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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

同辈心理健康病耻感量表中文版测评中学生的效度与信度

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中国心理卫生杂志 2025年第1期39卷 63-67页

作者：彭彪韩雪王慧杨棋凯罗杰长沙民政职业技术学院马克思主义学院长沙410004 贵州医科大学马克思主义学院贵阳550025 贵州师范大学附属中学贵阳550001 清镇市广大实验学校贵阳551499 岳阳市康复医院精神科湖南岳阳414022 贵州师范大学心理学院贵阳550025

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其... 详细信息

目的:检验同辈心理健康病耻感量表(PMHSS-R)中文版在中学生中的效度与信度。方法:选取1 099名中学生,随机分为样本1 (n=549)和样本2(n=550),分别进行探索性因子分析和验证性因子分析;总样本(n=1 099)用于考察内部一致性信度,2周后选取其中87名中学生进行重测;另外选取259名中学生(样本3),采用抑郁症病耻感量表(DSS)、专业心理支持求助态度量表简版(ATSPPHSF)进行效标效度检验。结果:探索性因子分析共提取出2个公因子,命名为病耻感意识、病耻感认同,累计方差贡献率为66.86%;验证性因子分析表明2因子模型拟合指数较好(χ~2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07);PMHSS-R中文版得分与DSS得分正相关(ICC=0.58,P<0.01),与ATSPPH-SF得分负相关(ICC=-0.40,P<0.01);总量表及2个因子的Cronbachα系数分别为0.90、0.92和0.85,重测信度(ICC)分别为0.84、0.76和0.78。结论:同辈心理健康病耻感量表(PMHSS-R)中文版评估中学生的心理健康病耻感具有良好效度与信度。

关键词：心理健康病耻感效度信度中学生

Estimation of buoy drifting based on adaptive parameter-varying time scale Kalman filter

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Journal of Control and Decision 2021年第3期8卷 353-362页

作者： han xue Tian Chai School of Navigation Jimei UniversityXiamenPeople’s Republic of China National and local joint engineering research center of ship aided navigation technology Jimei UniversityXiamenPeople’s Republic of China Fujian Shipping Research Institute Jimei UniversityXiamenPeople’s Republic of China Xiamen southeast International Shipping Research Center Jimei UniversityXiamenPeople’s Republic of China

To solve Kalman filter with dynamic time scale problem,an adaptive parameter-varying time scale kalman filter(APVTS-KF)is *** adaptive mechanism for choosing the covariance of state noise is ***-KF is used to estimate the buoy drifting trajectory with different report *** drifting data of four buoys are used to test the proposed *** influence of report interval,drifting distance,adaptive factor and noise covariance are analysed and *** experimental results and error analysis show that APVTS-KF is better than other algorithms in trajectory ***,Kalman filtering can be used for accurate trajectory estimation in the actual situation of buoy drifting with dynamic time intervals.

关键词： Kalman filter buoy drift state estimation

Effect of reduction pretreatments on PdAg/Al_(2)O_(3) for HCHO and CO oxidation

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Journal of Environmental Sciences 2023年第2期124卷 371-378页

作者： Liwei Meng xue han Lian Yu Yafei Wang Beijing Institute of Petrochemical Technology Beijing 102617China General Research Institute for Non-Ferrous Metals Beijing 100088China

PdAg/Al_(2)O_(3) were pretreated by CO and H2 reduction pretreatments,*** reduced catalysts were tested for HCHO and CO oxidation and characterized by Brunner Emmet Teller(BET),X-ray diffraction(XRD),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS)and oxygen temperature programmed desorption(O_(2)-TPD).These results indicate that the pretreatments have effect on PdAg reconstruction,PdAg particle size and active oxygen species,which are responsible for the catalytic *** with H2 reduction method,CO reduction is more suitable for PdAg/Al_(2)O_(3) ***/Al_(2)O_(3)-CO exhibited better catalytic performance.

关键词： PdAg Reduction method Catalytic oxidation CO

Seismic behavior of steel tubular bridge columns equipped with low-yield-point steel plates in the root replaceable pier

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 527-548页

作者： Li Haifeng Jiang Kaiping Chen Yisu han xue College of Civil Engineering Huaqiao UniversityXiamen 361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province(Huaqiao University) Xiamen 361021China The University of New South Wales SydneyNSW 2052Australia Xiamen Institute of Technology Xiamen 361021China

To enable rapid recovery of a steel bridge column after an earthquake,a novel tubular-section steel bridge column equipped with low-yield-point(LYP)steel tubular plates in the root replaceable pier is *** the purpose of discussing the seismic behavior of the novel steel bridge column,quasi-static tests and finite element simulation analyses of the specimens were carried *** effects of parameters such as the axial compression ratio,eccentricity,and thickness and material strength of the tubular plate in the energy-dissipating zone are *** results from seven specimens that were subjected to four failure modes are *** damage to the quasi-static specimens is localized to the replaceable energy-dissipating *** seismic behavior of the novel steel bridge columns is significantly influenced by the axial compression ratio and eccentricity of *** results show that the high stress area of the specimens is mainly concentrated in the connection zone between the LYP steel tubular plate and the bottom steel plate,which is consistent with the position of the quasi-static specimen when it was prone to ***,a calculation formula is proposed to facilitate the capacity prediction of this new steel tubular bridge column under repeated loading.

关键词： earthquake-resilient steel tubular bridge column low-yield-point steel seismic performance quasi-static test

Low CO content hydrogen production from oxidative steam reforming of ethanol over CuO-CeO_2 catalysts at low-temperature

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Journal of Energy Chemistry 2013年第6期22卷 861-868页

作者： xue han Yunbo Yu Hong He Jiaojiao Zhao Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

CuO-CeO2 catalysts were prepared by a urea precipitation method for the oxidative steam reforming of ethanol at *** catalytic performance was evaluated and the catalysts were characterized by inductively coupled plasma atomic emission spectroscopy,X-ray diffraction,temperature-programmed reduction,field emission scanning electron microscopy and thermo-gravimetric *** CuOCeO2 catalysts,H2 with low CO content was produced in the whole tested temperature range of 250–450 *** non-noble metal catalyst 20CuCe showed higher H2production rate than 1%Rh/CeO2 catalyst at 300–400 C and the advantage was more obvious after 20 h testing at400 *** results further confirmed that CuO-CeO2 catalysts may be suitable candidates for low temperature hydrogen production from ethanol.

关键词： CuO-CeO2 catalyst hydrogen production oxidative steam reforming low-temperature

Topic hierarchy construction from heterogeneous evidence

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Frontiers of Computer Science 2016年第1期10卷 136-146页

作者： han xue Bing QIN Ting LIU Shen LIU School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Harbin Engineering University Library Harbin Engineering University Harbin 150001 China

Existing studies on hierarchy construction mainly focus on text corpora and indiscriminately mix numerous top- ics, thus increasing the possibility of knowledge acquisition bottlenecks and misconceptions. To address these problems and provide a comprehensive and in-depth representation of domain specific topics, we propose a novel topic hierar- chy construction method with real-time update. This method combines heterogeneous evidence from multiple sources in- cluding folksonomy and encyclopedia, separately in both ini- tial topic hierarchy construction and topic hierarchy improve- ment. Results of comprehensive experiments indicate that the proposed method significantly outperforms state-of-the- art methods （t-test, p-value 〈 0.000 1）; recall has particularly improved by 20.4% to 38.7%.

关键词： hierarchy construction Chinese topic hierarchy,folksonomy heterogeneous evidence hierarchy update

Performance evaluation and optimization design of photoelectric pyrometer detection optical system

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Defence Technology（防务技术） 2020年第2期16卷 401-407页

作者： xue-yan han Ke-wei Huan Shan-ju Sheng School of Science Changchun University of Science and TechnologyChangchun 130022China

The measurement and control of high temperature play very important roles in national defense,military,scientific experiments,industrial and agricultural *** pyrometer is one of the important radiation thermometers for non-contact temperature *** has an important application in the field of high temperature measurement,and its performance directly affects the accuracy of temperature *** improving the design of the detection optical system of the photoelectric pyrometer,the imaging performance of the photoelectric pyrometer can be improved effectively,and the temperature measurement accuracy can be *** this paper,the temperature measurement principle of photoelectric pyrometer,the wo rking principle of the detection optical system and the composition of the system are *** optical components that affect the imaging of the optical system of the photoelectric pyrometer are *** optical pyrometer detection optical system is simulated by ZEMAX software,based on the analysis results,the Modulation Transfer Function(MTF)and the spot Diagram are used as the main evaluation criteria to optimize the design of the objective lens of the photoelectric pyrometer detection optical *** imaging performance of the photoelectric pyrometer detection optical system and the accuracy of temperature measurement of the photoelectric pyrometer are improved by optimization design of the detection optical system.

关键词： Photoelectric pyrometer Detection optical system ZEMAX MTF Spot diagram

Novel triple therapy for hemorrhagic ascites caused by endometriosis:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6206-6212页

作者： xue han Shi-Tai Zhang Gynecology Department Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Massive hemorrhagic ascites caused by endometriosis is exceedingly rare,and the treatment strategy remains ***,we report a case of endometriosis with massive hemorrhagic ascites treated with a novel triple therapy including conservative surgery,gonadotropin-releasing hormone agonist,and then *** SUMMARY A 28-year-old nulliparous patient was admitted to Shengjing Hospital of China Medical University,and exploratory laparoscopy was performed.A total of 9500 mL of brown ascites was aspirated from the pelvic cavity,the bilateral ovaries strongly adhered to the posterior of the uterus and were fixed to the pelvic floor,and endometriotic cysts were not observed in either *** pelvic and abdominal peritonea were covered with patchy red,white,and brown endometriotic lesions and *** surgical resection of endometriotic lesions on the peritoneum was performed while we simultaneously collected multiple peritoneal *** final pathological diagnosis was endometriosis coupled with hemorrhagic necrotic *** Postoperative injection of gonadotropin-releasing hormone agonist was provided three times,followed by dienogest administration,and we will continue to follow up with this ongoing treatment.

关键词： Endometriosis Hemorrhagic ascites Novel triple therapy Dienogest Recurrence Case report