检索结果-南通市图书馆

Yemazhui(Herba Eupatorii Lindleyani)ameliorates lipopolysaccharide-induced acute lung.injury via modulation of the toll-like receptor 4/nuclear factor kappa-B/nod-like receptor family pyrin domain-containing.3 protein sig.aling.pathway and intestinal flor

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第2期44卷 303-314页

作者： REN Li HAI yang yang xue LUO Xianqin Chong.ing.Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases College of Traditional Chinese MedicineChongqing Medical UniversityChongqing 400016China Colleg. of Basic Medicine Chongqing Medical UniversityChongqing 400016China

OBJECTIVE:To investig.te the impact of Yemazhui(Herba Eupatorii Lindleyani,HEL)ag.inst lipopolysaccharide(LPS)-induced acute lung.injury(ALI)and explore its underlying.mechanism in ***:The chemical constituents of HEL were analyzed by ultra-hig. performance liquid chromatog.aphyquadrupole time-of-flig.t mass spectrometry ***,HEL was found to suppress LPS-induced ALI in ***-week-old male Sprag.e-Dawley rats were randomly divided into 6 g.oups:control,LPS,Dexamethasone(Dex),HEL low dose 6 g.kg.HEL-L),HEL medium dose 18 g.kg.HEL-M)and HEL hig. dose 54 g.kg.HEL-H)*** model rats were intratracheally injected with 3 mg.kg.LPS to establish an ALI *** counts,lung.wet/dry weig.t ratio,as well as myeloperoxidase(MPO)activity were determined followed by the detection with hematoxylin and eosin staining.enzyme linked immunosorbent assay,quantitative real time polymerase chain reaction,western blotting.immunohistochemistry,and ***,to explore the effect of HEL on ALI-mediated intestinal flora,we performed 16s rRNA sequencing.analysis of intestinal ***:HEL attenuated LPS-induced inflammation in lung.tissue and intestinal flora *** study indicated that HEL suppressed the lung.coefficient and wet/dry weig.t ratio of LPS-induced ALI in rats,inhibited leukocytes exudation and MPO activity,and improved the patholog.cal injury of lung.*** addition,HEL reduced the expression of tumor necrosis factoralpha,interleukin-1beta(IL-1β)and interleukin-6(IL-6)in bronchoalveolar lavag. fluid and serum,and inhibited nuclear displacement of nuclear factor kappa-B p65(NF-κBp65).And 18 g.kg.HEL also reduced the expression levels of toll-like receptor 4(TLR4),myeloid differentiation factor 88,NF-κBp65,phosphorylated inhibitor kappa B alpha(phospho-IκBα),nod-like receptor family pyrin domain-containing.3 protein(NLRP3),IL-1β,and interleukin-18(IL-18)in lung.tissue,and reg.lated intestinal flora disturban

关键词： Yemazhui(Herba Eupatorii Lindleyani) acute lung.injury anti-inflammation toll-like receptor 4 nuclear factor kappa-B nod-like receptor family pyrin domain-containing.3 protein sig.al transduction g.strointestinal microbiome

Non-B-form DNA is associated with centromere stability in newly-formed polyploid wheat

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1479-1488页

作者： Cong.0} Yi Qian Liu Yuhong.Huang.Chang.Liu xianrui g.o Chaolan Fan Kaibiao Zhang.yang Liu Fang.u Han Institute of g.netics and Developmental Biolog. Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Non-B-form DNA differs from the classic B-DNA double helix structure and plays a crucial reg.latory role in replication and ***,the role of non-B-form DNA in centromeres,especially in polyploid wheat,remains ***,we systematically analyzed seven non-B-form DNA motif profiles(A-phased DNA repeat,direct repeat,g.quadruplex,inverted repeat,mirror repeat,short tandem repeat,and Z-DNA)in hexaploid *** found that three of these non-B-form DNA motifs were enriched at centromeric reg.ons,especially at the CENH3-binding.sites,sug.esting.that non-B-form DNA may create a favorable loading.environment for the CENH3 *** investig.te the dynamics of centromeric non-B form DNA during.the alloploidization process,we analyzed DNA secondary structure using.CENH3 ChIP-seq data from newly formed allotetraploid wheat and its two diploid *** found that newly formed allotetraploid wheat formed more non-B-form DNA in centromeric reg.ons compared with their parents,sug.esting.that non-B-form DNA is related to the localization of the centromeric reg.ons in newly formed ***,non-B-form DNA enriched in the centromeric reg.ons was found to preferentially form on young.LTR retrotransposons,explaining.CENH3's tendency to bind to young.r ***,our study describes the landscape of non-B-form DNA in the wheat g.nome,and sheds lig.t on its potential role in the evolution of polyploid centromeres.

关键词： non-B-form DNA polyploid wheat centromere retrotransposon

Desig. and Experimental Verification of a Roll Control Strateg. for Larg. Wing.pan Flapping.Wing.Aerial Vehicle

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Eng.neering 2024年第4期21卷 1644-1661页

作者： Rui Meng.Bifeng.Song.Jianlin Xuan Xiaojun yang Dong.xue School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China yangtze River Delta Research Institute of Northwestern Polytechnical University Taicang215400China

Most flapping.wing.aircraft wing. use a sing.e deg.ee of freedom to g.nerate lift and thrust by flapping.up and down,while relying.on the tail control surfaces to manag. ***,these aircraft have certain limitations,such as poor accuracy in attitude control and inadequate roll control *** paper presents a desig. for an active torsional mechanism at the wing.s trailing.edg.,which enables differential variations in the pitch ang.e of the left and rig.t wing. during.*** simple mechanical form sig.ificantly enhances the aircraft's roll control *** experimental verification of this mechanism was conducted in a wind tunnel using.the RoboEag.e flapping.wing.aerial vehicle that we *** study investig.ted the effects of the control strateg. on lift,thrust,and roll moment during.flapping.***,the impact of roll control on roll moment was examined under various wind speeds,flapping.frequencies,ang.es of attack,and wing.***,several rolling.maneuver flig.t tests were performed to evaluate the ag.lity of RoboEag.e,utilizing.both the elevon control strateg. and the new roll control *** results demonstrated that the new roll control strateg. effectively enhances the roll control capability,thereby improving.the attitude control capabilities of the flapping.wing.aircraft in complex wind field *** conclusion is supported by a comparison of the control time,maximum roll ang.e,averag. roll ang.lar velocity,and other relevant parameters between the two control strateg.es under identical roll control input.

关键词： Roll control Bio-inspired Roll moment Flapping.wing.aerial vehicle

Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141,DDHD2,and LHFPL5

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第1期18卷 81-97页

作者： Liwei Sun xueting.yang Amjad Khan xue Yu Han Zhang.Shirui Han Xiaerbati Habulieti yang Sun Rong.ong.Wang.xue Zhang McKusick-Zhang.Center for g.netic Medicine State Key Laboratory for Complex Severe and Rare DiseasesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing100005China Chong.ing.Key Laboratory of Human Embryo Eng.neering Center for Reproductive MedicineNational Key Clinical Speciality Construction Project(Obstetrics and Gynecology)Chongqing Health Center for Women and ChildrenChongqing400013China Chong.ing.Clinical Research Center for Reproductive Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing400013China Faculty of Biolog.cal Sciences Department of ZoologyUniversity of Lakki MarwatKhyber Pakhtunkhwa28420Pakistan Institute for Medical g.netics and Applied g.nomics University of TübingenTübingen72076Germany Alexander von Humboldt fellowship Foundation Berlin10117Germany Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Department of Laboratory Medicine State Key Laboratory for Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China

Hig.ly clinical and g.netic heterog.neity of neurodevelopmental disorders presents a major challeng. in clinical g.netics and *** variation analysis is imperative to analyze the disease phenotypes resulting.from multilocus g.nomic ***,a Pakistani family with parental consang.inity was presented,characterized with severe intellectual disability(ID),spastic parapleg.a,and *** mapping.integ.ated sing.e nucleotide polymorphism(SNP)array,whole-exome sequencing.and whole-g.nome sequencing.were performed,and homozyg.us variants in TMEM141(c.270g.A,***90^(*)),DDHD2(c.411+767_c.1249-327del),and LHFPL5(c.250delC,***84^(*))were identified.A Tmem141^(***90^(*)/***90^(*))mouse model was *** studies showed impairments in learning.ability and motor *** slice electrophysiolog. and g.lg. staining.demonstrated deficient synaptic plasticity in hippocampal neurons and abnormal dendritic branching.in cerebellar Purkinje *** electron microscopy showed abnormal mitochondrial ***,studies on a human in vitro neuronal model(SH-SY5Y cells)with stable shRNA-mediated knockdown of TMEM141 showed deleterious effect on bioenerg.tic function,possibly explaining.the pathog.nesis of replicated phenotypes in the cross-species mouse ***,panoramic variation analysis revealed that multilocus g.nomic variations of TMEM141,DDHD2,and LHFPL5 tog.ther caused variable phenotypes in ***,the biallelic loss-of-function variants of TMEM141 were responsible for syndromic ID.

关键词： neurodevelopmental disorder autosomal recessive intellectual disability consang.inity spastic parapleg.a hearing.loss TMEM141

Experimental Study on the Effect of Increased Downstroke Duration for an FWAV with Morphing.coupled Wing.Flapping.Config.ration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Eng.neering 2024年第1期21卷 192-208页

作者： Ang.Chen Bifeng.Song.ZhiheWang.Kang.Liu Dong.xue Xiaojun yang School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Harbin Institute of Technolog. Shenzhen 518055China

This paper is based on a previously developed bio-inspired Flapping.Wing.Aerial Vehicle(FWAV),RoboFalcon,which can fly with a morphing.coupled flapping.*** this paper,a simple flapping.stroke control system based on Hall effect sensors is desig.ed and applied,which is capable of assig.ing.different up-and down-stroke speeds for the RoboFalcon platform to achieve an adjustable downstroke *** aerodynamic and power characteristics of the morphing.coupled flapping.pattern and the conventional flapping.pattern with varying.downstroke ratios are measured throug. a wind tunnel experiment,and the corresponding.aerodynamic models are developed and analyzed by the nonlinear least squares *** relatively low power consumption of the slow-downstroke mode of this vehicle is verified throug. outdoor flig.t *** results of wind tunnel experiments and flig.t tests indicate that increased downstroke duration can improve aerodynamic and power performance for the RoboFalcon platform.

关键词： Flapping.wing.aerial vehicle(FWAV) Downstroke ratio Bio-inspired desig. Morphing.coupled flapping

Lig.in-reinforced PVDF electrolyte for dendrite-free quasi-solid-state Li metal battery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 1006-1016页

作者： Xin-yang Chen xue-Jie g.o Han-Yan Wu Yu-Long.Liu Xiao-Fei yang Run-Cang.Sun Center for Lig.ocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian116034China Division of Energ. Storag. Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China School of Chemistry Northeast Normal UniversityChangchun130024China

Quasi-solid-state lithium metal batteries(QSSLMBs)assembled with polyvinylidene fluoride(PVDF)are a promising.class of next-g.neration recharg.able batteries due to their safety,hig. energ. density,and superior interfacial ***,PVDF has a series of inherent drawbacks such as low ionic conductivity,ease of crystallization,and hydrophobic character that leading.to poor cell *** tackle these issues,a lig.in-reinforced PVDF electrolyte is proposed in this work to solve these drawbacks of PVDF and enhance the comprehensive performance of *** lithophilic polar g.oups of lig.in can promote uniform deposition of Li on the *** with the improved mechanical properties can efficiently prevent Li dendrites penetration throug. the *** addition,more active sites provided by lig.in can also enhance Li^(+)transport and lead to a faster electrochemical reaction *** from the ing.nious desig.,Li symmetric cells with 5%lig.in-PVDF quasi-solid-state electrolyte can operate for 900 h at a hig. current density/capacity of 5 mA·cm^(-2)/5 mAh·cm^(-2),while shortcircuiting.occurs after 56 h for the counterpart(pure PVDF).Moreover,a full cell of Li/5%lig.in-PVDF/LFP cell demonstrates a hig. capacity of 96.2 mAh·g.(-1)after 2000 cycles at 10 *** work is expected to open up promising.opportunities to develop other hig.-energ./power-density QSSLMBs.

关键词： Quasi-solid-state electrolyte Lig.in PVDF Dendrite-free Li metal battery

Lattice-distorted Pt wrinkled nanoparticles for hig.ly effective hydrog.n electrocatalysis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 3819-3826页

作者： xue Li Xiang.Han Zhenrui yang Shun Wang.Yun yang Juan Wang.Jiadong.Chen Zhong.ei Chen Huile Jin Wenzhou Key Lab of Advanced Energ. Storag. and Conversion Zhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute of New Materials and Industry Technolog. College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Department of Chemical Eng.neering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Modulating.Pt surfaces throug. the introduction of lattice distortion emerg.s as immensely effective strateg. that enhances the kinetics of alkaline hydrog.n evolution and oxidation *** this study,we fabricated lattice-distorted Pt wrinkled nanoparticles(LD-Pt WNPs)for efficient hydrog.n *** LD-Pt WNPs not only outperform the Pt/C benchmark in hydrog.n oxidation reaction,achieving.an excellent mass-specific current of 968.5 mA·mg.(Pt)^(-1)(9 times that of Pt/C),but also demonstrate outstanding.hydrog.n evolution reaction activity with a small overpotential of 58.0 *** experiments and density functional theory calculations reveal that lattice defects introduce an abundance of unsaturated coordination atoms while modifying.the d-band center of *** dual effect optimizes the binding.streng.h of crucial H and OH intermediates,leading.to a sig.ificant reduction in the energ. barrier of the reaction bottleneck,commonly known as the Volmer *** work unveils a fresh viewpoint on projecting.and developing.hig. efficiency electrocatalysts throug. defect eng.neering.

关键词： distortion nanoparticle hydrog.n evolution reaction defect eng.neering hydrog.n oxidation reaction

Inhibiting.shuttle effect of lithium polysulfides by double metal selenides for hig.-performance lithium-sulfur batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2546-2559页

作者： Lei Li xue-Jing.yang Yi-yang Li Bo Jin Hui Liu Meng.yang Cui Dong.Bo g.an Xing.You Lang.Qing.Jiang Key Laboratory of Automobile Materials Ministry of Educationand College of Materials Science and EngineeringJilin UniversityChangchun 130022China

Lithium-sulfur batteries(LSBs)have attracted the attention of more and more researchers due to the advantag.s of hig. energ. density,environmental friendliness,and low production ***,the low electronic conductivity of active material and shuttling.effect of lithium polysulfides(LiPSs)limit the commercial development of *** solve these problems,we desig. a core-shell composite with nitrog.n-doped carbon(NC)and two types of selenides(FeSe_(2)-NC@ZnSe-NC).The FeSe_(2)-NC@ZnSe-NC has a strong.adsorption capacity,and can effectively adsorb *** the same time,it also effectively alleviates the shuttling.effect of LiPSs,and improves the utilization of the active substance during.the charg./discharg. reaction *** mechanism involved in FeSe_(2)-NC@ZnSe-NC is demonstrated by both experiments and density-functional theory(DFT)*** electrochemical test results indicate that LSB with S/FeSe_(2)-NC@ZnSe-NC delivers an initial discharg. capacity of 1260 mAh·g.(-1)at *** after 500 cycles at 1C,the capacity decay rate per cycle is 0.031%,and the capacity retention rate is 85%.The FeSe_(2)-NC@ZnSe-NC core-shell structure verifies a rational strateg. to construct an electrode material for hig.-performance LSBs.

关键词： Lithium-sulfur batteries Shuttling.effect Metal selenide Nitrog.n-doped carbon Lithium polysulfides

Desig. and fabrication of self-suspending.aluminum-plastic/semiconductor photocatalyst devices for solar energ. conversion

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 615-625页

作者： Zhi-Ang.Zhao Jing.un Mao Cheng.ing.Lu Shuang.iao yang Qing.ong.Qian Qing.ua Chen Hun xue Xiaoli Sun Min-Quan yang Colleg. of Environmental and Resource Sciences College of Carbon Neutral Modern IndustryFujian Key Laboratory of Pollution Control and Resource ReuseFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Eng.neering Polymer Research Institute of Sichuan UniversityChengdu 610065China

The desig. and synthesis of self-suspending.photocatalyst device with easy recyclability is important for practical ***,this work utilizes aluminum-plastic packag. waste as raw material to prepare an aluminum-plastic supported TiO_(2)(AP-TiO_(2))photocatalyst device throug. 3D printing.desig. and surface deposition method.A series of characterizations were carried out to explore the structure,morpholog. and performance of the AP-TiO_(2)*** UV lig.t illumination,the AP-TiO_(2)-50 efficiently deg.ade 93.6%tetracycline hydrochloride(THC)after 4 hr,which increases by 8.3%compared with that of TiO_(2)powder suspension system with the same catalyst *** on it,AP-ZnO,AP-CdS,AP-g.C_3N_4and AP-Pt-TiO_(2)are also fabricated,and applied in photocatalytic deg.adation and hydrog.n evolution,which all exhibit hig.er photoactivities than powder suspension *** work provides a new avenue for the fabrication of advanced recyclable photocatalyst ***,the work offers a novel sig.t for the hig.-value utilization of aluminum-plastic packag. waste,which has positive implications for environmental protection.

关键词： TiO_(2) Self-suspending Photocatalyst device Aluminum plastic