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Advancements in life-on-a-chip: The impact of “Beyond limits Manufacturing” technology

Chinese Chemical Letters 2024年第5期35卷 13-16页

作者： Weiwei He Hongbo Zhang xudong lin lili Zhu Tingting Zheng Hao Pei Yang Tian Min Zhang Guoyue Shi Lei Wu Jianlong Zhao Gulinuer Wumaier Shengqing li Yufang Xu Honglin li Xuhong Qian Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Department of Pulmonary and Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China lingang Laboratory Shanghai 200031China

This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic chips.These chips consist of intricately etched channels,wells,and chambers that enable precise control and observation of fluids,cells,and biochemical reactions,facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli,drugs,or disease conditions.The review highlights the application of a novel technology,“Beyond limit Manufacturing”(BLM),in the development of sophisticated three-dimensional cell models and model organism microchips.Modelorganism-on-a-chip and organ-on-a-chip(OoC)are among the thriving developments in the field of microfluidics,allowing for the reconstruction of living microenvironments and implementation of multiple stimuli.The review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions,emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

关键词： Beyond limit Manufacturing Model-organism-on-a-chip Organ-on-a-chip

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Design of high-temperature superconductors at moderate pressures by alloying AlH3 or GaH3

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Matter and Radiation at Extremes 2024年第1期9卷 94-103页

作者： Xiaowei liang xudong Wei Eva Zurek Aitor Bergara Peifang li Guoying Gao Yongjun Tian Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry State University of New York at BuffaloBuffaloNew York 14260-3000USA Physics Department and EHU Quantum Center University of the Basque CountryUPV/EHU48080 BilbaoSpain Donostia International Physics Center(DIPC) 20018 DonostiaSpain Centro de Física de Materiales CFM Centro Mixto CSIC-UPV/EHU20018 DonostiaSpain Extreme Conditions Physics Research Team College of Physics and Electronic InformationInner Mongolia Minzu UniversityTongliao 028043China

Since the discovery of hydride superconductors,a significant challenge has been to reduce the pressure required for their stabilization.In this context,we propose that alloying could be an effective strategy to achieve this.We focus on a series of alloyed hydrides with the AMH_(6)composition,which can be made via alloying A15 AH_(3)(A=Al or Ga)with M(M=a group IIIB or IVB metal),and study their behavior under pressure.Seven of them are predicted to maintain the A15-type structure,similar to AH_(3)under pressure,providing a platform for studying the effects of alloying on the stability and superconductivity of AH_(3).Among these,the A15-type phases of AlZrH_(6)and AlHfH_(6)are found to be thermodynamically stable in the pressure ranges of 40–150 and 30–181 GPa,respectively.Furthermore,they remain dynamically stable at even lower pressures,as low as 13 GPa for AlZrH_(6)and 6 GPa for AlHfH_(6).These pressures are significantly lower than that required for stabilizing A15 AlH3.Additionally,the introduction of Zr or Hf increases the electronic density of states at the Fermi level compared with AlH3.This enhancement leads to higher critical temperatures(Tc)of 75 and 76 K for AlZrH_(6)and AlHfH_(6)at 20 and 10 GPa,respectively.In the case of GaMH_(6)alloys,where M represents Sc,Ti,Zr,or Hf,these metals reinforce the stability of the A15-type structure and reduce the lowest thermodynamically stable pressure for GaH_(3) from 160 GPa to 116,95,80,and 85 GPa,respectively.Particularly noteworthy are the A15-type GaMH_(6)alloys,which remain dynamically stable at low pressures of 97,28,5,and 6 GPa,simultaneously exhibiting high Tc of 88,39,70,and 49 K at 100,35,10,and 10 GPa,respectively.Overall,these findings enrich the family of A15-type superconductors and provide insights for the future exploration of high-temperature hydride superconductors that can be stabilized at lower pressures.

关键词： alloying alloys superconductors

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Unidirectional movement behavior of underwater bubbles on the wettability gradient mesh via asymmetrical bounce

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Science China Chemistry 2024年第8期 2606-2613页

作者： Yuzhen Ning Zhihong Zhao Shuang Ben Qiang li Cunming Yu xudong Zhang Huawei Chen Kesong liu Lei Jiang School of Mechanical Engineering and Automation Beihang University Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of Chemistry Beihang University Research Institute of Aero-Engine Beihang University School of Materials Science and Engineering Shenyang Ligong University Tianmushan Laboratory The Analysis & Testing Center Beihang University

The impact of underwater bubbles on solid surfaces with a gradient wettability is important for fundamental science and technological applications. Despite progress in the translational motion of underwater bubbles on asymmetric surface, a fundamental dynamic understanding of asymmetrical bounce behavior of the underwater bubble needs to be further improved.Herein, we investigate asymmetrical bounce of underwater bubbles after impacting the wettability gradient copper mesh surface.Asymmetrical bounce of the underwater bubble on the wettability gradient mesh(WGM) surface is composed by asymmetrical spread in the spread process and asymmetrical recoil in the recoil process, which induce the unidirectional movement behavior.Additionally, effective bubble-size manipulation can be easily implemented due to different volumes of bubbles remaining at different locations of WGM surface. We envision that this work will provide a new understanding of asymmetrical bounce behavior of the underwater bubble on the wettability gradient surface, and propose a novel and feasible strategy for constructing the underwater bubble manipulation system.

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Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action(EQIA)study:a national cohort study in China from 2017 to 2019

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Frontiers of Medicine 2024年第2期18卷 315-326页

作者： Wei Cheng Jieqing Chen xudong Ma Jialu Sun Sifa Gao Ye Wang Longxiang Su Lu Wang Wei Du Huaiwu He Yujie Chen Zunzhu li Qi li Jianhua Sun Hongbo Luo Jinbang liu Guangliang Shan Bing Du Yanhong Guo Dawei liu Chang Yin Xiang Zhou on behalf of the China National Critical Care Quality Control Center-the ECMO quality improvement action(EQIA)study Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China Information Center Department/Department of Information Management State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing100730China Department of Medical Administration National Health Commission of the People’s Republic of ChinaBeijing100044China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Epidemiology and Biostatistics Institute of Basic Medicine SciencesChinese Academy of Medical Sciences(CAMS)&School of Basic MedicinePeking Union Medical CollegeBeijing100730China National Institute of Hospital Administration National Health Commission of the People’s Republic of ChinaBeijing100044China 不详

This cohort study was performed to explore the influence of intensive care unit(ICU)quality on in-hospital mortality of veno-venous(V-V)extracorporeal membrane oxygenation(ECMO)-supported patients in China.The study involved all V-V ECMO-supported patients in 318 of 1700 tertiary hospitals from 2017 to 2019,using data from the National Clinical Improvement System and China National Critical Care Quality Control Center.ICU quality was assessed by quality control indicators and capacity parameters.Among the 2563 V-V ECMO-supported patients in 318 hospitals,a significant correlation was found between ECMO-related complications and prognosis.The reintubation rate within 48 hours after extubation and the total ICU mortality rate were independent risk factors for higher in-hospital mortality of V-V ECMO-supported patients(cutoff:1.5%and 7.0%;95%confidence interval:1.05–1.48 and 1.04–1.45;odds ratios:1.25 and 1.23;P=0.012 and P=0.015,respectively).Meanwhile,the V-V ECMO center volume was a protective factor(cutoff of≥50 cases within the 3-year study period;95%confidence interval:0.57–0.83,odds ratio:0.69,P=0.0001).The subgroup analysis of 864 patients in 11 high-volume centers further strengthened these findings.Thus,ICU quality may play an important role in improving the prognosis of V-V ECMO-supported patients.

关键词： veno-venous extracorporeal membrane oxygenation in-hospital mortality high-volume centers quality control intensive care unit capacity parameters

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改进YOLOv7的小目标检测算法研究

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计算机工程与应用 2024年第1期60卷 122-134页

作者：李安达吴瑞明李旭东浙江科技学院浙江省食品物流装备技术研究重点实验室杭州310023

随着深度学习在国内目标检测的不断应用,常规的大、中目标检测已经取得惊人的进步,但由于卷积网络本身的局限性,针对小目标检测依然会出现漏检、误检的问题,以数据集Visdrone2019和数据集FloW-Img为例,对YOLOv7模型进行研究,在网络结构... 详细信息

随着深度学习在国内目标检测的不断应用,常规的大、中目标检测已经取得惊人的进步,但由于卷积网络本身的局限性,针对小目标检测依然会出现漏检、误检的问题,以数据集Visdrone2019和数据集FloW-Img为例,对YOLOv7模型进行研究,在网络结构上对骨干网的ELAN模块进行改进,将Focal NeXt block加入到ELAN模块的长短梯度路径中融合来强化输出小目标的特征质量和提高输出特征包含的上下文信息含量,在头部网络引入RepLKDeXt模块,该模块不仅可以取代SPPCSPC模块来简化模型整体结构还可以利用多通道、大卷积核和Cat操作来优化ELAN-H结构,最后引入SIOU损失函数取代CIOU函数以此提高该模型的鲁棒性。结果表明改进后的YOLOv7模型参数量减少计算复杂性降低并在小目标密度高的Visdrone 2019数据集上的检测性能近似不变,在小目标稀疏的FloW-Img数据集上涨幅9.05个百分点,进一步简化了模型并增加了模型的适用范围。

关键词： YOLOv7模型小目标检测大卷积核损失函数

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巨大芽孢杆菌在赤泥脱碱中的应用及作用机制

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中国有色金属学报 2024年第3期34卷 947-958页

作者：王林李望朱晓波燕旭东河南理工大学化学化工学院焦作454000

赤泥是氧化铝生产过程中产生的工业废渣,其强碱性使得赤泥存在环境污染风险高、资源化利用困难等问题。因此,急需寻求赤泥脱碱的有效方法和新途径。微生物脱碱法因其经济有效、无二次污染的特点而备受关注。本文利用巨大芽孢杆菌菌液对... 详细信息

赤泥是氧化铝生产过程中产生的工业废渣,其强碱性使得赤泥存在环境污染风险高、资源化利用困难等问题。因此,急需寻求赤泥脱碱的有效方法和新途径。微生物脱碱法因其经济有效、无二次污染的特点而备受关注。本文利用巨大芽孢杆菌菌液对赤泥脱碱,通过高效液相色谱(HPLC)、XRD、SEM-EDS和FT-IR分别对细菌代谢产物、脱碱前后矿物的物相组成、微观形貌和官能团结构进行分析,研究了巨大芽孢杆菌对赤泥脱碱的作用机制。结果表明:在菌量为5.67×10^(13)CFU/mL、液固比为25(mL/g)和温度为35℃的条件下可将脱碱样品的pH值降低至8.55,10 d的单次脱碱率达到30.4%,比无菌添加时的pH值降低了1.48,脱碱率提高22.6%;脱碱后赤泥中方钠石、钙霞石等碱性矿物的衍射峰强度减弱,方解石的衍射峰强度增强,赤泥表面有菌株附着,并出现明显的溶蚀形貌,一些碱性矿物的铝硅酸盐结构被溶解;巨大芽孢杆菌主要利用代谢产生的两种含量较高的有机酸(苹果酸和丙酸)与赤泥中的碱性物质发生酸碱中和,实现对赤泥的脱碱。

关键词：赤泥脱碱巨大芽孢杆菌有机酸作用机制

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Human gut microbiota： the links with dementia development

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Protein & Cell 2017年第2期8卷 90-102页

作者： Rashad Alkasir Jing li xudong li Miao Jin Baoli Zhu Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China China-Japan Friendship Hospital Beijing 100029 China Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases The First Attainted Hospital College of Medicine Zhejiang University Hangzhou 310058 China

痴呆是是足够很好的影响工作的一份人日报的大脑疾病的一个全面范畴。痴呆的最普通的类型是 Alzheimers 疾病，它做大多数盒子。新研究显示胃肠的道 microbiota 直接通过触发新陈代谢的疾病和低档发炎进步被连接到痴呆致病。新奇策略通... 详细信息

痴呆是是足够很好的影响工作的一份人日报的大脑疾病的一个全面范畴。痴呆的最普通的类型是 Alzheimers 疾病，它做大多数盒子。新研究显示胃肠的道 microbiota 直接通过触发新陈代谢的疾病和低档发炎进步被连接到痴呆致病。新奇策略通过 ? microbiota 的调整为痴呆和另外的相关疾病的精神病学的治疗为这些混乱并且作为一个助手的管理被建议 ?( 例如与 probiotics 的使用) 。

关键词：胃肠道菌群痴呆症阿尔茨海默氏症人类脑部疾病代谢性疾病发病机制相关疾病

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Epidemiological Characteristics of Osteoarthritis in Yichang City—Hubei Province,China,2017–2018

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China CDC weekly 2021年第16期3卷 335-339页

作者： Yingying Zhang Jiajuan Yang Tanchun Yu li Ma Yuewei Cheng xudong li Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina Yichang Center for Disease Control and Prevention YichangHubeiChina Zhongguancun Institute of National Health Big Data BeijingChina Shandong Provincial Armed Police Corps Hospital JinanShandongChina.

Summary What is already known about this topic?OA has been listed as the fastest increasing major public health problem and ranked second as a cause of disability by World Health Organization(WHO).With population aging,osteoarthritis(OA)is causing an increased economic burden for individuals and society and is attracting an increasing amount of scientific attention.

关键词： ranked attracting listed

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A bioinspired bubble removal method in microchannels based on angiosperm xylem embolism repair

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Microsystems & Nanoengineering 2022年第2期8卷 237-247页

作者： lihua Guo Yuanchang liu Penghui Ran Gang Wang Jie Shan xudong li Chong liu Jingmin li Key Laboratory for Micro/Nano Technology and System of liaoning Province Dalian University of TechnologyDalianChina Department of Mechanical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUK

It is difficult to remove and eliminate bubbles in microchannels in many devices used in various biomedical fields,such as those needed for microfluidic immunoassays,point-of-care testing,and cell biology evaluations.Accumulated bubbles are associated with a number of negative outcomes,including a decrease in device sensitivity,inaccuracy of analysis results,and even functional failure.Xylem conduits of angiosperm have the ability to remove bubbles in obstructed conduits.Inspired by such an embolism repair mechanism,this paper proposes a bioinspired bubble removal method,which exhibits a prominent ability to dissolve bubbles continuously within a large range of flow rates(2μL/min-850 plVmin)while retaining the stability and continuity of the flow without auxiliary equipment.Such a method also shows significant bubble removal stability in dealing with Newtonian liquids and non-Newtonian fluids,especially with high viscosity(6.76 Pa s)and low velocity(152 nL/min).Such advantages associated with the proposed bioinspired method reveal promising application prospects in macro/microfluidic fields ranging from 3D printing,implantable devices,virus detection,and biomedical fluid processing to microscale reactor operation and beyond.

关键词： bubble remove method

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何谓与何为:体育共同富裕的四重逻辑

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上海体育大学学报 2024年第7期48卷 86-96页

作者：李桂花李旭东吉林大学马克思主义学院吉林长春130012

体育共同富裕是中国式现代化两个内在要求在新发展阶段上套嵌生成的实践型概念,从多维度理顺和建构其内在逻辑是把握其生成规律、引导其发展趋向的基础。从概念逻辑看,对体育共同富裕概念进行合取式阐释和析取式阐释较为单薄,关系式阐... 详细信息

体育共同富裕是中国式现代化两个内在要求在新发展阶段上套嵌生成的实践型概念,从多维度理顺和建构其内在逻辑是把握其生成规律、引导其发展趋向的基础。从概念逻辑看,对体育共同富裕概念进行合取式阐释和析取式阐释较为单薄,关系式阐释能够辩证地对其进行科学界定;从理论逻辑看,体育共同富裕是历史唯物主义在中国特色社会主义历史空间的特殊展开,批判资本逻辑宰制下的“体育异化”与“两极分化”,以“劳动”为核心范畴在体育与富裕的主客体关系中构建理论框架,并在当代得到理论发展;从实践逻辑看,只有坚持党的领导、完善体育基本公共服务、盘活体育资产并公平分配其价值,方能实现共同富裕,促进体育的“本质复归”;从价值逻辑看,体育共同富裕使体育正义的分配面向更加彰显,是人类文明新形态的生动注脚,也是“两个和解”解放理想的现实开端。

关键词：体育共同富裕体育资产体育正义自由劳动中国式现代化

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