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Lung cancer risk in never-smokers:An overview of environmental and genetic factors

Chinese Journal of Cancer Research 2021年第5期33卷 548-562页

作者： Elvin S Cheng Marianne Weber Julia Steinberg xue qin yu The Daffodil Centre the University of Sydneya joint venture with Cancer Council NSWSydneyNSW 2011Australia

Lung cancer is the leading cause of cancer-related mortality globally,accounting for 1.8 million deaths in *** the vast majority are caused by tobacco smoking,15%-25%of all lung cancer cases occur in lifelong *** International Agency for Research on Cancer(IARC)has classified multiple agents with sufficient evidence for lung carcinogenesis in humans,which include tobacco smoking,as well as several environmental exposures such as radon,second-hand tobacco smoke,outdoor air pollution,household combustion of coal and several occupational ***,the IARC evaluation had not been stratified based on smoking status,and notably lung cancer in never-smokers(LCINS)has different epidemiological,clinicopathologic and molecular characteristics from lung cancer in *** several risk factors proposed for the development of LCINS,environmental factors have the most available evidence for their association with LCINS and their roles cannot be ***,while initial genetic studies largely focused on lung cancer as a whole,recent studies have also identified genetic risk factors for *** article presents an overview of several environmental factors associated with LCINS,and some of the emerging evidence for genetic factors associated with *** increased understanding of the risk factors associated with LCINS not only helps to evaluate a never-smoker’s personal risk for lung cancer,but also has important public health implications for the prevention and early detection of the *** evidence on causal associations could inform longer-term policy reform in a range of areas including occupational health and safety,urban design,energy use and particle emissions,and the importance of considering the impacts of second-hand smoke in tobacco control policy.

关键词： Lung cancer never-smoker risk factor environmental factor genetic factor

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Multiple myeloma survival in New South Wales, Australia, by treatment era to 2020

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Cancer Biology & Medicine 2024年第8期21卷 703-711页

作者： Eleonora Feletto qingwei Luo Anna Kelly Marianne Weber David Goldsbury Katherine Barron Karen Canfell xue qin yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydney NSW 2006Australia

Objective: Australia has relatively high multiple myeloma(MM) incidence and mortality rates. Advancements in MM treatment over recent decades have driven improvements in MM survival in high-income countries;however, reporting in Australia is limited. We investigated temporal trends in population-wide MM survival across 3 periods of treatment advancements in New South Wales(NSW), ***: Individuals with an MM diagnosis in the NSW Cancer Registry between 1985 and 2015 with vital follow-up to 2020, were categorized into 3 previously defined treatment eras according to their diagnosis date(1985±1995, chemotherapy only;1996±2007, autologous stem cell transplantation;and 2008±2015, novel agents including proteasome inhibitors and immunomodulatory drugs). Both relative survival and cause-specific survival according to Fine and Gray's competing risks cumulative incidence function were calculated by treatment era and age at ***: Overall, 11,591 individuals were included in the study, with a median age of 70 years at diagnosis. Five-year relative survival improved over the 36-year(1985±2020) study period(31.0% in 1985±1995;41.9% in 1996±2007;and 56.1% in 2008±2015). For individuals diagnosed before 70 years of age, the 5-year relative survival nearly doubled, from 36.5% in 1985±1995 to 68.5% in 2008±2015. Improvements for those > 70 years of age were less pronounced between 1985±1995 and 1996±2007;however, significant improvements were observed for those diagnosed in 2008±2015. Similar overall and age-specific patterns were observed for causespecific survival. After adjustment for gender and age at diagnosis, treatment era was strongly associated with both relative and cause-specific survival(P < 0.0001).Conclusions: Survival of individuals with MM is improving in Australia with treatment advances. However, older age groups continue to experience poor survival outcomes with only modest improvements over time. Given the increasing prevalence of MM in

关键词： Multiple myeloma cancer epidemiology survival analysis competing risk analysis Australia

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Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study

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Cancer Biology & Medicine 2024年第8期21卷 692-702页

作者： Md Mijanur Rahman Michael David David Goldsbury Karen Canfell Kou Kou Paramita Dasgupta Peter Baade xue qin yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydneyNSW 1340Australia School of Medicine and Dentistry Griffith UniversityGold CoastQLD 4222Australia Cancer Council Queensland BrisbaneQLD 4006Australia

Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common ***: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average ***: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expec

关键词： Cancer diagnosis life expectancy loss of life expectancy area-level socioeconomic status flexible parametric model

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Widening socioeconomic disparity in lung cancer incidence among men in New South Wales, Australia, 1987–2011

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Chinese Journal of Cancer Research 2017年第5期29卷 395-401页

作者： xue qin yu qingwei Luo Clare Kahn Camilla Cahill Marianne Weber Paul Grogan Ahmedin Jemal Dianne L O'Connell Cancer Research Division Cancer Council NSW Sydney School of Public Health University of Sydney Sanofi Australia Cancer Council Australia Surveillance and Health Services Research American Cancer Society School of Medicine and Public Health University of Newcastle

Objective：We assessed the trends in lung cancer incidence over a 25-year period by socioeconomic groups for men in New South Wales（NSW）,***：Men diagnosed with lung cancer between 1987 and 2011 were divided into five quintiles according to an Index of Education and Occupation（IEO）.We assessed relative socioeconomic differences over time by calculating age-standardized incidence ratios（SIRs）by 5-year period of diagnosis,and estimated absolute differences by comparing the observed and expected numbers of cases using the highest IEO quintile as the ***：Lung cancer incidence for men decreased from 1987 to 2011 for all IEO quintiles,with a greater rate of decline for men living in the highest IEO ***,the relative disparity increased significantly over the 25-year period（P=0.0006）.For example,the SIR for the lowest IEO quintile increased from 1.28 during 1987–1991 to 1.74during 2007–*** differences also increased with the proportion of＂potentially preventable＂cases doubling from 14.5% in 1987–1991 to 30.2% in 2007–***：Despite the overall decline in lung cancer incidence among men in NSW over the past 25 years,there was a significant increase in disparity across socioeconomic areas in both relative and absolute terms.

关键词： Australia lung cancer socioeconomic inequality temporal trends tobacco control tobacco smoking

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Influence of PPV,PRV and PRRSV on Efficacy of the Lapinized Hog Cholera Vaccine and Pathogenicity of Classical swine fever virus

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Journal of Integrative Agriculture 2012年第11期11卷 1892-1897页

作者： NING Yi-bao ZHAO yun WANG qin FAN xue-zheng qin yu-ming ZHANG Guang-chuan XU Lu QIU Hui-shen WANG Zai-shi SONG Li SHEN qing-chun ZHAO Qi-zu China National Classical Swine Fever Reference Laboratory/China Institute of Veterinary Drug Control Beijing 100081 P.R. China

Classical swine fever caused by Classical swine fever virus （CSFV） is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reasons. In this study, we conducted animal experiments to examine the influence of single or mixed infection with Porcine parvo virus （PPV）, Pseudorabies virus （PRV） and Porcine reproductive and respiratory syndrome virus （PRRSV） on the protective immunity induced by the Lapinized hog cholera virus （HCLV） vaccine and the pathogenicity of CSFV. In experiment 1, pigs were first inoculated with PPV, PRV or PRRSV, then immunized with HCLV, and finally challenged with a highly virulent CSFV Shimen strain. All of the pigs immunized with HCLV survived after the challenge, while all of the pigs in the non-immunized control group died after the challenge. The pigs in the group immunized with HCLV did not show any clinical symptoms of classical swine fever and were negative with CSFV after the challenge. The pigs infected with the non-CSFV before HCLV immunization did not display any clinical symptoms after the challenge with CSFV Shiman strain, but 11 of the 12 pigs were positive with CSFV. In experiment 2, pre-infections with PPV, PRV, and PRRSV were followed by inoculation with a low-virulence CSFV strain （CSFV 39）, and then the pigs were challenged with the CSFV Shimen strain. Infections by either PPV, PRV or PRRSV did not enhance the virulence of CSFV-39, but pigs infected by a mixture of the 3 viruses developed clinical symptoms after inoculation with CSFV-39. The mixed infection also increased mortality caused by the challenge with the CSFV Shimen strain. Together, these results showed PPV, PRV and PRRSV infections in pigs can reduce the efficacy of the HCLV vaccine and enhance the pathogenicity of CSFV, which may partly explain the immunization failure against CSFV in some swine

关键词： Lapinized hog cholera virus vaccination pathogenicity mixed infection influence

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民国初年有关制宪问题的争论——以马相伯的经历为视角的考察

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复旦学报（社会科学版） 2012年第2期54卷 112-122页

作者：薛玉琴杭州师范大学人文学院浙江310036

制定一部良善的宪法,是民国初年民主宪政实验的首要问题,各种政治力量围绕制宪问题展开了激烈的争论与斗争。作为原立宪派的代表人物,总统府高等政治顾问、研究宪法委员会成员之一,马相伯参与了民初宪法的研究与讨论。他从历史、国情与... 详细信息

制定一部良善的宪法,是民国初年民主宪政实验的首要问题,各种政治力量围绕制宪问题展开了激烈的争论与斗争。作为原立宪派的代表人物,总统府高等政治顾问、研究宪法委员会成员之一,马相伯参与了民初宪法的研究与讨论。他从历史、国情与学理出发,阐述了宪法制定的立场和主张:在国家结构上,主张采行单一制;在中央与地方关系上,赞同在加强中央集权的同时,给予地方自治权力;在政体方面,主张实行总统制,加大行政权力,建立强有力的政府;此外,他坚决反对定孔教为国教。这些观点与主张虽然并不完全从属于原立宪派,但一定程度上反映了该派对于宪法问题之立场与意见。这种过于理想化的思想与主张最终不自觉地为袁世凯进行专制集权统治所利用。马相伯的这一段政治经历为深入考察民初制宪之争提供了一个重要视角和个案,从中反映出制宪之争对于民初政治之影响。

关键词：民国初年马相伯制宪之争宪政协商

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褚辅成与浙江辛亥革命

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杭州师范大学学报（社会科学版） 2011年第5期33卷 32-39页

作者：薛玉琴杭州师范大学人文学院浙江杭州310036

褚辅成是浙江辛亥革命的元勋之一。甲午战争之后,在日益深重的民族危机面前,褚辅成跨出国门,在东京加入中国同盟会,由传统士绅转变成一位革命者。在浙江辛亥革命中,褚辅成积极谋划、参与组织和领导省城杭州以及嘉兴等地的光复活动。光... 详细信息

褚辅成是浙江辛亥革命的元勋之一。甲午战争之后,在日益深重的民族危机面前,褚辅成跨出国门,在东京加入中国同盟会,由传统士绅转变成一位革命者。在浙江辛亥革命中,褚辅成积极谋划、参与组织和领导省城杭州以及嘉兴等地的光复活动。光复以后,他又为浙江省政治秩序的稳定、民主政治的推行作出了积极贡献。但由于其阶级的局限性,政治理论与经验的不成熟,褚辅成在革命活动中也存在严重不足:在光复之后浙江省新生政权的巩固与建设中,褚辅成等革命派排斥立宪派,不能与原立宪派人士真诚合作,致使民主政治建设事业遭受顿挫。

关键词：褚辅成浙江辛亥革命革命派立宪派

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论社会主义核心价值体系濡化机制的建构

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理论导刊 2011年第7期 34-36页

作者：薛玉琴青岛大学思政部山东青岛266071

建构社会主义核心价值体系濡化机制,是全球化背景下掌握意识形态主动权的必然要求,是统一思想、凝聚力量的现实需要。建构社会主义核心价值体系濡化机制可以从理论创新、科学灌输、舆论引导和制度保障等四大现实进路入手。

关键词：社会主义核心价值体系濡化机制内化

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马相伯研究七十年

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杭州师范大学学报（社会科学版） 2008年第6期30卷 90-94页

作者：薛玉琴杭州师范大学人文学院浙江杭州310036

马相伯是中国近代著名的政治家、教育家、宗教家,他一生的思想与活动对中国近代社会产生了广泛的影响。70年来,马相伯研究取得了许多重要成果,笔者在回顾与分析马相伯研究现状的基础上,指出其存在的问题与不足,并提出了今后马相伯研究... 详细信息

马相伯是中国近代著名的政治家、教育家、宗教家,他一生的思想与活动对中国近代社会产生了广泛的影响。70年来,马相伯研究取得了许多重要成果,笔者在回顾与分析马相伯研究现状的基础上,指出其存在的问题与不足,并提出了今后马相伯研究的几点建议。

关键词：马相伯研究综述问题与不足

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Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing Shi yu Song xue-xue Liang Ting Chen Huang-yu Hao xue Han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

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