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大剂量替加环素联合多黏菌素治疗多重耐药鲍曼不动杆菌肺炎疗效及安全性分析

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医药论坛杂志 2024年第10期45卷 1099-1102页

作者：李林珈陈学昂平煤神马医疗集团总医院药品调剂科河南平顶山467000 平煤神马医疗集团总医院呼吸内科河南平顶山467000

目的分析大剂量替加环素联合多黏菌素治疗多重耐药鲍曼不动杆菌(MDR-AB)肺炎的疗效及安全性。方法前瞻性研究,纳入平煤神马医疗集团总医院2021年5月—2023年5月收治的86例MDR-AB患者,随机将患者分为两组,各43例。对照组采用常规剂量替... 详细信息

目的分析大剂量替加环素联合多黏菌素治疗多重耐药鲍曼不动杆菌(MDR-AB)肺炎的疗效及安全性。方法前瞻性研究,纳入平煤神马医疗集团总医院2021年5月—2023年5月收治的86例MDR-AB患者,随机将患者分为两组,各43例。对照组采用常规剂量替加环素+多黏菌素治疗,观察组采用大剂量替加环素+多黏菌素治疗,持续用药10 d。治疗后评估两组疗效,测定两组细菌清除情况。记录两组临床指标(退热时间、咳嗽消失时间、肺部啰音消失时间、细菌转阴时间);治疗期间观察并记录不良反应发生情况。结果观察组治疗总有效率和细菌清除率高于对照组(P0.05)。结论大剂量替加环素联合多黏菌素治疗MDR-AB肺炎可提高疗效,患者各主要症状更好更快缓解,病原菌清除率提高,且不会增加药物使用安全性风险。

关键词：鲍曼不动杆菌多重耐药肺炎多黏菌素替加环素大剂量

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硼酸/硼硅酸盐生物活性玻璃促创面愈合进展

硅酸盐学报 2024年第2期52卷 681-693页

作者：柳春玉王雪舒丹李帅杰张丽艳崔旭李红龙潘浩波中国科学院深圳先进技术研究院生物医药与技术研究所人体组织与器官退行性研究中心广东深圳518055 深圳市中科海世御生物科技有限公司广东深圳518120 南方科技大学广东深圳518055

随着社会老龄化的加剧,慢性创伤患者的发病率和死亡率激增。高复发率慢性创面难以得到简单有效和低成本的治疗,加重了医疗系统的负担,致使临床对高疗效、新疗法和创新产品的需求持续增长。近年来研究表明,生物活性玻璃可以通过调节免疫... 详细信息

随着社会老龄化的加剧,慢性创伤患者的发病率和死亡率激增。高复发率慢性创面难以得到简单有效和低成本的治疗,加重了医疗系统的负担,致使临床对高疗效、新疗法和创新产品的需求持续增长。近年来研究表明,生物活性玻璃可以通过调节免疫相关巨噬细胞、内皮细胞、真皮成纤维细胞和表皮细胞等,促进伤口愈合,成为一种具有临床应用前景的伤口敷料。特别是硼酸盐和硼硅酸盐组成的生物活性玻璃显示出可控的降解速率,可针对伤口愈合不同病理阶段,持续性释放功能离子并调控伤口微环境,以此诱导血管新生和加速病理伤口组织稳态恢复。本文简要概述了硼酸/硼硅酸盐生物活性玻璃结构与性能关系,重点介绍了其临床应用研究进展,并对未来生物活性玻璃创面敷料的发展进行了展望。

关键词：硼酸/硼硅酸盐生物活性玻璃伤口愈合功能离子慢性创面血管生成

Melatonin Alleviates Abscisic Acid Deficiency Inhibition on Photosynthesis and Antioxidant Systems in Rice under Salt Stress

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1421-1440页

作者： Feiyu Yan Xin Chen zhenzhen Wang Yuxuan Xia Dehui zheng Sirui xue Hongliang zhao zhiwei Huang Yuan Niu Guoliang z.ang School of Life Sciences and Food Engineering Huaiyin Institute of TechnologyHuai’an223003China Jianghuai Plain Crop Industry Engineering Research Institute Huaiyin Institute of TechnologyHuai’an223003China

Melatonin and abscisic acid,as major plant hormones,play important roles in the physiological and biochemical activities of crops,but the interaction between the two under salt stress is not yet *** study investigated the endogenous levels of melatonin and abscisic acid in rice by using exogenous melatonin,abscisic acid,and their synthetic inhibitors,and examined their interactions under salt *** research results indicate that melatonin and abscisic acid can improve rice salt *** alleviated the salt sensitivity caused by abscisic acid deﬁciency,increased antioxidant enzyme activity and antioxidant content in rice treated with abscisic acid synth-esis inhibitors,and reduced total reactive oxygen species content and thiobarbituric acid reactive substance *** also increased the activity of key photosynthetic enzymes and the content of photosynthetic pigments,maintaining the parameters of photosynthetic gas exchange and chlorophyllﬂ*** summary,melatonin alleviated the effects of abscisic acid deﬁciency on photosynthesis and antioxidant systems in rice and improved salt *** study is beneﬁcial for expanding the understanding of melatonin regulation of crop salt tolerance.

关键词： Melatonin abscisic acid salt stress rice photosynthesis antioxidant system

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光切面法的电力钢管塔法兰肋板焊缝三维重构

机械设计与制造 2024年第1期395卷 133-138页

作者：刘源泂薛海浪岳泽宇汤勃武汉科技大学冶金装备及其控制教育部重点实验室湖北武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室湖北武汉430081 江苏鸿光杆塔有限公司设计部江苏宜兴214200

针对电力钢管塔法兰肋板自动焊接中焊缝引导问题,提出一种基于线激光光切面的肋板焊缝三维重构和测量方法。构建面阵相机和线激光测量平台,采用张正友法标定测量模型,建立光平面上点空间坐标和相机图像坐标对应关系。对实物进行光切面... 详细信息

针对电力钢管塔法兰肋板自动焊接中焊缝引导问题,提出一种基于线激光光切面的肋板焊缝三维重构和测量方法。构建面阵相机和线激光测量平台,采用张正友法标定测量模型,建立光平面上点空间坐标和相机图像坐标对应关系。对实物进行光切面扫描实验,通过测量模型求解对应点空间坐标,基于Visual Studio平台对空间点云三维重构,采用随机采样一致性(RANSAC)迭代法实现肋板所在平面的点云分割,基于法线及k邻域搜索结合的点云边缘提取算法进行边缘提取,以采样点与其k邻所对应投影点连线的最大夹角为判定原则提高点云边界识别精度,最后设计基于统计滤波点云筛选原则实现各目标焊缝的分割。实验结果表明,光切平面测量模型标定后相对误差≤1.46%,焊缝拟合后长度最大绝对误差0.97mm,相对误差≤1.29%,该方法可同时提取两条目标焊缝,具有高效率、低成本等特点。

关键词：电力钢管塔肋板焊缝光切面法三维重构焊缝提取

Matrix-Mediated Color-Tunable Ultralong Organic Room Temperature Phosphorescence of 7H-Benzo[c]carbazole Derivatives

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CCS Chemistry 2024年第3期6卷 798-811页

作者： Chen Qian xue z.ang zhimin Ma Xiaohua Fu zewei Li Huiwen Jin Mingxing Chen Hong Jiang zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this *** powders of BCz and its derivatives merely exhibit blue fluorescence at ambient ***,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room ***,the UORTP color can be tuned between green and yellow depending on the *** ultralong phosphorescence originates from the generation of charge-separated states via *** matrixes play a key role in both stabilizing charge-separated states and controlling UORTP *** interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room *** Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical *** work gains a deeper insight into the mechanism of UORTP and paves a new approach to applying organic phosphorescent materials to underwater coating and imaging.

关键词： 7H-Benzo[c]carbazole ultralong organic room temperature phosphorescence ion radical matrix-mediated color tunning underwater application

Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3513-3527页

作者： xue Liang Kunpeng Liu Xin Jia Cuiqin Cheng Meiqi z.ang Lingdong Kong Qiqi Li zhe Liu Min Li Junliang Li Yao Wang Anlong Xu School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanning 530004China Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Bile acids(BAs)are natural metabolites in mammals and have the potential to function as drugs against viral ***,the limited understanding of chenodeoxycholic acid(CDCA)receptors and downstream signaling,along with its lower suppression efficiency in inhibiting virus infection limits its clinical *** this study,we demonstrate that farnesoid X receptor(FXR),the receptor of CDCA,negatively regulates interferon signaling,thereby contributing to the reduced effectiveness of CDCA against virus *** deficiency or pharmacological inhibition enhances interferon signaling activation to suppress virus ***,FXR impairs the DNA binding and transcriptional abilities of activated interferon regulatory factor 3(IRF3)through *** IRF3 transcriptional activity by FXReIRF3 interaction significantly undermines the expression of Interferon Beta 1(IFNB1)and the antiviral response of cells,especially upon the CDCA *** FXR-deficient cells,or when combined with z-guggulsterone(GUGG)treatment,CDCA exhibits a more potent ability to restrict virus ***,these findings suggest that FXR serves as a limiting factor for CDCA in inhibiting virus replication,which can be attributed to the“signaling-brake”roles of FXR in interferon *** FXR inhibition represents a promising pharmaceutical strategy for the clinical application of BAs metabolites as antiviral drugs.

关键词： Bile acids FXR IRF3 Interferon transcription RNA virus z-guggulsterone Broad-spectrum antiviral activity Synergistic inhibitory effect

Distinguishing Oil and Water Layers in a Porous Cracked Medium by Interpreting Acoustic Logging Data on the Basis of Hudson Theory

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Journal of Earth Science 2017年第3期28卷 500-506页

作者： xue'ang z.ang zhuwen Wang zhichao Yang Engineering Research Center of Nuclear Technology Application Ministry of EducationEast China University of TechnologyNanchang 330013China Faculty of GeoExploration Science and Technology Jilin UniversityChangchun 130000China School of Geophysics and Measurement-Control Technology East China University of TechnologyNanchang 330013China

During surveys, water layers may interfere with the detection of oil layers. In order to distinguish between oil and water layers in a porous cracked medium, research on the properties of cracks and oil and water layers and their relation to acoustic logging rules is essential. On the basis of Hudson＇s crack theory, we simulated oil and water layers in crack-porous medium with different crack parameters corresponding to the well-field response. We found that in a cracked medium with high crack angle or low number density of cracks, compressional and shear wave velocities are sensitive to crack characteristics; further, these velocities are more sensitive to crack characteristics when the waves propagate through the water layer than when they propagate through the oil layer. Compressional and shear wave velocities increase with an increase in crack angle： in the water layer, the increase is approximately linear. On comparing the full waveforms observed in the oil and water layers, we find that the amplitudes of most waves are higher in the water layer. Among the considered waves, the Stoneley wave suffers maximum amplitude attenuation in the oil layer. The maximum excitation intensity for oil layer is greater than that for the water layer. These results can guide further cracked media logging field exploration work.

关键词： crack acoustic logging Hudson theory numerical simulation reservoir

A fringe jump counting method for the phase measurement in the HCN laser interferometer on EAST and its FPGA-based implementation

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Plasma Science and Technology 2024年第4期26卷 156-161页

作者：姚远杨曜提昂宋扬张家敏王琰张耀刘海庆揭银先 Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Anhui Electrical Engineering Professional Technique College Hefei 230022People’s Republic of China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601People’s Republic of China

Electron density in fusion plasma is usually diagnosed using laser-aided interferometers. The phase difference signal obtained after phase demodulation is wrapped, which is also called a fringe jump. A method has been developed to unwrap the phase difference signal in real time using FPGA, specifically designed to handle fringe jumps in the hydrogen cyanide(HCN) laser interferometer on the EAST superconducting tokamak. This method is designed for a phase demodulator using the fast Fourier transform(FFT) method at the front end. The method is better adapted for hardware implementation compared to complex mathematical analysis algorithms, such as field programmable gate array(FPGA). It has been applied to process the phase measurement results of the HCN laser interferometer on EAST in real time. Electron density results show good confidence in the fringe jump unwrapping method. Further possible application in other laser interferometers, such as the POlarimeter-INTerferometer(POINT)system on EAST tokamak is also discussed.

关键词： electron density laser-aided interferometer fringe jump unwrapping FPGA EAST

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浇注工艺对双金属行星轮轴承复合质量的影响

热加工工艺 2024年第12期53卷 62-66,72页

作者：张伟匡锐魏昂周林薛飞张慧虹盖泽海军装备部陕西西安710000 中国船舶集团有限公司第十二研究所陕西兴平713102 上海船舶设备研究所上海200031

采用不同铸造工艺参数对某行星轮轴承表面进行zSnSb11Cu6锡基合金的复合浇注,通过磁粉探伤、超声波探伤及结合强度检测,研究了不同浇注模具、不同合金浇注温度对双金属行星轮轴承复合质量的影响。结果表明:采用金属型模具、合金浇注温度... 详细信息

采用不同铸造工艺参数对某行星轮轴承表面进行zSnSb11Cu6锡基合金的复合浇注,通过磁粉探伤、超声波探伤及结合强度检测,研究了不同浇注模具、不同合金浇注温度对双金属行星轮轴承复合质量的影响。结果表明:采用金属型模具、合金浇注温度为430℃时可获得比砂型模具、420℃及450℃浇注时更好的合金表面质量和结合强度。经后续工艺验证及小批量生产试制,证实了工艺的稳定性。

关键词：轴承锡基合金浇注工艺复合

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