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A survey of impulse control disorders in Parkinson’s disease patients in Shanghai area and literature review

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Translational Neurodegeneration 2016年第1期5卷 28-32页

作者： xue-ping wang Ming Wei Qin Xiao Department of Neurology and Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina

Background:Levodopa and dopamine agonists are the main treatments for Parkinson’s disease(PD)in recent *** drug dosages are linked to some severe side effects,one of which is impulse control disorders(ICD).Many studies have reported the related risk factors of ICDs,such as dopamine agonist,male sex,younger age,earlier age of onset and so *** study aims to investigate the incidence of ICD in Chinese PD patients from Shanghai area,explore the association of ICD with dopamine replacement therapy(DRT).Methods:Two hundred seventeen PD patients were consecutively recruited from the Movement Disorder Clinic of Ruijin Hospital from March to October *** Impulsive Disorders Interview was used to assess the PD *** patients with possible ICD would undergo a further interview by a movement disorder specialist to confirm the *** information was also ***:Nine PD patients(4.15%)showed ICD behaviors as follows:hypersexuality(4,1.84%),pathological gambling(3,1.38%),binge eating(1,0.46%),compulsive shopping(1,0.46%).Compared with the non-ICD PD group,ICD PD group took more dopamine agonists(LED 119.4±86.4 mg/d vs 60.5±80.5 mg/d,P=0.019),had higher total levodopa equivalent dosage(TLED 912.81±878.73 mg/d vs 503.78±359.14 mg/d,P=0.031),and had higher H&Y stage(2.33±0.87 vs 1.41±0.52,p=0.013).However,logistic regression analysis didn’t reveal the above factors as independent risk factors of ICD behaviors in our ***:The incidence of ICDs behaviors in PD patients in our study is much lower than in western ***-PD group took higher dopamine agonists and higher total levodopa equivalent dosage,even though logistic regression analysis didn’t reveal them as independent risk factors.

关键词： Parkinson’s disease ICD Dopamine replacement therapy

Global-in-Time L^(p)-L^(q) Estimates for Solutions of the Kramers-Fokker-Planck Equation

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Communications in Mathematical Research 2022年第4期38卷 560-578页

作者： xue ping wang Lu Zhu Laboratoire de Mathématiques Jean Leray UMR CNRS 6629Universitéde Nantes44322 Nantes Cedex 3France College of Science Hohai University210024 NanjingChina

In this work,we prove an optimal global-in-time L^(p)-L^(q) estimate for solutions to the Kramers-Fokker-Planck equation with short range potential in dimension *** result shows that the decay rate as t-→+∞ is the same as the heat equation in x-variables and the divergence rate as t→O_(+) is related to the sub-ellipticity with loss of one third derivatives of the Kramers-Fokker-Planck operator.

关键词： Global-in-time estimates nonselfadjoint operators kinetic equation Kramers-Fokker-Planck operator

Hyperpolarization activated cation current (If) in cardiac myocytes from pulmonary vein sleeves in the canine with atrial fibrillation

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Journal of Geriatric Cardiology 2012年第4期9卷 366��-374页

作者： Jia-Yue Li Hong-Juan wang Bin Xu xue-ping wang Yi-Cheng Fu Mei-Yan Chen De-Xian Zhang Yan Liu Qiao xue Yang Li Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective To investigate the characteristics of ectopic automaticity and cation current (If) of cardiac myocytes from pulmonary vein sleeves (PVs) in canines with atrial fibrillation. Methods The canines (8–10 years old) were subjected to long-term, rapid atrial pacing (RAP) for 10 weeks, which induced the atrial fibrillation model. Disassociation of PVs of canines yielded single cardiac myocytes from a Landengorff column. Action potential, If and hyperpolarisation activated cyclic nucleotide-gated (HCN) currents were measured with the patch-clamp technique. Results Compared with the control group, cardiac myocytes from the RAP canine PVs had spontaneous diastolic depolarization, shorter action potential duration, and larger If densities. In the group of RAP cells, the half maximal activation potential (V1/2) was found to be less negative (��105.5 ±5.2 mV) compared to control cells (��87.3 ±4.9 mV). Current densities of If were increased significantly by β-adrenergic receptor stimulation with isoproterenol and caused an acceleration of current activation. In contrast, If currents in the RAP were reduced by carvedilol, a selective beta-adrenergic receptor. Another important finding is that HCN4-based channels may make a significant contribution to If in PVs cells, but not HCN2. Meanwhile, HCN4 current significantly increases in canine PVs cardiac myocytes with RAP. Conclusions The spontaneous action potential and larger If currentwere observed in the PVs cardiac myocytes using RAP, whichmay contribute tomore ectopic activity events to trigger and maintain atrial fibrillation.

关键词： Atrial fibrillation Canine Cardiac myocytes Cation current β-receptor

Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction

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Journal of Geriatric Cardiology 2013年第1期10卷 39-51页

作者： Yun-Feng Lan Jian-Cheng Zhang Jin-Lao Gao xue-ping wang Zhou Fang Yi-Cheng Fu Mei-Yan Chen Min Lin Qiao xue Yang Li Institute of Geriatric Cardiology of Chinese PLA General Hospital 28 Fuxing Road 100853 Beijing China Provincial Clinical Medicine College of Fujian Medical University Fujian 350001 China

Objectives To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit *** Rabbitswith occlusion of the left anterior descending coronary arterywere prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation surgery of the left coronary artery, a polyethylene tube was placed near the left stellate ganglion in the subcutis of the neck for the purpose of administering NGF 400 U/d for eight weeks (HMI + NGF group). Cardiomyocytes were isolated from regions of the non-infarcted left ventricular wall and the action potentials and ion currents in these cellswere recorded using whole-cell patch clamps. Results Comparedwith HMI and control cardiomyocytes, significant prolongation of APD50 or APD90 (Action potential duration (APD) measured at 50% and 90% of repolarization) in HMI + NGF cardiomyocytes was found. The results showed that the 4-aminopyridine sensitive transient outward potassium current (Ito), the rapidly activated omponent of delayed rectifier potassium current (IKr), the slowly activated component of delayed rectifier potassium current (IKs), and the L-type calcium current (ICaL) were significantly altered in NGF + HMI cardiomyocytes compared with HMI and control cells. Conclusions Our results suggest thatNGF treatment significantly prolongsAPDinHMI cardiomyocytes and that a decrease in outward potassium currents and an increase of inward Ca2+ current are likely the underlying mechanism of action.

关键词： Action potential Cardiomyocytes Myocardial infarction Nervous growth factor

Recycling Strategy and Recyclability Assessment Model Based on the Artificial Neural Network

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厦门大学学报（自然科学版） 2002年第S1期41卷 153-154页

作者： LIU Zhi-feng, LIU xue-ping, wang Shu-wang, LIU Guang-fu (College of Mechanical & Auto Engineering, Hefei University of Techno logy, Hefei 230009, China)

Now, a rapidly growing concern for the environmental protection and resource utilization has stimulated many new activities in the in dustrialized world for coping with urgent environmental problems created by the steadily increasing consumption of industrial products. Increasingly stringent r egulations and widely expressed public concern for the environment highlight the importance of disposing solid waste generated from industrial and consumable pr oducts. How to efficiently recycle and tackle this problem has been a very impo rtant issue over the world. Designing products for recyclability is driven by environmental and economic goals. To obtain good recyclability, two measures can be adopted. One is better recycling strategy and technology; the other is design for recycling (DFR). The recycling strategies of products generally inclu de: reuse, service, remanufacturing, recycling of production scraps during the p roduct usage, recycle (separation first) and disposal. Recyclability assessment is a very important content in DFR. This paper first discusses the content of D FR and strategies and types related to products recyclability, and points out th at easy or difficult recyclability depends on the design phase. Then method and procedure of recyclability assessment based on ANN is explored in detail. The pr ocess consists of selection of the ANN input and output parameters, control of t he sample quality and construction and training of the neural network. At la st, the case study shows this method is simple and operative.

关键词： recycling strategy product recycling artificial neural network assessment model design for recycling

Observation on the Therapeutic Effect of Acupuncture for Treatment of Acute Waist Sprain

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Journal of Acupuncture and Tuina Science 2003年第2期1卷 56-57页

作者： ZOU Min ZHANG Ying-xue wang ping-xiang WU xue-fei Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China Department of New Medicine Pan County Hospital of TCM Guizhou 553500 China

To compare the clinical effect of needling the Ashi point (4 cm lateral to the lower border of the spinous process of cervical vertebra) plus Yaotongdian on the hand and point injection on the Ashi point with Triamoninde. The curative effect of acupuncture was better than that of point injection. Key Words Sprain, Acute - Psoas Muscles - Acupuncture Therapy Author: ZOU Min (1961-), female, junor consultant doctorTranslator: WU xue-fei

关键词： Sprain, Acute Psoas Muscles Acupuncture Therapy

Creep Behaviour of Wood Flour/Poly(vinyl chloride) Composites

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Journal of Wuhan University of Technology(Materials Science) 2009年第3期24卷 440-447页

作者：贾明印王克俭 Institute of Plastics Machinery and Engineering Beijing University of Chemical Technology

The experimental creep data were focused on wood-flour （WF）/poly vinyl chloride （PVC） composites with the variations in additive concentrations of wood flour, silane coupling agent, organomodified montmorillonite （OMMT） and nano-cacium carbonate （nano-CaCO3）. Their effects were analyzed using the Four-element Burger Model incorporating microscopic mechanisms. Total creep strain was low with increasing WF while elastic strain was high and plastic flow strain was low in modeling. Modification of WF with silane was beneficial to creep resistance, so did adding low ratio of OMMT （1.5 wt%） and nano-CaCO3 in composites. Thus, it was effective in reducing creep either by stiffening the PVC matrix using rigid nano-particles or by improving their adhesion with resin. However, superfluous quantity of any additament did not benefit the improvement owing to either earlier destruction of their agglomerates or stress-concentrated cracks in the over-incrassated interface.

关键词： composite creep wood flour poly (vinyl chloride) nano-particle

Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes

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World Journal of Gastroenterology 2001年第4期7卷 583-586页

作者： Hong-Chao Zhou De-Zhong Xu xue-ping wang Jing-Xia Zhang Ying-Huang Yong-ping Yan Yong Zhu Bo-Quan Jin Department of Epidemiology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Immunology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Department of Immunology the Fourth Military Medical University Xi'an 710033 Shaanxi Province China. juliu@***

AIM: To identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL). METHODS: Utilizing the method of computer prediction followed by a 4h(51)Cr release assay confirmation. RESULTS: The results showed that peripheral blood mononuclear cells (PBMC) obtained from two HLA-A2 positive donors who were infected with HCV could lyse autologous target cells labeled with peptide "ALAHGVRAL (core 150-158)". The rates of specific lysis of the cells from the two donors were 37.5% and 15.8%, respectively. Blocking of the CTL response with anti-CD4 mAb caused no significant decrease of the specific lysis. But blocking of CTL response with anti-CD8 mAb could abolish the lysis. CONCLUSION: The peptide (core 150-158) is the candidate epitope recognized by HLAA2 restricted CTL.

关键词： Amino Acid Sequence Antibodies, Viral B-Lymphocytes Cell Line Epitope Mapping HLA-A2 Antigen Hepacivirus Hepatitis C Humans Peptide Fragments Predictive Value of Tests Research Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic Viral Core Proteins

In-hospital medical complications associated with patient dependency after acute ischemic stroke： data from the China National Stroke Registry

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Chinese Medical Journal 2013年第7期126卷 1236-1241页

作者： wang Peng-lian ZHAO Xing-quan DU Wan-liang wang An-xin JI Rui-jun YANG Zhong-hua wang Chun-xue LIU Li-ping wang Yi-long JU Yi wang Yong-jun Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background The mortality of stroke patients is strongly affected by medical complications. However, there are limited data investigating the effect of in-hospital medical complications on the dependency of stroke patients worldwide. We prospectively and systematically investigated the effect of medical complications on dependency of patients at 3, 6 and 12 months after stroke using the China National Stroke Registry （CNSR）. Methods This prospective cohort study collected data of patients age 〉18 years with acute ischemic stroke in 132 clinical centers distributed across 32 provinces and four municipalities （including Hong Kong region） of China, from September 2007 to August 2008. Data on medical complications, dependency and other information were obtained from paper-based registry forms. Medical complications associated with stroke outcomes were assessed using multivariable Logistic regression. Results Of 11 560 patients with acute ischemic stroke, 1826 （15.80%） presented with in-hospital medical complications. In-hospital medical complications were independent risk factors for dependency of patients at 3 months （adjusted odds ratio （OR） 2.367, 95% confidence interval （CI） 2.021-2.771）, 6 months （adjusted OR 2.257, 95% CI 1.922-2.650）, and 12 months （adjusted OR 1.820, 95% CI 1.538-2.154） after acute ischemic stroke. Conclusion The results demonstrated that the short-term and long-term dependency of acute ischemic stroke patients is significantly associated with in-hospital medical complications in China.

关键词： disability ischemic stroke outcome medical complications