检索结果-南通市图书馆

A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2263-2280页

作者： Leilei Wang Shanshan He Rong Liu yuan xue yuan Quan Rongying Shi xueying Yang Qing Lin Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer ***,the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment(TME).Here,we developed a pH/reactive oxygen species(ROS)dual-response system to enhance chemoimmunotherapy for *** system productively accumulated in tumors by specific binding of phenylboronic acid(PBA)to sialic acids(SA).The nanoparticles(NPs)rapidly swelled and released quercetin(QUE)and doxorubicin(DOX)upon the stimulation of tumor microenvironment(TME).The in vitro and in vivo results consistently demonstrated that the NPs improved anti-tumor efficacy and prolonged survival of mice,significantly enhancing the effects of the *** study revealed DOX was an ICD inducer,stimulating immune responses and promoting maturation of dendritic cells(DCs).Additionally,QUE served as a TME regulator by inhibiting the cyclooxygenase-2(COX2)-prostaglandin E2(PGE2)axis,which influenced various immune cells,including increasing cytotoxic T cells(CLTs)infiltration,promoting M1 macrophage polarization,and reducing regulatory T cells(Tregs)*** combination synergistically facilitated chemoimmunotherapy efficacy by remodeling the immunosuppressive *** work presents a promising strategy to increase anti-tumor efficiency of chemotherapeutic agents.

关键词： Quercetin Nanoparticle Responsiveness Chemoimmunotherapy Tumor immune microenvironment

Effect of Al content on modification behavior of non-metallic inclusions in high-strength steel treated with rare earth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第8期31卷 1886-1899页

作者： Zhan-peng Tie xue-yuan Jiang Hai-yan Tang ·Gen Li Yu-hang Wang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Continuous Casting Business Section CISDI Engineering Co.Ltd.Chongqing 401122China Special Steel Institute Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

The influence of Al content(0.0053,0.0171,and 0.0578 wt.%)on the modification behavior of non-metallic inclusions in 20CrMoVTiB steel treated with rare earth elements was studied through high-temperature experiments and thermodynamic *** results showed that the modification products varied with the Al content in steel under 0.01 wt.%of Ce *** formation sequence of typical rare earth inclusions in steel with the increase in Al content was Ce_(2)O_(3)→CeAlO_(3)→CeAl_(11)O_(18),and the final stable products were highly Al content *** the Al content was 0.0053 wt.%,the stable phase in steel was Ce2O3;while the[Al]reached 0.0171 wt.%,the stable phase became CeA1O_(3).As the A1 content reached 0.0578 wt.%,CeAl_(11)O_(18) became the stable *** a result,increasing the Al content could inhibit the precipitation of Ce_(2)O_(3) inclusions in steel while promote the formation of CeAIO3 and CeAl_(11)O_(18) *** addition,both Ca treatment and Ce treatment could effectively refine the size of inclusions in steel by changing their ***,the feeding amount of Ca wire into molten steel should be appropriately reduced under the condition of adding Ce simultaneously,which is expected to be beneficial for an improved Ce treatment effect.

关键词： Rare earth Al content Steel Inclusion Thermodynamics Ca treatment

Advances in methane emissions from agricultural sources:Part *** and mitigation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第6期140卷 279-291页

作者： Xiaokun Wu Ying Zhang Yinghui Han Yagang Zhang Yuhang Zhang Xiaodan Cheng Pei Zhong xue yuan yuanxun Zhang Zhengqiang Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071003China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Interdisciplinary Mathematics Institute University of South CarolinaColumbiaSC 29208United States Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

Methane is one of the major greenhouse gases(GHGs)and agriculture is recognized as its primary *** accounting is a prerequisite for developing effective agriculture mitigation *** this review,methane accounting methods and research status for various agricultural emission source including rice fields,animal enteric fermentation and livestock and poultry manure management were overview,and the influencing factors of each emission source were analyzed and *** the same time,it analyzes the different research efforts involving agricultural methane accounting and makes recommendations based on the actual ***,mitigation strategies based on accounting results and actual situation are *** review aims to provide basic data and reference for agriculture-oriented countries and regions to actively participate in climate action and carry out effective methane emission mitigation.

关键词： Methane emission Agricultural sources Accounting methodology Mitigation Emission influencing factors

Therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2183-2193页

作者： Qi Hu Xiao-Pin Chen Zhi-Jun Tang xue-yuan Zhu Chun Liu College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina Intensive Care Unit The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND According to the theory of traditional Chinese medicine(TCM),the spleen and stomach are the basis of acquired nature and the source of qi and blood *** surgery and chemotherapy,patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome,leading to decreased immune *** Yiqi decoction,a classic TCM prescription,has the effect of tonifying middle-jiao and invigorating qi,boosting Yang,and suppressing immune-related ***,it is widely used in the treatment of spleen and stomach qi deficiency *** To investigate the effect of Buzhong Yiqi decoction on spleen and stomach qi deficiency in patients with colorectal *** One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively *** patients were divided equally into control and observation *** groups underwent conventional rehabilitation surgery,and the observation group was supplemented with Buzhong Yiqi *** 26.0 was used for statistical ***χ2 test was used for univariate analysis;independent sample t-tests were used in all *** No significant differences were observed preoperatively in the general characteristics of the two *** days post-surgery,the abdominal distension,emaciation,loose stool,loss of appetite,and vomiting scores were significantly lower in the observation group than in the control group(P<0.05).Immune function and interleukin(IL)-10 levels in the observation group were significantly higher than those of the control group,whereas IL-6,tumor necrosis factor-α,and C-reactive protein levels,tumor biological indexes,and adverse reactions in the observation group were significantly lower than those of the control group(P<0.05).One month after surgery,the patients’quality of life in the observation group was significantly high

关键词： Buzhong Yiqi decoction Colorectal cancer Laparoscopic radical surgery Immune function Inflammatory mediators Spleen

Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin Yang Hong-Yong Xiang Ming Niu Jia-Cheng Deng xue-yuan Li Wen-Jie Hao Hong-Sheng Ou-Yang Tong-Yu Liu Xiao-Chun Tang Da-Xin Pang Hong-Ming yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第9期30卷 1189-1212页

作者： Jin-Lian Jiang Yi-Yang Zhou Wei-Wei Zhong Lin-Yan Luo Si-Ying Liu Xiao-Yu Xie Mao-yuan Mu Zhi-Gang Jiang yuan xue Jian Zhang Yi-Huai He Department of Infectious Diseases Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Respiratory Medicine Anshun People’s HospitalAnshun 561099Guizhou ProvinceChina Department of General Practice Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Intervention Radiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Liver Diseases Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Digestion Dafang County People’s HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1(UGT1A1)plays a crucial role in metabolizing and detoxifying endogenous and exogenous ***,its contribution to the progression of liver damage remains *** To determine the role and mechanism of UGT1A1 in liver damage *** We investigated the relationship between UGT1A1 expression and liver injury through clinical ***,the impact and mechanism of UGT1A1 on the progression of liver injury was analyzed through a mouse model *** Patients with UGT1A1 gene mutations showed varying degrees of liver damage,while patients with acute-onchronic liver failure(ACLF)exhibited relatively reduced levels of UGT1A1 protein in the liver as compared to patients with chronic *** suggests that low UGT1A1 levels may be associated with the progression of liver *** mouse models of liver injury induced by carbon tetrachloride(CCl_(4))and concanavalin A(ConA),the hepatic levels of UGT1A1 protein were found to be *** mice with lipopolysaccharide or liver steatosis-mediated liver-injury progression,the hepatic protein levels of UGT1A1 were decreased,which is consistent with the observations in patients with ***1A1 knockout exacerbated CCl_(4)-and ConA-induced liver injury,hepatocyte apoptosis and necroptosis in mice,intensified hepatocyte endoplasmic reticulum(ER)stress and oxidative stress,and disrupted lipid *** UGT1A1 is upregulated as a compensatory response during liver injury,and interference with this upregulation process may worsen liver ***1A1 reduces ER stress,oxidative stress,and lipid metabolism disorder,thereby mitigating hepatocyte apoptosis and necroptosis.

关键词： Uridine diphosphate glucuronosyltransferase 1A1 Liver injury progression Endoplasmic reticulum stress Oxidative stress Lipid metabolism disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代德国构建集体认同的困境与破局

探索与争鸣 2024年第2期 162-176,F0003,180页

作者：薛原上海交通大学外国语学院德语系上海200240

欧洲民族国家的集体认同是一个难题:它们往往在作为民族国家的坚守、对共同政治文化的接受,还有作为“欧洲人”的共同身份这三种立场之间摇摆不定。在欧洲逐步迈向“超国家”共同体的今天,德国的集体认同对于认识欧洲民族国家与欧洲国... 详细信息

欧洲民族国家的集体认同是一个难题:它们往往在作为民族国家的坚守、对共同政治文化的接受,还有作为“欧洲人”的共同身份这三种立场之间摇摆不定。在欧洲逐步迈向“超国家”共同体的今天,德国的集体认同对于认识欧洲民族国家与欧洲国家共同体之间的关系有着重要意义,它深刻影响着德国国内的稳定和团结,主导着其外交和安全政策走向,也构筑着德国未来发展的愿景。二战以后,德国以逐步削弱“德国性”、接近“西方”的方式获得国家集体认同。这就是代表德国民族主义的“主导文化”以及代表政治文化的“宪法爱国主义”的争端之所在。而这一对矛盾,在欧洲层面可以得到疏解和升华。欧洲文化价值共同体与欧洲宪法爱国主义合一的愿景,可以成为德国乃至其他欧洲国家集体认同构建的最高目标。

关键词：集体认同德国主导文化欧洲认同

全球化浪潮中的一座孤岛--德国小说《账单待付》中的岛屿母题

在线全文

学校读者我要写书评

暂无评论

同济大学学报（社会科学版） 2024年第4期35卷 1-14页

作者：薛原上海交通大学德语系上海200240

“岛屿”母题在21世纪的德国哲学和文学中书写了浓墨重彩的篇章。德国著名哲学家彼得·斯洛特戴克回溯了人类文明中的三次全球化,并用“岛屿化”和“全球化”来隐喻人类自我保护和开拓疆域之间的关系。他笔下全球化的宏大“水晶宫”破... 详细信息

“岛屿”母题在21世纪的德国哲学和文学中书写了浓墨重彩的篇章。德国著名哲学家彼得·斯洛特戴克回溯了人类文明中的三次全球化,并用“岛屿化”和“全球化”来隐喻人类自我保护和开拓疆域之间的关系。他笔下全球化的宏大“水晶宫”破碎之后,个体以“泡沫化”的生存形式寻求自我免疫。德国作家英格-玛丽亚·马尔克以2008年全球金融危机为背景构思的小说《账单待付》描写了一个在全球化浪潮中被推至城市边缘的生存孤岛。借助多重叙事技巧,马尔克不仅展现了一群在各自社会圈层中坠落的人们的悲喜,更是敏锐地透视了当代德国人泡沫式的“孤岛文化”,展开了一幅全球化时代德国现实主义的画卷。

关键词：全球化斯洛特戴克岛屿母题孤岛文化《账单待付》

Inherently Chiral and Symmetrical Heteroatom-Doped Zigzag-Type Hydrocarbon Belts

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第5期6卷 1198-1210页

作者： xue-yuan Wang Xin-Yu Zhang Shuo Tong Qing-Hui Guo Mei-Ling Tan Cheng-Jun Li Mei-Xiang Wang Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084

hydrocarbon belts due to their potential applications in carbon *** contrast,heteroatomembedded zigzag hydrocarbon belts as advanced design strategies with fascinating structures and desirable,unique properties have remained largely unexplored,and inherently chiral ones are ***,we report the synthesis of a diversity of symmetric and highly enantiopure inherently chiral O-and N-doped zigzag-type hydrocarbon belts starting from strainless macrocycles based on fjord-stitching *** readily available pertriflated resorcin[6]arene underwent partial hydrolyses and intramolecular S_(N)Ar reactions to form a calix[3](9H-xanthene)derivative and a prochiral half-belt *** transformations of calix[3](9H-xanthene)into C_(3v)-symmetric molecular belts were achieved by closing the rest of the fjords with triple intramolecular S_(N)Ar reactions and Yamamoto homo coupling reactions,as well as palladiumcatalyzed intermolecular acridination reactions with primary *** prochiral half-belt underwent enantioselective desymmetrizative mono-acridination to afford an inherently chiral N,O_(4)-bridged pseudo-belt with an enantiomeric excess(ee)value of>99%under the catalysis of Pd(OAc)_(2)and(R)-*** closure reactions of the pseudo-belt produced diverse heteroatom-inlayed zigzag-type hydrocarbon belts of inherent ***,we showed the unique cavity structures of the belts and demonstrated interesting chiroptic properties of the inherently enantiopure chiral *** research opens the door for the exploration of novel and sophisticated symmetric and inherently chiral molecular nanobelt structures with outstanding physical and chemical properties,as well as potential applications.

关键词： zigzag-type molecular belt heterocycle chiroptical property fjord-stitching strategy resorcinarene