechanical Finite Element Analysis and Clinical Study after the Resection of Ischiopubic Tumors

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Chinese Medical Sciences Journal 2012年第3期27卷 153-160页

作者： Ya-qi He xue-lin z.ang Bing-hang Tang ang Yang CT Room Zhongshan Hospital of Sun Yat-sen University(People's Hospital of Zhongshan City)ZhongshanGuangdong 528403China Radiology Imaging Center Southern HospitalSouthern Medical UniversityGuangzhou 510515China

Objective To investigate the changes of hipbone biomechanics after the resection of ischiopubic tumors and their relationships with the complications in the convalescent stage, and directing the postoperative pelvic reconstruction. Methods DICOM data were used to create an intact hipbone finite element model and postoperative model. The biomechanical indices on the same region in the two models under the same boundary condition were compared. The differences of displacement, stress, and strain of the two models were analyzed with statistical methods. Results The distribution areas of the hipbone nodes' displacement, stress, and strain were similar before and after the simulated operation. The sacroiliac joint nodes' displacement (P=0.040) and strain (P=0.000), and the acetabular roof nodes' stress (P=0.000) and strain (P=0.005) of two models had significant differences, respectively. But the sacroiliac joint nodes' stress (P=0.076) and the greater sciatic notch nodes' stress (P=0.825) and strain (P=0.506) did not have significant differences. Conclusions The resection of ischiopubic tumors mainly affect the biomechanical states of the homolateral sacroiliac joint and acetabular roof. The complications in the convalescent stage are due to the biomechanical changes of the sacroiliac joint and the acetabular roof and disappearances of the stabilization and connection functions of the pubic symphysis and superior ramus of pubis.

关键词： hipbone biomechanics finite element analysis model